Mutagenetix > Incidental Mutation

Incidental Mutation 'R7420:Dnah2'

575617

Institutional Source

Beutler Lab

Gene Symbol

Dnah2

Ensembl Gene

ENSMUSG00000005237

Gene Name

dynein, axonemal, heavy chain 2

Synonyms

2900022L05Rik, D330014H01Rik, Dnahc2, Dnhd3

MMRRC Submission

045498-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R7420 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

69311635-69439934 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 69369623 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Alanine to Threonine at position 1618 (A1618T)

Ref Sequence

ENSEMBL: ENSMUSP00000104299 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000035539] [ENSMUST00000108659]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000035539
AA Change: A1618T

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)

SMART Domains

Protein: ENSMUSP00000047329
Gene: ENSMUSG00000005237
AA Change: A1618T

Domain	Start	End	E-Value	Type
low complexity region	4	25	N/A	INTRINSIC
Pfam:DHC_N1	273	429	6.6e-37	PFAM
Pfam:DHC_N1	432	761	1.3e-54	PFAM
Pfam:DHC_N2	1253	1668	3.4e-144	PFAM
AAA	1826	1962	2.95e-1	SMART
Pfam:AAA_5	2108	2251	1.3e-5	PFAM
AAA	2437	2584	3.63e-5	SMART
Pfam:AAA_8	2752	3022	1.1e-75	PFAM
Pfam:MT	3034	3370	8.7e-55	PFAM
Pfam:AAA_9	3386	3616	7.4e-68	PFAM
Pfam:Dynein_heavy	3748	4453	1.2e-220	PFAM

Predicted Effect

possibly damaging
Transcript: ENSMUST00000108659
AA Change: A1618T

PolyPhen 2 Score 0.941 (Sensitivity: 0.80; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000104299
Gene: ENSMUSG00000005237
AA Change: A1618T

Domain	Start	End	E-Value	Type
low complexity region	4	25	N/A	INTRINSIC
Pfam:DHC_N1	274	429	1.1e-47	PFAM
Pfam:DHC_N1	438	760	1.5e-75	PFAM
Pfam:DHC_N2	1255	1666	4.4e-144	PFAM
low complexity region	1711	1720	N/A	INTRINSIC
AAA	1832	1968	2.95e-1	SMART
Blast:AAA	2111	2251	2e-86	BLAST
AAA	2443	2590	3.63e-5	SMART
Pfam:AAA_8	2758	3028	5.5e-77	PFAM
Pfam:MT	3040	3376	7.6e-55	PFAM
Pfam:AAA_9	3396	3621	7.5e-94	PFAM
Pfam:Dynein_heavy	3759	4458	4.9e-264	PFAM

Meta Mutation Damage Score

0.3893

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.6%
20x: 98.7%

Validation Efficiency

95% (54/57)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Dyneins are microtubule-associated motor protein complexes composed of several heavy, light, and intermediate chains. The axonemal dyneins, found in cilia and flagella, are components of the outer and inner dynein arms attached to the peripheral microtubule doublets. DNAH2 is an axonemal inner arm dynein heavy chain (Chapelin et al., 1997 [PubMed 9256245]).[supplied by OMIM, Mar 2008]

