Incidental Mutation 'R7426:Dock3'
ID |
576094 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Dock3
|
Ensembl Gene |
ENSMUSG00000039716 |
Gene Name |
dedicator of cyto-kinesis 3 |
Synonyms |
Moca, PBP |
MMRRC Submission |
045504-MU
|
Accession Numbers |
|
Essential gene? |
Possibly essential
(E-score: 0.549)
|
Stock # |
R7426 (G1)
|
Quality Score |
225.009 |
Status
|
Validated
|
Chromosome |
9 |
Chromosomal Location |
106770024-107109108 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
C to A
at 106772782 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Methionine to Isoleucine
at position 490
(M490I)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000127059
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000044532]
[ENSMUST00000069036]
[ENSMUST00000159283]
[ENSMUST00000166152]
[ENSMUST00000171095]
|
AlphaFold |
no structure available at present |
Predicted Effect |
probably benign
Transcript: ENSMUST00000044532
AA Change: M1968I
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
SMART Domains |
Protein: ENSMUSP00000047652 Gene: ENSMUSG00000039716 AA Change: M1968I
Domain | Start | End | E-Value | Type |
SH3
|
9 |
66 |
3.85e-9 |
SMART |
Pfam:DOCK_N
|
69 |
412 |
1.4e-120 |
PFAM |
Pfam:DOCK-C2
|
417 |
608 |
7.7e-56 |
PFAM |
low complexity region
|
854 |
867 |
N/A |
INTRINSIC |
low complexity region
|
892 |
916 |
N/A |
INTRINSIC |
Pfam:DHR-2
|
1121 |
1628 |
9e-133 |
PFAM |
low complexity region
|
1679 |
1690 |
N/A |
INTRINSIC |
low complexity region
|
1693 |
1704 |
N/A |
INTRINSIC |
low complexity region
|
1730 |
1754 |
N/A |
INTRINSIC |
low complexity region
|
1880 |
1902 |
N/A |
INTRINSIC |
low complexity region
|
1963 |
1977 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000069036
|
SMART Domains |
Protein: ENSMUSP00000066534 Gene: ENSMUSG00000032575
Domain | Start | End | E-Value | Type |
Pfam:Armet
|
13 |
165 |
3.2e-77 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000159283
|
SMART Domains |
Protein: ENSMUSP00000124562 Gene: ENSMUSG00000032575
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
21 |
N/A |
INTRINSIC |
Pfam:Armet
|
26 |
171 |
9.1e-74 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000159620
|
SMART Domains |
Protein: ENSMUSP00000123907 Gene: ENSMUSG00000032575
Domain | Start | End | E-Value | Type |
Pfam:Armet
|
18 |
120 |
1.7e-44 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000160503
|
SMART Domains |
Protein: ENSMUSP00000124453 Gene: ENSMUSG00000032575
Domain | Start | End | E-Value | Type |
Pfam:Armet
|
17 |
118 |
1.6e-44 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000166152
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000171095
AA Change: M490I
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
SMART Domains |
Protein: ENSMUSP00000127059 Gene: ENSMUSG00000039716 AA Change: M490I
Domain | Start | End | E-Value | Type |
Pfam:Ded_cyto
|
1 |
172 |
8.9e-52 |
PFAM |
low complexity region
|
223 |
234 |
N/A |
INTRINSIC |
low complexity region
|
237 |
248 |
N/A |
INTRINSIC |
