Mutagenetix > Incidental Mutation

Incidental Mutation 'R7424:Plxna2'

575890

Institutional Source

Beutler Lab

Gene Symbol

Plxna2

Ensembl Gene

ENSMUSG00000026640

Gene Name

plexin A2

Synonyms

2810428A13Rik, OCT, PlexA2, Plxn2

MMRRC Submission

045502-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R7424 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

194618218-194816869 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 194806339 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Asparagine at position 1641 (I1641N)

Ref Sequence

ENSEMBL: ENSMUSP00000027952 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000027952]

AlphaFold

P70207

PDB Structure

Plexin A2 / Semaphorin 6A complex [X-RAY DIFFRACTION]
Mouse Plexin A2 extracellular domain [X-RAY DIFFRACTION]
Mouse Plexin A2, extracellular domains 1-4 [X-RAY DIFFRACTION]
Plexin A2 in complex with Semaphorin 6A [X-RAY DIFFRACTION]
Complex of mouse Plexin A2 - Semaphorin 3A - Neuropilin-1 [X-RAY DIFFRACTION]

Predicted Effect

probably damaging
Transcript: ENSMUST00000027952
AA Change: I1641N

PolyPhen 2 Score 0.984 (Sensitivity: 0.74; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000027952
Gene: ENSMUSG00000026640
AA Change: I1641N

Domain	Start	End	E-Value	Type
low complexity region	16	29	N/A	INTRINSIC
Sema	50	492	1.65e-132	SMART
PSI	510	560	8e-12	SMART
PSI	655	702	6.35e-6	SMART
PSI	803	856	1.24e-8	SMART
IPT	857	952	6.36e-21	SMART
IPT	953	1038	1.02e-24	SMART
IPT	1040	1140	1.48e-21	SMART
IPT	1142	1237	8.81e-6	SMART
transmembrane domain	1238	1260	N/A	INTRINSIC
Pfam:Plexin_cytopl	1311	1864	1.9e-261	PFAM

