Mutagenetix > Incidental Mutation

Incidental Mutation 'R7411:Slc35f3'

575087

Institutional Source

Beutler Lab

Gene Symbol

Slc35f3

Ensembl Gene

ENSMUSG00000057060

Gene Name

solute carrier family 35, member F3

Synonyms

B230375D17Rik

MMRRC Submission

045492-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.160) question?

Stock #

R7411 (G1)

Quality Score

217.468

Status

Not validated

Chromosome

Chromosomal Location

126865734-127122717 bp(+) (GRCm39)

Type of Mutation

critical splice acceptor site

DNA Base Change (assembly)

CTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTC to CTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTC at 127115777 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000104390 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000108759]

AlphaFold

Q1LZI2

Predicted Effect

probably benign
Transcript: ENSMUST00000108759

SMART Domains

Protein: ENSMUSP00000104390
Gene: ENSMUSG00000057060

Domain	Start	End	E-Value	Type
low complexity region	25	49	N/A	INTRINSIC
Pfam:EamA	67	223	3.2e-7	PFAM
Pfam:SLC35F	145	374	3.2e-6	PFAM

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.7%
20x: 99.1%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 70 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1810055G02Rik	C	T	19: 3,767,241 (GRCm39)	T276I	possibly damaging	Het
Abca17	A	G	17: 24,547,543 (GRCm39)	I277T	possibly damaging	Het
Abcb11	C	T	2: 69,134,280 (GRCm39)		probably null	Het
Abcc12	C	A	8: 87,287,479 (GRCm39)	R122L	possibly damaging	Het
Abcc8	A	G	7: 45,815,341 (GRCm39)		probably null	Het
Adam28	C	T	14: 68,864,396 (GRCm39)	R469K	probably damaging	Het
Adamts18	T	C	8: 114,504,362 (GRCm39)	Y243C	probably damaging	Het
Agbl3	T	C	6: 34,791,754 (GRCm39)	S619P	probably damaging	Het
Alpk3	A	T	7: 80,742,600 (GRCm39)	T806S	probably benign	Het
Armh3	A	C	19: 45,953,874 (GRCm39)	V170G	probably benign	Het
Atoh1	T	A	6: 64,706,914 (GRCm39)	I203N	probably damaging	Het
Cables1	A	G	18: 11,973,572 (GRCm39)	E237G	probably benign	Het
Cacna1d	A	G	14: 30,074,947 (GRCm39)	M1T	probably null	Het
Ccdc91	C	T	6: 147,493,696 (GRCm39)	Q363*	probably null	Het
Cdhr17	A	T	5: 17,029,763 (GRCm39)	T500S	possibly damaging	Het
Ceacam5	T	A	7: 17,484,678 (GRCm39)	D473E	probably damaging	Het
Cfap54	T	A	10: 92,704,617 (GRCm39)	D2821V	unknown	Het
Clca3a2	A	G	3: 144,507,860 (GRCm39)	S737P	probably damaging	Het
Clec4n	T	A	6: 123,209,145 (GRCm39)	M70K	probably benign	Het
Dnai3	A	G	3: 145,802,900 (GRCm39)	V97A	probably damaging	Het
Dstyk	G	A	1: 132,345,404 (GRCm39)	G21S	probably benign	Het
Efcab3	T	G	11: 104,890,549 (GRCm39)	N4210K	probably benign	Het
Enpp5	A	G	17: 44,392,366 (GRCm39)	D265G	probably damaging	Het
Gabrb1	T	C	5: 72,279,538 (GRCm39)		probably null	Het