low complexity region
|
260 |
275 |
N/A |
INTRINSIC |
low complexity region
|
402 |
424 |
N/A |
INTRINSIC |
low complexity region
|
485 |
499 |
N/A |
INTRINSIC |
|
Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 99.0%
|
Validation Efficiency |
97% (114/118) |
MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is specifically expressed in the central nervous system (CNS). It encodes a member of the DOCK (dedicator of cytokinesis) family of guanine nucleotide exchange factors (GEFs). This protein, dedicator of cytokinesis 3 (DOCK3), is also known as modifier of cell adhesion (MOCA) and presenilin-binding protein (PBP). The DOCK3 and DOCK1, -2 and -4 share several conserved amino acids in their DHR-2 (DOCK homology region 2) domains that are required for GEF activity, and bind directly to WAVE proteins [Wiskott-Aldrich syndrome protein (WASP) family Verprolin-homologous proteins] via their DHR-1 domains. The DOCK3 induces axonal outgrowth in CNS by stimulating membrane recruitment of the WAVE complex and activating the small G protein Rac1. This gene is associated with an attention deficit hyperactivity disorder-like phenotype by a complex chromosomal rearrangement. [provided by RefSeq, Aug 2010] PHENOTYPE: Mice homozygous for a null allele exhibit abnormal behaviors and muscular weakness associated with axonal dystrophy. [provided by MGI curators]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 117 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Abca15 |
C |
A |
7: 119,945,221 (GRCm39) |
N432K |
possibly damaging |
Het |
Abitram |
A |
G |
4: 56,804,230 (GRCm39) |
I82V |
probably null |
Het |
Adamtsl5 |
G |
A |
10: 80,180,693 (GRCm39) |
T123I |
probably benign |
Het |
Aff4 |
T |
C |
11: 53,263,702 (GRCm39) |
S241P |
probably damaging |
Het |
Agl |
A |
G |
3: 116,552,404 (GRCm39) |
L510P |
|
Het |
Aox1 |
A |
T |
1: 58,329,142 (GRCm39) |
K196* |
probably null |
Het |
Arhgef37 |
A |
G |
18: 61,637,456 (GRCm39) |
L402P |
probably damaging |
Het |
Arid4b |
T |
C |
13: 14,355,891 (GRCm39) |
|
probably null |
Het |
Atp5pb |
A |
G |
3: 105,851,118 (GRCm39) |
V193A |
probably benign |
Het |
Atp8b3 |
A |
G |
10: 80,365,463 (GRCm39) |
|
probably null |
Het |
Baz2a |
G |
T |
10: 127,951,947 (GRCm39) |
R555L |
probably damaging |
Het |
Casp4 |
G |
T |
9: 5,321,345 (GRCm39) |
S32I |
possibly damaging |
Het |
Cd300lb |
A |
G |
11: 114,819,128 (GRCm39) |
V167A |
probably damaging |
Het |
Cdc42bpg |
C |
T |
19: 6,368,428 (GRCm39) |
T1042I |
probably damaging |
Het |
Ceacam20 |
T |
C |
7: 19,704,159 (GRCm39) |
F70S |
probably damaging |
Het |
Cep162 |
C |
T |
9: 87,074,819 (GRCm39) |
V1388I |
probably damaging |
Het |
Cfap65 |
A |
G |
1: 74,959,585 (GRCm39) |
V855A |
possibly damaging |
Het |
Chil3 |
G |
T |
3: 106,063,022 (GRCm39) |
D189E |
probably benign |
Het |
Cln3 |
A |
G |
7: 126,180,912 (GRCm39) |
I43T |
probably benign |
Het |
Cntnap5a |
A |
G |
1: 116,370,110 (GRCm39) |
Q909R |
probably benign |
Het |
Ctsd |
C |
A |
7: 141,937,278 (GRCm39) |
A77S |
probably damaging |