Allele List at MGI

Other mutations in this stock

Total: 56 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca6	A	G	11: 110,141,303 (GRCm39)	V6A	probably benign	Het
Adam29	T	A	8: 56,325,933 (GRCm39)	M174L	probably benign	Het
Ano1	G	A	7: 144,209,378 (GRCm39)	T274I	probably benign	Het
Atad5	A	T	11: 79,986,688 (GRCm39)	T592S	probably benign	Het
Bud13	C	T	9: 46,199,113 (GRCm39)	P158L	probably benign	Het
Card19	T	C	13: 49,361,613 (GRCm39)	Y6C	probably damaging	Het
Cd36	C	G	5: 17,993,272 (GRCm39)	V393L	probably benign	Het
Cd79a	A	T	7: 24,596,971 (GRCm39)	R9*	probably null	Het
Cep164	T	C	9: 45,679,840 (GRCm39)	H1131R	probably benign	Het
Chia1	T	A	3: 106,037,980 (GRCm39)	S321T	probably benign	Het
Chrnd	T	A	1: 87,122,543 (GRCm39)	V217E	possibly damaging	Het
Cmtm7	T	C	9: 114,592,462 (GRCm39)		probably null	Het
Csn1s2a	T	C	5: 87,927,865 (GRCm39)	S60P	possibly damaging	Het
Defa30	T	A	8: 21,625,471 (GRCm39)	N78K	probably benign	Het
Dnah9	A	G	11: 66,008,233 (GRCm39)		probably null	Het
Epn1	A	T	7: 5,100,687 (GRCm39)	T546S	possibly damaging	Het
Fam135a	A	G	1: 24,051,567 (GRCm39)	S1443P	possibly damaging	Het
Fam13b	G	T	18: 34,627,664 (GRCm39)	P179Q	probably damaging	Het
Git2	T	C	5: 114,868,431 (GRCm39)	T647A	probably benign	Het
Gli2	T	C	1: 118,763,669 (GRCm39)	N1494S	probably benign	Het
Gm4952	G	A	19: 12,604,265 (GRCm39)	G226R	probably damaging	Het
Gm5460	T	A	14: 33,758,714 (GRCm39)	F156I	probably damaging	Het
Heatr5b	A	T	17: 79,115,909 (GRCm39)	V849D	probably damaging	Het
Hepacam	A	G	9: 37,292,005 (GRCm39)	D111G	probably benign	Het
Hk1	T	C	10: 62,105,761 (GRCm39)	D895G	probably damaging	Het
Irag1	A	T	7: 110,470,680 (GRCm39)	Y678*	probably null	Het
Kdm5b	T	C	1: 134,532,235 (GRCm39)	V471A	probably benign	Het
Klhdc8b	A	G	9: 108,326,317 (GRCm39)	Y239H	possibly damaging	Het
Krt15	A	T	11: 100,026,386 (GRCm39)	V100E	possibly damaging	Het
Krt82	T	C	15: 101,454,022 (GRCm39)	T229A	probably damaging	Het
Lrrc37	A	T	11: 103,504,451 (GRCm39)	S2506T	probably benign	Het
Lztr1	T	C	16: 17,341,993 (GRCm39)	L656P	probably damaging	Het
Mfrp	T	C	9: 44,013,773 (GRCm39)		probably benign	Het
Nfe2l1	A	G	11: 96,710,739 (GRCm39)	S497P	probably benign	Het
Or2ag1b	G	A	7: 106,288,227 (GRCm39)	A237V	possibly damaging	Het
Or8b44	G	T	9: 38,410,359 (GRCm39)	L131F	probably benign	Het
Otud4	C	A	8: 80,390,737 (GRCm39)	T418K	probably benign	Het
Pcdhb21	A	G	18: 37,648,256 (GRCm39)	N462D	probably damaging	Het
Plch1	A	G	3: 63,630,278 (GRCm39)	S497P	probably damaging	Het
Plekha8	T	C	6: 54,590,179 (GRCm39)	V48A	probably damaging	Het
Ppp2r5d	A	T	17: 46,998,507 (GRCm39)	F121L	probably null	Het
Prxl2c	C	T	13: 64,445,131 (GRCm39)	G164D	possibly damaging	Het
Sdad1	G	A	5: 92,453,596 (GRCm39)	A64V	possibly damaging	Het
Selenop	G	T	15: 3,309,052 (GRCm39)	A335S	probably damaging	Het
Shc3	T	C	13: 51,585,271 (GRCm39)	N448S	probably benign	Het
Shcbp1	G	A	8: 4,798,737 (GRCm39)	T394I	probably benign	Het
Slc39a11	G	T	11: 113,138,648 (GRCm39)	A276E	probably damaging	Het
Son	AGAACCCCCAGCCGCAGGAGCCGAACCCCCAGCCGCAGGAGCCGAACCCCCAGCCGCAGGAGCCGAACCCCCAGCCG	AGAACCCCCAGCCGCAGGAGCCGAACCCCCAGCCGCAGGAGCCGAACCCCCAGCCG	16: 91,457,222 (GRCm39)		probably benign	Het
Speg	T	A	1: 75,407,549 (GRCm39)	S3185R	probably damaging	Het
Tmem100	A	T	11: 89,926,579 (GRCm39)	*135Y	probably null	Het
Ube2o	A	T	11: 116,430,898 (GRCm39)	F1001I	probably damaging	Het
Usp7	T	C	16: 8,527,985 (GRCm39)	D148G	probably benign	Het
Vmn2r16	A	G	5: 109,511,736 (GRCm39)	T648A	probably damaging	Het
Vmn2r67	A	G	7: 84,785,944 (GRCm39)	L687P	possibly damaging	Het
Zcchc14	ACCGCCGCCGCCGCCGCC	ACCGCCGCCGCCGCC	8: 122,378,530 (GRCm39)		probably benign	Het
Zfp800	A	G	6: 28,243,718 (GRCm39)	S416P	probably benign	Het

