Incidental Mutation 'R0626:Trip11'
| ID |
57535 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Trip11
|
| Ensembl Gene |
ENSMUSG00000021188 |
| Gene Name |
thyroid hormone receptor interactor 11 |
| Synonyms |
3110031G15Rik, TRIP230, 2610511G22Rik, GMAP-210, 6030460N08Rik |
| MMRRC Submission |
038815-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R0626 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
12 |
| Chromosomal Location |
101800304-101879463 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 101852235 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Arginine to Glycine
at position 610
(R610G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000021605
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000021605]
[ENSMUST00000176728]
[ENSMUST00000177183]
[ENSMUST00000177536]
|
| AlphaFold |
E9Q512 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000021605
AA Change: R610G
PolyPhen 2
Score 0.540 (Sensitivity: 0.88; Specificity: 0.90)
|
| SMART Domains |
Protein: ENSMUSP00000021605
Gene: ENSMUSG00000021188
AA Change: R610G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
2 |
26 |
N/A |
INTRINSIC |
|
coiled coil region
|
54 |
130 |
N/A |
INTRINSIC |
|
coiled coil region
|
167 |
194 |
N/A |
INTRINSIC |
|
coiled coil region
|
218 |
702 |
N/A |
INTRINSIC |
|
coiled coil region
|
754 |
990 |
N/A |
INTRINSIC |
|
coiled coil region
|
1022 |
1051 |
N/A |
INTRINSIC |
|
coiled coil region
|
1196 |
1261 |
N/A |
INTRINSIC |
|
low complexity region
|
1310 |
1322 |
N/A |
INTRINSIC |
|
coiled coil region
|
1336 |
1481 |
N/A |
INTRINSIC |
|
coiled coil region
|
1547 |
1657 |
N/A |
INTRINSIC |
|
coiled coil region
|
1681 |
1771 |
N/A |
INTRINSIC |
|
low complexity region
|
1934 |
1945 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000176728
|
| SMART Domains |
Protein: ENSMUSP00000134992
Gene: ENSMUSG00000021188
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
2 |
26 |
N/A |
INTRINSIC |
|
Pfam:Orthopox_A5L
|
48 |
282 |
6.5e-9 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000177183
AA Change: R325G
PolyPhen 2
Score 0.270 (Sensitivity: 0.91; Specificity: 0.88)
|
| SMART Domains |
Protein: ENSMUSP00000134976
Gene: ENSMUSG00000021188
AA Change: R325G
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
33 |
158 |
N/A |
INTRINSIC |
|
coiled coil region
|
179 |
417 |
N/A |
INTRINSIC |
|
coiled coil region
|
469 |
705 |
N/A |
INTRINSIC |
|
coiled coil region
|
737 |
766 |
N/A |
INTRINSIC |
|
coiled coil region
|
911 |
976 |
N/A |
INTRINSIC |
|
low complexity region
|
1025 |
1037 |
N/A |
INTRINSIC |
|
coiled coil region
|
1051 |
1196 |
N/A |
INTRINSIC |
|
coiled coil region
|
1262 |
1372 |
N/A |
INTRINSIC |
|
coiled coil region
|
1396 |
1486 |
N/A |
INTRINSIC |
|
low complexity region
|
1649 |
1660 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000177480
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000177536
|
| SMART Domains |
Protein: ENSMUSP00000135669
Gene: ENSMUSG00000021188
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
2 |
26 |
N/A |
INTRINSIC |
|
coiled coil region
|
53 |
129 |
N/A |
INTRINSIC |
|
coiled coil region
|
166 |
193 |
N/A |
INTRINSIC |
|
coiled coil region
|
217 |
