Mutagenetix > Incidental Mutation

Incidental Mutation 'R7406:Olfr904'

574747

Institutional Source

Beutler Lab

Gene Symbol

Olfr904

Ensembl Gene

ENSMUSG00000094380

Gene Name

olfactory receptor 904

Synonyms

GA_x6K02T2PVTD-32156773-32157705, MOR167-3

MMRRC Submission

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.077) question?

Stock #

R7406 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

38463144-38468995 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 38464143 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Lysine at position 34 (M34K)

Ref Sequence

ENSEMBL: ENSMUSP00000150057 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000058153] [ENSMUST00000216724]

AlphaFold

Q7TRC9

Predicted Effect

possibly damaging
Transcript: ENSMUST00000058153
AA Change: M34K

PolyPhen 2 Score 0.885 (Sensitivity: 0.82; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000057148
Gene: ENSMUSG00000094380
AA Change: M34K

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	308	5.7e-51	PFAM
Pfam:7tm_1	41	291	1.5e-23	PFAM

Predicted Effect

possibly damaging
Transcript: ENSMUST00000216724
AA Change: M34K

PolyPhen 2 Score 0.885 (Sensitivity: 0.82; Specificity: 0.94)

Meta Mutation Damage Score

0.1795

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 99.0%

Validation Efficiency

98% (60/61)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 60 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2810459M11Rik	T	C	1: 86,046,509	S183P	possibly damaging	Het
2900092C05Rik	A	G	7: 12,515,464	T75A	possibly damaging	Het
Abhd8	A	G	8: 71,461,762	V74A	probably benign	Het
Agrn	A	C	4: 156,172,301	S1282R	possibly damaging	Het
Atf5	T	C	7: 44,812,956	N248S	possibly damaging	Het
Atp2a3	A	G	11: 72,978,750	Y497C	probably damaging	Het
BC053393	A	G	11: 46,577,458	T120A	possibly damaging	Het
Bpifa2	T	G	2: 154,009,819	S58R	probably benign	Het
Cacna1h	C	T	17: 25,385,626	E1238K	possibly damaging	Het
Ccdc71	T	A	9: 108,463,324	L112*	probably null	Het
Cd300e	A	T	11: 115,055,302	I111N	probably damaging	Het
Cdkl3	A	T	11: 52,033,542	E552D	probably benign	Het
Chst5	A	G	8: 111,890,613	V125A	probably benign	Het
Clock	A	T	5: 76,266,845	M1K	probably null	Het
Cops7b	T	A	1: 86,601,130	L193Q	probably benign	Het
Csmd1	T	C	8: 16,288,693	T467A	probably damaging	Het
Ctr9	A	G	7: 111,053,408	E971G	unknown	Het
Dcp2	A	G	18: 44,410,187	T271A	probably benign	Het
Dsp	A	G	13: 38,197,196	N2639S	possibly damaging	Het
Fam160a1	T	C	3: 85,730,477	I172V	probably benign	Het
Gm11168	C	G	9: 3,006,912	C212W	probably benign	Het
Gpr179	G	T	11: 97,351,594	D141E	probably damaging	Het
Hdhd2	C	T	18: 76,944,115	T89M	probably benign	Het
Hist1h2bc	A	G	13: 23,684,359	Y43C	probably damaging	Het
Krt6b	T	G	15: 101,679,078	T194P	probably benign	Het
Lrp1b	T	C	2: 41,376,018		probably null	Het
Maneal	A	T	4: 124,860,368	I214N	possibly damaging	Het
Map1lc3b	T	A	8: 121,590,616	C11S	unknown	Het
Mapt	G	A	11: 104,322,524	G296E	possibly damaging	Het
Mettl7a3	T	C	15: 100,335,408	V160A	probably benign	Het
Mgam	A	G	6: 40,663,525	N509S	probably benign	Het
Mrgprx1	T	A	7: 48,021,985	I5F	possibly damaging	Het
Mroh5	T	C	15: 73,787,734	D416G	probably benign	Het
Ncan	T	G	8: 70,110,099	D503A	probably benign	Het
Nedd1	A	T	10: 92,711,323		probably null	Het
Ogdh	A	G	11: 6,348,351	T641A	probably benign	Het
Olfr11	T	C	13: 21,639,146	I126V	probably benign	Het
Olfr730	T	A	14: 50,186,558	I221F	probably damaging	Het
Olfr818	A	T	10: 129,945,566	D50E	probably benign	Het
Pcdhga8	A	C	18: 37,726,185	Q98P	possibly damaging	Het
Pik3c2a	A	G	7: 116,354,007	Y1218H	probably damaging	Het
Ppp3cc	A	T	14: 70,245,938	S229T	possibly damaging	Het
Prss43	T	G	9: 110,828,696	I221S	probably damaging	Het
Rasal1	A	T	5: 120,662,937	T221S	probably benign	Het
Serpinb9f	G	T	13: 33,334,560	E348*	probably null	Het
Sfxn5	A	G	6: 85,267,907	Y169H	probably damaging	Het
Skint9	T	C	4: 112,389,231	N228S	probably benign	Het
Slx4ip	A	T	2: 137,000,242	D29V	probably damaging	Het
Snx29	G	T	16: 11,755,316	G474V	probably damaging	Het
Spata6	T	A	4: 111,780,820	D282E	possibly damaging	Het
Srek1	A	T	13: 103,769,382	V77E	probably damaging	Het
Tnfrsf22	T	C	7: 143,640,827	D121G	probably damaging	Het
Ucma	G	A	2: 4,985,359	W122*	probably null	Het
Vmn2r124	T	C	17: 18,062,044	M113T	unknown	Het
Vmn2r54	A	T	7: 12,616,223		probably null	Het
Vmn2r8	A	G	5: 108,800,576	L482S	probably benign	Het
Vwa3a	T	A	7: 120,778,915	I476N	probably damaging	Het
Vwa8	A	C	14: 78,982,234		probably null	Het
Wdr26	A	T	1: 181,187,675	S390R	probably damaging	Het
Zbtb40	A	T	4: 137,000,894	S471T	probably benign	Het