Other mutations in Dnah2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00087:Dnah2	APN	11	69,383,498 (GRCm39)	missense	possibly damaging	0.93
IGL00418:Dnah2	APN	11	69,385,892 (GRCm39)	splice site	probably benign
IGL00772:Dnah2	APN	11	69,342,083 (GRCm39)	missense	probably damaging	0.97
IGL00819:Dnah2	APN	11	69,364,176 (GRCm39)	critical splice donor site	probably null
IGL00827:Dnah2	APN	11	69,339,283 (GRCm39)	missense	probably damaging	1.00
IGL01060:Dnah2	APN	11	69,368,918 (GRCm39)	missense	possibly damaging	0.86
IGL01340:Dnah2	APN	11	69,384,010 (GRCm39)	missense	probably damaging	0.99
IGL01349:Dnah2	APN	11	69,366,432 (GRCm39)	missense	probably damaging	0.99
IGL01413:Dnah2	APN	11	69,323,790 (GRCm39)	missense	probably damaging	0.99
IGL01451:Dnah2	APN	11	69,365,017 (GRCm39)	splice site	probably benign
IGL01480:Dnah2	APN	11	69,349,197 (GRCm39)	missense	possibly damaging	0.91
IGL01537:Dnah2	APN	11	69,406,906 (GRCm39)	missense	probably benign	0.17
IGL01592:Dnah2	APN	11	69,321,913 (GRCm39)	missense	probably benign	0.14
IGL01612:Dnah2	APN	11	69,355,889 (GRCm39)	splice site	probably benign
IGL01667:Dnah2	APN	11	69,435,221 (GRCm39)	missense	probably benign
IGL01667:Dnah2	APN	11	69,411,767 (GRCm39)	missense	probably damaging	0.98
IGL01691:Dnah2	APN	11	69,430,269 (GRCm39)	missense	probably benign
IGL02019:Dnah2	APN	11	69,365,111 (GRCm39)	missense	probably damaging	1.00
IGL02039:Dnah2	APN	11	69,390,038 (GRCm39)	missense	probably damaging	1.00
IGL02076:Dnah2	APN	11	69,313,385 (GRCm39)	missense	probably damaging	0.99
IGL02085:Dnah2	APN	11	69,349,011 (GRCm39)	missense	probably benign	0.07
IGL02158:Dnah2	APN	11	69,348,949 (GRCm39)	missense	probably benign
IGL02381:Dnah2	APN	11	69,337,118 (GRCm39)	missense	probably benign	0.25
IGL02681:Dnah2	APN	11	69,343,759 (GRCm39)	missense	probably benign	0.40
IGL02957:Dnah2	APN	11	69,339,333 (GRCm39)	missense	possibly damaging	0.96
IGL02961:Dnah2	APN	11	69,409,240 (GRCm39)	missense	probably damaging	1.00
IGL02969:Dnah2	APN	11	69,412,013 (GRCm39)	missense	possibly damaging	0.80
IGL03117:Dnah2	APN	11	69,327,117 (GRCm39)	splice site	probably benign
IGL03120:Dnah2	APN	11	69,312,674 (GRCm39)	missense	probably damaging	1.00
IGL03183:Dnah2	APN	11	69,349,314 (GRCm39)	missense	possibly damaging	0.94
IGL03197:Dnah2	APN	11	69,350,089 (GRCm39)	missense	probably damaging	1.00
IGL03263:Dnah2	APN	11	69,420,207 (GRCm39)	critical splice donor site	probably null
IGL03333:Dnah2	APN	11	69,385,949 (GRCm39)	missense	probably damaging	1.00
IGL03338:Dnah2	APN	11	69,387,403 (GRCm39)	missense	probably benign	0.13
argyrios	UTSW	11	69,407,416 (GRCm39)	missense	possibly damaging	0.47
Aureus	UTSW	11	69,320,174 (GRCm39)	missense	probably damaging	1.00
platinum	UTSW	11	69,348,868 (GRCm39)	missense	probably damaging	0.96
R0334_dnah2_144	UTSW	11	69,327,662 (GRCm39)	missense	probably damaging	1.00
R2150_dnah2_212	UTSW	11	69,406,587 (GRCm39)	missense	probably benign	0.14
BB005:Dnah2	UTSW	11	69,321,661 (GRCm39)	missense	probably damaging	0.98
BB015:Dnah2	UTSW	11	69,321,661 (GRCm39)	missense	probably damaging	0.98
E0370:Dnah2	UTSW	11	69,406,441 (GRCm39)	splice site	probably null
P0026:Dnah2	UTSW	11	69,355,773 (GRCm39)	missense	probably damaging	1.00
R0133:Dnah2	UTSW	11	69,311,835 (GRCm39)	missense	probably damaging	1.00
