Incidental Mutation 'R7419:Robo4'
| ID |
575541 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Robo4
|
| Ensembl Gene |
ENSMUSG00000032125 |
| Gene Name |
roundabout guidance receptor 4 |
| Synonyms |
Magic roundabout, 1200012D01Rik |
| MMRRC Submission |
045497-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.224)
|
| Stock # |
R7419 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
9 |
| Chromosomal Location |
37313198-37325319 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to C
at 37314105 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Leucine
at position 119
(I119L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000150722
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000102895]
[ENSMUST00000115046]
[ENSMUST00000115048]
[ENSMUST00000156972]
[ENSMUST00000214185]
|
| AlphaFold |
Q8C310 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000102895
AA Change: I119L
PolyPhen 2
Score 0.214 (Sensitivity: 0.92; Specificity: 0.88)
|
| SMART Domains |
Protein: ENSMUSP00000099959
Gene: ENSMUSG00000032125
AA Change: I119L
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
37 |
N/A |
INTRINSIC |
|
IG
|
48 |
144 |
2.51e0 |
SMART |
|
IGc2
|
160 |
225 |
6.86e-11 |
SMART |
|
FN3
|
263 |
343 |
2.05e0 |
SMART |
|
FN3
|
358 |
440 |
1.27e-3 |
SMART |
|
low complexity region
|
488 |
494 |
N/A |
INTRINSIC |
|
low complexity region
|
544 |
562 |
N/A |
INTRINSIC |
|
low complexity region
|
720 |
733 |
N/A |
INTRINSIC |
|
low complexity region
|
748 |
762 |
N/A |
INTRINSIC |
|
low complexity region
|
775 |
799 |
N/A |
INTRINSIC |
|
low complexity region
|
855 |
866 |
N/A |
INTRINSIC |
|
low complexity region
|
871 |
880 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000115046
AA Change: I119L
PolyPhen 2
Score 0.214 (Sensitivity: 0.92; Specificity: 0.88)
|
| SMART Domains |
Protein: ENSMUSP00000110698
Gene: ENSMUSG00000032125
AA Change: I119L
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
37 |
N/A |
INTRINSIC |
|
IG
|
48 |
144 |
2.51e0 |
SMART |
|
IGc2
|
160 |
225 |
6.86e-11 |
SMART |
|
FN3
|
263 |
343 |
2.05e0 |
SMART |
|
FN3
|
358 |
440 |
1.27e-3 |
SMART |
|
low complexity region
|
484 |
500 |
N/A |
INTRINSIC |
|
low complexity region
|
540 |
546 |
N/A |
INTRINSIC |
|
low complexity region
|
596 |
614 |
N/A |
INTRINSIC |
|
low complexity region
|
747 |
756 |
N/A |
INTRINSIC |
|
low complexity region
|
779 |
792 |
N/A |
INTRINSIC |
|
low complexity region
|
807 |
821 |
N/A |
INTRINSIC |
|
low complexity region
|
834 |
858 |
N/A |
INTRINSIC |
|
low complexity region
|
914 |
925 |
N/A |
INTRINSIC |
|
low complexity region
|
930 |
939 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000115048
|
| SMART Domains |
Protein: ENSMUSP00000110700
Gene: ENSMUSG00000032125
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
37 |
N/A |
INTRINSIC |
|
IG
|
48 |
144 |
2.51e0 |
SMART |
|
IGc2
|
160 |
225 |
6.86e-11 |
SMART |
|
FN3
|
263 |
343 |
2.05e0 |
SMART |
|
FN3
|
358 |
440 |
1.27e-3 |
SMART |
|
low complexity region
|
488 |
494 |
N/A |
INTRINSIC |
|
low complexity region
|
544 |
562 |
N/A |
INTRINSIC |
|
low complexity region
|
695 |
704 |
N/A |
INTRINSIC |
|
low complexity region
|
727 |
740 |
N/A |
INTRINSIC |
|
low complexity region
|
755 |
769 |
N/A |
INTRINSIC |
|
low complexity region
|
782 |
806 |
N/A |
INTRINSIC |
|
low complexity region
|
862 |
873 |
N/A |
INTRINSIC |
|
low complexity region
|
878 |
887 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000156972
AA Change: I119L
PolyPhen 2
Score 0.136 (Sensitivity: 0.92; Specificity: 0.86)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000214185
AA Change: I119L
PolyPhen 2
Score 0.179 (Sensitivity: 0.92; Specificity: 0.87)
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 98.9%
|
| Validation Efficiency |
99% (93/94) |
| MGI Phenotype |
