Incidental Mutation 'R7409:Ddx60'
ID 574928
Institutional Source Beutler Lab
Gene Symbol Ddx60
Ensembl Gene ENSMUSG00000037921
Gene Name DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
Synonyms
MMRRC Submission 045490-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.145) question?
Stock # R7409 (G1)
Quality Score 225.009
Status Validated
Chromosome 8
Chromosomal Location 61928087-62038244 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) C to A at 61958578 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Threonine to Lysine at position 488 (T488K)
Ref Sequence ENSEMBL: ENSMUSP00000091197 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000070631] [ENSMUST00000093485] [ENSMUST00000154398]
AlphaFold E9PZQ1
Predicted Effect probably benign
Transcript: ENSMUST00000070631
AA Change: T488K

PolyPhen 2 Score 0.243 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000070741
Gene: ENSMUSG00000037921
AA Change: T488K

DomainStartEndE-ValueType
low complexity region 99 110 N/A INTRINSIC
low complexity region 364 376 N/A INTRINSIC
DEXDc 758 949 1.05e-15 SMART
Blast:DEXDc 1007 1132 4e-24 BLAST
HELICc 1245 1328 4.35e-13 SMART
low complexity region 1362 1373 N/A INTRINSIC
Blast:DEXDc 1503 1584 1e-20 BLAST
Predicted Effect probably benign
Transcript: ENSMUST00000093485
AA Change: T488K

PolyPhen 2 Score 0.243 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000091197
Gene: ENSMUSG00000037921
AA Change: T488K

DomainStartEndE-ValueType
low complexity region 99 110 N/A INTRINSIC
low complexity region 364 376 N/A INTRINSIC
DEXDc 759 950 1.05e-15 SMART
Blast:DEXDc 1008 1133 4e-24 BLAST
HELICc 1246 1329 4.35e-13 SMART
low complexity region 1363 1374 N/A INTRINSIC
Blast:DEXDc 1504 1585 1e-20 BLAST
Predicted Effect probably benign
Transcript: ENSMUST00000154398
AA Change: T488K

PolyPhen 2 Score 0.243 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000122841
Gene: ENSMUSG00000037921
AA Change: T488K

DomainStartEndE-ValueType
low complexity region 99 110 N/A INTRINSIC
low complexity region 364 376 N/A INTRINSIC
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.6%
Validation Efficiency 98% (82/84)
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit normal immunity to several viruses (IAV, EMCV, SINV) but increased susceptibility to VSV infection. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 84 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2610301B20Rik T A 4: 10,881,834 (GRCm38) C94S probably benign Het
2610507B11Rik G T 11: 78,268,757 (GRCm38) R544L probably damaging Het
Adgrb2 C T 4: 130,019,069 (GRCm38) A1329V probably benign Het
Aida A G 1: 183,318,874 (GRCm38) T215A probably benign Het
Alpk2 A G 18: 65,306,952 (GRCm38) S457P probably benign Het
