Incidental Mutation 'R7406:Tnfrsf22'
ID 574741
Institutional Source Beutler Lab
Gene Symbol Tnfrsf22
Ensembl Gene ENSMUSG00000010751
Gene Name tumor necrosis factor receptor superfamily, member 22
Synonyms Tnfrh2, mDcTrailr2, 2810028K06Rik, SOBa, C130035G06Rik
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.059) question?
Stock # R7406 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 143634806-143649661 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to C at 143640827 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 121 (D121G)
Ref Sequence ENSEMBL: ENSMUSP00000075018 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000075588] [ENSMUST00000084396] [ENSMUST00000146692] [ENSMUST00000171066]
AlphaFold Q9ER62
Predicted Effect probably damaging
Transcript: ENSMUST00000075588
AA Change: D121G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000075018
Gene: ENSMUSG00000010751
AA Change: D121G

DomainStartEndE-ValueType
transmembrane domain 15 34 N/A INTRINSIC
TNFR 48 82 9.53e-2 SMART
TNFR 85 124 3.31e-10 SMART
TNFR 126 165 6.48e-4 SMART
transmembrane domain 177 196 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000084396
AA Change: D121G

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000081432
Gene: ENSMUSG00000010751
AA Change: D121G

DomainStartEndE-ValueType
transmembrane domain 15 34 N/A INTRINSIC
TNFR 48 82 9.53e-2 SMART
TNFR 85 124 3.31e-10 SMART
TNFR 126 165 6.48e-4 SMART
low complexity region 166 177 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000146692
AA Change: D121G

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000119297
Gene: ENSMUSG00000010751
AA Change: D121G

DomainStartEndE-ValueType
transmembrane domain 15 34 N/A INTRINSIC
TNFR 48 82 9.53e-2 SMART
TNFR 85 124 3.31e-10 SMART
TNFR 126 165 6.48e-4 SMART
low complexity region 166 177 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000171066
SMART Domains Protein: ENSMUSP00000126384
Gene: ENSMUSG00000010751