PHENOTYPE: Mice homozygous for a reporter/null allele display enhanced VEGF-induced endothelial migration, tube formation and vascular permeability, and show increased pathologic angiogenesis and vascular leak in models of oxygen-induced retinopathy and choroidal neovascularization. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 94 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca13 |
T |
C |
11: 9,226,959 (GRCm39) |
S572P |
probably damaging |
Het |
| Abca13 |
T |
C |
11: 9,247,833 (GRCm39) |
Y2527H |
probably damaging |
Het |
| Abcc5 |
A |
G |
16: 20,241,173 (GRCm39) |
I4T |
possibly damaging |
Het |
| Adamts12 |
C |
T |
15: 11,317,365 (GRCm39) |
T1355I |
probably benign |
Het |
| Aloxe3 |
A |
G |
11: 69,018,353 (GRCm39) |
T117A |
probably benign |
Het |
| Asb15 |
A |
G |
6: 24,556,555 (GRCm39) |
I17V |
probably benign |
Het |
| Atf2 |
A |
G |
2: 73,672,777 (GRCm39) |
V194A |
probably benign |
Het |
| Capn7 |
T |
C |
14: 31,071,779 (GRCm39) |
V221A |
probably benign |
Het |
| Ccdc107 |
A |
T |
4: 43,493,512 (GRCm39) |
S28C |
probably benign |
Het |
| Cct4 |
C |
T |
11: 22,946,420 (GRCm39) |
T162I |
probably benign |
Het |
| Cdc40 |
A |
T |
10: 40,717,439 (GRCm39) |
H417Q |
probably damaging |
Het |
| Celf1 |
A |
G |
2: 90,833,588 (GRCm39) |
I115V |
probably benign |
Het |
| Ces3a |
A |
G |
8: 105,783,056 (GRCm39) |
Y395C |
probably damaging |
Het |
| Cfh |
C |
A |
1: 140,033,204 (GRCm39) |
C798F |
probably damaging |
Het |
| Clstn3 |
T |
C |
6: 124,435,088 (GRCm39) |
T313A |
probably benign |
Het |
| Crmp1 |
T |
A |
5: 37,436,229 (GRCm39) |
M329K |
probably benign |
Het |
| Csf2ra |
C |
T |
19: 61,215,491 (GRCm39) |
A76T |
possibly damaging |
Het |
| Cspg4 |
T |
A |
9: 56,795,727 (GRCm39) |
V1154E |
possibly damaging |
Het |
| Cyp2a4 |
A |
T |
7: 26,014,188 (GRCm39) |
N455I |
probably benign |
Het |
| Cyp4a32 |
T |
G |
4: 115,468,234 (GRCm39) |
M268R |
probably benign |
Het |
| Dcaf13 |
T |
A |
15: 38,993,615 (GRCm39) |
I236N |
probably damaging |
Het |
| Dennd2a |
A |
G |
6: 39,500,397 (GRCm39) |
I56T |
probably damaging |
Het |
| Eif2d |
T |
A |
1: 131,098,793 (GRCm39) |
S530R |
probably benign |
Het |
| Ep300 |
T |
A |
15: 81,532,715 (GRCm39) |
M1651K |
unknown |
Het |
| Epha3 |
G |
A |
16: 63,418,657 (GRCm39) |
T596I |
probably damaging |
Het |
| Fam171a2 |
C |
T |
11: 102,329,628 (GRCm39) |
C377Y |
possibly damaging |
Het |
| Fat4 |
T |
A |
3: 39,054,385 (GRCm39) |
N4142K |
probably damaging |
Het |
| Galnt5 |
C |
A |
2: 57,904,937 (GRCm39) |
S500Y |
probably damaging |
Het |
| Gas6 |
A |
G |
8: 13,521,456 (GRCm39) |
V431A |
probably benign |
Het |
| Gm7544 |
C |
T |
1: 82,933,502 (GRCm39) |
C56Y |
unknown |
Het |
| Golgb1 |
T |
A |
16: 36,733,281 (GRCm39) |
L884I |
possibly damaging |
Het |
| Gpatch2l |
T |
G |
12: 86,312,025 (GRCm39) |
|
probably null |
Het |
| Gpr33 |
T |
C |
12: 52,070,050 (GRCm39) |
T330A |
probably benign |
Het |
| H2bw2 |
G |
A |
X: 135,828,471 (GRCm39) |
R120K |
unknown |
Het |
| Ifi205 |
A |
G |
1: 173,855,874 (GRCm39) |
M52T |
possibly damaging |
Het |
| Ino80 |
A |
T |
2: 119,210,495 (GRCm39) |
D1346E |
probably benign |
Het |
| Ino80c |
T |
C |
18: 24,241,836 (GRCm39) |
K183R |
unknown |
Het |
| Itgal |
G |
T |
7: 126,906,047 (GRCm39) |
R379L |
probably benign |
Het |
| Itih3 |
T |
A |
14: 30,636,730 (GRCm39) |
T582S |
probably benign |
Het |
| Kcnb2 |
T |
C |
1: 15,781,251 (GRCm39) |
S708P |
possibly damaging |
Het |
| Kcnt1 |
A |
T |
2: 25,806,011 (GRCm39) |
Y1200F |
probably benign |
Het |
| L3mbtl4 |
G |
A |
17: 68,948,537 (GRCm39) |
D473N |
probably benign |
Het |
| Lama1 |
T |
G |
17: 68,024,169 (GRCm39) |
I89R |
|
Het |
| Lama2 |
A |
G |
10: 27,142,630 (GRCm39) |
I616T |
probably benign |
Het |
| Lipm |
A |
C |
19: 34,093,881 (GRCm39) |
D266A |
probably benign |
Het |
| Lrrc4c |
A |
T |
2: 97,460,106 (GRCm39) |
H244L |
probably benign |
Het |