Ap4b1 G A 3: 103,812,158 (GRCm38) V63I probably damaging Het
Apaf1 A G 10: 91,067,246 (GRCm38) V182A probably damaging Het
B4galnt4 G A 7: 141,067,003 (GRCm38) probably null Het
Cacna1a T G 8: 84,533,402 (GRCm38) D331E probably damaging Het
Carmil2 A G 8: 105,692,791 (GRCm38) probably null Het
Cdkn1b A T 6: 134,921,317 (GRCm38) Q133L probably benign Het
Cep192 G C 18: 67,834,803 (GRCm38) S786T possibly damaging Het
Cfap97 G A 8: 46,192,696 (GRCm38) R537H probably benign Het
Clpx C G 9: 65,324,247 (GRCm38) A552G possibly damaging Het
Cryl1 G A 14: 57,286,385 (GRCm38) T240I probably damaging Het
Dennd4b A G 3: 90,273,952 (GRCm38) H805R probably benign Het
Dnmbp T C 19: 43,890,557 (GRCm38) D25G unknown Het
Dysf A C 6: 84,149,682 (GRCm38) D1293A probably benign Het
Efl1 T C 7: 82,697,913 (GRCm38) L549P probably damaging Het
Eif5 T C 12: 111,540,263 (GRCm38) probably benign Het
Eva1c A G 16: 90,869,656 (GRCm38) K156E probably damaging Het
Fbxw10 T G 11: 62,876,780 (GRCm38) V814G possibly damaging Het
Gfap C T 11: 102,894,532 (GRCm38) R206Q probably benign Het
Gjb6 A T 14: 57,124,153 (GRCm38) L217* probably null Het
Gpatch11 T A 17: 78,839,166 (GRCm38) L80Q probably damaging Het
Gramd1b T C 9: 40,327,431 (GRCm38) Q225R probably damaging Het
Gsdmc2 A G 15: 63,833,346 (GRCm38) S173P possibly damaging Het
Hars C G 18: 36,770,113 (GRCm38) R388P probably damaging Het
Ighm C T 12: 113,422,232 (GRCm38) R129H Het
Igsf9 A G 1: 172,495,274 (GRCm38) I602V probably benign Het
Inpp4b T G 8: 81,952,685 (GRCm38) probably null Het
Itch C A 2: 155,199,382 (GRCm38) T450K probably damaging Het
Kcnq1 T C 7: 143,109,415 (GRCm38) F20L unknown Het
Kmt2d G T 15: 98,855,354 (GRCm38) A153E probably damaging Het
Macf1 T A 4: 123,504,470 (GRCm38) N750I probably damaging Het
Marveld2 T A 13: 100,611,476 (GRCm38) H365L probably damaging Het
Med13l T A 5: 118,754,321 (GRCm38) D1936E probably benign Het
Mettl8 A T 2: 70,973,343 (GRCm38) V200E probably damaging Het
Mrgbp T G 2: 180,585,342 (GRCm38) S157A possibly damaging Het
Mrps35 A G 6: 147,055,983 (GRCm38) T169A possibly damaging Het
Mycbp2 A T 14: 103,288,744 (GRCm38) Y551N probably damaging Het
Myo18b T C 5: 112,874,105 (GRCm38) R474G probably benign Het
Nfx1 T A 4: 41,021,830 (GRCm38) S979R possibly damaging Het
Nlrp1a T C 11: 71,122,808 (GRCm38) T539A probably benign Het
Oca2 T A 7: 56,414,397 (GRCm38) D713E probably benign Het
Olfr433 T A 1: 174,042,533 (GRCm38) H194Q probably benign Het
Olfr60 C T 7: 140,345,405 (GRCm38) V195I probably benign Het
Olfr768 A G 10: 129,093,212 (GRCm38) I254T probably damaging Het
Olfr816 A T 10: 129,912,251 (GRCm38) V9D possibly damaging Het
Omt2b A C 9: 78,328,612 (GRCm38) Y73S probably benign Het
Pde11a G T 2: 76,005,984 (GRCm38) Q20K Het
