Incidental Mutation 'R7413:Or52n3'
ID 575218
Institutional Source Beutler Lab
Gene Symbol Or52n3
Ensembl Gene ENSMUSG00000073917
Gene Name olfactory receptor family 52 subfamily N member 3
Synonyms MOR34-7, Olfr665, GA_x6K02T2PBJ9-7509539-7510489
Accession Numbers
Essential gene? Probably non essential (E-score: 0.090) question?
Stock # R7413 (G1)
Quality Score 225.009
Status Not validated
Chromosome 7
Chromosomal Location 104529916-104530866 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 104530057 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 48 (I48F)
Ref Sequence ENSEMBL: ENSMUSP00000150603 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000098165] [ENSMUST00000215761] [ENSMUST00000216257] [ENSMUST00000216971]
AlphaFold Q8VG79
Predicted Effect probably benign
Transcript: ENSMUST00000098165
AA Change: I48F

PolyPhen 2 Score 0.070 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000095768
Gene: ENSMUSG00000073917
AA Change: I48F

DomainStartEndE-ValueType
Pfam:7tm_4 33 313 6.4e-105 PFAM
Pfam:7TM_GPCR_Srsx 37 310 1e-5 PFAM
Pfam:7tm_1 43 295 1.4e-17 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000215761
AA Change: I48F

PolyPhen 2 Score 0.070 (Sensitivity: 0.94; Specificity: 0.84)
Predicted Effect probably benign
Transcript: ENSMUST00000216257
AA Change: I48F

PolyPhen 2 Score 0.070 (Sensitivity: 0.94; Specificity: 0.84)
Predicted Effect probably benign
Transcript: ENSMUST00000216971
AA Change: I48F

