Incidental Mutation 'R7407:Zfp629'
ID |
574792 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Zfp629
|
Ensembl Gene |
ENSMUSG00000045639 |
Gene Name |
zinc finger protein 629 |
Synonyms |
9330199A09Rik |
MMRRC Submission |
045488-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.220)
|
Stock # |
R7407 (G1)
|
Quality Score |
225.009 |
Status
|
Not validated
|
Chromosome |
7 |
Chromosomal Location |
127206203-127214969 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to C
at 127209415 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Aspartic acid to Glycine
at position 798
(D798G)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000053760
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000058038]
[ENSMUST00000084564]
[ENSMUST00000122066]
[ENSMUST00000128731]
[ENSMUST00000131318]
[ENSMUST00000132524]
[ENSMUST00000134446]
[ENSMUST00000151107]
[ENSMUST00000152315]
|
AlphaFold |
Q6A085 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000058038
AA Change: D798G
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
SMART Domains |
Protein: ENSMUSP00000053760 Gene: ENSMUSG00000045639 AA Change: D798G
Domain | Start | End | E-Value | Type |
low complexity region
|
27 |
43 |
N/A |
INTRINSIC |
low complexity region
|
93 |
104 |
N/A |
INTRINSIC |
ZnF_C2H2
|
149 |
171 |
4.01e-5 |
SMART |
ZnF_C2H2
|
177 |
199 |
2.09e-3 |
SMART |
ZnF_C2H2
|
205 |
227 |
6.08e-5 |
SMART |
ZnF_C2H2
|
233 |
255 |
2.99e-4 |
SMART |
ZnF_C2H2
|
261 |
283 |
1.45e-2 |
SMART |
ZnF_C2H2
|
289 |
311 |
1.13e-4 |
SMART |
ZnF_C2H2
|
317 |
339 |
9.88e-5 |
SMART |
ZnF_C2H2
|
345 |
367 |
9.73e-4 |
SMART |
ZnF_C2H2
|
373 |
395 |
9.22e-5 |
SMART |
ZnF_C2H2
|
401 |
423 |
6.08e-5 |
SMART |
ZnF_C2H2
|
429 |
451 |
7.78e-3 |
SMART |
ZnF_C2H2
|
457 |
479 |
3.95e-4 |
SMART |
ZnF_C2H2
|
485 |
507 |
1.15e-5 |
SMART |
ZnF_C2H2
|
513 |
535 |
2.91e-2 |
SMART |
ZnF_C2H2
|
568 |
590 |
9.58e-3 |
SMART |
ZnF_C2H2
|
661 |
683 |
3.16e-3 |
SMART |
ZnF_C2H2
|
713 |
735 |
9.73e-4 |
SMART |
low complexity region
|
737 |
754 |
N/A |
INTRINSIC |
ZnF_C2H2
|
766 |
788 |
2.57e-3 |
SMART |
ZnF_C2H2
|
840 |
862 |
1.14e0 |
SMART |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000084564
AA Change: D798G
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
SMART Domains |
Protein: ENSMUSP00000081612 Gene: ENSMUSG00000045639 AA Change: D798G
Domain | Start | End | E-Value | Type |
low complexity region
|
27 |
43 |
N/A |
INTRINSIC |
low complexity region
|
93 |
104 |
N/A |
INTRINSIC |
ZnF_C2H2
|
149 |
171 |
4.01e-5 |
SMART |
ZnF_C2H2
|
177 |
199 |
2.09e-3 |
SMART |
ZnF_C2H2
|
205 |
227 |
6.08e-5 |
SMART |
ZnF_C2H2
|
233 |
255 |
2.99e-4 |
SMART |
ZnF_C2H2
|
261 |
283 |
1.45e-2 |
SMART |