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.8%
20x: 99.4%

Validation Efficiency

99% (76/77)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the plexin-A family of semaphorin co-receptors. Semaphorins are a large family of secreted or membrane-bound proteins that mediate repulsive effects on axon pathfinding during nervous system development. A subset of semaphorins are recognized by plexin-A/neuropilin transmembrane receptor complexes, triggering a cellular signal transduction cascade that leads to axon repulsion. This plexin-A family member is thought to transduce signals from semaphorin-3A and -3C. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-out allele show abnormal granule cell migration in the adult cerebellum and aberrant projection of mossy fibers in hippocampal slices. Mice homozygous for an ENU-induced allele are smaller and show granule cell migration defects and mild ataxia with incomplete penetrance. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 79 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
6430548M08Rik	C	T	8: 120,145,545 (GRCm38)	R71C	probably damaging	Het
Aanat	A	T	11: 116,595,629 (GRCm38)		probably benign	Het
Ahrr	G	T	13: 74,257,545 (GRCm38)	S91*	probably null	Het
Ampd1	A	T	3: 103,088,442 (GRCm38)	N223Y	probably benign	Het
Ankar	T	G	1: 72,680,058 (GRCm38)	N544T	probably damaging	Het
Ankk1	A	G	9: 49,418,750 (GRCm38)	S302P	possibly damaging	Het
Bcr	T	C	10: 75,157,100 (GRCm38)	V809A	probably benign	Het
Bpifb2	A	G	2: 153,890,540 (GRCm38)	N353S	possibly damaging	Het
Cyth1	A	T	11: 118,184,009 (GRCm38)		probably null	Het
Ddx5	A	T	11: 106,782,180 (GRCm38)	N506K	probably benign	Het
Dnaja1	A	T	4: 40,730,244 (GRCm38)	I239F	probably benign	Het
Ethe1	C	T	7: 24,606,251 (GRCm38)	T141I	probably damaging	Het
Fam160b2	T	C	14: 70,594,007 (GRCm38)	H29R	probably damaging	Het
Gdap2	A	T	3: 100,202,066 (GRCm38)	I36F	unknown	Het
Gm13030	A	T	4: 138,871,266 (GRCm38)	D115E	unknown	Het
Gm13103	C	T	4: 143,853,209 (GRCm38)	P455S	probably benign	Het
Gm17019	A	T	5: 15,029,372 (GRCm38)	L227Q	probably damaging	Het
Gm9195	T	A	14: 72,435,777 (GRCm38)	E2517D	possibly damaging	Het
Gramd2	T	A	9: 59,708,071 (GRCm38)	V39D	possibly damaging	Het
Hmcn1	C	T	1: 150,630,266 (GRCm38)	W3836*	probably null	Het
Hspa14	C	T	2: 3,489,041 (GRCm38)	D494N	possibly damaging	Het
Ifit2	A	G	19: 34,573,198 (GRCm38)	N46S	probably benign	Het
Ifna6	A	T	4: 88,827,807 (GRCm38)	E131V	possibly damaging	Het
Ift140	T	C	17: 25,037,036 (GRCm38)	V504A	possibly damaging	Het
Irgc1	T	C	7: 24,432,228 (GRCm38)	N388S	probably damaging	Het
Itgal	T	A	7: 127,317,365 (GRCm38)	V743E	probably benign	Het
Itih5	T	C	2: 10,245,637 (GRCm38)	S716P	probably damaging	Het
Kcnab1	A	T	3: 65,266,503 (GRCm38)	K78N	possibly damaging	Het
Kif1a	A	T	1: 93,054,317 (GRCm38)	V787E	possibly damaging	Het
Krt15	A	T	11: 100,135,560 (GRCm38)	V100E	possibly damaging	Het
Krt39	A	T	11: 99,518,091 (GRCm38)	V293E	probably damaging	Het
Lrrn4	A	G	2: 132,869,743 (GRCm38)	F720S	possibly damaging	Het