R0190:Dnah2	UTSW	11	69,326,075 (GRCm39)	missense	probably damaging	1.00
R0334:Dnah2	UTSW	11	69,327,662 (GRCm39)	missense	probably damaging	1.00
R0359:Dnah2	UTSW	11	69,420,357 (GRCm39)	missense	probably benign	0.00
R0386:Dnah2	UTSW	11	69,338,687 (GRCm39)	missense	probably damaging	1.00
R0414:Dnah2	UTSW	11	69,390,064 (GRCm39)	missense	probably benign	0.26
R0427:Dnah2	UTSW	11	69,343,705 (GRCm39)	missense	probably damaging	0.99
R0433:Dnah2	UTSW	11	69,350,114 (GRCm39)	missense	probably damaging	1.00
R0442:Dnah2	UTSW	11	69,339,368 (GRCm39)	missense	probably damaging	1.00
R0462:Dnah2	UTSW	11	69,350,027 (GRCm39)	missense	probably damaging	1.00
R0463:Dnah2	UTSW	11	69,313,952 (GRCm39)	missense	probably damaging	1.00
R0611:Dnah2	UTSW	11	69,390,020 (GRCm39)	missense	probably damaging	1.00
R0626:Dnah2	UTSW	11	69,368,509 (GRCm39)	missense	probably benign	0.07
R0924:Dnah2	UTSW	11	69,312,134 (GRCm39)	missense	probably damaging	1.00
R0968:Dnah2	UTSW	11	69,339,345 (GRCm39)	missense	possibly damaging	0.67
R1066:Dnah2	UTSW	11	69,338,645 (GRCm39)	missense	probably damaging	1.00
R1183:Dnah2	UTSW	11	69,337,474 (GRCm39)	missense	possibly damaging	0.95
R1184:Dnah2	UTSW	11	69,390,016 (GRCm39)	missense	probably damaging	1.00
R1186:Dnah2	UTSW	11	69,406,526 (GRCm39)	missense	probably damaging	0.99
R1453:Dnah2	UTSW	11	69,341,876 (GRCm39)	missense	probably damaging	0.99
R1498:Dnah2	UTSW	11	69,411,493 (GRCm39)	splice site	probably null
R1538:Dnah2	UTSW	11	69,368,028 (GRCm39)	missense	probably benign	0.17
R1574:Dnah2	UTSW	11	69,405,514 (GRCm39)	missense	probably benign	0.26
R1574:Dnah2	UTSW	11	69,405,514 (GRCm39)	missense	probably benign	0.26
R1590:Dnah2	UTSW	11	69,412,024 (GRCm39)	missense	probably benign	0.00
R1590:Dnah2	UTSW	11	69,313,580 (GRCm39)	critical splice donor site	probably null
R1655:Dnah2	UTSW	11	69,364,680 (GRCm39)	missense	probably damaging	1.00
R1695:Dnah2	UTSW	11	69,405,517 (GRCm39)	missense	possibly damaging	0.74
R1726:Dnah2	UTSW	11	69,388,715 (GRCm39)	missense	probably damaging	1.00
R1764:Dnah2	UTSW	11	69,314,369 (GRCm39)	missense	probably damaging	1.00
R1815:Dnah2	UTSW	11	69,366,400 (GRCm39)	missense	probably damaging	1.00
R1822:Dnah2	UTSW	11	69,405,630 (GRCm39)	missense	probably damaging	1.00
R1859:Dnah2	UTSW	11	69,328,712 (GRCm39)	missense	probably damaging	0.99
R1911:Dnah2	UTSW	11	69,406,578 (GRCm39)	missense	possibly damaging	0.64
R1913:Dnah2	UTSW	11	69,355,756 (GRCm39)	missense	probably damaging	1.00
R1981:Dnah2	UTSW	11	69,365,151 (GRCm39)	missense	probably damaging	1.00
R2010:Dnah2	UTSW	11	69,349,184 (GRCm39)	critical splice donor site	probably null
R2016:Dnah2	UTSW	11	69,327,896 (GRCm39)	missense	probably damaging	0.97
R2017:Dnah2	UTSW	11	69,327,896 (GRCm39)	missense	probably damaging	0.97
R2044:Dnah2	UTSW	11	69,415,066 (GRCm39)	missense	probably benign	0.14
R2077:Dnah2	UTSW	11	69,387,432 (GRCm39)	missense	possibly damaging	0.73
R2096:Dnah2	UTSW	11	69,346,742 (GRCm39)	missense	probably damaging	0.98
R2099:Dnah2	UTSW	11	69,384,063 (GRCm39)	missense	probably damaging	1.00
R2127:Dnah2	UTSW	11	69,349,011 (GRCm39)	missense	probably benign	0.02
R2128:Dnah2	UTSW	11	69,349,011 (GRCm39)	missense	probably benign	0.02
R2146:Dnah2	UTSW	11	69,406,587 (GRCm39)	missense	probably benign	0.14