Het |
Dnah12 |
T |
A |
14: 26,445,781 (GRCm39) |
S781T |
probably benign |
Het |
Dnah17 |
T |
A |
11: 117,981,543 (GRCm39) |
Q1716L |
probably null |
Het |
Erg |
T |
C |
16: 95,260,015 (GRCm39) |
|
probably null |
Het |
Farp2 |
A |
T |
1: 93,548,950 (GRCm39) |
M1019L |
possibly damaging |
Het |
Fcgbp |
A |
G |
7: 27,785,949 (GRCm39) |
K462R |
probably benign |
Het |
Fn1 |
A |
T |
1: 71,688,384 (GRCm39) |
N173K |
probably damaging |
Het |
Fsip2 |
A |
T |
2: 82,810,441 (GRCm39) |
L2253F |
probably damaging |
Het |
Gabrd |
C |
T |
4: 155,469,970 (GRCm39) |
R413H |
possibly damaging |
Het |
Galnt5 |
A |
T |
2: 57,907,151 (GRCm39) |
D538V |
probably damaging |
Het |
Gje1 |
T |
A |
10: 14,592,223 (GRCm39) |
L186F |
probably damaging |
Het |
Gm16686 |
A |
T |
4: 88,673,563 (GRCm39) |
C89S |
unknown |
Het |
Gna15 |
G |
T |
10: 81,338,831 (GRCm39) |
A336E |
probably benign |
Het |
Golga4 |
C |
T |
9: 118,388,563 (GRCm39) |
S1895L |
probably benign |
Het |
Gon4l |
A |
T |
3: 88,814,829 (GRCm39) |
M1933L |
probably benign |
Het |
Gpr183 |
T |
C |
14: 122,192,156 (GRCm39) |
S122G |
possibly damaging |
Het |
Gtf2h4 |
G |
A |
17: 35,980,250 (GRCm39) |
T348I |
probably damaging |
Het |
Hace1 |
T |
C |
10: 45,481,636 (GRCm39) |
Y120H |
probably damaging |
Het |
Hivep2 |
C |
T |
10: 14,007,061 (GRCm39) |
H1220Y |
possibly damaging |
Het |
Hmx2 |
T |
C |
7: 131,156,232 (GRCm39) |
F66S |
probably benign |
Het |
Hoxd12 |
A |
T |
2: 74,505,569 (GRCm39) |
S47C |
possibly damaging |
Het |
Hp |
C |
A |
8: 110,301,832 (GRCm39) |
|
probably null |
Het |
Idh3a |
T |
A |
9: 54,508,492 (GRCm39) |
D355E |
probably benign |
Het |
Itga2b |
A |
T |
11: 102,347,120 (GRCm39) |
M921K |
probably benign |
Het |
Jcad |
A |
G |
18: 4,675,529 (GRCm39) |
D1097G |
probably benign |
Het |
Kdm5b |
A |
T |
1: 134,523,571 (GRCm39) |
T249S |
probably benign |
Het |
Klhl11 |
G |
T |
11: 100,355,178 (GRCm39) |
H214Q |
probably benign |
Het |
L3hypdh |
A |
T |
12: 72,131,705 (GRCm39) |
Y76N |
probably damaging |
Het |
Lama4 |
G |
T |
10: 38,921,751 (GRCm39) |
R424L |
possibly damaging |
Het |
Lepr |
A |
G |
4: 101,602,853 (GRCm39) |
I214V |
probably benign |
Het |
Lipc |
G |
T |
9: 70,709,450 (GRCm39) |
N432K |
probably benign |
Het |
Lipm |
C |
T |
19: 34,093,598 (GRCm39) |
A216V |
possibly damaging |
Het |
Lrrc23 |
A |
G |
6: 124,756,088 (GRCm39) |
S2P |
unknown |
Het |
Lyst |
T |
A |
13: 13,812,109 (GRCm39) |
D840E |
probably benign |
Het |
Mmp23 |
T |
A |
4: 155,736,041 (GRCm39) |
T204S |
probably damaging |
Het |
Mms19 |
T |
C |
19: 41,936,717 (GRCm39) |
T785A |
probably benign |
Het |
Mov10 |
A |
T |
3: 104,707,368 (GRCm39) |
|
probably null |
Het |
Mtf2 |
A |
G |
5: 108,248,836 (GRCm39) |
T383A |
probably benign |
Het |
Myo5c |
G |
A |
9: 75,158,809 (GRCm39) |
|
probably null |
Het |
Nfxl1 |
A |
T |
5: 72,681,517 (GRCm39) |
C671* |
probably null |
Het |
Npepps |
A |
G |
11: 97,103,982 (GRCm39) |
V813A |
probably benign |
Het |
Nrn1 |
C |
A |
13: 36,910,825 (GRCm39) |
W69L |
probably damaging |
Het |
Oprd1 |
A |