ZnF_C2H2
|
289 |
311 |
1.13e-4 |
SMART |
ZnF_C2H2
|
317 |
339 |
9.88e-5 |
SMART |
ZnF_C2H2
|
345 |
367 |
9.73e-4 |
SMART |
ZnF_C2H2
|
373 |
395 |
9.22e-5 |
SMART |
ZnF_C2H2
|
401 |
423 |
6.08e-5 |
SMART |
ZnF_C2H2
|
429 |
451 |
7.78e-3 |
SMART |
ZnF_C2H2
|
457 |
479 |
3.95e-4 |
SMART |
ZnF_C2H2
|
485 |
507 |
1.15e-5 |
SMART |
ZnF_C2H2
|
513 |
535 |
2.91e-2 |
SMART |
ZnF_C2H2
|
568 |
590 |
9.58e-3 |
SMART |
ZnF_C2H2
|
661 |
683 |
3.16e-3 |
SMART |
ZnF_C2H2
|
713 |
735 |
9.73e-4 |
SMART |
low complexity region
|
737 |
754 |
N/A |
INTRINSIC |
ZnF_C2H2
|
766 |
788 |
2.57e-3 |
SMART |
ZnF_C2H2
|
840 |
862 |
1.14e0 |
SMART |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000122066
AA Change: D798G
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
SMART Domains |
Protein: ENSMUSP00000113903 Gene: ENSMUSG00000045639 AA Change: D798G
Domain | Start | End | E-Value | Type |
low complexity region
|
27 |
43 |
N/A |
INTRINSIC |
low complexity region
|
93 |
104 |
N/A |
INTRINSIC |
ZnF_C2H2
|
149 |
171 |
4.01e-5 |
SMART |
ZnF_C2H2
|
177 |
199 |
2.09e-3 |
SMART |
ZnF_C2H2
|
205 |
227 |
6.08e-5 |
SMART |
ZnF_C2H2
|
233 |
255 |
2.99e-4 |
SMART |
ZnF_C2H2
|
261 |
283 |
1.45e-2 |
SMART |
ZnF_C2H2
|
289 |
311 |
1.13e-4 |
SMART |
ZnF_C2H2
|
317 |
339 |
9.88e-5 |
SMART |
ZnF_C2H2
|
345 |
367 |
9.73e-4 |
SMART |
ZnF_C2H2
|
373 |
395 |
9.22e-5 |
SMART |
ZnF_C2H2
|
401 |
423 |
6.08e-5 |
SMART |
ZnF_C2H2
|
429 |
451 |
7.78e-3 |
SMART |
ZnF_C2H2
|
457 |
479 |
3.95e-4 |
SMART |
ZnF_C2H2
|
485 |
507 |
1.15e-5 |
SMART |
ZnF_C2H2
|
513 |
535 |
2.91e-2 |
SMART |
ZnF_C2H2
|
568 |
590 |
9.58e-3 |
SMART |
ZnF_C2H2
|
661 |
683 |
3.16e-3 |
SMART |
ZnF_C2H2
|
713 |
735 |
9.73e-4 |
SMART |
low complexity region
|
737 |
754 |
N/A |
INTRINSIC |
ZnF_C2H2
|
766 |
788 |
2.57e-3 |
SMART |
ZnF_C2H2
|
840 |
862 |
1.14e0 |
SMART |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000128731
|
SMART Domains |
Protein: ENSMUSP00000140505 Gene: ENSMUSG00000045639
Domain | Start | End | E-Value | Type |
low complexity region
|
78 |
90 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000131318
|
SMART Domains |
Protein: ENSMUSP00000116375 Gene: ENSMUSG00000045639
Domain | Start | End | E-Value | Type |
low complexity region
|
27 |
43 |
N/A |
INTRINSIC |
low complexity region
|
93 |
104 |
N/A |
INTRINSIC |
ZnF_C2H2
|
149 |
171 |
4.01e-5 |
SMART |
ZnF_C2H2
|
177 |
199 |
2.09e-3 |
SMART |
ZnF_C2H2
|
205 |
227 |
6.08e-5 |
SMART |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000132524
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000134446
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000151107
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000152315
|