R2147:Dnah2	UTSW	11	69,406,587 (GRCm39)	missense	probably benign	0.14
R2150:Dnah2	UTSW	11	69,406,587 (GRCm39)	missense	probably benign	0.14
R2404:Dnah2	UTSW	11	69,328,047 (GRCm39)	missense	probably damaging	0.99
R2510:Dnah2	UTSW	11	69,415,032 (GRCm39)	nonsense	probably null
R2517:Dnah2	UTSW	11	69,407,470 (GRCm39)	missense	probably damaging	1.00
R3014:Dnah2	UTSW	11	69,321,304 (GRCm39)	missense	probably benign
R3741:Dnah2	UTSW	11	69,339,295 (GRCm39)	missense	probably damaging	1.00
R3814:Dnah2	UTSW	11	69,383,476 (GRCm39)	splice site	probably null
R3872:Dnah2	UTSW	11	69,320,174 (GRCm39)	missense	probably damaging	1.00
R3873:Dnah2	UTSW	11	69,320,174 (GRCm39)	missense	probably damaging	1.00
R3874:Dnah2	UTSW	11	69,320,174 (GRCm39)	missense	probably damaging	1.00
R3875:Dnah2	UTSW	11	69,320,174 (GRCm39)	missense	probably damaging	1.00
R3881:Dnah2	UTSW	11	69,342,173 (GRCm39)	missense	possibly damaging	0.94
R3953:Dnah2	UTSW	11	69,344,929 (GRCm39)	missense	probably damaging	1.00
R3956:Dnah2	UTSW	11	69,374,847 (GRCm39)	missense	probably benign	0.00
R4501:Dnah2	UTSW	11	69,368,485 (GRCm39)	missense	probably benign
R4515:Dnah2	UTSW	11	69,356,457 (GRCm39)	missense	possibly damaging	0.61
R4612:Dnah2	UTSW	11	69,374,193 (GRCm39)	missense	possibly damaging	0.93
R4625:Dnah2	UTSW	11	69,354,487 (GRCm39)	missense	probably damaging	1.00
R4627:Dnah2	UTSW	11	69,356,202 (GRCm39)	missense	probably damaging	1.00
R4642:Dnah2	UTSW	11	69,387,385 (GRCm39)	missense	probably benign	0.00
R4683:Dnah2	UTSW	11	69,349,768 (GRCm39)	missense	probably damaging	1.00
R4698:Dnah2	UTSW	11	69,389,358 (GRCm39)	missense	probably damaging	1.00
R4710:Dnah2	UTSW	11	69,368,903 (GRCm39)	missense	probably damaging	1.00
R4712:Dnah2	UTSW	11	69,407,416 (GRCm39)	missense	possibly damaging	0.47
R4713:Dnah2	UTSW	11	69,367,514 (GRCm39)	missense	probably damaging	1.00
R4717:Dnah2	UTSW	11	69,320,183 (GRCm39)	missense	probably benign	0.00
R4740:Dnah2	UTSW	11	69,348,868 (GRCm39)	missense	probably damaging	0.96
R4780:Dnah2	UTSW	11	69,364,697 (GRCm39)	missense	probably damaging	0.97
R4825:Dnah2	UTSW	11	69,314,031 (GRCm39)	missense	probably damaging	1.00
R4864:Dnah2	UTSW	11	69,313,416 (GRCm39)	missense	probably damaging	0.98
R4868:Dnah2	UTSW	11	69,354,474 (GRCm39)	missense	probably damaging	1.00
R4879:Dnah2	UTSW	11	69,367,517 (GRCm39)	missense	probably damaging	1.00
R4908:Dnah2	UTSW	11	69,411,973 (GRCm39)	missense	probably benign	0.00
R4911:Dnah2	UTSW	11	69,389,930 (GRCm39)	critical splice donor site	probably null
R4954:Dnah2	UTSW	11	69,430,322 (GRCm39)	missense	possibly damaging	0.61
R4962:Dnah2	UTSW	11	69,346,799 (GRCm39)	nonsense	probably null
R5015:Dnah2	UTSW	11	69,388,708 (GRCm39)	missense	possibly damaging	0.89
R5049:Dnah2	UTSW	11	69,338,992 (GRCm39)	missense	probably damaging	1.00
R5055:Dnah2	UTSW	11	69,411,599 (GRCm39)	missense	possibly damaging	0.67
R5153:Dnah2	UTSW	11	69,411,759 (GRCm39)	missense	possibly damaging	0.84
R5155:Dnah2	UTSW	11	69,313,362 (GRCm39)	missense	probably damaging	1.00
R5186:Dnah2	UTSW	11	69,326,710 (GRCm39)	missense	probably damaging	1.00
R5187:Dnah2	UTSW	11	69,349,746 (GRCm39)	missense	probably benign	0.15
R5208:Dnah2	UTSW	11	69,349,746 (GRCm39)	missense	probably benign	0.15
R5252:Dnah2	UTSW	11	69,420,295 (GRCm39)	missense	probably damaging	0.98