517 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 99.4%
- 3x: 99.0%
- 10x: 97.9%
- 20x: 96.2%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene was identified based on the interaction of its protein product with thyroid hormone receptor beta. This protein is associated with the Golgi apparatus. The N-terminal region of the protein binds Golgi membranes and the C-terminal region binds the minus ends of microtubules; thus, the protein is thought to play a role in assembly and maintenance of the Golgi ribbon structure around the centrosome. Mutations in this gene cause achondrogenesis type IA.[provided by RefSeq, Mar 2010]
PHENOTYPE: Mice homozygous for a null allele exhibit neonatal lethality associated with small size, lung hypoplasia, omphalocele, and ventricular septal defects. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(12) : Gene trapped(11) Chemically induced(1)
|
| Other mutations in this stock |
Total: 108 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700012B07Rik |
T |
C |
11: 109,679,547 (GRCm39) |
|
probably benign |
Het |
| 6430571L13Rik |
T |
A |
9: 107,219,707 (GRCm39) |
D53E |
possibly damaging |
Het |
| A2ml1 |
T |
A |
6: 128,527,736 (GRCm39) |
N1018I |
probably damaging |
Het |
| Abi3 |
C |
A |
11: 95,727,937 (GRCm39) |
A85S |
probably benign |
Het |
| Acsl5 |
A |
T |
19: 55,272,904 (GRCm39) |
M340L |
probably benign |
Het |
| Adam29 |
T |
A |
8: 56,324,612 (GRCm39) |
H614L |
probably benign |
Het |
| Adgrg6 |
A |
T |
10: 14,312,628 (GRCm39) |
S720T |
probably damaging |
Het |
| Adrb2 |
G |
T |
18: 62,312,441 (GRCm39) |
A128E |
probably damaging |
Het |
| Afap1l1 |
T |
C |
18: 61,872,291 (GRCm39) |
E510G |
probably benign |
Het |
| Angel1 |
A |
G |
12: 86,764,487 (GRCm39) |
|
probably null |
Het |
| Aox3 |
T |
G |
1: 58,211,458 (GRCm39) |
I1005S |
possibly damaging |
Het |
| Apc |
C |
A |
18: 34,451,507 (GRCm39) |
P2767Q |
probably damaging |
Het |
| Apob |
T |
G |
12: 8,066,193 (GRCm39) |
D4387E |
probably benign |
Het |
| Apobr |
T |
C |
7: 126,185,827 (GRCm39) |
V446A |
possibly damaging |
Het |
| Arhgap28 |
A |
T |
17: 68,203,108 (GRCm39) |
|
probably null |
Het |
| Aspm |
G |
T |
1: 139,419,339 (GRCm39) |
K3001N |
probably damaging |
Het |
| Asxl3 |
G |
T |
18: 22,655,937 (GRCm39) |
V1316F |
probably benign |
Het |
| Atp2a1 |
T |
A |
7: 126,046,162 (GRCm39) |
|
probably null |
Het |
| Bach1 |
A |
G |
16: 87,526,359 (GRCm39) |
D607G |
possibly damaging |
Het |
| Batf3 |
A |
G |
1: 190,832,935 (GRCm39) |
D27G |
probably damaging |
Het |
| Baz1a |
G |
T |
12: 55,022,055 (GRCm39) |
Q76K |
probably damaging |
Het |
| Bdnf |
G |
A |
2: 109,553,883 (GRCm39) |
V86M |
probably benign |
Het |
| Birc7 |
A |
G |
2: 180,573,098 (GRCm39) |
I172V |
probably benign |
Het |
| Bod1l |
A |
C |
5: 41,988,880 (GRCm39) |
V409G |
probably damaging |
Het |
| Cacna1e |
T |
A |
1: 154,364,563 (GRCm39) |
E337V |
probably damaging |
Het |
| Cacna1h |
A |
G |
17: 25,612,520 (GRCm39) |
F287L |
possibly damaging |
Het |
| Ces1e |
A |
G |
8: 93,950,671 (GRCm39) |
Y37H |
probably benign |
Het |
| Clasrp |
A |
T |
7: 19,318,418 (GRCm39) |
|
probably benign |
Het |
| Clec2d |
T |
A |
6: 129,160,090 (GRCm39) |
S35T |
probably damaging |
Het |
| Cntn4 |
T |
A |
6: 106,639,539 (GRCm39) |