SMART Domains |
Protein: ENSMUSP00000114772 Gene: ENSMUSG00000045639
Domain | Start | End | E-Value | Type |
low complexity region
|
27 |
43 |
N/A |
INTRINSIC |
low complexity region
|
93 |
104 |
N/A |
INTRINSIC |
ZnF_C2H2
|
149 |
171 |
4.01e-5 |
SMART |
ZnF_C2H2
|
177 |
195 |
1.24e2 |
SMART |
|
Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.0%
|
Validation Efficiency |
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 48 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
4933405O20Rik |
A |
G |
7: 50,249,626 (GRCm39) |
N220S |
probably damaging |
Het |
Abcb8 |
T |
C |
5: 24,605,674 (GRCm39) |
V186A |
probably benign |
Het |
Actbl2 |
A |
T |
13: 111,392,752 (GRCm39) |
E362D |
probably damaging |
Het |
Adamts17 |
C |
A |
7: 66,697,304 (GRCm39) |
Y28* |
probably null |
Het |
Agtr1b |
T |
C |
3: 20,369,895 (GRCm39) |
D237G |
possibly damaging |
Het |
Amer2 |
A |
G |
14: 60,616,291 (GRCm39) |
D162G |
probably damaging |
Het |
Ankub1 |
T |
C |
3: 57,572,624 (GRCm39) |
E366G |
probably benign |
Het |
Ap5z1 |
A |
G |
5: 142,452,330 (GRCm39) |
I88V |
probably benign |
Het |
Ccdc186 |
T |
C |
19: 56,801,817 (GRCm39) |
N100S |
probably benign |
Het |
Cldn19 |
A |
G |
4: 119,112,882 (GRCm39) |
D38G |
probably damaging |
Het |
Crat |
C |
T |
2: 30,294,577 (GRCm39) |
R497Q |
probably benign |
Het |
Deaf1 |
G |
A |
7: 140,877,492 (GRCm39) |
A545V |
possibly damaging |
Het |
Dicer1 |
G |
T |
12: 104,688,610 (GRCm39) |
Y322* |
probably null |
Het |
Dnajb7 |
G |
T |
15: 81,291,827 (GRCm39) |
T170K |
possibly damaging |
Het |
Flrt2 |
A |
T |
12: 95,746,074 (GRCm39) |
E137D |
probably damaging |
Het |
Galnt12 |
T |
C |
4: 47,120,362 (GRCm39) |
F482L |
probably damaging |
Het |
Gm32742 |
A |
G |
9: 51,067,974 (GRCm39) |
V336A |
probably damaging |
Het |
Gpatch8 |
G |
A |
11: 102,370,656 (GRCm39) |
R961W |
unknown |
Het |
Hcn4 |
A |
G |
9: 58,766,653 (GRCm39) |
E738G |
unknown |
Het |
Kdelr3 |
A |
G |
15: 79,409,039 (GRCm39) |
Y76C |
probably damaging |
Het |
Krt77 |
T |
C |
15: 101,768,530 (GRCm39) |
S494G |
unknown |
Het |
Letmd1 |
G |
T |
15: 100,367,119 (GRCm39) |
A39S |
probably benign |
Het |
Lrrc7 |
G |
A |
3: 157,840,878 (GRCm39) |
R1387W |
probably damaging |
Het |
Meltf |
T |
C |
16: 31,713,553 (GRCm39) |
Y599H |
probably damaging |
Het |
Mybpc1 |
T |
A |
10: 88,385,209 (GRCm39) |
I477L |
probably damaging |
Het |
Nf1 |
A |
G |
11: 79,338,969 (GRCm39) |
D1174G |
probably damaging |
Het |
Or2t6 |
T |
A |
14: 14,175,402 (GRCm38) |
I227L |
probably benign |
Het |
Or8b44 |
T |
A |
9: 38,410,800 (GRCm39) |
Y278* |
probably null |
Het |
Palld |
G |
T |
8: 61,968,975 (GRCm39) |
S1283* |
probably null |
Het |
Pcmtd2 |
T |
C |
2: 181,488,398 (GRCm39) |