Map2	G	A	1: 66,414,824 (GRCm38)	A958T	possibly damaging	Het
Map3k9	A	G	12: 81,724,097 (GRCm38)	S906P	probably benign	Het
Mdc1	T	C	17: 35,853,309 (GRCm38)	S1250P	probably benign	Het
Meltf	G	A	16: 31,884,946 (GRCm38)	V164I	probably damaging	Het
Mtap	T	G	4: 89,179,462 (GRCm38)		probably null	Het
Mtus1	C	A	8: 41,022,406 (GRCm38)	V184F	probably damaging	Het
Myh1	A	T	11: 67,213,663 (GRCm38)	D1015V	probably damaging	Het
Ndrg1	T	C	15: 66,944,938 (GRCm38)		probably null	Het
Nkd1	G	T	8: 88,585,175 (GRCm38)	V130L	probably benign	Het
Nsfl1c	A	G	2: 151,500,753 (GRCm38)	D81G	probably benign	Het
Nt5c1b	T	A	12: 10,381,391 (GRCm38)		probably null	Het
Nucb1	T	C	7: 45,498,778 (GRCm38)	K204E	possibly damaging	Het
Nwd1	T	G	8: 72,675,173 (GRCm38)	M774R	possibly damaging	Het
Olfr165	A	T	16: 19,407,194 (GRCm38)	V274E	probably damaging	Het
Olfr262	A	T	19: 12,240,954 (GRCm38)	S236T	possibly damaging	Het
Olfr654	G	C	7: 104,588,700 (GRCm38)	E299Q	probably damaging	Het
Pan3	T	A	5: 147,536,272 (GRCm38)		probably null	Het
Pcdh15	A	T	10: 74,506,485 (GRCm38)	T1135S	probably benign	Het
Pfas	A	G	11: 69,000,092 (GRCm38)	I331T	probably damaging	Het
Ptar1	A	T	19: 23,718,101 (GRCm38)	R311W	probably damaging	Het
Ranbp2	T	G	10: 58,479,194 (GRCm38)	M1912R	probably damaging	Het
Rbm12	A	G	2: 156,097,303 (GRCm38)	F350L	possibly damaging	Het
Sdhaf1	T	C	7: 30,322,043 (GRCm38)	D96G	probably benign	Het
Serpinb6b	T	A	13: 32,968,667 (GRCm38)	M53K	probably damaging	Het
Sh2d6	A	T	6: 72,517,164 (GRCm38)	L147Q	probably benign	Het
Slc19a2	T	A	1: 164,260,876 (GRCm38)	C298S	probably benign	Het
Son	AGAACCCCCAGCCGCAGGAGCCGAACCCCCAGCCGCAGGAGCCGAACCCCCAGCCGCAGGAGCCGAACCCCCAGCCG	AGAACCCCCAGCCGCAGGAGCCGAACCCCCAGCCGCAGGAGCCGAACCCCCAGCCG	16: 91,660,334 (GRCm38)		probably benign	Het
St8sia2	T	A	7: 73,960,902 (GRCm38)	Q211L	possibly damaging	Het
Sult2a2	T	C	7: 13,734,897 (GRCm38)	I96T	possibly damaging	Het
Tab2	G	T	10: 7,907,483 (GRCm38)	H678Q	probably damaging	Het
Tnfaip6	A	G	2: 52,038,216 (GRCm38)	E14G	probably benign	Het
Trip11	A	T	12: 101,885,198 (GRCm38)	L869H	probably damaging	Het
Tslp	T	C	18: 32,819,080 (GRCm38)	Y133H	not run	Het
Ttn	A	G	2: 76,932,143 (GRCm38)	V3374A	unknown	Het
Ttn	T	C	2: 76,740,990 (GRCm38)	I26520V	probably damaging	Het
Tubgcp2	T	A	7: 140,007,924 (GRCm38)	I263F	possibly damaging	Het
Uaca	A	G	9: 60,870,110 (GRCm38)	E593G	probably damaging	Het
Unc13b	C	T	4: 43,172,235 (GRCm38)	T1021I	unknown	Het
Ush1c	T	A	7: 46,225,555 (GRCm38)	I131F	probably benign	Het
Usp24	C	A	4: 106,379,107 (GRCm38)	D997E	probably benign	Het
Usp54	T	C	14: 20,577,040 (GRCm38)	T517A	probably benign	Het
Vmn1r151	A	T	7: 22,499,080 (GRCm38)	M200K	possibly damaging	Het
Vmn2r43	T	C	7: 8,255,329 (GRCm38)	D295G	probably damaging	Het
Vmn2r70	G	A	7: 85,563,868 (GRCm38)	P444S	probably damaging	Het
Vmn2r85	G	T	10: 130,418,980 (GRCm38)	P612T	probably damaging	Het
Vps13d	A	T	4: 145,148,747 (GRCm38)	V1736D		Het
Zbtb11	A	T	16: 55,990,487 (GRCm38)	H336L	probably benign	Het

