Incidental Mutation 'R7424:Olfr262'
ID 575957
Institutional Source Beutler Lab
Gene Symbol Olfr262
Ensembl Gene ENSMUSG00000067519
Gene Name olfactory receptor 262
Synonyms MOR214-1, GA_x6K02T2N4A9-18144-19082, MOR214-9
MMRRC Submission 045502-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.090) question?
Stock # R7424 (G1)
Quality Score 225.009
Status Validated
Chromosome 19
Chromosomal Location 12240721-12241659 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to T at 12240954 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Serine to Threonine at position 236 (S236T)
Ref Sequence ENSEMBL: ENSMUSP00000085120 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000087818]
AlphaFold Q8VFV8
Predicted Effect possibly damaging
Transcript: ENSMUST00000087818
AA Change: S236T

PolyPhen 2 Score 0.648 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000085120
Gene: ENSMUSG00000067519
AA Change: S236T

DomainStartEndE-ValueType
Pfam:7tm_4 32 309 2.3e-55 PFAM
Pfam:7tm_1 42 291 1.2e-20 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.4%
Validation Efficiency 99% (76/77)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 79 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
6430548M08Rik C T 8: 120,145,545 (GRCm38) R71C probably damaging Het
Aanat A T 11: 116,595,629 (GRCm38) probably benign Het
Ahrr G T 13: 74,257,545 (GRCm38) S91* probably null Het
Ampd1 A T 3: 103,088,442 (GRCm38) N223Y probably benign Het
Ankar T G 1: 72,680,058 (GRCm38) N544T probably damaging Het
Ankk1 A G 9: 49,418,750 (GRCm38) S302P possibly damaging Het
Bcr T C 10: 75,157,100 (GRCm38) V809A probably benign Het
Bpifb2 A G 2: 153,890,540 (GRCm38) N353S possibly damaging Het
Cyth1 A T 11: 118,184,009 (GRCm38) probably null Het
Ddx5 A T 11: 106,782,180 (GRCm38) N506K probably benign Het
Dnaja1 A T 4: 40,730,244 (GRCm38) I239F probably benign Het
Ethe1 C T 7: 24,606,251 (GRCm38) T141I probably damaging Het
Fam160b2 T C 14: 70,594,007 (GRCm38) H29R probably damaging Het
Gdap2 A T 3: 100,202,066 (GRCm38) I36F unknown Het
Gm13030 A T 4: 138,871,266 (GRCm38) D115E unknown Het
Gm13103 C T 4: 143,853,209 (GRCm38) P455S probably benign Het
Gm17019 A T 5: 15,029,372 (GRCm38) L227Q probably damaging Het
Gm9195 T A 14: 72,435,777 (GRCm38) E2517D possibly damaging Het
Gramd2 T A 9: 59,708,071 (GRCm38) V39D possibly damaging Het
Hmcn1 C T 1: 150,630,266 (GRCm38) W3836* probably null Het
Hspa14 C T 2: 3,489,041 (GRCm38) D494N possibly damaging Het
Ifit2 A G 19: 34,573,198 (GRCm38) N46S probably benign Het
Ifna6 A T 4: 88,827,807 (GRCm38) E131V possibly damaging Het
Ift140 T C 17: 25,037,036 (GRCm38) V504A possibly damaging Het
Irgc1 T C 7: 24,432,228 (GRCm38) N388S probably damaging Het
Itgal T A 7: 127,317,365 (GRCm38) V743E probably benign Het