D556E |
probably benign |
Het |
| Cntnap5c |
A |
T |
17: 58,349,422 (GRCm39) |
D245V |
probably benign |
Het |
| Col5a1 |
T |
A |
2: 27,818,255 (GRCm39) |
L160* |
probably null |
Het |
| Col6a6 |
T |
C |
9: 105,654,943 (GRCm39) |
E926G |
probably benign |
Het |
| Cpsf2 |
T |
A |
12: 101,951,490 (GRCm39) |
H142Q |
probably benign |
Het |
| Cr2 |
A |
C |
1: 194,853,419 (GRCm39) |
S20A |
possibly damaging |
Het |
| Ct45a |
G |
A |
X: 55,590,399 (GRCm39) |
P134L |
probably benign |
Het |
| Cyp2j5 |
A |
T |
4: 96,547,749 (GRCm39) |
H164Q |
probably benign |
Het |
| D430041D05Rik |
G |
C |
2: 103,998,295 (GRCm39) |
P1836R |
probably damaging |
Het |
| Dmbt1 |
G |
A |
7: 130,703,811 (GRCm39) |
V1124M |
probably damaging |
Het |
| Dmxl2 |
T |
C |
9: 54,323,838 (GRCm39) |
H1182R |
probably damaging |
Het |
| Dnah2 |
A |
T |
11: 69,368,509 (GRCm39) |
S1709T |
probably benign |
Het |
| Dop1b |
T |
C |
16: 93,560,844 (GRCm39) |
V776A |
probably damaging |
Het |
| Emc3 |
T |
C |
6: 113,492,992 (GRCm39) |
T220A |
probably benign |
Het |
| Entpd1 |
A |
C |
19: 40,715,769 (GRCm39) |
N312T |
probably benign |
Het |
| Fam8a1 |
A |
T |
13: 46,824,699 (GRCm39) |
I229F |
probably damaging |
Het |
| Fancc |
G |
A |
13: 63,465,205 (GRCm39) |
P501S |
probably damaging |
Het |
| Fasn |
T |
C |
11: 120,702,751 (GRCm39) |
R1704G |
probably damaging |
Het |
| Fsip2 |
A |
G |
2: 82,819,302 (GRCm39) |
I5012V |
probably benign |
Het |
| Glce |
T |
C |
9: 61,968,282 (GRCm39) |
T290A |
probably benign |
Het |
| Gns |
G |
A |
10: 121,219,349 (GRCm39) |
|
probably null |
Het |
| Gsdma2 |
A |
G |
11: 98,542,810 (GRCm39) |
N190S |
probably damaging |
Het |
| Hectd4 |
T |
A |
5: 121,415,887 (GRCm39) |
S563T |
probably benign |
Het |
| Hmcn1 |
T |
C |
1: 150,674,470 (GRCm39) |
|
probably null |
Het |
| Jup |
A |
T |
11: 100,267,589 (GRCm39) |
M578K |
probably benign |
Het |
| Kir3dl1 |
G |
A |
X: 135,434,594 (GRCm39) |
|
probably null |
Het |
| Krt75 |
A |
G |
15: 101,482,025 (GRCm39) |
F81S |
probably benign |
Het |
| Lrp1 |
G |
T |
10: 127,403,233 (GRCm39) |
D2113E |
probably damaging |
Het |
| Maged2 |
T |
A |
X: 149,594,830 (GRCm39) |
N176Y |
probably damaging |
Het |
| Mrc1 |
T |
A |
2: 14,333,382 (GRCm39) |
C1354* |
probably null |
Het |
| Mup7 |
A |
C |
4: 60,069,742 (GRCm39) |
V74G |
possibly damaging |
Het |
| Naca |
A |
G |
10: 127,877,031 (GRCm39) |
|
probably benign |
Het |
| Nav3 |
T |
G |
10: 109,659,325 (GRCm39) |
Y764S |
probably damaging |
Het |
| Nkpd1 |
A |
T |
7: 19,257,099 (GRCm39) |
T293S |
probably benign |
Het |
| Numb |
A |
G |
12: 83,842,614 (GRCm39) |
Y510H |
probably damaging |
Het |
| Nynrin |
T |
G |
14: 56,105,492 (GRCm39) |
L834R |
probably damaging |
Het |
| Or11g27 |
T |
C |
14: 50,771,159 (GRCm39) |
S97P |
possibly damaging |
Het |
| Or2ak5 |
G |
T |
11: 58,611,347 (GRCm39) |
H176N |
probably benign |
Het |
| Or8g18 |
T |
A |
9: 39,149,162 (GRCm39) |
N186I |
possibly damaging |
Het |
| Otog |
T |
C |
7: 45,920,797 (GRCm39) |
V1000A |
possibly damaging |
Het |
| Pafah1b3 |
A |
G |
7: 24,996,554 (GRCm39) |
V43A |
possibly damaging |
Het |
| Pcnx1 |
A |
G |
12: 82,030,450 (GRCm39) |
Y1775C |
possibly damaging |
Het |
| Phka1 |
G |
A |
X: 101,564,437 (GRCm39) |
R1074C |