C |
4: 131,841,378 (GRCm39) |
D193E |
probably benign |
Het |
Or2ag1b |
T |
A |
7: 106,288,417 (GRCm39) |
I174F |
possibly damaging |
Het |
Or52p1 |
C |
T |
7: 104,267,059 (GRCm39) |
H58Y |
probably damaging |
Het |
Or55b3 |
A |
T |
7: 102,126,883 (GRCm39) |
Y65N |
probably damaging |
Het |
Or56b2j |
T |
A |
7: 104,352,796 (GRCm39) |
D7E |
probably benign |
Het |
Or6c202 |
A |
G |
10: 128,996,620 (GRCm39) |
Y78H |
possibly damaging |
Het |
Or6c209 |
T |
C |
10: 129,483,027 (GRCm39) |
I10T |
probably damaging |
Het |
Or6k6 |
A |
C |
1: 173,944,753 (GRCm39) |
F276L |
probably benign |
Het |
Pcdhac1 |
G |
T |
18: 37,225,550 (GRCm39) |
V788L |
probably benign |
Het |
Pcdhb11 |
G |
A |
18: 37,556,313 (GRCm39) |
V548M |
probably damaging |
Het |
Pde4c |
A |
T |
8: 71,201,621 (GRCm39) |
E517V |
possibly damaging |
Het |
Pdzd7 |
T |
C |
19: 45,022,086 (GRCm39) |
R521G |
possibly damaging |
Het |
Pik3c2a |
T |
A |
7: 115,972,089 (GRCm39) |
K780N |
probably damaging |
Het |
Plb1 |
T |
G |
5: 32,478,591 (GRCm39) |
|
probably null |
Het |
Plcb4 |
T |
A |
2: 135,842,139 (GRCm39) |
L1041Q |
probably benign |
Het |
Pnpla6 |
G |
A |
8: 3,566,540 (GRCm39) |
|
probably null |
Het |
Ppat |
A |
T |
5: 77,063,826 (GRCm39) |
N441K |
probably damaging |
Het |
Ppp1r1b |
G |
A |
11: 98,246,305 (GRCm39) |
A132T |
probably damaging |
Het |
Prl2c2 |
A |
C |
13: 13,172,065 (GRCm39) |
|
probably null |
Het |
Prr14 |
T |
C |
7: 127,074,458 (GRCm39) |
I330T |
probably benign |
Het |
Pycr1 |
T |
C |
11: 120,533,749 (GRCm39) |
D36G |
probably benign |
Het |
Rabep2 |
T |
A |
7: 126,037,891 (GRCm39) |
I221N |
probably damaging |
Het |
Rad23b |
A |
G |
4: 55,370,469 (GRCm39) |
D165G |
probably benign |
Het |
Reln |
G |
A |
5: 22,176,951 (GRCm39) |
T1905I |
probably damaging |
Het |
Ripor2 |
T |
C |
13: 24,878,188 (GRCm39) |
V321A |
probably benign |
Het |
Rnf43 |
A |
G |
11: 87,622,678 (GRCm39) |
D466G |
probably benign |
Het |
Rpl6 |
A |
T |
5: 121,343,655 (GRCm39) |
R63W |
possibly damaging |
Het |
S100a14 |
A |
G |
3: 90,435,511 (GRCm39) |
T102A |
probably benign |
Het |
Samd11 |
C |
A |
4: 156,333,857 (GRCm39) |
V195L |
probably benign |
Het |
Scaper |
G |
A |
9: 55,669,561 (GRCm39) |
Q372* |
probably null |
Het |
Sec14l5 |
G |
T |
16: 4,998,739 (GRCm39) |
C593F |
probably damaging |
Het |
Sema6d |
T |
C |
2: 124,496,078 (GRCm39) |
Y41H |
probably damaging |
Het |
Serac1 |
G |
A |
17: 6,119,589 (GRCm39) |
R114W |
probably damaging |
Het |
Slc12a4 |
T |
C |
8: 106,677,468 (GRCm39) |
E388G |
probably benign |
Het |
Smarcd3 |
T |
C |
5: 24,800,810 (GRCm39) |
T164A |
probably benign |
Het |
Smtn |
C |
A |
11: 3,480,249 (GRCm39) |
R324L |
probably benign |
Het |
Spata31d1c |
C |
T |
13: 65,183,175 (GRCm39) |
P239L |
probably benign |
Het |
Srcap |
T |
C |
7: 127,137,689 (GRCm39) |
V1013A |
possibly damaging |
Het |
Sv2b |
T |
C |
7: 74,773,812 (GRCm39) |
N553S |
probably damaging |
Het |
Tex35 |
T |
A |
1: 156,932,656 (GRCm39) |
N52I |
probably damaging |
Het |
Ticrr |
T |
C |
7: 79,343,734 (GRCm39) |