V183A |
possibly damaging |
Het |
Pcsk5 |
T |
A |
19: 17,652,880 (GRCm39) |
I269F |
probably damaging |
Het |
Pkd1 |
T |
C |
17: 24,813,568 (GRCm39) |
L4036P |
probably damaging |
Het |
Pkhd1l1 |
A |
G |
15: 44,458,407 (GRCm39) |
N4151S |
possibly damaging |
Het |
Rcor3 |
C |
T |
1: 191,785,972 (GRCm39) |
S422N |
probably benign |
Het |
Rhag |
A |
G |
17: 41,142,225 (GRCm39) |
I223V |
possibly damaging |
Het |
Ssbp4 |
A |
G |
8: 71,051,672 (GRCm39) |
Y231H |
probably damaging |
Het |
Syce1l |
C |
T |
8: 114,381,770 (GRCm39) |
Q237* |
probably null |
Het |
Tenm4 |
T |
C |
7: 96,423,194 (GRCm39) |
V663A |
possibly damaging |
Het |
Timd6 |
A |
G |
11: 46,468,217 (GRCm39) |
Y97C |
probably damaging |
Het |
Trim6 |
T |
C |
7: 103,875,108 (GRCm39) |
I115T |
probably damaging |
Het |
Vinac1 |
A |
G |
2: 128,880,729 (GRCm39) |
I399T |
|
Het |
Vmn1r25 |
T |
A |
6: 57,956,044 (GRCm39) |
T82S |
possibly damaging |
Het |
Vmn2r28 |
A |
G |
7: 5,484,308 (GRCm39) |
S631P |
probably damaging |
Het |
Xpo1 |
T |
A |
11: 23,235,823 (GRCm39) |
V637E |
probably damaging |
Het |
Xpo6 |
A |
T |
7: 125,770,224 (GRCm39) |
M62K |
probably damaging |
Het |
Ypel5 |
A |
G |
17: 73,153,374 (GRCm39) |
N26S |
possibly damaging |
Het |
Zbtb24 |
C |
A |
10: 41,340,775 (GRCm39) |
Q624K |
possibly damaging |
Het |
Zfp687 |
C |
T |
3: 94,914,841 (GRCm39) |
R1220H |
probably damaging |
Het |
|
Other mutations in Zfp629 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00957:Zfp629
|
APN |
7 |
127,211,896 (GRCm39) |
missense |
probably damaging |
0.97 |
IGL01541:Zfp629
|
APN |
7 |
127,211,917 (GRCm39) |
utr 5 prime |
probably benign |
|
IGL02116:Zfp629
|
APN |
7 |
127,211,890 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02134:Zfp629
|
APN |
7 |
127,211,042 (GRCm39) |
missense |
probably benign |
0.22 |
IGL02547:Zfp629
|
APN |
7 |
127,210,846 (GRCm39) |
splice site |
probably null |
|
IGL02858:Zfp629
|
APN |
7 |
127,209,484 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02867:Zfp629
|
APN |
7 |
127,209,203 (GRCm39) |
unclassified |
probably benign |
|
IGL02889:Zfp629
|
APN |
7 |
127,209,203 (GRCm39) |
unclassified |
probably benign |
|
R6768_Zfp629_044
|
UTSW |
7 |
127,209,997 (GRCm39) |
missense |
probably benign |
0.03 |
R0020:Zfp629
|
UTSW |
7 |
127,210,341 (GRCm39) |
missense |
probably benign |
0.02 |
R0137:Zfp629
|
UTSW |
7 |
127,210,858 (GRCm39) |
missense |
probably damaging |
1.00 |
R0219:Zfp629
|
UTSW |
7 |
127,211,255 (GRCm39) |
missense |
probably damaging |
1.00 |
R1061:Zfp629
|
UTSW |
7 |
127,211,161 (GRCm39) |
missense |
probably damaging |
1.00 |
R1182:Zfp629
|
UTSW |
7 |
127,209,274 (GRCm39) |
missense |
probably damaging |
1.00 |