probably damaging |
Het |
| Pi4ka |
T |
A |
16: 17,111,765 (GRCm39) |
Y1570F |
probably benign |
Het |
| Piezo2 |
T |
C |
18: 63,152,329 (GRCm39) |
K2588E |
probably damaging |
Het |
| Pkd1 |
A |
G |
17: 24,794,549 (GRCm39) |
T2079A |
probably damaging |
Het |
| Plekhd1 |
G |
T |
12: 80,764,075 (GRCm39) |
Q212H |
probably damaging |
Het |
| Plekhh1 |
C |
T |
12: 79,087,359 (GRCm39) |
R16* |
probably null |
Het |
| Polm |
C |
A |
11: 5,786,207 (GRCm39) |
R120L |
probably damaging |
Het |
| Ptpn22 |
T |
C |
3: 103,767,721 (GRCm39) |
M1T |
probably null |
Het |
| Ptprh |
G |
A |
7: 4,567,271 (GRCm39) |
L534F |
probably benign |
Het |
| Rabl6 |
C |
T |
2: 25,482,778 (GRCm39) |
|
probably null |
Het |
| Rap2a |
A |
G |
14: 120,716,403 (GRCm39) |
S89G |
probably damaging |
Het |
| Rara |
A |
T |
11: 98,862,406 (GRCm39) |
|
probably null |
Het |
| Reck |
A |
G |
4: 43,930,295 (GRCm39) |
D623G |
probably benign |
Het |
| Relt |
A |
T |
7: 100,498,023 (GRCm39) |
L237Q |
probably damaging |
Het |
| Rngtt |
A |
G |
4: 33,329,598 (GRCm39) |
|
probably null |
Het |
| Rtn4rl2 |
T |
G |
2: 84,710,763 (GRCm39) |
Y167S |
probably damaging |
Het |
| Sec24c |
C |
T |
14: 20,738,505 (GRCm39) |
R353C |
probably damaging |
Het |
| Slc35g2 |
T |
C |
9: 100,435,495 (GRCm39) |
S59G |
probably benign |
Het |
| Smarcd2 |
A |
T |
11: 106,158,241 (GRCm39) |
M107K |
probably benign |
Het |
| Smg1 |
T |
C |
7: 117,781,606 (GRCm39) |
N1227S |
possibly damaging |
Het |
| Snrnp200 |
A |
G |
2: 127,063,734 (GRCm39) |
N638D |
possibly damaging |
Het |
| Sntb1 |
A |
G |
15: 55,506,179 (GRCm39) |
S465P |
probably benign |
Het |
| Sp4 |
A |
G |
12: 118,263,314 (GRCm39) |
L244P |
probably damaging |
Het |
| Sulf1 |
A |
G |
1: 12,887,716 (GRCm39) |
|
probably null |
Het |
| Tbc1d17 |
T |
C |
7: 44,492,509 (GRCm39) |
T385A |
probably benign |
Het |
| Tbx10 |
C |
A |
19: 4,047,873 (GRCm39) |
D206E |
probably benign |
Het |
| Tcea2 |
C |
T |
2: 181,329,431 (GRCm39) |
P275S |
probably damaging |
Het |
| Tns3 |
C |
A |
11: 8,443,121 (GRCm39) |
R414L |
probably benign |
Het |
| Ugt2b1 |
T |
C |
5: 87,073,720 (GRCm39) |
K213R |
probably null |
Het |
| Unc80 |
A |
G |
1: 66,647,601 (GRCm39) |
S1514G |
probably benign |
Het |
| Usp7 |
G |
T |
16: 8,511,778 (GRCm39) |
Q867K |
possibly damaging |
Het |
| Vim |
T |
C |
2: 13,579,463 (GRCm39) |
V74A |
probably benign |
Het |
| Vmn1r234 |
A |
G |
17: 21,450,007 (GRCm39) |
Y307C |
probably benign |
Het |
| Vmn2r74 |
A |
T |
7: 85,610,517 (GRCm39) |
Y58* |
probably null |
Het |
| Wdr36 |
C |
A |
18: 32,983,584 (GRCm39) |
A445E |
probably damaging |
Het |
| Xpo5 |
T |
A |
17: 46,532,359 (GRCm39) |
W465R |
probably damaging |
Het |
| Zscan4d |
T |
A |
7: 10,898,946 (GRCm39) |
R110S |
probably damaging |
Het |
|
| Other mutations in Trip11 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00430:Trip11
|
APN |
12 |
101,852,406 (GRCm39) |
missense |
probably benign |
0.37 |
|
IGL00484:Trip11
|
APN |
12 |
101,851,570 (GRCm39) |
nonsense |
probably null |
|
|
IGL00972:Trip11
|
APN |
12 |
101,860,596 (GRCm39) |
missense |
probably null |
1.00 |
|
IGL01476:Trip11
|
APN |
12 |
101,865,170 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL01591:Trip11
|
APN |
12 |