| Lrrtm3 |
T |
C |
10: 63,923,925 (GRCm39) |
E414G |
probably damaging |
Het |
| Ltbp4 |
A |
G |
7: 27,029,192 (GRCm39) |
V231A |
unknown |
Het |
| Me3 |
G |
T |
7: 89,385,927 (GRCm39) |
R92L |
probably damaging |
Het |
| Mroh7 |
T |
G |
4: 106,541,115 (GRCm39) |
I1175L |
probably benign |
Het |
| Muc16 |
A |
G |
9: 18,553,258 (GRCm39) |
M4345T |
probably benign |
Het |
| Mug2 |
A |
G |
6: 122,017,529 (GRCm39) |
Y422C |
possibly damaging |
Het |
| N6amt1 |
T |
G |
16: 87,164,454 (GRCm39) |
S214A |
possibly damaging |
Het |
| Ogfrl1 |
G |
A |
1: 23,422,063 (GRCm39) |
Q24* |
probably null |
Het |
| Or12e14 |
A |
T |
2: 87,677,406 (GRCm39) |
T264S |
probably benign |
Het |
| Or1ad6 |
T |
A |
11: 50,860,152 (GRCm39) |
Y102* |
probably null |
Het |
| Or2ag2b |
T |
C |
7: 106,417,551 (GRCm39) |
L87P |
possibly damaging |
Het |
| Or4f14 |
G |
A |
2: 111,742,435 (GRCm39) |
P280L |
probably damaging |
Het |
| Or4k6 |
A |
C |
14: 50,475,448 (GRCm39) |
V298G |
possibly damaging |
Het |
| Or4x13 |
A |
G |
2: 90,231,803 (GRCm39) |
D266G |
probably damaging |
Het |
| Or6b6 |
A |
G |
7: 106,571,353 (GRCm39) |
M66T |
probably benign |
Het |
| Or7g23 |
A |
C |
9: 19,086,642 (GRCm39) |
M110R |
possibly damaging |
Het |
| Or8g23 |
T |
A |
9: 38,971,465 (GRCm39) |
I166L |
probably benign |
Het |
| Or8k3 |
C |
T |
2: 86,058,557 (GRCm39) |
G253R |
probably damaging |
Het |
| Oser1 |
A |
T |
2: 163,253,364 (GRCm39) |
D48E |
probably benign |
Het |
| Piwil4 |
G |
A |
9: 14,613,691 (GRCm39) |
P867L |
probably damaging |
Het |
| Pla2g6 |
C |
T |
15: 79,189,898 (GRCm39) |
|
probably null |
Het |
| Plxna1 |
A |
G |
6: 89,334,584 (GRCm39) |
L15P |
unknown |
Het |
| Ppan |
C |
T |
9: 20,803,140 (GRCm39) |
T404I |
probably benign |
Het |
| Pros1 |
C |
A |
16: 62,748,433 (GRCm39) |
Y635* |
probably null |
Het |
| Rabep2 |
G |
A |
7: 126,043,342 (GRCm39) |
R414Q |
probably benign |
Het |
| Rbms3 |
T |
A |
9: 116,651,894 (GRCm39) |
E201V |
probably damaging |
Het |
| S100b |
A |
T |
10: 76,095,820 (GRCm39) |
D66V |
probably damaging |
Het |
| Serpina1f |
A |
G |
12: 103,656,101 (GRCm39) |
S376P |
probably damaging |
Het |
| Slc24a4 |
T |
C |
12: 102,193,350 (GRCm39) |
|
probably null |
Het |
| Slc30a6 |
T |
C |
17: 74,730,424 (GRCm39) |
V438A |
probably benign |
Het |
| Sobp |
A |
G |
10: 42,897,804 (GRCm39) |
S594P |
probably benign |
Het |
| Tcstv1b |
A |
G |
13: 120,634,994 (GRCm39) |
E92G |
probably damaging |
Het |
| Tmem45b |
T |
C |
9: 31,339,334 (GRCm39) |
D213G |
probably benign |
Het |
| Topbp1 |
T |
A |
9: 103,200,543 (GRCm39) |
D525E |
probably benign |
Het |
| Trim30c |
G |
T |
7: 104,037,472 (GRCm39) |
L165I |
probably benign |
Het |
| Unc13b |
A |
T |
4: 43,174,023 (GRCm39) |
D1617V |
unknown |
Het |
| Ush1c |
A |
G |
7: 45,878,679 (GRCm39) |
L112P |
probably damaging |
Het |
| Vipr1 |
T |
A |
9: 121,490,539 (GRCm39) |
I195N |
probably damaging |
Het |
| Vmn2r38 |
A |
C |
7: 9,078,354 (GRCm39) |
V676G |
probably damaging |
Het |
| Vmn2r87 |
A |
T |
10: 130,307,992 (GRCm39) |
Y749N |
probably damaging |
Het |
| Vps13d |
A |
T |
4: 144,842,073 (GRCm39) |
S2615R |
|
Het |
| Whrn |
A |
G |
4: 63,334,330 (GRCm39) |
V828A |
possibly damaging |
Het |
| Zbp1 |
A |
G |
2: 173,050,958 (GRCm39) |
V304A |
probably benign |
Het |
| Zeb2 |
A |
T |
2: 44,886,359 (GRCm39) |
N899K |
probably benign |
Het |
| Zfp148 |
T |
C |
16: 33,317,511 (GRCm39) |
S728P |
possibly damaging |
Het |
| Zfp518a |
T |
A |
19: 40,902,207 (GRCm39) |
I712N |
possibly damaging |
Het |
| Zfp683 |
T |
C |
4: 133,786,211 (GRCm39) |
V446A |
probably benign |
Het |
| Zranb3 |
A |
T |
1: 127,891,588 (GRCm39) |
V796D |
possibly damaging |
Het |
|
| Other mutations in Robo4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00090:Robo4
|
APN |
9 |
37,322,400 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00392:Robo4
|
APN |