Other mutations in Plxna2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00227:Plxna2	APN	1	194,644,657 (GRCm38)	missense	probably damaging	1.00
IGL00332:Plxna2	APN	1	194,789,830 (GRCm38)	missense	probably damaging	0.98
IGL00392:Plxna2	APN	1	194,800,568 (GRCm38)	missense	probably damaging	1.00
IGL00432:Plxna2	APN	1	194,644,096 (GRCm38)	missense	probably benign	0.03
IGL00704:Plxna2	APN	1	194,751,461 (GRCm38)	missense	probably damaging	0.99
IGL00737:Plxna2	APN	1	194,746,239 (GRCm38)	splice site	probably benign
IGL01078:Plxna2	APN	1	194,786,693 (GRCm38)	unclassified	probably benign
IGL01354:Plxna2	APN	1	194,762,435 (GRCm38)	missense	probably benign	0.02
IGL01432:Plxna2	APN	1	194,644,318 (GRCm38)	missense	possibly damaging	0.58
IGL01459:Plxna2	APN	1	194,764,570 (GRCm38)	missense	probably benign	0.00
IGL01525:Plxna2	APN	1	194,712,311 (GRCm38)	missense	probably benign	0.00
IGL01656:Plxna2	APN	1	194,790,161 (GRCm38)	missense	possibly damaging	0.52
IGL01825:Plxna2	APN	1	194,788,902 (GRCm38)	missense	probably damaging	0.98
IGL01862:Plxna2	APN	1	194,643,950 (GRCm38)	missense	possibly damaging	0.87
IGL01899:Plxna2	APN	1	194,751,488 (GRCm38)	missense	probably damaging	1.00
IGL01996:Plxna2	APN	1	194,799,776 (GRCm38)	missense	probably damaging	0.99
IGL02123:Plxna2	APN	1	194,794,383 (GRCm38)	missense	probably damaging	1.00
IGL02226:Plxna2	APN	1	194,644,424 (GRCm38)	missense	probably damaging	1.00
IGL02227:Plxna2	APN	1	194,752,089 (GRCm38)	missense	probably damaging	1.00
IGL02415:Plxna2	APN	1	194,643,964 (GRCm38)	missense	probably damaging	1.00
IGL02440:Plxna2	APN	1	194,746,150 (GRCm38)	missense	probably benign	0.10
IGL02545:Plxna2	APN	1	194,786,690 (GRCm38)	unclassified	probably benign
IGL02553:Plxna2	APN	1	194,751,438 (GRCm38)	missense	probably benign	0.08
IGL02882:Plxna2	APN	1	194,762,570 (GRCm38)	missense	probably damaging	1.00
IGL02946:Plxna2	APN	1	194,749,309 (GRCm38)	splice site	probably benign
IGL03062:Plxna2	APN	1	194,762,550 (GRCm38)	missense	possibly damaging	0.72
IGL03095:Plxna2	APN	1	194,801,127 (GRCm38)	missense	probably damaging	1.00
IGL03293:Plxna2	APN	1	194,804,945 (GRCm38)	missense	probably damaging	0.99
G1Funyon:Plxna2	UTSW	1	194,790,175 (GRCm38)	missense	probably benign	0.01
PIT4514001:Plxna2	UTSW	1	194,794,937 (GRCm38)	missense	probably benign	0.00
R0024:Plxna2	UTSW	1	194,643,995 (GRCm38)	missense	possibly damaging	0.57
R0040:Plxna2	UTSW	1	194,643,896 (GRCm38)	missense	probably benign	0.13
R0040:Plxna2	UTSW	1	194,643,896 (GRCm38)	missense	probably benign	0.13
R0063:Plxna2	UTSW	1	194,644,939 (GRCm38)	missense	probably benign	0.00
R0063:Plxna2	UTSW	1	194,644,939 (GRCm38)	missense	probably benign	0.00
R0217:Plxna2	UTSW	1	194,644,598 (GRCm38)	missense	probably damaging	1.00
R0316:Plxna2	UTSW	1	194,644,150 (GRCm38)	missense	probably damaging	1.00