Itih5 T C 2: 10,245,637 (GRCm38) S716P probably damaging Het
Kcnab1 A T 3: 65,266,503 (GRCm38) K78N possibly damaging Het
Kif1a A T 1: 93,054,317 (GRCm38) V787E possibly damaging Het
Krt15 A T 11: 100,135,560 (GRCm38) V100E possibly damaging Het
Krt39 A T 11: 99,518,091 (GRCm38) V293E probably damaging Het
Lrrn4 A G 2: 132,869,743 (GRCm38) F720S possibly damaging Het
Map2 G A 1: 66,414,824 (GRCm38) A958T possibly damaging Het
Map3k9 A G 12: 81,724,097 (GRCm38) S906P probably benign Het
Mdc1 T C 17: 35,853,309 (GRCm38) S1250P probably benign Het
Meltf G A 16: 31,884,946 (GRCm38) V164I probably damaging Het
Mtap T G 4: 89,179,462 (GRCm38) probably null Het
Mtus1 C A 8: 41,022,406 (GRCm38) V184F probably damaging Het
Myh1 A T 11: 67,213,663 (GRCm38) D1015V probably damaging Het
Ndrg1 T C 15: 66,944,938 (GRCm38) probably null Het
Nkd1 G T 8: 88,585,175 (GRCm38) V130L probably benign Het
Nsfl1c A G 2: 151,500,753 (GRCm38) D81G probably benign Het
Nt5c1b T A 12: 10,381,391 (GRCm38) probably null Het
Nucb1 T C 7: 45,498,778 (GRCm38) K204E possibly damaging Het
Nwd1 T G 8: 72,675,173 (GRCm38) M774R possibly damaging Het
Olfr165 A T 16: 19,407,194 (GRCm38) V274E probably damaging Het
Olfr654 G C 7: 104,588,700 (GRCm38) E299Q probably damaging Het
Pan3 T A 5: 147,536,272 (GRCm38) probably null Het
Pcdh15 A T 10: 74,506,485 (GRCm38) T1135S probably benign Het
Pfas A G 11: 69,000,092 (GRCm38) I331T probably damaging Het
Plxna2 T A 1: 194,806,339 (GRCm38) I1641N probably damaging Het
Ptar1 A T 19: 23,718,101 (GRCm38) R311W probably damaging Het
Ranbp2 T G 10: 58,479,194 (GRCm38) M1912R probably damaging Het
Rbm12 A G 2: 156,097,303 (GRCm38) F350L possibly damaging Het
Sdhaf1 T C 7: 30,322,043 (GRCm38) D96G probably benign Het
Serpinb6b T A 13: 32,968,667 (GRCm38) M53K probably damaging Het
Sh2d6 A T 6: 72,517,164 (GRCm38) L147Q probably benign Het
Slc19a2 T A 1: 164,260,876 (GRCm38) C298S probably benign Het
Son AGAACCCCCAGCCGCAGGAGCCGAACCCCCAGCCGCAGGAGCCGAACCCCCAGCCGCAGGAGCCGAACCCCCAGCCG AGAACCCCCAGCCGCAGGAGCCGAACCCCCAGCCGCAGGAGCCGAACCCCCAGCCG 16: 91,660,334 (GRCm38) probably benign Het
St8sia2 T A 7: 73,960,902 (GRCm38) Q211L possibly damaging Het
Sult2a2 T C 7: 13,734,897 (GRCm38) I96T possibly damaging Het
Tab2 G T 10: 7,907,483 (GRCm38) H678Q probably damaging Het
Tnfaip6 A G 2: 52,038,216 (GRCm38) E14G probably benign Het
Trip11 A T 12: 101,885,198 (GRCm38) L869H probably damaging Het
Tslp T C 18: 32,819,080 (GRCm38) Y133H not run Het
Ttn T C 2: 76,740,990 (GRCm38) I26520V probably damaging Het
Ttn A G 2: 76,932,143 (GRCm38) V3374A unknown Het
Tubgcp2 T A 7: 140,007,924 (GRCm38) I263F possibly damaging Het
Uaca A G 9: 60,870,110 (GRCm38) E593G probably damaging Het
Unc13b C T 4: 43,172,235 (GRCm38) T1021I unknown Het