9 |
37,319,525 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00491:Robo4
|
APN |
9 |
37,317,231 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
IGL00792:Robo4
|
APN |
9 |
37,319,507 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01062:Robo4
|
APN |
9 |
37,317,296 (GRCm39) |
missense |
probably benign |
0.08 |
|
IGL01287:Robo4
|
APN |
9 |
37,324,336 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
IGL02289:Robo4
|
APN |
9 |
37,319,496 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02486:Robo4
|
APN |
9 |
37,319,670 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02851:Robo4
|
APN |
9 |
37,324,678 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02898:Robo4
|
APN |
9 |
37,319,472 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02965:Robo4
|
APN |
9 |
37,321,765 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
IGL03071:Robo4
|
APN |
9 |
37,315,580 (GRCm39) |
splice site |
probably benign |
|
|
IGL03102:Robo4
|
APN |
9 |
37,315,481 (GRCm39) |
missense |
probably damaging |
1.00 |
|
H8562:Robo4
|
UTSW |
9 |
37,317,106 (GRCm39) |
intron |
probably benign |
|
|
PIT4305001:Robo4
|
UTSW |
9 |
37,322,687 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0056:Robo4
|
UTSW |
9 |
37,315,773 (GRCm39) |
missense |
probably benign |
0.03 |
|
R0068:Robo4
|
UTSW |
9 |
37,315,773 (GRCm39) |
missense |
probably benign |
0.03 |
|
R0233:Robo4
|
UTSW |
9 |
37,313,977 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0233:Robo4
|
UTSW |
9 |
37,313,977 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0416:Robo4
|
UTSW |
9 |
37,316,062 (GRCm39) |
splice site |
probably benign |
|
|
R1005:Robo4
|
UTSW |
9 |
37,319,547 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1174:Robo4
|
UTSW |
9 |
37,324,348 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1183:Robo4
|
UTSW |
9 |
37,319,348 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1254:Robo4
|
UTSW |
9 |
37,322,136 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1398:Robo4
|
UTSW |
9 |
37,319,372 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1505:Robo4
|
UTSW |
9 |
37,314,523 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1701:Robo4
|
UTSW |
9 |
37,314,739 (GRCm39) |
missense |
probably benign |
0.44 |
|
R1834:Robo4
|
UTSW |
9 |
37,324,355 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1899:Robo4
|
UTSW |
9 |
37,315,366 (GRCm39) |
splice site |
probably benign |
|
|
R2203:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R2204:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R2351:Robo4
|
UTSW |
9 |
37,322,956 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2448:Robo4
|
UTSW |
9 |
37,313,958 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R2847:Robo4
|
UTSW |
9 |
37,315,772 (GRCm39) |
nonsense |
probably null |
|
|
R2851:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R2852:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R2877:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R3123:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R3124:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R3125:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R3805:Robo4
|
UTSW |
9 |
37,315,734 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R3806:Robo4
|
UTSW |
9 |
37,315,734 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R3892:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R3905:Robo4
|
UTSW |
9 |
37,314,801 (GRCm39) |
nonsense |
probably null |
|
|
R3938:Robo4
|
UTSW |
9 |
37,313,313 (GRCm39) |
start gained |
probably benign |
|
|
R4261:Robo4
|
UTSW |
9 |
37,316,877 (GRCm39) |
missense |
probably benign |
0.04 |
|
R4434:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R4435:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R4561:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R4562:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R4568:Robo4
