Incidental Mutation 'R7425:Ankrd35'
ID 575971
Institutional Source Beutler Lab
Gene Symbol Ankrd35
Ensembl Gene ENSMUSG00000038354
Gene Name ankyrin repeat domain 35
Synonyms 4732436F15Rik
MMRRC Submission 045503-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R7425 (G1)
Quality Score 225.009
Status Not validated
Chromosome 3
Chromosomal Location 96577447-96598348 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 96592104 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Glycine at position 797 (S797G)
Ref Sequence ENSEMBL: ENSMUSP00000047244 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000048427]
AlphaFold E9Q9D8
Predicted Effect not run
Transcript: ENSMUST00000048427
AA Change: S797G
SMART Domains Protein: ENSMUSP00000047244
Gene: ENSMUSG00000038354
AA Change: S797G

DomainStartEndE-ValueType
ANK 53 82 4.03e-5 SMART
ANK 86 115 6.46e-4 SMART
ANK 119 148 4.36e-1 SMART
ANK 152 181 1.4e-4 SMART
ANK 185 214 2.25e-3 SMART
ANK 218 247 6.24e2 SMART
coiled coil region 294 339 N/A INTRINSIC
low complexity region 438 455 N/A INTRINSIC
low complexity region 487 498 N/A INTRINSIC
low complexity region 524 536 N/A INTRINSIC
coiled coil region 606 653 N/A INTRINSIC
coiled coil region 729 799 N/A INTRINSIC
low complexity region 815 829 N/A INTRINSIC
coiled coil region 847 956 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 68 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110002E22Rik A G 3: 137,771,456 (GRCm39) E215G probably benign Het
Adam8 T A 7: 139,572,394 (GRCm39) probably benign Het
Anxa3 T A 5: 96,982,680 (GRCm39) H259Q probably benign Het
Ap3d1 T A 10: 80,557,426 (GRCm39) Q302L probably damaging Het
Atg2a T C 19: 6,305,682 (GRCm39) V1294A probably benign Het
Atp13a5 G A 16: 29,116,278 (GRCm39) Q613* probably null Het
Bltp1 T A 3: 37,002,490 (GRCm39) H1478Q probably benign Het
Bltp1 A T 3: 37,037,543 (GRCm39) H2448L probably benign Het
Bmpr2 T G 1: 59,906,510 (GRCm39) N534K probably benign Het
C1qbp T C 11: 70,869,072 (GRCm39) probably null Het
C1qbp G T 11: 70,869,073 (GRCm39) probably null Het
C1ql3 T G 2: 13,015,229 (GRCm39) K144Q possibly damaging Het
C3 T C 17: 57,511,039 (GRCm39) M1656V possibly damaging Het
Cand1 A T 10: 119,052,148 (GRCm39) Y252N probably benign Het
Capn13 T C 17: 73,625,053 (GRCm39) I632M probably benign Het
Catsperb A G 12: 101,557,757 (GRCm39) E776G probably damaging Het
Ccnl1 A T 3: 65,856,179 (GRCm39) V242D probably damaging Het
Cd68 T C 11: 69,555,938 (GRCm39) D200G probably benign Het
Cela3a T C 4: 137,132,899 (GRCm39) N118D probably benign Het
Celsr2 A G 3: 108,309,773 (GRCm39) C1609R probably damaging Het
Cep85l G C 10: 53,177,666 (GRCm39) Q458E probably damaging Het
Cnga1 T G 5: 72,766,868 (GRCm39) E190D probably benign Het
Cntnap3 G A 13: 64,906,066 (GRCm39) R847C probably damaging Het
Cntrob G A 11: 69,205,560 (GRCm39) Q425* probably null Het
Commd9 G A 2: 101,730,245 (GRCm39) W128* probably null Het
Csnk1a1 C T 18: 61,718,330 (GRCm39) S352L unknown Het
Dact2 A G 17: 14,416,593 (GRCm39) S536P probably damaging Het
Ddx25 A G 9: 35,465,882 (GRCm39) I113T probably benign Het