R5296:Dnah2	UTSW	11	69,349,746 (GRCm39)	missense	probably benign	0.15
R5298:Dnah2	UTSW	11	69,349,746 (GRCm39)	missense	probably benign	0.15
R5299:Dnah2	UTSW	11	69,349,746 (GRCm39)	missense	probably benign	0.15
R5301:Dnah2	UTSW	11	69,349,746 (GRCm39)	missense	probably benign	0.15
R5324:Dnah2	UTSW	11	69,348,819 (GRCm39)	missense	probably benign	0.07
R5350:Dnah2	UTSW	11	69,406,862 (GRCm39)	missense	possibly damaging	0.48
R5377:Dnah2	UTSW	11	69,312,674 (GRCm39)	missense	probably damaging	1.00
R5393:Dnah2	UTSW	11	69,391,683 (GRCm39)	missense	probably benign
R5421:Dnah2	UTSW	11	69,326,462 (GRCm39)	missense	probably damaging	1.00
R5452:Dnah2	UTSW	11	69,415,209 (GRCm39)	missense	probably damaging	1.00
R5461:Dnah2	UTSW	11	69,364,177 (GRCm39)	critical splice donor site	probably null
R5474:Dnah2	UTSW	11	69,349,746 (GRCm39)	missense	probably benign	0.15
R5476:Dnah2	UTSW	11	69,349,746 (GRCm39)	missense	probably benign	0.15
R5477:Dnah2	UTSW	11	69,349,746 (GRCm39)	missense	probably benign	0.15
R5510:Dnah2	UTSW	11	69,349,746 (GRCm39)	missense	probably benign	0.15
R5527:Dnah2	UTSW	11	69,328,014 (GRCm39)	nonsense	probably null
R5566:Dnah2	UTSW	11	69,407,395 (GRCm39)	nonsense	probably null
R5587:Dnah2	UTSW	11	69,328,068 (GRCm39)	missense	probably damaging	1.00
R5628:Dnah2	UTSW	11	69,349,746 (GRCm39)	missense	probably benign	0.15
R5688:Dnah2	UTSW	11	69,349,746 (GRCm39)	missense	probably benign	0.15
R5690:Dnah2	UTSW	11	69,382,370 (GRCm39)	missense	probably benign	0.15
R5711:Dnah2	UTSW	11	69,326,216 (GRCm39)	missense	probably damaging	1.00
R5735:Dnah2	UTSW	11	69,321,643 (GRCm39)	missense	possibly damaging	0.93
R5826:Dnah2	UTSW	11	69,349,746 (GRCm39)	missense	probably benign	0.15
R5913:Dnah2	UTSW	11	69,339,256 (GRCm39)	missense	probably damaging	1.00
R5914:Dnah2	UTSW	11	69,349,746 (GRCm39)	missense	probably benign	0.15
R5960:Dnah2	UTSW	11	69,349,746 (GRCm39)	missense	probably benign	0.15
R5961:Dnah2	UTSW	11	69,349,746 (GRCm39)	missense	probably benign	0.15
R5961:Dnah2	UTSW	11	69,321,974 (GRCm39)	missense	probably damaging	1.00
R5977:Dnah2	UTSW	11	69,411,707 (GRCm39)	missense	possibly damaging	0.79
R6020:Dnah2	UTSW	11	69,391,665 (GRCm39)	missense	probably benign
R6036:Dnah2	UTSW	11	69,349,746 (GRCm39)	missense	probably benign	0.15
R6036:Dnah2	UTSW	11	69,349,746 (GRCm39)	missense	probably benign	0.15
R6050:Dnah2	UTSW	11	69,349,746 (GRCm39)	missense	probably benign	0.15
R6086:Dnah2	UTSW	11	69,406,834 (GRCm39)	missense	probably benign	0.30
R6115:Dnah2	UTSW	11	69,337,475 (GRCm39)	missense	probably damaging	1.00
R6123:Dnah2	UTSW	11	69,409,185 (GRCm39)	missense	probably benign	0.29
R6159:Dnah2	UTSW	11	69,349,746 (GRCm39)	missense	probably benign	0.15
R6159:Dnah2	UTSW	11	69,349,368 (GRCm39)	missense	probably damaging	1.00
R6163:Dnah2	UTSW	11	69,411,729 (GRCm39)	nonsense	probably null
R6171:Dnah2	UTSW	11	69,313,868 (GRCm39)	missense	probably damaging	1.00
R6263:Dnah2	UTSW	11	69,348,238 (GRCm39)	missense	probably damaging	1.00
R6298:Dnah2	UTSW	11	69,382,467 (GRCm39)	missense	probably benign	0.25
R6352:Dnah2	UTSW	11	69,339,053 (GRCm39)	missense	probably damaging	1.00
R6399:Dnah2	UTSW	11	69,349,344 (GRCm39)	missense	probably damaging	0.98
R6466:Dnah2	UTSW	11	69,430,241 (GRCm39)	missense	probably benign