Gm40460	CACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAG	CACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAG	7: 141,794,554 (GRCm39)		probably benign	Het
Guk1	A	G	11: 59,076,811 (GRCm39)	F91L		Het
Ints1	C	T	5: 139,750,015 (GRCm39)	E961K	possibly damaging	Het
Irx2	T	A	13: 72,777,182 (GRCm39)	M1K	probably null	Het
Jrk	C	T	15: 74,579,048 (GRCm39)	R79H	possibly damaging	Het
Kcnu1	G	T	8: 26,382,116 (GRCm39)	V489L	probably damaging	Het
Kctd7	C	T	5: 130,181,265 (GRCm39)	T209M	probably benign	Het
Kdm5a	T	A	6: 120,403,776 (GRCm39)	V1127E	probably damaging	Het
Klk6	A	G	7: 43,476,367 (GRCm39)	H69R	probably damaging	Het
Lck	T	C	4: 129,445,763 (GRCm39)	K340R	probably benign	Het
Lrrc75a	A	G	11: 62,496,734 (GRCm39)	L276P	probably damaging	Het
Med25	A	G	7: 44,527,667 (GRCm39)	W730R	probably damaging	Het
Muc4	T	C	16: 32,570,140 (GRCm39)	V400A	probably benign	Het
Myl10	G	C	5: 136,726,825 (GRCm39)	V70L	probably benign	Het
Myt1	C	A	2: 181,456,899 (GRCm39)	H906Q	probably damaging	Het
Ncl	A	T	1: 86,278,564 (GRCm39)	F673I	probably damaging	Het
Nfe2l1	G	T	11: 96,713,009 (GRCm39)	T216N	probably benign	Het
Nos2	G	A	11: 78,835,681 (GRCm39)		probably null	Het
Nphp4	T	A	4: 152,639,174 (GRCm39)	I935N	probably benign	Het
Ntn1	G	A	11: 68,276,915 (GRCm39)	A11V	probably benign	Het
Or2t26	A	T	11: 49,039,821 (GRCm39)	M246L	probably benign	Het
Or4c10b	T	C	2: 89,711,605 (GRCm39)	V145A	probably damaging	Het
Pate11	T	C	9: 36,386,980 (GRCm39)	V16A	possibly damaging	Het
Pcdha12	A	G	18: 37,154,661 (GRCm39)	Y460C	probably damaging	Het
Pcdha4	G	T	18: 37,086,111 (GRCm39)	R98L	probably benign	Het
Pitpnc1	A	G	11: 107,103,398 (GRCm39)	S234P	probably damaging	Het
Pmfbp1	A	T	8: 110,240,503 (GRCm39)	Y195F	probably damaging	Het
Prl6a1	T	C	13: 27,502,125 (GRCm39)	I164T	probably damaging	Het
Ptpn18	G	A	1: 34,511,273 (GRCm39)		probably null	Het
Rhbdl2	G	A	4: 123,723,435 (GRCm39)	A280T	possibly damaging	Het
Rsf1	CGGC	CGGCGGCGGGGGC	7: 97,229,139 (GRCm39)		probably benign	Het
Sema3a	T	G	5: 13,566,230 (GRCm39)	Y171*	probably null	Het
Set	A	G	2: 29,956,897 (GRCm39)	E22G	probably benign	Het
Sirpb1b	A	T	3: 15,608,057 (GRCm39)	D229E	probably benign	Het
Slc12a2	A	T	18: 58,074,085 (GRCm39)	I1096F	probably benign	Het
Slc30a5	T	C	13: 100,954,688 (GRCm39)	I159V	probably benign	Het
Slc6a20b	A	G	9: 123,434,013 (GRCm39)	I275T	probably benign	Het
Speer1e	T	A	5: 11,233,116 (GRCm39)		probably null	Het
Stradb	A	C	1: 59,027,677 (GRCm39)	D69A	possibly damaging	Het
Supt16	A	T	14: 52,415,508 (GRCm39)	V409E	probably damaging	Het
Tcea2	A	G	2: 181,328,457 (GRCm39)	N195S	probably damaging	Het
Thumpd3	T	C	6: 113,033,072 (GRCm39)	V270A	possibly damaging	Het
Urgcp	T	A	11: 5,668,116 (GRCm39)	H117L	probably benign	Het
Vps13c	T	A	9: 67,879,283 (GRCm39)	M3408K	probably damaging	Het
Wdfy4	A	C	14: 32,828,088 (GRCm39)	M1078R		Het
Ypel5	G	A	17: 73,153,439 (GRCm39)		probably null	Het