Peg10 CCACATCAGGATCCACATCAGGATGCACATCAGCATCAGGATCCCCATCAGGATGCACATCAGGATCCACATCAGGATGCACATCAG CCACATCAGGATCCACATCAGGATGCACATCAG 6: 4,756,398 (GRCm38) probably benign Het
Phrf1 C A 7: 141,259,292 (GRCm38) T800K unknown Het
Pramel4 T C 4: 144,068,491 (GRCm38) S486P probably benign Het
Proc T C 18: 32,127,460 (GRCm38) D204G probably benign Het
Rasgrp3 T A 17: 75,516,416 (GRCm38) I494N possibly damaging Het
Samm50 A G 15: 84,197,030 (GRCm38) D53G probably benign Het
Satb1 T C 17: 51,809,189 (GRCm38) D22G possibly damaging Het
Scarf2 T C 16: 17,807,054 (GRCm38) S658P probably damaging Het
Sfta2 T A 17: 35,614,518 (GRCm38) I29K unknown Het
Slc15a4 A T 5: 127,604,678 (GRCm38) S292T probably benign Het
Slc37a1 C T 17: 31,340,263 (GRCm38) T439I probably damaging Het
Slc4a9 C A 18: 36,530,805 (GRCm38) P294Q probably damaging Het
Slc52a3 T C 2: 152,004,166 (GRCm38) S16P probably damaging Het
Slc6a15 A G 10: 103,408,302 (GRCm38) I468V probably benign Het
Spag17 A T 3: 100,034,159 (GRCm38) D738V probably benign Het
Spag17 T C 3: 100,027,231 (GRCm38) S610P possibly damaging Het
Ssbp4 T C 8: 70,597,967 (GRCm38) R269G unknown Het
Tbl1xr1 A G 3: 22,203,190 (GRCm38) T406A possibly damaging Het
Tep1 A T 14: 50,866,855 (GRCm38) V194D possibly damaging Het
Thbs4 A T 13: 92,773,259 (GRCm38) C343* probably null Het
Tmed10 A T 12: 85,344,291 (GRCm38) S158T possibly damaging Het
Trbv3 T A 6: 41,048,590 (GRCm38) V38E probably damaging Het
Ttc6 T C 12: 57,696,986 (GRCm38) M1258T probably damaging Het
Ttn T C 2: 76,758,976 (GRCm38) D21281G probably damaging Het
Twistnb T G 12: 33,436,989 (GRCm38) C150W possibly damaging Het
Usp54 T C 14: 20,552,245 (GRCm38) R1346G probably damaging Het
Vmn2r8 C A 5: 108,808,583 (GRCm38) E58* probably null Het
Vps13d C T 4: 145,141,254 (GRCm38) E2009K Het
Vps33b T C 7: 80,285,269 (GRCm38) I320T probably damaging Het
Vwa8 A C 14: 78,982,234 (GRCm38) probably null Het
Ythdf1 T C 2: 180,911,993 (GRCm38) Y143C probably damaging Het
Zfp213 C T 17: 23,559,629 (GRCm38) probably null Het
Zfp219 A T 14: 52,007,113 (GRCm38) Y536* probably null Het
Other mutations in Ddx60
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00340:Ddx60 APN 8 61,958,646 (GRCm38) missense probably damaging 1.00
IGL00915:Ddx60 APN 8 61,987,431 (GRCm38) missense possibly damaging 0.79
IGL00931:Ddx60 APN 8 61,969,583 (GRCm38) missense probably benign 0.18
IGL01023:Ddx60 APN 8 61,942,514 (GRCm38) missense probably damaging 0.99
IGL01313:Ddx60 APN 8 61,982,526 (GRCm38) missense probably damaging 1.00
IGL01615:Ddx60 APN 8 61,963,740 (GRCm38) missense probably null 0.81
IGL01733:Ddx60 APN 8 61,983,865 (GRCm38) missense probably damaging 0.99
IGL01779:Ddx60 APN 8 62,017,823 (GRCm38) missense possibly damaging 0.94
IGL01900:Ddx60 APN 8 62,000,709 (GRCm38) splice site probably benign