R0440:Plxna2	UTSW	1	194,644,404 (GRCm38)	nonsense	probably null
R0505:Plxna2	UTSW	1	194,644,348 (GRCm38)	missense	possibly damaging	0.93
R0568:Plxna2	UTSW	1	194,751,386 (GRCm38)	missense	probably benign	0.00
R0669:Plxna2	UTSW	1	194,788,837 (GRCm38)	missense	probably damaging	0.99
R0674:Plxna2	UTSW	1	194,649,475 (GRCm38)	missense	probably benign	0.00
R0885:Plxna2	UTSW	1	194,644,556 (GRCm38)	missense	probably benign
R0898:Plxna2	UTSW	1	194,797,024 (GRCm38)	missense	probably damaging	1.00
R0940:Plxna2	UTSW	1	194,800,555 (GRCm38)	missense	probably benign	0.01
R1061:Plxna2	UTSW	1	194,644,093 (GRCm38)	missense	probably damaging	1.00
R1067:Plxna2	UTSW	1	194,780,510 (GRCm38)	splice site	probably null
R1222:Plxna2	UTSW	1	194,800,649 (GRCm38)	missense	probably damaging	1.00
R1345:Plxna2	UTSW	1	194,644,486 (GRCm38)	missense	probably damaging	1.00
R1363:Plxna2	UTSW	1	194,804,939 (GRCm38)	nonsense	probably null
R1432:Plxna2	UTSW	1	194,767,463 (GRCm38)	missense	probably benign	0.10
R1434:Plxna2	UTSW	1	194,751,540 (GRCm38)	splice site	probably benign
R1597:Plxna2	UTSW	1	194,749,306 (GRCm38)	splice site	probably benign
R1719:Plxna2	UTSW	1	194,644,370 (GRCm38)	missense	possibly damaging	0.93
R1778:Plxna2	UTSW	1	194,810,970 (GRCm38)	missense	probably benign	0.01
R1795:Plxna2	UTSW	1	194,806,303 (GRCm38)	missense	probably damaging	0.99
R1819:Plxna2	UTSW	1	194,790,186 (GRCm38)	missense	probably benign	0.03
R1926:Plxna2	UTSW	1	194,762,450 (GRCm38)	missense	probably benign	0.02
R1966:Plxna2	UTSW	1	194,644,700 (GRCm38)	missense	possibly damaging	0.91
R1987:Plxna2	UTSW	1	194,643,989 (GRCm38)	missense	probably damaging	1.00
R1988:Plxna2	UTSW	1	194,643,989 (GRCm38)	missense	probably damaging	1.00
R2034:Plxna2	UTSW	1	194,780,594 (GRCm38)	missense	probably benign	0.00
R2131:Plxna2	UTSW	1	194,644,750 (GRCm38)	missense	probably benign	0.01
R2171:Plxna2	UTSW	1	194,800,617 (GRCm38)	missense	probably damaging	1.00
R2217:Plxna2	UTSW	1	194,797,748 (GRCm38)	missense	probably damaging	1.00
R2311:Plxna2	UTSW	1	194,749,317 (GRCm38)	missense	probably damaging	1.00
R2340:Plxna2	UTSW	1	194,749,317 (GRCm38)	missense	probably damaging	1.00
R2342:Plxna2	UTSW	1	194,749,317 (GRCm38)	missense	probably damaging	1.00
R2423:Plxna2	UTSW	1	194,749,317 (GRCm38)	missense	probably damaging	1.00
R2424:Plxna2	UTSW	1	194,749,317 (GRCm38)	missense	probably damaging	1.00
R2425:Plxna2	UTSW	1	194,749,317 (GRCm38)	missense	probably damaging	1.00
R2842:Plxna2	UTSW	1	194,749,317 (GRCm38)	missense	probably damaging	1.00
R2971:Plxna2	UTSW	1	194,797,731 (GRCm38)	missense	probably damaging	1.00
R3236:Plxna2	UTSW	1	194,749,317 (GRCm38)	missense	probably damaging	1.00
R3731:Plxna2	UTSW	1	194,788,885 (GRCm38)	missense	probably benign	0.42
R3783:Plxna2	UTSW	1	194,807,521 (GRCm38)	missense	probably damaging	1.00
R3784:Plxna2	UTSW	1	194,644,617 (GRCm38)	missense	probably benign
