Incidental Mutation 'R7438:Kif21a'
| ID |
576777 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Kif21a
|
| Ensembl Gene |
ENSMUSG00000022629 |
| Gene Name |
kinesin family member 21A |
| Synonyms |
N-5 kinesin |
| MMRRC Submission |
045514-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R7438 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
15 |
| Chromosomal Location |
90817479-90934151 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 90877999 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Phenylalanine to Leucine
at position 270
(F270L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000104911
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000067205]
[ENSMUST00000088614]
[ENSMUST00000100304]
[ENSMUST00000109287]
[ENSMUST00000109288]
|
| AlphaFold |
Q9QXL2 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000067205
AA Change: F270L
PolyPhen 2
Score 0.991 (Sensitivity: 0.71; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000066911
Gene: ENSMUSG00000022629
AA Change: F270L
| Domain | Start | End | E-Value | Type |
|---|
|
KISc
|
7 |
379 |
8.97e-163 |
SMART |
|
Blast:KISc
|
469 |
513 |
9e-9 |
BLAST |
|
low complexity region
|
514 |
525 |
N/A |
INTRINSIC |
|
low complexity region
|
542 |
557 |
N/A |
INTRINSIC |
|
low complexity region
|
571 |
585 |
N/A |
INTRINSIC |
|
low complexity region
|
589 |
628 |
N/A |
INTRINSIC |
|
low complexity region
|
700 |
713 |
N/A |
INTRINSIC |
|
coiled coil region
|
924 |
1008 |
N/A |
INTRINSIC |
|
coiled coil region
|
1043 |
1066 |
N/A |
INTRINSIC |
|
low complexity region
|
1101 |
1112 |
N/A |
INTRINSIC |
|
low complexity region
|
1222 |
1234 |
N/A |
INTRINSIC |
|
low complexity region
|
1251 |
1271 |
N/A |
INTRINSIC |
|
WD40
|
1290 |
1327 |
1.21e-7 |
SMART |
|
WD40
|
1330 |
1368 |
7.28e-2 |
SMART |
|
WD40
|
1394 |
1432 |
3.33e-1 |
SMART |
|
WD40
|
1435 |
1477 |
7e-4 |
SMART |
|
WD40
|
1485 |
1523 |
2.4e-1 |
SMART |
|
WD40
|
1527 |
1566 |
1.48e-2 |
SMART |
|
WD40
|
1569 |
1606 |
2.07e-6 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000088614
AA Change: F270L
PolyPhen 2
Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000085985
Gene: ENSMUSG00000022629
AA Change: F270L
| Domain | Start | End | E-Value | Type |
|---|
|
KISc
|
7 |
379 |
8.97e-163 |
SMART |
|
Blast:KISc
|
469 |
513 |
1e-8 |
BLAST |
|
low complexity region
|
514 |
525 |
N/A |
INTRINSIC |
|
low complexity region
|
542 |
564 |
N/A |
INTRINSIC |
|
low complexity region
|
584 |
598 |
N/A |
INTRINSIC |
|
low complexity region
|
602 |
641 |
N/A |
INTRINSIC |
|
low complexity region
|
713 |
726 |
N/A |
INTRINSIC |
|
coiled coil region
|
937 |
1021 |
N/A |
INTRINSIC |
|
coiled coil region
|
1056 |
1079 |
N/A |
INTRINSIC |
|
low complexity region
|
1114 |
1125 |
N/A |
INTRINSIC |
|
low complexity region
|
1271 |
1283 |
N/A |
INTRINSIC |
|
low complexity region
|
1300 |
1316 |
N/A |
INTRINSIC |
|
WD40
|
1334 |
1371 |
1.21e-7 |
SMART |
|
WD40
|
1374 |
1412 |
7.28e-2 |
SMART |
|
WD40
|
1438 |
1476 |
3.33e-1 |
SMART |
|
WD40
|
1479 |
1521 |
7e-4 |
SMART |
|
WD40
|
1529 |
1567 |
2.4e-1 |
SMART |
|
WD40
|
1571 |
1610 |
1.48e-2 |
SMART |
|
WD40
|
1613 |
1650 |
2.07e-6 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000100304
AA Change: F270L
PolyPhen 2