IGL02110:Ddx60 APN 8 62,017,247 (GRCm38) critical splice donor site probably null
IGL02302:Ddx60 APN 8 61,975,832 (GRCm38) missense possibly damaging 0.85
IGL02468:Ddx60 APN 8 61,958,642 (GRCm38) missense probably damaging 1.00
IGL02569:Ddx60 APN 8 62,024,951 (GRCm38) missense possibly damaging 0.93
IGL02622:Ddx60 APN 8 61,942,436 (GRCm38) splice site probably null
IGL02657:Ddx60 APN 8 61,984,115 (GRCm38) missense probably benign 0.01
IGL02677:Ddx60 APN 8 61,988,132 (GRCm38) missense probably damaging 1.00
IGL02701:Ddx60 APN 8 61,979,341 (GRCm38) missense probably damaging 0.96
IGL02806:Ddx60 APN 8 61,956,122 (GRCm38) missense probably benign 0.00
IGL03137:Ddx60 APN 8 61,988,083 (GRCm38) missense possibly damaging 0.61
IGL03295:Ddx60 APN 8 61,956,121 (GRCm38) missense possibly damaging 0.82
IGL03387:Ddx60 APN 8 62,012,449 (GRCm38) missense probably damaging 1.00
IGL03411:Ddx60 APN 8 61,977,882 (GRCm38) critical splice acceptor site probably null
Scatter UTSW 8 62,021,314 (GRCm38) missense possibly damaging 0.80
shotgun UTSW 8 62,037,067 (GRCm38) missense probably benign 0.28
splay UTSW 8 62,021,309 (GRCm38) missense possibly damaging 0.80
G1Funyon:Ddx60 UTSW 8 62,000,597 (GRCm38) missense probably benign 0.01
PIT4504001:Ddx60 UTSW 8 61,958,113 (GRCm38) missense probably benign
PIT4677001:Ddx60 UTSW 8 61,972,254 (GRCm38) missense possibly damaging 0.87
R0090:Ddx60 UTSW 8 61,942,293 (GRCm38) missense probably damaging 1.00
R0266:Ddx60 UTSW 8 62,033,493 (GRCm38) missense possibly damaging 0.92
R0325:Ddx60 UTSW 8 61,983,855 (GRCm38) missense probably benign 0.00
R0367:Ddx60 UTSW 8 62,017,749 (GRCm38) missense possibly damaging 0.78
R0403:Ddx60 UTSW 8 61,994,541 (GRCm38) splice site probably benign
R0479:Ddx60 UTSW 8 61,969,657 (GRCm38) missense probably damaging 1.00
R0561:Ddx60 UTSW 8 62,017,794 (GRCm38) missense possibly damaging 0.93
R0844:Ddx60 UTSW 8 61,987,361 (GRCm38) missense probably benign 0.27
R1119:Ddx60 UTSW 8 61,942,544 (GRCm38) missense probably damaging 1.00
R1428:Ddx60 UTSW 8 61,958,159 (GRCm38) splice site probably benign
R1778:Ddx60 UTSW 8 61,974,176 (GRCm38) missense possibly damaging 0.85
R1840:Ddx60 UTSW 8 61,969,553 (GRCm38) missense probably damaging 0.99
R1964:Ddx60 UTSW 8 61,948,869 (GRCm38) missense probably benign 0.10
R1970:Ddx60 UTSW 8 61,972,206 (GRCm38) missense possibly damaging 0.93
R2101:Ddx60 UTSW 8 61,940,645 (GRCm38) missense probably damaging 1.00
R2174:Ddx60 UTSW 8 62,017,200 (GRCm38) missense probably benign 0.01
R2174:Ddx60 UTSW 8 61,956,141 (GRCm38) missense probably damaging 1.00
R2198:Ddx60 UTSW 8 61,958,063 (GRCm38) missense possibly damaging 0.79
R2332:Ddx60 UTSW 8 62,037,091 (GRCm38) missense probably benign 0.08