101,849,604 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01667:Trip11
|
APN |
12 |
101,845,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01764:Trip11
|
APN |
12 |
101,850,890 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01789:Trip11
|
APN |
12 |
101,838,090 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL01814:Trip11
|
APN |
12 |
101,850,747 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01898:Trip11
|
APN |
12 |
101,851,935 (GRCm39) |
missense |
probably benign |
|
|
IGL01924:Trip11
|
APN |
12 |
101,853,143 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL02020:Trip11
|
APN |
12 |
101,850,572 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02475:Trip11
|
APN |
12 |
101,861,942 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02544:Trip11
|
APN |
12 |
101,859,780 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02678:Trip11
|
APN |
12 |
101,849,649 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02714:Trip11
|
APN |
12 |
101,850,260 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02718:Trip11
|
APN |
12 |
101,852,284 (GRCm39) |
missense |
probably benign |
0.24 |
|
IGL02904:Trip11
|
APN |
12 |
101,853,097 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03012:Trip11
|
APN |
12 |
101,850,195 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03191:Trip11
|
APN |
12 |
101,865,184 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03327:Trip11
|
APN |
12 |
101,849,677 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
IGL03337:Trip11
|
APN |
12 |
101,851,278 (GRCm39) |
missense |
probably damaging |
1.00 |
|
NA:Trip11
|
UTSW |
12 |
101,860,580 (GRCm39) |
splice site |
probably null |
|
|
R0027:Trip11
|
UTSW |
12 |
101,851,428 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0028:Trip11
|
UTSW |
12 |
101,851,016 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0238:Trip11
|
UTSW |
12 |
101,850,987 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0238:Trip11
|
UTSW |
12 |
101,850,987 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0239:Trip11
|
UTSW |
12 |
101,850,987 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0239:Trip11
|
UTSW |
12 |
101,850,987 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0505:Trip11
|
UTSW |
12 |
101,851,931 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0556:Trip11
|
UTSW |
12 |
101,850,777 (GRCm39) |
nonsense |
probably null |
|
|
R0573:Trip11
|
UTSW |
12 |
101,853,119 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1519:Trip11
|
UTSW |
12 |
101,852,419 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1530:Trip11
|
UTSW |
12 |
101,879,026 (GRCm39) |
missense |
unknown |
|
|
R1647:Trip11
|
UTSW |
12 |
101,850,651 (GRCm39) |
nonsense |
probably null |
|
|
R1648:Trip11
|
UTSW |
12 |
101,850,651 (GRCm39) |
nonsense |
probably null |
|
|
R1856:Trip11
|
UTSW |
12 |
101,849,592 (GRCm39) |
nonsense |
probably null |
|
|
R2013:Trip11
|
UTSW |
12 |
101,803,981 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2017:Trip11
|
UTSW |
12 |
101,851,619 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2206:Trip11
|
UTSW |
12 |
101,839,701 (GRCm39) |
missense |
probably benign |
0.25 |
|
R2207:Trip11
|
UTSW |
12 |
101,839,701 (GRCm39) |
missense |
probably benign |