Dscam T A 16: 96,430,598 (GRCm39) D1630V probably damaging Het
Fndc7 A C 3: 108,783,975 (GRCm39) F211L probably benign Het
Fryl T C 5: 73,262,091 (GRCm39) T559A probably damaging Het
Hpx C A 7: 105,241,068 (GRCm39) D402Y probably damaging Het
Ints13 A G 6: 146,476,198 (GRCm39) probably null Het
Ipcef1 T C 10: 6,906,066 (GRCm39) K76E probably damaging Het
Kcnb2 A C 1: 15,780,031 (GRCm39) Q301P probably damaging Het
Lamp3 C T 16: 19,518,362 (GRCm39) probably null Het
Lmod2 A T 6: 24,603,475 (GRCm39) H150L probably benign Het
Lrch3 T C 16: 32,826,077 (GRCm39) F718S probably damaging Het
Mms22l T C 4: 24,596,287 (GRCm39) V1082A probably benign Het
Nbas G T 12: 13,519,881 (GRCm39) V1598L probably damaging Het
Nrxn3 C T 12: 89,479,870 (GRCm39) R671* probably null Het
Or4c110 A T 2: 88,832,544 (GRCm39) F29L Het
Or4c58 A G 2: 89,674,789 (GRCm39) L176P probably damaging Het
Or52e8 A T 7: 104,624,268 (GRCm39) L312* probably null Het
Or5a3 A C 19: 12,400,204 (GRCm39) H177P probably damaging Het
Or6d14 A T 6: 116,533,398 (GRCm39) E4V possibly damaging Het
Pcdhga6 T A 18: 37,841,619 (GRCm39) N446K probably damaging Het
Phlpp1 A T 1: 106,320,303 (GRCm39) I1433F probably benign Het
Pla2g6 G A 15: 79,192,933 (GRCm39) R245C probably damaging Het
Rgl3 G A 9: 21,888,123 (GRCm39) Q464* probably null Het
Ryr2 T C 13: 11,720,530 (GRCm39) D2706G probably benign Het
Sbf2 G A 7: 109,974,984 (GRCm39) Q718* probably null Het
Sdad1 T C 5: 92,447,980 (GRCm39) T252A probably benign Het
Sgk1 T C 10: 21,870,009 (GRCm39) L16P probably damaging Het
Slc38a8 A G 8: 120,212,327 (GRCm39) S339P possibly damaging Het
Slc44a4 T C 17: 35,140,667 (GRCm39) S287P possibly damaging Het
Syne1 T C 10: 5,375,760 (GRCm39) I111V probably damaging Het
Synm A C 7: 67,383,194 (GRCm39) S1489R probably damaging Het
Tfb2m A G 1: 179,365,269 (GRCm39) F232L probably benign Het
Traf3 A T 12: 111,227,095 (GRCm39) K328* probably null Het
Trim38 C A 13: 23,972,365 (GRCm39) Q229K probably benign Het
Vcan A G 13: 89,837,951 (GRCm39) I2531T probably damaging Het
Virma T A 4: 11,546,211 (GRCm39) I1683N possibly damaging Het
Vmn1r18 A T 6: 57,367,551 (GRCm39) M1K probably null Het
Vmn2r87 T C 10: 130,314,761 (GRCm39) N275S probably damaging Het
Vps13a T A 19: 16,701,066 (GRCm39) H701L probably benign Het
Vrk3 T A 7: 44,420,348 (GRCm39) probably null Het
Zfp993 T A 4: 146,742,098 (GRCm39) S141T possibly damaging Het
Other mutations in Ankrd35
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00819:Ankrd35 APN 3 96,590,350 (GRCm39) splice site probably null
IGL00896:Ankrd35 APN 3 96,591,592 (GRCm39) missense probably damaging 1.00
IGL01565:Ankrd35 APN 3 96,592,101 (GRCm39) missense probably damaging 0.99
IGL01837:Ankrd35 APN 3 96,587,982 (GRCm39) missense probably damaging 1.00
IGL02605:Ankrd35 APN 3 96,588,388 (GRCm39) splice site probably null
IGL02819:Ankrd35 APN 3 96,597,524 (GRCm39) missense possibly damaging 0.80
IGL02994:Ankrd35 APN 3 96,590,307 (GRCm39) splice site probably benign
IGL03083:Ankrd35 APN 3 96,592,117 (GRCm39) missense probably damaging 1.00
IGL03105:Ankrd35 APN 3 96,591,373 (GRCm39) missense probably benign
