|Institutional Source||Beutler Lab|
|Gene Name||oviductal glycoprotein 1|
|Synonyms||Chit5, MOGP, muc9, mucin 9, OGP, oviductin|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R7430 (G1)|
|Chromosomal Location||105973711-105987423 bp(+) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||G to C at 105986302 bp|
|Amino Acid Change||Alanine to Proline at position 464 (A464P)|
|Ref Sequence||ENSEMBL: ENSMUSP00000000573 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000000573] [ENSMUST00000163626]|
|Predicted Effect||probably damaging
AA Change: A464P
PolyPhen 2 Score 0.991 (Sensitivity: 0.71; Specificity: 0.97)
AA Change: A464P
|Predicted Effect||probably benign
|Coding Region Coverage||
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a large, carbohydrate-rich, epithelial glycoprotein with numerous O-glycosylation sites located within threonine, serine, and proline-rich tandem repeats. The gene is similar to members of the mucin and the glycosyl hydrolase 18 gene families. Regulation of expression may be estrogen-dependent. Gene expression and protein secretion occur during late follicular development through early cleavage-stage embryonic development. The protein is secreted from non-ciliated oviductal epithelial cells and associates with ovulated oocytes, blastomeres, and spermatozoan acrosomal regions. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for disruptions in this gene show no phenotypic abnormalities. Female reproduction is essentially normal. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Ovgp1||
(F):5'- TTCTGTGAATGCCTCAGGACC -3'
(R):5'- AGCAGTGGCCTTAGAAATCTCAG -3'
(F):5'- CTGGCTCTGAGAATACAGCCTTG -3'
(R):5'- CCTTAGAAATCTCAGGGATGGTC -3'