R3787:Plxna2	UTSW	1	194,643,934 (GRCm38)	missense	probably benign	0.10
R3845:Plxna2	UTSW	1	194,793,790 (GRCm38)	missense	probably damaging	0.96
R3927:Plxna2	UTSW	1	194,746,157 (GRCm38)	missense	probably benign	0.02
R3930:Plxna2	UTSW	1	194,794,910 (GRCm38)	missense	probably benign	0.17
R3964:Plxna2	UTSW	1	194,749,317 (GRCm38)	missense	probably damaging	1.00
R3980:Plxna2	UTSW	1	194,749,317 (GRCm38)	missense	probably damaging	1.00
R4067:Plxna2	UTSW	1	194,749,317 (GRCm38)	missense	probably damaging	1.00
R4120:Plxna2	UTSW	1	194,780,627 (GRCm38)	missense	probably damaging	1.00
R4231:Plxna2	UTSW	1	194,644,454 (GRCm38)	missense	probably damaging	1.00
R4257:Plxna2	UTSW	1	194,644,775 (GRCm38)	missense	probably damaging	1.00
R4396:Plxna2	UTSW	1	194,749,317 (GRCm38)	missense	probably damaging	1.00
R4397:Plxna2	UTSW	1	194,749,317 (GRCm38)	missense	probably damaging	1.00
R4418:Plxna2	UTSW	1	194,749,317 (GRCm38)	missense	probably damaging	1.00
R4444:Plxna2	UTSW	1	194,749,317 (GRCm38)	missense	probably damaging	1.00
R4446:Plxna2	UTSW	1	194,749,317 (GRCm38)	missense	probably damaging	1.00
R4482:Plxna2	UTSW	1	194,749,317 (GRCm38)	missense	probably damaging	1.00
R4487:Plxna2	UTSW	1	194,749,317 (GRCm38)	missense	probably damaging	1.00
R4489:Plxna2	UTSW	1	194,749,317 (GRCm38)	missense	probably damaging	1.00
R4571:Plxna2	UTSW	1	194,810,988 (GRCm38)	missense	possibly damaging	0.91
R4622:Plxna2	UTSW	1	194,812,150 (GRCm38)	missense	probably benign
R4623:Plxna2	UTSW	1	194,812,150 (GRCm38)	missense	probably benign
R4684:Plxna2	UTSW	1	194,762,594 (GRCm38)	missense	probably benign	0.42
R4688:Plxna2	UTSW	1	194,644,445 (GRCm38)	missense	probably damaging	1.00
R4855:Plxna2	UTSW	1	194,797,732 (GRCm38)	missense	probably benign	0.39
R4876:Plxna2	UTSW	1	194,643,775 (GRCm38)	missense	probably benign	0.02
R5161:Plxna2	UTSW	1	194,751,404 (GRCm38)	missense	probably benign
R5207:Plxna2	UTSW	1	194,788,899 (GRCm38)	missense	probably benign	0.19
R5479:Plxna2	UTSW	1	194,793,873 (GRCm38)	missense	probably benign
R5931:Plxna2	UTSW	1	194,810,870 (GRCm38)	missense	probably damaging	1.00
R6026:Plxna2	UTSW	1	194,799,814 (GRCm38)	missense	probably damaging	1.00
R6029:Plxna2	UTSW	1	194,799,575 (GRCm38)	missense	probably damaging	1.00
R6029:Plxna2	UTSW	1	194,794,427 (GRCm38)	missense	probably benign	0.00
R6059:Plxna2	UTSW	1	194,810,971 (GRCm38)	missense	possibly damaging	0.79
R6238:Plxna2	UTSW	1	194,790,196 (GRCm38)	missense	probably benign	0.01
R6322:Plxna2	UTSW	1	194,754,367 (GRCm38)	missense	possibly damaging	0.89
R6668:Plxna2	UTSW	1	194,810,088 (GRCm38)	missense	possibly damaging	0.68
R6709:Plxna2	UTSW	1	194,789,766 (GRCm38)	missense	probably benign	0.01
R6748:Plxna2	UTSW	1	194,794,182 (GRCm38)	splice site	probably null
R6838:Plxna2	UTSW	1	194,804,914 (GRCm38)	missense	possibly damaging	0.90
R6844:Plxna2	UTSW	1	194,793,828 (GRCm38)	missense	probably benign	0.08