Score 0.987 (Sensitivity: 0.73; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000097877
Gene: ENSMUSG00000022629
AA Change: F270L
| Domain | Start | End | E-Value | Type |
|---|
|
KISc
|
7 |
379 |
8.97e-163 |
SMART |
|
Blast:KISc
|
469 |
513 |
1e-8 |
BLAST |
|
low complexity region
|
514 |
525 |
N/A |
INTRINSIC |
|
low complexity region
|
542 |
564 |
N/A |
INTRINSIC |
|
low complexity region
|
584 |
598 |
N/A |
INTRINSIC |
|
low complexity region
|
602 |
641 |
N/A |
INTRINSIC |
|
low complexity region
|
713 |
726 |
N/A |
INTRINSIC |
|
coiled coil region
|
937 |
1021 |
N/A |
INTRINSIC |
|
coiled coil region
|
1056 |
1079 |
N/A |
INTRINSIC |
|
low complexity region
|
1271 |
1283 |
N/A |
INTRINSIC |
|
low complexity region
|
1300 |
1316 |
N/A |
INTRINSIC |
|
WD40
|
1334 |
1371 |
1.21e-7 |
SMART |
|
WD40
|
1374 |
1412 |
7.28e-2 |
SMART |
|
WD40
|
1438 |
1476 |
3.33e-1 |
SMART |
|
WD40
|
1479 |
1521 |
7e-4 |
SMART |
|
WD40
|
1529 |
1567 |
2.4e-1 |
SMART |
|
WD40
|
1571 |
1610 |
1.48e-2 |
SMART |
|
WD40
|
1613 |
1650 |
2.07e-6 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000109287
AA Change: F270L
PolyPhen 2
Score 0.174 (Sensitivity: 0.92; Specificity: 0.87)
|
| SMART Domains |
Protein: ENSMUSP00000104910
Gene: ENSMUSG00000022629
AA Change: F270L
| Domain | Start | End | E-Value | Type |
|---|
|
KISc
|
7 |
379 |
8.97e-163 |
SMART |
|
Blast:KISc
|
469 |
513 |
9e-9 |
BLAST |
|
low complexity region
|
514 |
525 |
N/A |
INTRINSIC |
|
low complexity region
|
542 |
557 |
N/A |
INTRINSIC |
|
low complexity region
|
571 |
585 |
N/A |
INTRINSIC |
|
low complexity region
|
589 |
628 |
N/A |
INTRINSIC |
|
low complexity region
|
700 |
713 |
N/A |
INTRINSIC |
|
coiled coil region
|
924 |
1008 |
N/A |
INTRINSIC |
|
coiled coil region
|
1043 |
1066 |
N/A |
INTRINSIC |
|
low complexity region
|
1101 |
1112 |
N/A |
INTRINSIC |
|
WD40
|
1229 |
1266 |
1.21e-7 |
SMART |
|
WD40
|
1269 |
1307 |
7.28e-2 |
SMART |
|
WD40
|
1333 |
1371 |
3.33e-1 |
SMART |
|
WD40
|
1374 |
1416 |
7e-4 |
SMART |
|
WD40
|
1424 |
1462 |
2.4e-1 |
SMART |
|
WD40
|
1466 |
1505 |
1.48e-2 |
SMART |
|
WD40
|
1508 |
1545 |
2.07e-6 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000109288
AA Change: F270L
PolyPhen 2
Score 0.369 (Sensitivity: 0.90; Specificity: 0.89)
|
| SMART Domains |
Protein: ENSMUSP00000104911
Gene: ENSMUSG00000022629
AA Change: F270L
| Domain | Start | End | E-Value | Type |
|---|
|
KISc
|
7 |
379 |
8.97e-163 |
SMART |
|
Blast:KISc
|
469 |
513 |
9e-9 |
BLAST |
|
low complexity region
|
514 |
525 |
N/A |
INTRINSIC |
|
low complexity region
|
542 |
557 |
N/A |
INTRINSIC |
|
low complexity region
|
571 |
585 |
N/A |
INTRINSIC |
|
low complexity region
|
589 |
628 |
N/A |
INTRINSIC |
|
low complexity region
|
700 |
713 |
N/A |
INTRINSIC |
|
coiled coil region
|
924 |
1008 |
N/A |
INTRINSIC |
|
coiled coil region
|
1043 |
1066 |
N/A |
INTRINSIC |
|
low complexity region
|
1205 |
1216 |
N/A |
INTRINSIC |
|
WD40
|
1235 |
1272 |
1.21e-7 |
SMART |
|
WD40
|
1275 |
1313 |
7.28e-2 |
SMART |
|
WD40
|
1339 |
1377 |
3.33e-1 |
SMART |
|
WD40
|
1380 |
1422 |
7e-4 |
SMART |
|
WD40
|
1430 |
1468 |
2.4e-1 |
SMART |
|
WD40
|
1472 |
1511 |
1.48e-2 |
SMART |
|
WD40
|
1514 |
1551 |
2.07e-6 |
SMART |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.3%
|
| Validation Efficiency |