DomainStartEndE-ValueType
Pfam:RNase_H 1 93 4e-6 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency 98% (60/61)
Allele List at MGI
Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2810459M11Rik T C 1: 86,046,509 S183P possibly damaging Het
2900092C05Rik A G 7: 12,515,464 T75A possibly damaging Het
Abhd8 A G 8: 71,461,762 V74A probably benign Het
Agrn A C 4: 156,172,301 S1282R possibly damaging Het
Atf5 T C 7: 44,812,956 N248S possibly damaging Het
Atp2a3 A G 11: 72,978,750 Y497C probably damaging Het
BC053393 A G 11: 46,577,458 T120A possibly damaging Het
Bpifa2 T G 2: 154,009,819 S58R probably benign Het
Cacna1h C T 17: 25,385,626 E1238K possibly damaging Het
Ccdc71 T A 9: 108,463,324 L112* probably null Het
Cd300e A T 11: 115,055,302 I111N probably damaging Het
Cdkl3 A T 11: 52,033,542 E552D probably benign Het
Chst5 A G 8: 111,890,613 V125A probably benign Het
Clock A T 5: 76,266,845 M1K probably null Het
Cops7b T A 1: 86,601,130 L193Q probably benign Het
Csmd1 T C 8: 16,288,693 T467A probably damaging Het
Ctr9 A G 7: 111,053,408 E971G unknown Het
Dcp2 A G 18: 44,410,187 T271A probably benign Het
Dsp A G 13: 38,197,196 N2639S possibly damaging Het
Fam160a1 T C 3: 85,730,477 I172V probably benign Het
Gm11168 C G 9: 3,006,912 C212W probably benign Het
Gpr179 G T 11: 97,351,594 D141E probably damaging Het
Hdhd2 C T 18: 76,944,115 T89M probably benign Het
Hist1h2bc A G 13: 23,684,359 Y43C probably damaging Het
Krt6b T G 15: 101,679,078 T194P probably benign Het
Lrp1b T C 2: 41,376,018 probably null Het
Maneal A T 4: 124,860,368 I214N possibly damaging Het
Map1lc3b T A 8: 121,590,616 C11S unknown Het
Mapt G A 11: 104,322,524 G296E possibly damaging Het
Mettl7a3 T C 15: 100,335,408 V160A probably benign Het
Mgam A G 6: 40,663,525 N509S probably benign Het
Mrgprx1 T A 7: 48,021,985 I5F possibly damaging Het
Mroh5 T C 15: 73,787,734 D416G probably benign Het
Ncan T G 8: 70,110,099 D503A probably benign Het
Nedd1 A T 10: 92,711,323 probably null Het
Ogdh A G 11: 6,348,351 T641A probably benign Het
Olfr11 T C 13: 21,639,146 I126V probably benign Het
Olfr730 T A 14: 50,186,558 I221F probably damaging Het
Olfr818 A T 10: 129,945,566 D50E probably benign Het
Olfr904 T A 9: 38,464,143 M34K possibly damaging Het
Pcdhga8 A C 18: 37,726,185 Q98P possibly damaging Het
Pik3c2a A G 7: 116,354,007 Y1218H probably damaging Het
Ppp3cc A T 14: 70,245,938 S229T possibly damaging Het
Prss43 T G 9: 110,828,696 I221S probably damaging Het
Rasal1 A T 5: 120,662,937 T221S probably benign Het
Serpinb9f G T 13: 33,334,560 E348* probably null Het
Sfxn5 A G 6: 85,267,907 Y169H probably damaging Het
Skint9 T C 4: 112,389,231 N228S probably benign Het
Slx4ip A T 2: 137,000,242 D29V probably damaging Het
Snx29 G T 16: 11,755,316 G474V probably damaging Het
Spata6 T A 4: 111,780,820 D282E possibly damaging Het
Srek1 A T 13: 103,769,382 V77E probably damaging Het
Ucma G A 2: 4,985,359 W122* probably null Het
Vmn2r124 T C 17: 18,062,044 M113T unknown Het
Vmn2r54 A T 7: 12,616,223 probably null Het
Vmn2r8 A G 5: 108,800,576 L482S probably benign Het
Vwa3a T A 7: 120,778,915 I476N probably damaging Het
Vwa8 A C 14: 78,982,234 probably null Het
Wdr26 A T 1: 181,187,675 S390R probably damaging Het
Zbtb40 A T 4: 137,000,894 S471T probably benign Het
Other mutations in Tnfrsf22
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01323:Tnfrsf22 APN 7 143643374 missense probably damaging 1.00
IGL01959:Tnfrsf22 APN 7 143643275 critical splice donor site probably null
IGL02395:Tnfrsf22 APN 7 143643316 missense probably damaging 1.00
IGL02608:Tnfrsf22 APN 7 143644796 nonsense probably null
IGL03054:Tnfrsf22 UTSW 7 143640795 missense probably damaging 1.00
R1987:Tnfrsf22 UTSW 7 143638389 unclassified probably benign
R2228:Tnfrsf22 UTSW 7 143644776 splice site probably null
R2229:Tnfrsf22 UTSW 7 143644776 splice site probably null
R4562:Tnfrsf22 UTSW 7 143649576 missense unknown
R4829:Tnfrsf22 UTSW 7 143643330 missense possibly damaging 0.91
R6486:Tnfrsf22 UTSW 7 143640756 missense possibly damaging 0.93
R6903:Tnfrsf22 UTSW 7 143639904 unclassified probably benign
R7146:Tnfrsf22 UTSW 7 143640819 missense probably damaging 1.00
R8108:Tnfrsf22 UTSW 7 143638373 missense unknown
R8969:Tnfrsf22 UTSW 7 143638436 missense unknown
R9613:Tnfrsf22 UTSW 7 143644846 missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- CCAGCAAGAAGTCCTGTACC -3'
(R):5'- GCACTCCGTACATCTGTGATGG -3'

Sequencing Primer
(F):5'- CAATGTCATCTGCCAAAGTATGAGAC -3'
(R):5'- ACTCCGTACATCTGTGATGGGAATG -3'
Posted On 2019-10-07