S1200P |
probably benign |
Het |
Tmem19 |
A |
G |
10: 115,183,604 (GRCm39) |
L125P |
probably damaging |
Het |
Trio |
A |
G |
15: 27,856,193 (GRCm39) |
V666A |
probably benign |
Het |
Ttn |
T |
C |
2: 76,747,627 (GRCm39) |
D4474G |
probably benign |
Het |
Usp43 |
A |
T |
11: 67,783,842 (GRCm39) |
S368T |
possibly damaging |
Het |
Vmn2r72 |
T |
A |
7: 85,400,348 (GRCm39) |
M234L |
probably benign |
Het |
Wdr93 |
T |
A |
7: 79,427,055 (GRCm39) |
|
probably null |
Het |
Wrap73 |
T |
A |
4: 154,240,584 (GRCm39) |
W359R |
probably damaging |
Het |
Ywhah |
A |
G |
5: 33,183,985 (GRCm39) |
I63V |
probably benign |
Het |
Zbtb7b |
G |
T |
3: 89,288,366 (GRCm39) |
P151T |
probably damaging |
Het |
Zfp318 |
A |
G |
17: 46,710,995 (GRCm39) |
N906S |
probably damaging |
Het |
Zfp423 |
C |
A |
8: 88,507,341 (GRCm39) |
C1001F |
probably damaging |
Het |
Zmym1 |
A |
G |
4: 126,943,191 (GRCm39) |
I399T |
possibly damaging |
Het |
Zmynd15 |
G |
A |
11: 70,353,014 (GRCm39) |
G296D |
probably benign |
Het |
Znfx1 |
T |
A |
2: 166,890,475 (GRCm39) |
I670F |
probably damaging |
Het |
|
Other mutations in Dock3 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00940:Dock3
|
APN |
9 |
106,788,576 (GRCm39) |
splice site |
probably benign |
|
IGL01067:Dock3
|
APN |
9 |
106,959,572 (GRCm39) |
critical splice donor site |
probably null |
|
IGL01160:Dock3
|
APN |
9 |
106,783,887 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01290:Dock3
|
APN |
9 |
106,835,599 (GRCm39) |
splice site |
probably benign |
|
IGL01291:Dock3
|
APN |
9 |
106,835,599 (GRCm39) |
splice site |
probably benign |
|
IGL01391:Dock3
|
APN |
9 |
106,784,433 (GRCm39) |
missense |
possibly damaging |
0.55 |
IGL01399:Dock3
|
APN |
9 |
106,870,670 (GRCm39) |
missense |
probably benign |
0.06 |
IGL01660:Dock3
|
APN |
9 |
106,909,563 (GRCm39) |
splice site |
probably benign |
|
IGL01752:Dock3
|
APN |
9 |
106,902,512 (GRCm39) |
splice site |
probably benign |
|
IGL01820:Dock3
|
APN |
9 |
106,773,092 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01908:Dock3
|
APN |
9 |
106,783,861 (GRCm39) |
missense |
possibly damaging |
0.81 |
IGL02191:Dock3
|
APN |
9 |
106,815,340 (GRCm39) |
missense |
probably benign |
|
IGL02227:Dock3
|
APN |
9 |
106,939,254 (GRCm39) |
missense |
probably damaging |
0.98 |
IGL02309:Dock3
|
APN |
9 |
106,790,351 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02408:Dock3
|
APN |
9 |
106,790,298 (GRCm39) |
splice site |
probably benign |
|
IGL02469:Dock3
|
APN |
9 |
106,863,215 (GRCm39) |
missense |
probably damaging |
0.98 |
IGL02545:Dock3
|
APN |
9 |
106,939,271 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02894:Dock3
|
APN |
9 |
106,807,298 (GRCm39) |
missense |
probably benign |
0.00 |
IGL02934:Dock3
|
APN |
9 |
106,900,944 (GRCm39) |
missense |
probably benign |
0.01 |
IGL03027:Dock3
|
APN |
9 |
106,870,677 (GRCm39) |
missense |
probably damaging |
0.98 |
IGL03068:Dock3
|
APN |
9 |
106,841,958 (GRCm39) |
missense |
possibly damaging |
0.82 |
IGL03128:Dock3
|
APN |
9 |
106,909,491 (GRCm39) |