R6478:Dnah2	UTSW	11	69,406,836 (GRCm39)	missense	probably benign	0.01
R6516:Dnah2	UTSW	11	69,356,212 (GRCm39)	missense	probably benign	0.34
R6538:Dnah2	UTSW	11	69,328,023 (GRCm39)	missense	possibly damaging	0.87
R6802:Dnah2	UTSW	11	69,314,516 (GRCm39)	missense	probably damaging	1.00
R6861:Dnah2	UTSW	11	69,346,789 (GRCm39)	missense	possibly damaging	0.64
R6869:Dnah2	UTSW	11	69,320,297 (GRCm39)	missense	probably damaging	1.00
R6894:Dnah2	UTSW	11	69,375,086 (GRCm39)	missense	probably benign	0.12
R6935:Dnah2	UTSW	11	69,312,567 (GRCm39)	missense	probably damaging	1.00
R7017:Dnah2	UTSW	11	69,382,373 (GRCm39)	nonsense	probably null
R7073:Dnah2	UTSW	11	69,321,318 (GRCm39)	nonsense	probably null
R7111:Dnah2	UTSW	11	69,337,579 (GRCm39)	splice site	probably null
R7125:Dnah2	UTSW	11	69,327,008 (GRCm39)	missense	probably damaging	0.99
R7137:Dnah2	UTSW	11	69,382,381 (GRCm39)	missense	probably damaging	1.00
R7190:Dnah2	UTSW	11	69,439,923 (GRCm39)	splice site	probably null
R7214:Dnah2	UTSW	11	69,321,935 (GRCm39)	missense	probably damaging	1.00
R7227:Dnah2	UTSW	11	69,312,222 (GRCm39)	missense	probably damaging	0.99
R7238:Dnah2	UTSW	11	69,349,972 (GRCm39)	critical splice donor site	probably null
R7256:Dnah2	UTSW	11	69,321,920 (GRCm39)	missense	probably damaging	1.00
R7267:Dnah2	UTSW	11	69,391,643 (GRCm39)	missense	probably damaging	1.00
R7421:Dnah2	UTSW	11	69,383,631 (GRCm39)	missense	probably benign	0.25
R7437:Dnah2	UTSW	11	69,389,453 (GRCm39)	missense	probably damaging	1.00
R7461:Dnah2	UTSW	11	69,439,816 (GRCm39)	critical splice donor site	probably null
R7473:Dnah2	UTSW	11	69,382,484 (GRCm39)	missense	probably damaging	0.99
R7528:Dnah2	UTSW	11	69,391,622 (GRCm39)	missense	probably damaging	0.99
R7613:Dnah2	UTSW	11	69,439,816 (GRCm39)	critical splice donor site	probably null
R7615:Dnah2	UTSW	11	69,326,130 (GRCm39)	missense	probably damaging	0.99
R7626:Dnah2	UTSW	11	69,389,511 (GRCm39)	missense	probably damaging	0.99
R7745:Dnah2	UTSW	11	69,342,144 (GRCm39)	nonsense	probably null
R7764:Dnah2	UTSW	11	69,348,984 (GRCm39)	missense	probably benign	0.29
R7793:Dnah2	UTSW	11	69,386,040 (GRCm39)	missense	probably benign	0.00
R7819:Dnah2	UTSW	11	69,407,419 (GRCm39)	missense	probably benign	0.01
R7881:Dnah2	UTSW	11	69,322,064 (GRCm39)	missense	probably damaging	1.00
R7900:Dnah2	UTSW	11	69,409,254 (GRCm39)	missense	probably damaging	1.00
R7916:Dnah2	UTSW	11	69,311,974 (GRCm39)	critical splice acceptor site	probably null
R7921:Dnah2	UTSW	11	69,411,660 (GRCm39)	missense	probably benign
R7928:Dnah2	UTSW	11	69,321,661 (GRCm39)	missense	probably damaging	0.98
R7937:Dnah2	UTSW	11	69,408,511 (GRCm39)	nonsense	probably null
R7995:Dnah2	UTSW	11	69,411,563 (GRCm39)	missense	possibly damaging	0.77
R8202:Dnah2	UTSW	11	69,369,649 (GRCm39)	missense	probably benign	0.00
R8208:Dnah2	UTSW	11	69,411,678 (GRCm39)	missense	probably benign	0.05
R8215:Dnah2	UTSW	11	69,326,193 (GRCm39)	missense	probably damaging	1.00
R8279:Dnah2	UTSW	11	69,366,399 (GRCm39)	missense	probably damaging	1.00
R8338:Dnah2	UTSW	11	69,378,122 (GRCm39)	missense	probably damaging	1.00
R8348:Dnah2	UTSW	11	69,320,273 (GRCm39)	missense	possibly damaging	0.95
R8405:Dnah2	UTSW	11	69,349,289 (GRCm39)	missense	probably damaging	1.00