R7069:Plxna2	UTSW	1	194,793,904 (GRCm38)	missense	possibly damaging	0.51
R7122:Plxna2	UTSW	1	194,644,568 (GRCm38)	nonsense	probably null
R7145:Plxna2	UTSW	1	194,649,522 (GRCm38)	missense	probably benign	0.31
R7189:Plxna2	UTSW	1	194,801,058 (GRCm38)	missense	possibly damaging	0.58
R7207:Plxna2	UTSW	1	194,644,019 (GRCm38)	missense	probably damaging	1.00
R7232:Plxna2	UTSW	1	194,712,260 (GRCm38)	missense	probably damaging	1.00
R7234:Plxna2	UTSW	1	194,806,390 (GRCm38)	missense	probably damaging	0.96
R7246:Plxna2	UTSW	1	194,644,282 (GRCm38)	missense	possibly damaging	0.74
R7255:Plxna2	UTSW	1	194,752,103 (GRCm38)	missense	probably benign	0.03
R7283:Plxna2	UTSW	1	194,644,883 (GRCm38)	missense	probably damaging	0.99
R7288:Plxna2	UTSW	1	194,796,919 (GRCm38)	missense	probably damaging	1.00
R7361:Plxna2	UTSW	1	194,799,779 (GRCm38)	missense	probably damaging	1.00
R7501:Plxna2	UTSW	1	194,643,895 (GRCm38)	missense	possibly damaging	0.95
R7528:Plxna2	UTSW	1	194,812,156 (GRCm38)	missense	probably damaging	1.00
R7529:Plxna2	UTSW	1	194,643,871 (GRCm38)	missense	probably benign	0.25
R7532:Plxna2	UTSW	1	194,644,819 (GRCm38)	missense	probably benign	0.13
R7959:Plxna2	UTSW	1	194,810,962 (GRCm38)	missense	probably damaging	1.00
R7959:Plxna2	UTSW	1	194,793,864 (GRCm38)	frame shift	probably null
R7960:Plxna2	UTSW	1	194,793,864 (GRCm38)	frame shift	probably null
R8261:Plxna2	UTSW	1	194,749,416 (GRCm38)	missense	probably damaging	1.00
R8301:Plxna2	UTSW	1	194,790,175 (GRCm38)	missense	probably benign	0.01
R8463:Plxna2	UTSW	1	194,644,046 (GRCm38)	missense	probably damaging	1.00
R8519:Plxna2	UTSW	1	194,793,958 (GRCm38)	missense	probably damaging	1.00
R8836:Plxna2	UTSW	1	194,796,935 (GRCm38)	missense	possibly damaging	0.94
R9010:Plxna2	UTSW	1	194,788,909 (GRCm38)	missense	possibly damaging	0.95
R9034:Plxna2	UTSW	1	194,793,889 (GRCm38)	missense	probably damaging	1.00
R9254:Plxna2	UTSW	1	194,810,166 (GRCm38)	missense	probably damaging	1.00
R9274:Plxna2	UTSW	1	194,788,828 (GRCm38)	missense	probably damaging	1.00
R9379:Plxna2	UTSW	1	194,810,166 (GRCm38)	missense	probably damaging	1.00
R9385:Plxna2	UTSW	1	194,749,416 (GRCm38)	missense	possibly damaging	0.95
R9422:Plxna2	UTSW	1	194,644,422 (GRCm38)	missense	probably damaging	1.00
R9451:Plxna2	UTSW	1	194,644,384 (GRCm38)	missense	probably benign	0.05
R9484:Plxna2	UTSW	1	194,644,894 (GRCm38)	missense	probably damaging	1.00
X0027:Plxna2	UTSW	1	194,644,433 (GRCm38)	missense	probably damaging	1.00
Z1088:Plxna2	UTSW	1	194,764,539 (GRCm38)	missense	probably benign	0.06
Z1088:Plxna2	UTSW	1	194,644,441 (GRCm38)	missense	possibly damaging	0.56

Predicted Primers

PCR Primer
(F):5'- AAGAGTCCTTTCAAGGTAAAGCAG -3'
(R):5'- GAGGCAATCAGAAGCACCTG -3'

Sequencing Primer
(F):5'- GCAGGTTTATTCTGAATTGATACAGC -3'
(R):5'- TCAGAAGCACCTGTAGCATG -3'

Posted On

2019-10-07