missense |
probably benign |
0.05 |
IGL03161:Dock3
|
APN |
9 |
106,900,987 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL03263:Dock3
|
APN |
9 |
106,807,330 (GRCm39) |
splice site |
probably benign |
|
IGL03279:Dock3
|
APN |
9 |
106,788,447 (GRCm39) |
splice site |
probably benign |
|
IGL03366:Dock3
|
APN |
9 |
106,882,632 (GRCm39) |
missense |
probably benign |
0.01 |
Implosion
|
UTSW |
9 |
106,815,125 (GRCm39) |
missense |
probably benign |
0.00 |
Squeeze
|
UTSW |
9 |
106,807,242 (GRCm39) |
missense |
probably damaging |
1.00 |
Tight
|
UTSW |
9 |
106,872,080 (GRCm39) |
missense |
probably damaging |
1.00 |
ANU05:Dock3
|
UTSW |
9 |
106,772,862 (GRCm39) |
missense |
probably benign |
|
R0025:Dock3
|
UTSW |
9 |
106,790,467 (GRCm39) |
missense |
possibly damaging |
0.90 |
R0025:Dock3
|
UTSW |
9 |
106,790,467 (GRCm39) |
missense |
possibly damaging |
0.90 |
R0030:Dock3
|
UTSW |
9 |
106,789,512 (GRCm39) |
missense |
possibly damaging |
0.64 |
R0076:Dock3
|
UTSW |
9 |
106,788,685 (GRCm39) |
splice site |
probably benign |
|
R0076:Dock3
|
UTSW |
9 |
106,788,685 (GRCm39) |
splice site |
probably benign |
|
R0206:Dock3
|
UTSW |
9 |
106,874,195 (GRCm39) |
nonsense |
probably null |
|
R0208:Dock3
|
UTSW |
9 |
106,874,195 (GRCm39) |
nonsense |
probably null |
|
R0384:Dock3
|
UTSW |
9 |
106,779,094 (GRCm39) |
splice site |
probably benign |
|
R0610:Dock3
|
UTSW |
9 |
106,900,987 (GRCm39) |
missense |
probably damaging |
0.99 |
R0731:Dock3
|
UTSW |
9 |
106,847,055 (GRCm39) |
missense |
probably damaging |
1.00 |
R1184:Dock3
|
UTSW |
9 |
106,846,999 (GRCm39) |
missense |
probably damaging |
1.00 |
R1350:Dock3
|
UTSW |
9 |
106,791,831 (GRCm39) |
missense |
possibly damaging |
0.52 |
R1393:Dock3
|
UTSW |
9 |
106,788,548 (GRCm39) |
missense |
probably damaging |
1.00 |
R1424:Dock3
|
UTSW |
9 |
106,790,392 (GRCm39) |
missense |
probably damaging |
1.00 |
R1469:Dock3
|
UTSW |
9 |
106,832,908 (GRCm39) |
missense |
probably benign |
0.37 |
R1469:Dock3
|
UTSW |
9 |
106,832,908 (GRCm39) |
missense |
probably benign |
0.37 |
R1539:Dock3
|
UTSW |
9 |
106,874,112 (GRCm39) |
missense |
probably benign |
0.23 |
R1539:Dock3
|
UTSW |
9 |
106,829,563 (GRCm39) |
missense |
probably damaging |
1.00 |
R1571:Dock3
|
UTSW |
9 |
106,815,158 (GRCm39) |
missense |
possibly damaging |
0.92 |
R1682:Dock3
|
UTSW |
9 |
106,851,040 (GRCm39) |
missense |
probably damaging |
0.98 |
R1795:Dock3
|
UTSW |
9 |
106,902,534 (GRCm39) |
missense |
probably damaging |
0.99 |
R1987:Dock3
|
UTSW |
9 |
106,985,620 (GRCm39) |
missense |
probably benign |
0.01 |
R2000:Dock3
|
UTSW |
9 |
106,870,160 (GRCm39) |
splice site |
probably benign |
|
R2074:Dock3
|
UTSW |
9 |
106,870,662 (GRCm39) |
missense |
possibly damaging |
0.46 |
R2114:Dock3
|
UTSW |
9 |
106,870,743 (GRCm39) |
missense |
probably benign |
0.00 |
R2265:Dock3
|
UTSW |
9 |
106,818,525 (GRCm39) |
missense |
probably damaging |
1.00 |
R2269:Dock3
|
UTSW |
9 |
106,818,525 (GRCm39) |
missense |
probably damaging |
1.00 |
R2370:Dock3
|
UTSW |
9 |
106,829,554 (GRCm39) |