R8407:Dnah2	UTSW	11	69,350,104 (GRCm39)	missense	probably benign	0.00
R8493:Dnah2	UTSW	11	69,343,804 (GRCm39)	missense	probably damaging	1.00
R8673:Dnah2	UTSW	11	69,405,523 (GRCm39)	missense	probably benign	0.23
R8725:Dnah2	UTSW	11	69,415,005 (GRCm39)	missense	probably damaging	1.00
R8727:Dnah2	UTSW	11	69,415,005 (GRCm39)	missense	probably damaging	1.00
R8730:Dnah2	UTSW	11	69,384,087 (GRCm39)	missense	possibly damaging	0.73
R8804:Dnah2	UTSW	11	69,356,511 (GRCm39)	missense	probably benign	0.01
R8876:Dnah2	UTSW	11	69,382,348 (GRCm39)	missense	probably damaging	1.00
R8894:Dnah2	UTSW	11	69,383,048 (GRCm39)	missense	probably benign	0.01
R8938:Dnah2	UTSW	11	69,328,754 (GRCm39)	missense	probably damaging	0.99
R9044:Dnah2	UTSW	11	69,420,247 (GRCm39)	missense	probably benign
R9085:Dnah2	UTSW	11	69,320,224 (GRCm39)	missense	possibly damaging	0.69
R9110:Dnah2	UTSW	11	69,435,208 (GRCm39)	missense	probably benign
R9156:Dnah2	UTSW	11	69,313,687 (GRCm39)	missense
R9251:Dnah2	UTSW	11	69,406,619 (GRCm39)	missense	probably damaging	1.00
R9258:Dnah2	UTSW	11	69,368,079 (GRCm39)	missense	probably damaging	1.00
R9279:Dnah2	UTSW	11	69,409,104 (GRCm39)	missense	probably benign	0.01
R9318:Dnah2	UTSW	11	69,375,155 (GRCm39)	missense	probably benign	0.07
R9321:Dnah2	UTSW	11	69,338,939 (GRCm39)	critical splice donor site	probably null
R9350:Dnah2	UTSW	11	69,384,073 (GRCm39)	missense	probably benign	0.10
R9358:Dnah2	UTSW	11	69,406,592 (GRCm39)	missense	probably damaging	0.99
R9417:Dnah2	UTSW	11	69,326,990 (GRCm39)	missense	probably damaging	1.00
R9420:Dnah2	UTSW	11	69,368,942 (GRCm39)	missense	probably benign	0.09
R9438:Dnah2	UTSW	11	69,364,220 (GRCm39)	missense	probably damaging	1.00
R9469:Dnah2	UTSW	11	69,321,896 (GRCm39)	missense	probably damaging	1.00
R9487:Dnah2	UTSW	11	69,406,617 (GRCm39)	missense	possibly damaging	0.47
R9495:Dnah2	UTSW	11	69,345,208 (GRCm39)	missense	possibly damaging	0.89
R9579:Dnah2	UTSW	11	69,368,041 (GRCm39)	missense	probably damaging	1.00
R9608:Dnah2	UTSW	11	69,344,888 (GRCm39)	missense	probably null	1.00
R9651:Dnah2	UTSW	11	69,341,824 (GRCm39)	critical splice donor site	probably null
R9662:Dnah2	UTSW	11	69,343,763 (GRCm39)	missense	probably benign
RF004:Dnah2	UTSW	11	69,328,013 (GRCm39)	missense	probably benign	0.24
U24488:Dnah2	UTSW	11	69,374,648 (GRCm39)	missense	probably damaging	0.99
X0021:Dnah2	UTSW	11	69,339,388 (GRCm39)	missense	possibly damaging	0.81
Z1088:Dnah2	UTSW	11	69,321,619 (GRCm39)	missense	probably damaging	1.00
Z1176:Dnah2	UTSW	11	69,312,647 (GRCm39)	missense	possibly damaging	0.46
Z1176:Dnah2	UTSW	11	69,407,349 (GRCm39)	missense	probably damaging	1.00
Z1176:Dnah2	UTSW	11	69,407,307 (GRCm39)	missense	probably damaging	1.00
Z1176:Dnah2	UTSW	11	69,389,493 (GRCm39)	missense	probably benign	0.12
Z1176:Dnah2	UTSW	11	69,377,880 (GRCm39)	missense	possibly damaging	0.46
Z1176:Dnah2	UTSW	11	69,341,946 (GRCm39)	missense	probably benign
Z1177:Dnah2	UTSW	11	69,435,383 (GRCm39)	critical splice acceptor site	probably null
Z1177:Dnah2	UTSW	11	69,354,279 (GRCm39)	missense	possibly damaging	0.63

Predicted Primers

PCR Primer
(F):5'- TGAAAATGTTCTCCCTGGGAAG -3'
(R):5'- TTCCAGAAGTGGCAACGTTGA -3'

Sequencing Primer
(F):5'- AAATGTTCTCCCTGGGAAGTCCTTTC -3'
(R):5'- GGGTAGCTCATAACCATCTCTGATG -3'

Posted On

2019-10-07