|
UTSW |
9 |
37,316,118 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R4695:Robo4
|
UTSW |
9 |
37,314,495 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4921:Robo4
|
UTSW |
9 |
37,313,856 (GRCm39) |
missense |
probably benign |
|
|
R5000:Robo4
|
UTSW |
9 |
37,319,664 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5056:Robo4
|
UTSW |
9 |
37,316,102 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5125:Robo4
|
UTSW |
9 |
37,319,256 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5178:Robo4
|
UTSW |
9 |
37,319,256 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5278:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R5279:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R5285:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R5347:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R5348:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R5361:Robo4
|
UTSW |
9 |
37,324,674 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5403:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R5404:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R5488:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R5489:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R5490:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R5494:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R5629:Robo4
|
UTSW |
9 |
37,319,658 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5736:Robo4
|
UTSW |
9 |
37,316,093 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R5796:Robo4
|
UTSW |
9 |
37,322,970 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5987:Robo4
|
UTSW |
9 |
37,322,696 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6178:Robo4
|
UTSW |
9 |
37,316,926 (GRCm39) |
nonsense |
probably null |
|
|
R6189:Robo4
|
UTSW |
9 |
37,314,829 (GRCm39) |
missense |
probably benign |
0.35 |
|
R6365:Robo4
|
UTSW |
9 |
37,322,008 (GRCm39) |
missense |
probably benign |
0.34 |
|
R6528:Robo4
|
UTSW |
9 |
37,315,664 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R6887:Robo4
|
UTSW |
9 |
37,313,363 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R7196:Robo4
|
UTSW |
9 |
37,314,001 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R7408:Robo4
|
UTSW |
9 |
37,322,277 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7486:Robo4
|
UTSW |
9 |
37,316,870 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7707:Robo4
|
UTSW |
9 |
37,324,418 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7839:Robo4
|
UTSW |
9 |
37,322,055 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8079:Robo4
|
UTSW |
9 |
37,313,931 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R8081:Robo4
|
UTSW |
9 |
37,316,936 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8280:Robo4
|
UTSW |
9 |
37,315,372 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8526:Robo4
|
UTSW |
9 |
37,314,801 (GRCm39) |
nonsense |
probably null |
|
|
R8547:Robo4
|
UTSW |
9 |
37,315,674 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R8735:Robo4
|
UTSW |
9 |
37,319,577 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R8836:Robo4
|
UTSW |
9 |
37,317,130 (GRCm39) |
missense |
unknown |
|
|
R8889:Robo4
|
UTSW |
9 |
37,314,601 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9018:Robo4
|
UTSW |
9 |
37,315,520 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9182:Robo4
|
UTSW |
9 |
37,313,206 (GRCm39) |
start gained |
probably benign |
|
|
R9375:Robo4
|
UTSW |
9 |
37,316,158 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9621:Robo4
|
UTSW |
9 |
37,317,509 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- ATGAGGTGCAGATCATCCGG -3'
(R):5'- GAACATGCTTACCCAATTCTGC -3'
Sequencing Primer
(F):5'- GTGCAGATCATCCGGCCAAC -3'
(R):5'- AGTTTAACCTAGTTCTCCATCCCAAG -3'
|
| Posted On |
2019-10-07 |
Incidental Mutation