missense |
probably damaging |
1.00 |
R2377:Dock3
|
UTSW |
9 |
106,773,090 (GRCm39) |
missense |
probably damaging |
0.98 |
R2385:Dock3
|
UTSW |
9 |
106,868,324 (GRCm39) |
missense |
probably damaging |
1.00 |
R2426:Dock3
|
UTSW |
9 |
106,791,740 (GRCm39) |
missense |
possibly damaging |
0.76 |
R3076:Dock3
|
UTSW |
9 |
106,818,725 (GRCm39) |
critical splice acceptor site |
probably null |
|
R3122:Dock3
|
UTSW |
9 |
106,788,542 (GRCm39) |
missense |
probably damaging |
0.99 |
R4052:Dock3
|
UTSW |
9 |
106,850,995 (GRCm39) |
missense |
probably damaging |
0.99 |
R4294:Dock3
|
UTSW |
9 |
106,807,242 (GRCm39) |
missense |
probably damaging |
1.00 |
R4623:Dock3
|
UTSW |
9 |
106,939,244 (GRCm39) |
missense |
possibly damaging |
0.61 |
R4664:Dock3
|
UTSW |
9 |
106,870,743 (GRCm39) |
missense |
possibly damaging |
0.71 |
R4705:Dock3
|
UTSW |
9 |
106,902,535 (GRCm39) |
missense |
probably damaging |
1.00 |
R4771:Dock3
|
UTSW |
9 |
106,829,557 (GRCm39) |
missense |
possibly damaging |
0.89 |
R4898:Dock3
|
UTSW |
9 |
106,870,171 (GRCm39) |
missense |
possibly damaging |
0.75 |
R4898:Dock3
|
UTSW |
9 |
106,807,266 (GRCm39) |
missense |
probably damaging |
1.00 |
R4948:Dock3
|
UTSW |
9 |
106,868,354 (GRCm39) |
missense |
probably damaging |
0.96 |
R4961:Dock3
|
UTSW |
9 |
106,818,515 (GRCm39) |
missense |
probably damaging |
1.00 |
R4986:Dock3
|
UTSW |
9 |
106,809,182 (GRCm39) |
missense |
probably damaging |
1.00 |
R5054:Dock3
|
UTSW |
9 |
106,815,105 (GRCm39) |
missense |
probably damaging |
1.00 |
R5065:Dock3
|
UTSW |
9 |
106,832,883 (GRCm39) |
missense |
probably damaging |
1.00 |
R5081:Dock3
|
UTSW |
9 |
106,868,292 (GRCm39) |
missense |
probably damaging |
1.00 |
R5101:Dock3
|
UTSW |
9 |
106,846,980 (GRCm39) |
missense |
probably damaging |
1.00 |
R5135:Dock3
|
UTSW |
9 |
106,810,196 (GRCm39) |
missense |
probably damaging |
1.00 |
R5227:Dock3
|
UTSW |
9 |
106,863,269 (GRCm39) |
missense |
probably damaging |
1.00 |
R5257:Dock3
|
UTSW |
9 |
106,874,124 (GRCm39) |
missense |
probably damaging |
1.00 |
R5258:Dock3
|
UTSW |
9 |
106,874,124 (GRCm39) |
missense |
probably damaging |
1.00 |
R5273:Dock3
|
UTSW |
9 |
106,777,904 (GRCm39) |
critical splice donor site |
probably null |
|
R5322:Dock3
|
UTSW |
9 |
106,779,028 (GRCm39) |
missense |
probably benign |
0.14 |
R5482:Dock3
|
UTSW |
9 |
106,855,937 (GRCm39) |
nonsense |
probably null |
|
R5553:Dock3
|
UTSW |
9 |
106,868,309 (GRCm39) |
missense |
possibly damaging |
0.81 |
R5631:Dock3
|
UTSW |
9 |
106,832,898 (GRCm39) |
missense |
probably benign |
0.01 |
R5739:Dock3
|
UTSW |
9 |
106,850,995 (GRCm39) |
missense |
possibly damaging |
0.92 |
R5838:Dock3
|
UTSW |
9 |
106,772,687 (GRCm39) |
missense |
possibly damaging |
0.51 |
R5888:Dock3
|
UTSW |
9 |
106,901,002 (GRCm39) |
missense |
probably benign |
0.12 |
R5960:Dock3
|
UTSW |
9 |
106,788,554 (GRCm39) |
nonsense |
probably null |
|
R5974:Dock3
|
UTSW |
9 |
106,871,261 (GRCm39) |
missense |
probably damaging |
1.00 |
R6116:Dock3
|
UTSW |
9 |
106,809,161 (GRCm39) |