R2338:Ddx60 UTSW 8 62,012,436 (GRCm38) missense possibly damaging 0.91
R2379:Ddx60 UTSW 8 62,037,088 (GRCm38) missense probably damaging 1.00
R4010:Ddx60 UTSW 8 61,956,144 (GRCm38) missense probably benign 0.25
R4010:Ddx60 UTSW 8 61,954,535 (GRCm38) missense possibly damaging 0.65
R4133:Ddx60 UTSW 8 61,972,220 (GRCm38) missense probably damaging 0.99
R4282:Ddx60 UTSW 8 61,994,393 (GRCm38) missense probably damaging 0.99
R4382:Ddx60 UTSW 8 61,948,978 (GRCm38) splice site probably null
R4561:Ddx60 UTSW 8 61,942,461 (GRCm38) missense probably damaging 0.96
R4572:Ddx60 UTSW 8 61,987,421 (GRCm38) missense probably damaging 1.00
R4581:Ddx60 UTSW 8 62,023,261 (GRCm38) missense possibly damaging 0.90
R4635:Ddx60 UTSW 8 62,037,067 (GRCm38) missense probably benign 0.28
R4698:Ddx60 UTSW 8 62,012,424 (GRCm38) missense probably benign 0.01
R4807:Ddx60 UTSW 8 61,979,338 (GRCm38) missense probably damaging 1.00
R4858:Ddx60 UTSW 8 62,021,314 (GRCm38) missense possibly damaging 0.80
R4964:Ddx60 UTSW 8 61,979,338 (GRCm38) missense probably damaging 1.00
R5120:Ddx60 UTSW 8 61,945,906 (GRCm38) missense probably benign 0.01
R5187:Ddx60 UTSW 8 61,974,188 (GRCm38) missense probably damaging 1.00
R5222:Ddx60 UTSW 8 61,984,158 (GRCm38) missense probably damaging 0.99
R5400:Ddx60 UTSW 8 62,010,002 (GRCm38) missense possibly damaging 0.65
R5500:Ddx60 UTSW 8 61,950,451 (GRCm38) missense probably benign 0.28
R5514:Ddx60 UTSW 8 61,958,057 (GRCm38) missense probably damaging 1.00
R5668:Ddx60 UTSW 8 62,000,578 (GRCm38) missense probably benign 0.38
R5742:Ddx60 UTSW 8 61,948,921 (GRCm38) missense probably benign
R5772:Ddx60 UTSW 8 61,948,897 (GRCm38) missense probably damaging 1.00
R5810:Ddx60 UTSW 8 62,012,388 (GRCm38) nonsense probably null
R5815:Ddx60 UTSW 8 61,963,722 (GRCm38) missense probably damaging 0.98
R5820:Ddx60 UTSW 8 61,956,121 (GRCm38) missense possibly damaging 0.82
R5866:Ddx60 UTSW 8 61,940,740 (GRCm38) missense probably damaging 1.00
R5881:Ddx60 UTSW 8 62,037,070 (GRCm38) missense probably damaging 1.00
R5977:Ddx60 UTSW 8 62,021,410 (GRCm38) critical splice donor site probably null
R6048:Ddx60 UTSW 8 62,000,582 (GRCm38) missense probably benign 0.01
R6061:Ddx60 UTSW 8 62,023,241 (GRCm38) missense probably null 0.01
R6153:Ddx60 UTSW 8 61,945,940 (GRCm38) missense possibly damaging 0.47
R6287:Ddx60 UTSW 8 61,950,578 (GRCm38) missense probably damaging 1.00
R6415:Ddx60 UTSW 8 61,983,905 (GRCm38) missense probably benign 0.00
R6416:Ddx60 UTSW 8 61,998,681 (GRCm38) missense probably benign
R6416:Ddx60 UTSW 8 61,977,950 (GRCm38) missense probably benign 0.00
R6660:Ddx60 UTSW 8 61,956,239 (GRCm38) missense probably benign 0.00
R6694:Ddx60 UTSW 8 62,037,070 (GRCm38) missense probably damaging 1.00
R6715:Ddx60 UTSW 8 61,983,890 (GRCm38) missense probably benign 0.03