Ush1c T A 7: 46,225,555 (GRCm38) I131F probably benign Het
Usp24 C A 4: 106,379,107 (GRCm38) D997E probably benign Het
Usp54 T C 14: 20,577,040 (GRCm38) T517A probably benign Het
Vmn1r151 A T 7: 22,499,080 (GRCm38) M200K possibly damaging Het
Vmn2r43 T C 7: 8,255,329 (GRCm38) D295G probably damaging Het
Vmn2r70 G A 7: 85,563,868 (GRCm38) P444S probably damaging Het
Vmn2r85 G T 10: 130,418,980 (GRCm38) P612T probably damaging Het
Vps13d A T 4: 145,148,747 (GRCm38) V1736D Het
Zbtb11 A T 16: 55,990,487 (GRCm38) H336L probably benign Het
Other mutations in Olfr262
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01432:Olfr262 APN 19 12,241,527 (GRCm38) missense probably damaging 0.99
IGL02170:Olfr262 APN 19 12,240,756 (GRCm38) missense probably benign
IGL02748:Olfr262 APN 19 12,240,840 (GRCm38) missense probably benign 0.01
IGL02896:Olfr262 APN 19 12,240,989 (GRCm38) nonsense probably null
R0365:Olfr262 UTSW 19 12,241,076 (GRCm38) missense probably benign 0.13
R0374:Olfr262 UTSW 19 12,241,141 (GRCm38) missense probably damaging 1.00
R1226:Olfr262 UTSW 19 12,241,586 (GRCm38) missense probably benign
R1319:Olfr262 UTSW 19 12,241,502 (GRCm38) missense probably damaging 1.00
R1426:Olfr262 UTSW 19 12,241,182 (GRCm38) missense possibly damaging 0.81
R1453:Olfr262 UTSW 19 12,241,592 (GRCm38) missense probably benign
R1675:Olfr262 UTSW 19 12,240,831 (GRCm38) missense probably benign 0.37
R1773:Olfr262 UTSW 19 12,241,659 (GRCm38) start codon destroyed probably null 0.03
R1778:Olfr262 UTSW 19 12,241,455 (GRCm38) missense probably benign
R1820:Olfr262 UTSW 19 12,241,248 (GRCm38) missense probably damaging 1.00
R3161:Olfr262 UTSW 19 12,241,496 (GRCm38) missense probably benign 0.06
R3412:Olfr262 UTSW 19 12,241,590 (GRCm38) missense probably benign 0.00
R4387:Olfr262 UTSW 19 12,241,139 (GRCm38) missense probably damaging 0.98
R4389:Olfr262 UTSW 19 12,241,139 (GRCm38) missense probably damaging 0.98
R4782:Olfr262 UTSW 19 12,241,572 (GRCm38) missense probably benign 0.01
R4885:Olfr262 UTSW 19 12,240,718 (GRCm38) splice site probably null
R4915:Olfr262 UTSW 19 12,241,373 (GRCm38) missense probably benign 0.31
R5254:Olfr262 UTSW 19 12,241,248 (GRCm38) missense probably damaging 1.00
R5726:Olfr262 UTSW 19 12,241,280 (GRCm38) missense probably damaging 0.99
R6579:Olfr262 UTSW 19 12,241,362 (GRCm38) missense probably benign
R7062:Olfr262 UTSW 19 12,240,725 (GRCm38) missense probably benign
R9491:Olfr262 UTSW 19 12,241,242 (GRCm38) missense probably benign 0.01
R9736:Olfr262 UTSW 19 12,241,556 (GRCm38) missense probably damaging 0.97
Predicted Primers PCR Primer
(F):5'- GTGTCCCTAGTTGCAGATTGTC -3'
(R):5'- GTGACATGCCACAGTTGTTAG -3'

Sequencing Primer
(F):5'- CTGTTCTTCAGACTGTATATCAATGG -3'
(R):5'- ACATGCCACAGTTGTTAGTTCTG -3'
Posted On 2019-10-07