FR4304:Ankrd35 UTSW 3 96,591,163 (GRCm39) utr 3 prime probably benign
FR4342:Ankrd35 UTSW 3 96,590,831 (GRCm39) frame shift probably null
FR4737:Ankrd35 UTSW 3 96,591,165 (GRCm39) utr 3 prime probably benign
R0003:Ankrd35 UTSW 3 96,591,331 (GRCm39) missense probably damaging 1.00
R0047:Ankrd35 UTSW 3 96,591,379 (GRCm39) missense probably benign 0.00
R0551:Ankrd35 UTSW 3 96,591,276 (GRCm39) missense probably benign 0.08
R1420:Ankrd35 UTSW 3 96,592,054 (GRCm39) missense probably benign 0.13
R1455:Ankrd35 UTSW 3 96,585,471 (GRCm39) missense probably damaging 1.00
R2201:Ankrd35 UTSW 3 96,586,564 (GRCm39) missense possibly damaging 0.93
R3522:Ankrd35 UTSW 3 96,592,378 (GRCm39) missense probably damaging 1.00
R3605:Ankrd35 UTSW 3 96,589,497 (GRCm39) nonsense probably null
R4166:Ankrd35 UTSW 3 96,586,471 (GRCm39) splice site probably null
R4651:Ankrd35 UTSW 3 96,591,343 (GRCm39) missense probably benign 0.00
R4668:Ankrd35 UTSW 3 96,586,524 (GRCm39) missense probably damaging 1.00
R4916:Ankrd35 UTSW 3 96,591,438 (GRCm39) missense probably benign
R4921:Ankrd35 UTSW 3 96,592,140 (GRCm39) missense possibly damaging 0.61
R4953:Ankrd35 UTSW 3 96,590,989 (GRCm39) missense possibly damaging 0.56
R5180:Ankrd35 UTSW 3 96,587,789 (GRCm39) missense probably damaging 1.00
R5583:Ankrd35 UTSW 3 96,592,219 (GRCm39) missense probably damaging 1.00
R5604:Ankrd35 UTSW 3 96,592,215 (GRCm39) missense probably benign 0.02
R5613:Ankrd35 UTSW 3 96,590,334 (GRCm39) missense possibly damaging 0.76
R6165:Ankrd35 UTSW 3 96,590,623 (GRCm39) missense possibly damaging 0.93
R6413:Ankrd35 UTSW 3 96,592,129 (GRCm39) missense probably damaging 0.96
R6711:Ankrd35 UTSW 3 96,590,784 (GRCm39) nonsense probably null
R6834:Ankrd35 UTSW 3 96,590,599 (GRCm39) missense possibly damaging 0.68
R6841:Ankrd35 UTSW 3 96,577,742 (GRCm39) missense probably damaging 1.00
R7028:Ankrd35 UTSW 3 96,590,650 (GRCm39) missense possibly damaging 0.92
R7396:Ankrd35 UTSW 3 96,590,813 (GRCm39) missense probably damaging 1.00
R7815:Ankrd35 UTSW 3 96,592,117 (GRCm39) missense probably damaging 1.00
R7887:Ankrd35 UTSW 3 96,592,216 (GRCm39) missense probably damaging 1.00
R8103:Ankrd35 UTSW 3 96,586,997 (GRCm39) missense possibly damaging 0.93
R8318:Ankrd35 UTSW 3 96,592,038 (GRCm39) missense probably damaging 1.00
R8492:Ankrd35 UTSW 3 96,589,529 (GRCm39) critical splice donor site probably null
R8527:Ankrd35 UTSW 3 96,589,353 (GRCm39) missense probably damaging 1.00
R8542:Ankrd35 UTSW 3 96,589,353 (GRCm39) missense probably damaging 1.00
R8742:Ankrd35 UTSW 3 96,586,502 (GRCm39) missense probably damaging 1.00
R8963:Ankrd35 UTSW 3 96,587,003 (GRCm39) nonsense probably null
R9029:Ankrd35 UTSW 3 96,591,460 (GRCm39) missense probably benign 0.43
R9229:Ankrd35 UTSW 3 96,592,215 (GRCm39) missense probably benign 0.02
R9488:Ankrd35 UTSW 3 96,589,343 (GRCm39) missense probably damaging 1.00
R9669:Ankrd35 UTSW 3 96,587,797 (GRCm39) missense probably damaging 1.00
R9761:Ankrd35 UTSW 3 96,591,733 (GRCm39) missense possibly damaging 0.80
Z1177:Ankrd35 UTSW 3 96,591,086 (GRCm39) missense probably damaging 0.96
Predicted Primers
Posted On 2019-10-07