Other mutations in Slc35f3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00687:Slc35f3	APN	8	127,108,903 (GRCm39)	missense	probably benign	0.02
IGL00956:Slc35f3	APN	8	127,108,963 (GRCm39)	missense	probably damaging	1.00
IGL01105:Slc35f3	APN	8	127,025,553 (GRCm39)	missense	probably damaging	1.00
IGL01710:Slc35f3	APN	8	127,115,900 (GRCm39)	missense	probably benign	0.00
IGL01771:Slc35f3	APN	8	127,115,951 (GRCm39)	missense	probably benign	0.00
IGL02254:Slc35f3	APN	8	127,115,862 (GRCm39)	missense	probably damaging	1.00
IGL02610:Slc35f3	APN	8	127,047,956 (GRCm39)	missense	probably damaging	1.00
R1666:Slc35f3	UTSW	8	127,115,960 (GRCm39)	missense	probably damaging	0.98
R2510:Slc35f3	UTSW	8	127,025,445 (GRCm39)	start gained	probably benign
R2520:Slc35f3	UTSW	8	127,121,312 (GRCm39)	missense	possibly damaging	0.81
R3807:Slc35f3	UTSW	8	127,115,978 (GRCm39)	missense	probably damaging	1.00
R4644:Slc35f3	UTSW	8	127,047,809 (GRCm39)	missense	possibly damaging	0.87
R4675:Slc35f3	UTSW	8	127,047,935 (GRCm39)	nonsense	probably null
R4976:Slc35f3	UTSW	8	127,116,020 (GRCm39)	splice site	probably null
R5037:Slc35f3	UTSW	8	127,116,011 (GRCm39)	missense	probably damaging	0.99
R5225:Slc35f3	UTSW	8	127,117,846 (GRCm39)	missense	probably damaging	0.98
R5259:Slc35f3	UTSW	8	127,115,872 (GRCm39)	missense	probably damaging	1.00
R5856:Slc35f3	UTSW	8	127,047,819 (GRCm39)	missense	probably benign	0.07
R5925:Slc35f3	UTSW	8	127,115,946 (GRCm39)	missense	probably benign	0.24
R6254:Slc35f3	UTSW	8	127,047,833 (GRCm39)	missense	possibly damaging	0.96
R6748:Slc35f3	UTSW	8	127,121,377 (GRCm39)	nonsense	probably null
R6785:Slc35f3	UTSW	8	127,121,198 (GRCm39)	missense	probably benign	0.02
R7002:Slc35f3	UTSW	8	127,115,773 (GRCm39)	critical splice acceptor site	unknown
R7291:Slc35f3	UTSW	8	127,121,297 (GRCm39)	missense	probably benign	0.02
R7456:Slc35f3	UTSW	8	127,115,779 (GRCm39)	critical splice acceptor site	unknown
R7790:Slc35f3	UTSW	8	127,115,777 (GRCm39)	critical splice acceptor site	probably benign
R7852:Slc35f3	UTSW	8	127,121,219 (GRCm39)	missense	probably damaging	1.00
R8000:Slc35f3	UTSW	8	127,047,812 (GRCm39)	missense	probably benign
R8277:Slc35f3	UTSW	8	127,115,925 (GRCm39)	missense	possibly damaging	0.88
R8827:Slc35f3	UTSW	8	127,115,780 (GRCm39)	critical splice acceptor site	probably benign
R8983:Slc35f3	UTSW	8	127,115,775 (GRCm39)	critical splice acceptor site	probably benign
R9205:Slc35f3	UTSW	8	127,115,928 (GRCm39)	missense	probably damaging	0.96
R9355:Slc35f3	UTSW	8	127,108,967 (GRCm39)	missense	probably damaging	0.97
R9475:Slc35f3	UTSW	8	127,108,993 (GRCm39)	missense	probably damaging	1.00
R9492:Slc35f3	UTSW	8	127,048,026 (GRCm39)	missense	probably damaging	1.00
R9714:Slc35f3	UTSW	8	127,115,781 (GRCm39)	critical splice acceptor site	probably benign
R9729:Slc35f3	UTSW	8	127,115,777 (GRCm39)	critical splice acceptor site	probably benign
R9769:Slc35f3	UTSW	8	127,121,336 (GRCm39)	missense	probably damaging	0.99
X0067:Slc35f3	UTSW	8	127,109,062 (GRCm39)	missense	probably damaging	0.99

Predicted Primers

Posted On

2019-10-07