R1187:Zfp629
|
UTSW |
7 |
127,209,401 (GRCm39) |
missense |
probably benign |
|
R1187:Zfp629
|
UTSW |
7 |
127,211,059 (GRCm39) |
missense |
probably damaging |
1.00 |
R1217:Zfp629
|
UTSW |
7 |
127,211,916 (GRCm39) |
start gained |
probably benign |
|
R1507:Zfp629
|
UTSW |
7 |
127,211,033 (GRCm39) |
nonsense |
probably null |
|
R1526:Zfp629
|
UTSW |
7 |
127,209,931 (GRCm39) |
missense |
possibly damaging |
0.69 |
R1622:Zfp629
|
UTSW |
7 |
127,211,012 (GRCm39) |
missense |
probably damaging |
1.00 |
R1704:Zfp629
|
UTSW |
7 |
127,210,036 (GRCm39) |
missense |
probably benign |
0.06 |
R1918:Zfp629
|
UTSW |
7 |
127,211,172 (GRCm39) |
missense |
probably damaging |
1.00 |
R2147:Zfp629
|
UTSW |
7 |
127,209,616 (GRCm39) |
missense |
probably damaging |
1.00 |
R2156:Zfp629
|
UTSW |
7 |
127,211,551 (GRCm39) |
missense |
probably benign |
0.00 |
R2258:Zfp629
|
UTSW |
7 |
127,210,963 (GRCm39) |
missense |
probably damaging |
1.00 |
R2994:Zfp629
|
UTSW |
7 |
127,210,228 (GRCm39) |
missense |
probably damaging |
0.99 |
R3735:Zfp629
|
UTSW |
7 |
127,211,950 (GRCm39) |
splice site |
probably benign |
|
R4287:Zfp629
|
UTSW |
7 |
127,211,110 (GRCm39) |
missense |
probably damaging |
1.00 |
R4610:Zfp629
|
UTSW |
7 |
127,211,492 (GRCm39) |
missense |
probably benign |
0.26 |
R4758:Zfp629
|
UTSW |
7 |
127,209,758 (GRCm39) |
missense |
probably damaging |
1.00 |
R4899:Zfp629
|
UTSW |
7 |
127,210,190 (GRCm39) |
missense |
possibly damaging |
0.69 |
R4922:Zfp629
|
UTSW |
7 |
127,211,299 (GRCm39) |
missense |
probably damaging |
1.00 |
R5414:Zfp629
|
UTSW |
7 |
127,210,454 (GRCm39) |
missense |
probably damaging |
0.97 |
R5772:Zfp629
|
UTSW |
7 |
127,210,307 (GRCm39) |
missense |
probably damaging |
1.00 |
R5907:Zfp629
|
UTSW |
7 |
127,209,542 (GRCm39) |
missense |
probably damaging |
1.00 |
R6768:Zfp629
|
UTSW |
7 |
127,209,997 (GRCm39) |
missense |
probably benign |
0.03 |
R7122:Zfp629
|
UTSW |
7 |
127,210,484 (GRCm39) |
missense |
probably damaging |
0.99 |
R7156:Zfp629
|
UTSW |
7 |
127,211,463 (GRCm39) |
nonsense |
probably null |
|
R7446:Zfp629
|
UTSW |
7 |
127,210,201 (GRCm39) |
missense |
probably benign |
0.00 |
R7780:Zfp629
|
UTSW |
7 |
127,211,601 (GRCm39) |
missense |
probably benign |
0.12 |
R7871:Zfp629
|
UTSW |
7 |
127,211,167 (GRCm39) |
missense |
probably damaging |
1.00 |
R8542:Zfp629
|
UTSW |
7 |
127,210,364 (GRCm39) |
nonsense |
probably null |
|
R9095:Zfp629
|
UTSW |
7 |
127,209,547 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Predicted Primers |
PCR Primer
(F):5'- AGACCTACTTCACAGGGAGAC -3'
(R):5'- GCAGCACCAGAAAGTCCATG -3'
Sequencing Primer
(F):5'- CTGGGTGACAGCTCCTATGG -3'
(R):5'- CCAGAAAGTCCATGCGGGTG -3'
|
Posted On |
2019-10-07 |