missense |
probably damaging |
1.00 |
R6162:Dock3
|
UTSW |
9 |
106,841,998 (GRCm39) |
missense |
possibly damaging |
0.88 |
R6176:Dock3
|
UTSW |
9 |
106,790,147 (GRCm39) |
missense |
probably benign |
0.05 |
R6219:Dock3
|
UTSW |
9 |
106,872,080 (GRCm39) |
missense |
probably damaging |
1.00 |
R6238:Dock3
|
UTSW |
9 |
106,790,147 (GRCm39) |
missense |
probably benign |
0.05 |
R6266:Dock3
|
UTSW |
9 |
106,841,952 (GRCm39) |
missense |
probably damaging |
0.99 |
R6291:Dock3
|
UTSW |
9 |
106,785,631 (GRCm39) |
missense |
probably benign |
|
R6531:Dock3
|
UTSW |
9 |
106,844,415 (GRCm39) |
missense |
probably benign |
|
R6567:Dock3
|
UTSW |
9 |
106,773,946 (GRCm39) |
missense |
probably benign |
0.13 |
R6572:Dock3
|
UTSW |
9 |
106,866,674 (GRCm39) |
missense |
probably damaging |
0.99 |
R6620:Dock3
|
UTSW |
9 |
106,815,125 (GRCm39) |
missense |
probably benign |
0.00 |
R6726:Dock3
|
UTSW |
9 |
107,036,651 (GRCm39) |
nonsense |
probably null |
|
R7085:Dock3
|
UTSW |
9 |
106,779,086 (GRCm39) |
missense |
probably damaging |
1.00 |
R7151:Dock3
|
UTSW |
9 |
106,841,916 (GRCm39) |
missense |
possibly damaging |
0.68 |
R7320:Dock3
|
UTSW |
9 |
106,772,723 (GRCm39) |
missense |
probably benign |
0.20 |
R7357:Dock3
|
UTSW |
9 |
106,882,568 (GRCm39) |
missense |
probably benign |
0.34 |
R7423:Dock3
|
UTSW |
9 |
106,844,370 (GRCm39) |
missense |
probably damaging |
0.98 |
R7439:Dock3
|
UTSW |
9 |
106,900,931 (GRCm39) |
missense |
probably damaging |
1.00 |
R7452:Dock3
|
UTSW |
9 |
106,866,664 (GRCm39) |
missense |
probably damaging |
1.00 |
R7470:Dock3
|
UTSW |
9 |
106,882,644 (GRCm39) |
missense |
probably damaging |
1.00 |
R7879:Dock3
|
UTSW |
9 |
106,785,700 (GRCm39) |
missense |
probably benign |
0.05 |
R8047:Dock3
|
UTSW |
9 |
106,870,208 (GRCm39) |
missense |
possibly damaging |
0.93 |
R8308:Dock3
|
UTSW |
9 |
106,790,371 (GRCm39) |
missense |
probably benign |
0.00 |
R8837:Dock3
|
UTSW |
9 |
106,774,539 (GRCm39) |
missense |
probably benign |
|
R8862:Dock3
|
UTSW |
9 |
106,855,927 (GRCm39) |
missense |
probably damaging |
1.00 |
R8952:Dock3
|
UTSW |
9 |
106,850,958 (GRCm39) |
missense |
probably benign |
0.03 |
R9230:Dock3
|
UTSW |
9 |
106,807,223 (GRCm39) |
missense |
probably damaging |
1.00 |
R9269:Dock3
|
UTSW |
9 |
106,818,522 (GRCm39) |
missense |
probably benign |
0.01 |
R9272:Dock3
|
UTSW |
9 |
106,774,569 (GRCm39) |
missense |
probably benign |
0.00 |
R9344:Dock3
|
UTSW |
9 |
106,870,763 (GRCm39) |
missense |
probably damaging |
1.00 |
R9757:Dock3
|
UTSW |
9 |
106,901,035 (GRCm39) |
missense |
possibly damaging |
0.48 |
R9764:Dock3
|
UTSW |
9 |
106,959,713 (GRCm39) |
missense |
probably benign |
0.00 |
R9766:Dock3
|
UTSW |
9 |
106,788,483 (GRCm39) |
missense |
probably benign |
0.01 |
X0023:Dock3
|
UTSW |
9 |
106,863,197 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
Predicted Primers |
PCR Primer
(F):5'- AAGCTGCTCATGGAAGGTGG -3'
(R):5'- CTTTGGGCATTCCTCAGAGG -3'
Sequencing Primer
(F):5'- TGGTGCAGCTGCCTCTCTG -3'
(R):5'- TTCCTCAGAGGCCCCAC -3'
|
Posted On |
2019-10-07 |