PolyPhen 2 Score 0.070 (Sensitivity: 0.94; Specificity: 0.84)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.2%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 62 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A1cf T C 19: 31,895,524 (GRCm39) probably null Het
Agbl4 A T 4: 111,514,495 (GRCm39) D502V probably benign Het
Akap5 T A 12: 76,375,678 (GRCm39) V370E possibly damaging Het
Alms1 T C 6: 85,605,288 (GRCm39) C1844R probably benign Het
Apaf1 T C 10: 90,831,542 (GRCm39) K1191E probably benign Het
Bsn C T 9: 108,016,690 (GRCm39) R107Q possibly damaging Het
Catsperb G T 12: 101,447,307 (GRCm39) R269L probably damaging Het
Ccer1 T C 10: 97,529,804 (GRCm39) S156P unknown Het
Cdh16 C T 8: 105,346,572 (GRCm39) A241T probably benign Het
Cdk5rap2 A G 4: 70,172,972 (GRCm39) S1367P probably damaging Het
Cds2 C T 2: 132,135,235 (GRCm39) P42L probably benign Het
Col15a1 T C 4: 47,245,431 (GRCm39) Y61H possibly damaging Het
Dclre1a G A 19: 56,531,082 (GRCm39) P755S probably damaging Het
Ddi1 A T 9: 6,265,670 (GRCm39) M233K probably damaging Het
Dpp4 T C 2: 62,187,333 (GRCm39) Y474C probably damaging Het
Epha7 T A 4: 28,871,838 (GRCm39) M389K probably benign Het
Ephb3 T C 16: 21,033,457 (GRCm39) F181S probably damaging Het
Epor G A 9: 21,874,776 (GRCm39) probably benign Het
Fbp2 C A 13: 62,985,067 (GRCm39) V285L probably benign Het
Flnc A T 6: 29,452,258 (GRCm39) D1694V probably damaging Het
Ganab T A 19: 8,882,339 (GRCm39) M98K probably benign Het
Gcm2 A G 13: 41,259,230 (GRCm39) S80P probably damaging Het
Gls A G 1: 52,254,735 (GRCm39) S247P probably benign Het
Gne T C 4: 44,044,857 (GRCm39) N426D probably benign Het
Ifne A T 4: 88,797,840 (GRCm39) *193R probably null Het
Igf2r G T 17: 12,917,115 (GRCm39) S1595* probably null Het
Krt26 C T 11: 99,225,887 (GRCm39) M226I probably benign Het
Lars2 G A 9: 123,288,568 (GRCm39) V805I probably benign Het
Lrrc57 C A 2: 120,436,577 (GRCm39) R177L probably damaging Het
Lrrn1 A G 6: 107,546,083 (GRCm39) E627G probably benign Het
Magel2 CCCTCCTCCTCCTCCTCCTCCT CCCTCCTCCTCCTCCTCCT 7: 62,027,592 (GRCm39) probably benign Het
Mdga1 A T 17: 30,069,647 (GRCm39) V133E probably damaging Het
Med12l A G 3: 58,998,971 (GRCm39) T644A probably benign Het
Meis1 T A 11: 18,938,357 (GRCm39) D218V probably damaging Het
Myo15b A G 11: 115,768,970 (GRCm39) E1439G Het
Naa12 T C 18: 80,254,874 (GRCm39) V56A possibly damaging Het
Nckipsd G A 9: 108,691,280 (GRCm39) V401I probably benign Het
Nrg3 T C 14: 38,092,669 (GRCm39) I655V probably damaging Het
Oprm1 A T 10: 6,778,919 (GRCm39) I107F probably damaging Het
Or4k42 A C 2: 111,319,933 (GRCm39) I190R probably benign Het
Or5p51 T C 7: 107,444,721 (GRCm39) D73G probably damaging Het
Osbpl7 T C 11: 96,945,704 (GRCm39) probably null Het
Pcdh18 T G 3: 49,699,232 (GRCm39) S1077R possibly damaging Het
Pcdhb16 A T 18: 37,611,975 (GRCm39) K312* probably null Het
Plekhh2 A T 17: 84,873,724 (GRCm39) E336D probably benign Het
Ptprd A T 4: 76,165,076 (GRCm39) S49T probably benign Het
Pxdn A G 12: 30,052,927 (GRCm39) I1035V probably benign Het
Rlf C T 4: 121,007,297 (GRCm39) G671D probably damaging Het
Rsf1 GGCGGCGGC GGCGGCGGCCGCGGCGGC 7: 97,229,128 (GRCm39) probably benign Het
Selenbp2 A G 3: 94,607,404 (GRCm39) Q275R probably benign Het
Slc10a1 G T 12: 81,007,396 (GRCm39) F128L probably benign Het
Slitrk1 A T 14: 109,149,357 (GRCm39) Y451* probably null Het
Spata31f3 TCATTCAACACTTTGGAGAGCTCTGAACTCTGGCCATTCAACACTTTGGAGAGCTCTGAACTCTGGCCATTCAACACTTTGGAGAGCTCTGAACTCTGGTCATTCAACACTTTGG TCATTCAACACTTTGGAGAGCTCTGAACTCTGGCCATTCAACACTTTGGAGAGCTCTGAACTCTGGTCATTCAACACTTTGG 4: 42,871,823 (GRCm39) probably benign Het
Stambpl1 G C 19: 34,204,116 (GRCm39) G69R probably damaging Het
Surf4 G T 2: 26,814,455 (GRCm39) R149S probably benign Het
Tmem151a T C 19: 5,132,702 (GRCm39) Y168C probably damaging Het
Ttc39c A G 18: 12,861,746 (GRCm39) K416R possibly damaging Het
Tut4 T C 4: 108,406,533 (GRCm39) I1367T possibly damaging Het
Vit T C 17: 78,932,309 (GRCm39) I472T probably damaging Het
Vmn1r212 A C 13: 23,067,718 (GRCm39) L205R probably damaging Het
Wscd2 T C 5: 113,715,402 (GRCm39) I414T probably benign Het
Zfp1005 A C 2: 150,108,081 (GRCm39) T14P possibly damaging Het
Other mutations in Or52n3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00227:Or52n3 APN 7 104,530,724 (GRCm39) missense probably benign 0.01
IGL01408:Or52n3 APN 7 104,530,037 (GRCm39) missense probably benign 0.02
IGL02022:Or52n3 APN 7 104,530,141 (GRCm39) missense probably damaging 1.00
R0349:Or52n3 UTSW 7 104,530,199 (GRCm39) missense possibly damaging 0.48
R0585:Or52n3 UTSW 7 104,530,706 (GRCm39) missense probably damaging 1.00
R1518:Or52n3 UTSW 7 104,530,515 (GRCm39) nonsense probably null
R1659:Or52n3 UTSW 7 104,530,387 (GRCm39) missense probably benign 0.00
R1727:Or52n3 UTSW 7 104,530,721 (GRCm39) missense probably benign 0.11
R1762:Or52n3 UTSW 7 104,530,447 (GRCm39) missense probably damaging 0.99
R4052:Or52n3 UTSW 7 104,530,810 (GRCm39) missense probably damaging 0.99
R4208:Or52n3 UTSW 7 104,530,810 (GRCm39) missense probably damaging 0.99
R5486:Or52n3 UTSW 7 104,530,168 (GRCm39) missense probably benign 0.02
R5513:Or52n3 UTSW 7 104,530,706 (GRCm39) missense probably damaging 1.00
R6148:Or52n3 UTSW 7 104,530,289 (GRCm39) missense possibly damaging 0.84
R6593:Or52n3 UTSW 7 104,530,640 (GRCm39) missense probably damaging 1.00
R7143:Or52n3 UTSW 7 104,530,393 (GRCm39) missense probably damaging 1.00
R7189:Or52n3 UTSW 7 104,530,348 (GRCm39) nonsense probably null
R8690:Or52n3 UTSW 7 104,530,762 (GRCm39) missense probably damaging 1.00
R8819:Or52n3 UTSW 7 104,530,862 (GRCm39) missense possibly damaging 0.90
R8820:Or52n3 UTSW 7 104,530,862 (GRCm39) missense possibly damaging 0.90
R9430:Or52n3 UTSW 7 104,530,204 (GRCm39) missense possibly damaging 0.92
R9464:Or52n3 UTSW 7 104,530,050 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- TATTACCAAGCATAGAGTGTGACTC -3'
(R):5'- TAGCGGTCGAGAGCCATAAG -3'

Sequencing Primer
(F):5'- GAGTGTGACTCATTTTCTACTGATC -3'
(R):5'- AGACTCCATGCCTGTTAACATGTG -3'
Posted On 2019-10-07