0.25 |
|
R2304:Trip11
|
UTSW |
12 |
101,865,236 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R2328:Trip11
|
UTSW |
12 |
101,845,086 (GRCm39) |
makesense |
probably null |
|
|
R2513:Trip11
|
UTSW |
12 |
101,803,986 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R3499:Trip11
|
UTSW |
12 |
101,859,953 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R4105:Trip11
|
UTSW |
12 |
101,860,581 (GRCm39) |
nonsense |
probably null |
|
|
R4124:Trip11
|
UTSW |
12 |
101,861,957 (GRCm39) |
nonsense |
probably null |
|
|
R4126:Trip11
|
UTSW |
12 |
101,861,957 (GRCm39) |
nonsense |
probably null |
|
|
R4128:Trip11
|
UTSW |
12 |
101,861,957 (GRCm39) |
nonsense |
probably null |
|
|
R4175:Trip11
|
UTSW |
12 |
101,861,957 (GRCm39) |
nonsense |
probably null |
|
|
R4176:Trip11
|
UTSW |
12 |
101,861,957 (GRCm39) |
nonsense |
probably null |
|
|
R4181:Trip11
|
UTSW |
12 |
101,860,027 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4296:Trip11
|
UTSW |
12 |
101,852,127 (GRCm39) |
nonsense |
probably null |
|
|
R4302:Trip11
|
UTSW |
12 |
101,860,027 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4306:Trip11
|
UTSW |
12 |
101,853,198 (GRCm39) |
missense |
probably benign |
|
|
R4342:Trip11
|
UTSW |
12 |
101,850,575 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4576:Trip11
|
UTSW |
12 |
101,852,499 (GRCm39) |
nonsense |
probably null |
|
|
R4586:Trip11
|
UTSW |
12 |
101,849,600 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R4634:Trip11
|
UTSW |
12 |
101,803,875 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4696:Trip11
|
UTSW |
12 |
101,851,549 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R4792:Trip11
|
UTSW |
12 |
101,851,705 (GRCm39) |
missense |
probably benign |
0.10 |
|
R4903:Trip11
|
UTSW |
12 |
101,853,065 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5001:Trip11
|
UTSW |
12 |
101,851,169 (GRCm39) |
nonsense |
probably null |
|
|
R5017:Trip11
|
UTSW |
12 |
101,812,879 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5227:Trip11
|
UTSW |
12 |
101,851,179 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5231:Trip11
|
UTSW |
12 |
101,851,860 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5539:Trip11
|
UTSW |
12 |
101,851,386 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5754:Trip11
|
UTSW |
12 |
101,851,924 (GRCm39) |
nonsense |
probably null |
|
|
R5755:Trip11
|
UTSW |
12 |
101,851,924 (GRCm39) |
nonsense |
probably null |
|
|
R5890:Trip11
|
UTSW |
12 |
101,852,231 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5910:Trip11
|
UTSW |
12 |
101,849,738 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6083:Trip11
|
UTSW |
12 |
101,856,001 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6208:Trip11
|
UTSW |
12 |
101,865,154 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6216:Trip11
|
UTSW |
12 |
101,856,859 (GRCm39) |
missense |
probably benign |
0.31 |
|
R6315:Trip11
|
UTSW |
12 |
101,851,837 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R6413:Trip11
|
UTSW |
12 |
101,851,790 (GRCm39) |
missense |
probably benign |
0.12 |
|
R6590:Trip11
|
UTSW |
12 |
101,851,710 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R6690:Trip11
|
UTSW |
12 |
101,851,710 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R6914:Trip11