Other mutations in Olfr904

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01352:Olfr904	APN	9	38464734	missense	probably benign
IGL01966:Olfr904	APN	9	38464929	missense	possibly damaging	0.82
IGL02328:Olfr904	APN	9	38464676	missense	probably benign
IGL03394:Olfr904	APN	9	38464221	missense	probably damaging	1.00
R0085:Olfr904	UTSW	9	38464662	missense	probably benign	0.37
R0125:Olfr904	UTSW	9	38464461	nonsense	probably null
R1506:Olfr904	UTSW	9	38464143	missense	probably benign	0.02
R1545:Olfr904	UTSW	9	38464519	missense	probably benign	0.37
R1610:Olfr904	UTSW	9	38464631	missense	probably damaging	0.97
R2008:Olfr904	UTSW	9	38464241	missense	probably damaging	1.00
R2424:Olfr904	UTSW	9	38464832	missense	probably damaging	0.99
R3824:Olfr904	UTSW	9	38464526	missense	probably benign	0.13
R3964:Olfr904	UTSW	9	38464683	missense	probably benign	0.25
R4093:Olfr904	UTSW	9	38464083	missense	probably null	1.00
R4454:Olfr904	UTSW	9	38464642	missense	probably benign	0.03
R5650:Olfr904	UTSW	9	38464727	nonsense	probably null
R6921:Olfr904	UTSW	9	38464247	missense	probably benign	0.01
R7597:Olfr904	UTSW	9	38464506	missense	probably benign	0.01
R7959:Olfr904	UTSW	9	38464915	missense	probably damaging	0.99

Predicted Primers

PCR Primer
(F):5'- TTCACTGGTGGGGAAAGAACC -3'
(R):5'- GAAATATAGCTGGGTTAAACATCCC -3'

Sequencing Primer
(F):5'- CCAGGATAGGAAGAGAGATCATTTTC -3'
(R):5'- CCCATGTAAGAAATTGCATTCTTGC -3'

Posted On

2019-10-07