R6720:Ddx60 UTSW 8 62,000,689 (GRCm38) missense probably benign 0.10
R6937:Ddx60 UTSW 8 62,037,069 (GRCm38) missense probably damaging 1.00
R7153:Ddx60 UTSW 8 61,988,108 (GRCm38) missense possibly damaging 0.71
R7274:Ddx60 UTSW 8 61,940,108 (GRCm38) critical splice donor site probably null
R7464:Ddx60 UTSW 8 61,940,674 (GRCm38) missense possibly damaging 0.82
R7670:Ddx60 UTSW 8 61,975,792 (GRCm38) missense probably damaging 1.00
R7904:Ddx60 UTSW 8 61,977,890 (GRCm38) missense possibly damaging 0.81
R7992:Ddx60 UTSW 8 61,954,535 (GRCm38) missense probably benign 0.03
R8124:Ddx60 UTSW 8 61,983,911 (GRCm38) missense probably benign
R8125:Ddx60 UTSW 8 61,983,911 (GRCm38) missense probably benign
R8126:Ddx60 UTSW 8 61,983,911 (GRCm38) missense probably benign
R8155:Ddx60 UTSW 8 62,017,171 (GRCm38) missense possibly damaging 0.61
R8174:Ddx60 UTSW 8 62,017,250 (GRCm38) splice site probably null
R8192:Ddx60 UTSW 8 61,977,968 (GRCm38) missense probably damaging 1.00
R8271:Ddx60 UTSW 8 61,940,108 (GRCm38) critical splice donor site probably null
R8301:Ddx60 UTSW 8 62,000,597 (GRCm38) missense probably benign 0.01
R8304:Ddx60 UTSW 8 61,998,769 (GRCm38) missense possibly damaging 0.67
R8319:Ddx60 UTSW 8 61,942,635 (GRCm38) critical splice donor site probably null
R8374:Ddx60 UTSW 8 61,974,171 (GRCm38) missense probably benign 0.01
R8401:Ddx60 UTSW 8 61,956,243 (GRCm38) missense possibly damaging 0.57
R8487:Ddx60 UTSW 8 61,974,150 (GRCm38) missense probably damaging 1.00
R8804:Ddx60 UTSW 8 61,958,606 (GRCm38) missense probably benign 0.27
R8826:Ddx60 UTSW 8 61,945,956 (GRCm38) missense probably benign 0.02
R8829:Ddx60 UTSW 8 61,940,661 (GRCm38) missense probably damaging 1.00
R8881:Ddx60 UTSW 8 62,021,309 (GRCm38) missense possibly damaging 0.80
R8884:Ddx60 UTSW 8 61,994,519 (GRCm38) missense possibly damaging 0.86
R8990:Ddx60 UTSW 8 61,974,134 (GRCm38) nonsense probably null
R9122:Ddx60 UTSW 8 61,989,864 (GRCm38) missense probably benign 0.16
R9225:Ddx60 UTSW 8 62,017,841 (GRCm38) missense probably benign 0.36
R9278:Ddx60 UTSW 8 61,977,978 (GRCm38) missense possibly damaging 0.83
R9293:Ddx60 UTSW 8 62,009,960 (GRCm38) missense possibly damaging 0.89
R9405:Ddx60 UTSW 8 61,972,214 (GRCm38) missense probably benign 0.03
R9766:Ddx60 UTSW 8 62,012,278 (GRCm38) missense probably damaging 1.00
X0003:Ddx60 UTSW 8 62,033,417 (GRCm38) missense possibly damaging 0.88
X0019:Ddx60 UTSW 8 61,963,692 (GRCm38) missense probably benign 0.01
Z1177:Ddx60 UTSW 8 62,000,588 (GRCm38) missense possibly damaging 0.92
Predicted Primers PCR Primer
(F):5'- GGAGGTCCTGGTTTCTGAAAC -3'
(R):5'- CGTGTCACACATCTGAATGCC -3'

Sequencing Primer
(F):5'- CTTGTATCCCAGGAAGAAG -3'
(R):5'- GTCACACATCTGAATGCCTTAATGAC -3'
Posted On 2019-10-07