|
UTSW |
12 |
101,812,879 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6938:Trip11
|
UTSW |
12 |
101,803,886 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7015:Trip11
|
UTSW |
12 |
101,859,942 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7023:Trip11
|
UTSW |
12 |
101,852,126 (GRCm39) |
missense |
probably benign |
0.13 |
|
R7133:Trip11
|
UTSW |
12 |
101,850,329 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7271:Trip11
|
UTSW |
12 |
101,850,611 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7424:Trip11
|
UTSW |
12 |
101,851,457 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7431:Trip11
|
UTSW |
12 |
101,850,278 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R7472:Trip11
|
UTSW |
12 |
101,851,639 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7491:Trip11
|
UTSW |
12 |
101,851,694 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7752:Trip11
|
UTSW |
12 |
101,853,233 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7763:Trip11
|
UTSW |
12 |
101,811,114 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7779:Trip11
|
UTSW |
12 |
101,849,796 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7844:Trip11
|
UTSW |
12 |
101,844,403 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8055:Trip11
|
UTSW |
12 |
101,803,924 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8076:Trip11
|
UTSW |
12 |
101,849,741 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8288:Trip11
|
UTSW |
12 |
101,860,643 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R8294:Trip11
|
UTSW |
12 |
101,811,160 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R8318:Trip11
|
UTSW |
12 |
101,879,063 (GRCm39) |
missense |
unknown |
|
|
R8690:Trip11
|
UTSW |
12 |
101,839,656 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R8879:Trip11
|
UTSW |
12 |
101,828,857 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8964:Trip11
|
UTSW |
12 |
101,811,315 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9005:Trip11
|
UTSW |
12 |
101,845,131 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9013:Trip11
|
UTSW |
12 |
101,851,377 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9020:Trip11
|
UTSW |
12 |
101,850,770 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R9041:Trip11
|
UTSW |
12 |
101,845,127 (GRCm39) |
missense |
probably benign |
0.06 |
|
R9234:Trip11
|
UTSW |
12 |
101,811,990 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9447:Trip11
|
UTSW |
12 |
101,850,148 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9631:Trip11
|
UTSW |
12 |
101,859,807 (GRCm39) |
missense |
probably benign |
|
|
R9641:Trip11
|
UTSW |
12 |
101,859,957 (GRCm39) |
nonsense |
probably null |
|
|
R9691:Trip11
|
UTSW |
12 |
101,850,123 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9751:Trip11
|
UTSW |
12 |
101,850,765 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
X0020:Trip11
|
UTSW |
12 |
101,852,172 (GRCm39) |
nonsense |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- GCCTTTTCCCATTCCAGCATAGCAG -3'
(R):5'- GAGAAGCAGAGAACCCATCAGCTTG -3'
Sequencing Primer
(F):5'- CAGAGAAATCTGCTTGTTGCCAG -3'
(R):5'- CCCATCAGCTTGAGGATGATAAAATG -3'
|
| Posted On |
2013-07-11 |
Incidental Mutation