100% (88/88) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the KIF4 subfamily of kinesin-like motor proteins. The encoded protein is characterized by an N-terminal motor domain a coiled-coil stalk domain and a C-terminal WD-40 repeat domain. This protein may be involved in microtubule dependent transport. Mutations in this gene are the cause of congenital fibrosis of extraocular muscles-1. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Mar 2010]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 87 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcc4 |
T |
C |
14: 118,853,858 (GRCm39) |
S425G |
probably benign |
Het |
| Adam29 |
A |
G |
8: 56,324,609 (GRCm39) |
I615T |
probably damaging |
Het |
| Arap2 |
A |
T |
5: 62,906,818 (GRCm39) |
I67N |
probably damaging |
Het |
| Asxl2 |
C |
T |
12: 3,477,108 (GRCm39) |
|
probably benign |
Het |
| Atp13a4 |
C |
T |
16: 29,260,014 (GRCm39) |
G607D |
|
Het |
| Atp2c2 |
G |
A |
8: 120,474,936 (GRCm39) |
V514M |
probably damaging |
Het |
| Baiap3 |
A |
G |
17: 25,468,082 (GRCm39) |
C311R |
possibly damaging |
Het |
| Becn1 |
A |
C |
11: 101,185,052 (GRCm39) |
S137R |
probably benign |
Het |
| C1qtnf6 |
G |
T |
15: 78,409,574 (GRCm39) |
T91K |
probably benign |
Het |
| C8a |
T |
C |
4: 104,718,626 (GRCm39) |
K110E |
probably damaging |
Het |
| Camta2 |
A |
G |
11: 70,574,714 (GRCm39) |
|
probably null |
Het |
| Capn8 |
T |
A |
1: 182,426,240 (GRCm39) |
Y192N |
probably damaging |
Het |
| Ccdc170 |
C |
T |
10: 4,508,512 (GRCm39) |
Q579* |
probably null |
Het |
| Cenpa |
G |
T |
5: 30,824,292 (GRCm39) |
|
probably benign |
Het |
| Cltc |
A |
G |
11: 86,616,054 (GRCm39) |
V404A |
probably benign |
Het |
| Cyp3a11 |
A |
T |
5: 145,802,710 (GRCm39) |
L261Q |
probably benign |
Het |
| Daw1 |
T |
A |
1: 83,170,436 (GRCm39) |
S249R |
probably benign |
Het |
| Dchs1 |
T |
A |
7: 105,404,155 (GRCm39) |
I2796F |
probably benign |
Het |
| Dis3l2 |
T |
C |
1: 86,673,222 (GRCm39) |
|
probably null |
Het |
| Dnah5 |
A |
T |
15: 28,347,098 (GRCm39) |
D2527V |
probably damaging |
Het |
| Dsg4 |
G |
A |
18: 20,599,685 (GRCm39) |
R767Q |
probably damaging |
Het |
| Edaradd |
A |
G |
13: 12,493,338 (GRCm39) |
I118T |
probably damaging |
Het |
| Fam83h |
A |
G |
15: 75,876,275 (GRCm39) |
F354S |
possibly damaging |
Het |
| Fat3 |
A |
G |
9: 15,899,778 (GRCm39) |
V3085A |
probably benign |
Het |
| Fer |
A |
G |
17: 64,440,516 (GRCm39) |
D711G |
possibly damaging |
Het |
| G6pc1 |
G |
T |
11: 101,267,503 (GRCm39) |
V318F |
probably benign |
Het |
| Gal3st1 |
C |
A |
11: 3,948,227 (GRCm39) |
H145N |
probably benign |
Het |
| Helz |
C |
T |
11: 107,552,856 (GRCm39) |
P1211S |
probably damaging |
Het |
| Herc1 |
A |
G |
9: 66,302,038 (GRCm39) |
I667V |
probably benign |
Het |
| Herc2 |
T |
A |
7: 55,753,466 (GRCm39) |
|
probably null |
Het |
| Hivep1 |
C |
T |
13: 42,308,387 (GRCm39) |
T209I |
probably damaging |
Het |
| Hsph1 |
A |
G |
5: 149,542,485 (GRCm39) |
Y678H |
probably damaging |
Het |
| Ift122 |
C |
T |
6: 115,903,263 (GRCm39) |
R1176C |
probably benign |
Het |
| Ighv1-23 |
T |
C |
12: 114,728,095 (GRCm39) |
D109G |
probably damaging |
Het |
| Itgb3 |
T |
C |
11: 104,534,403 (GRCm39) |
V420A |
possibly damaging |
Het |
| Kcnk13 |
C |
A |
12: 100,027,985 (GRCm39) |
N353K |
probably damaging |
Het |
| Kit |
T |
A |
5: 75,799,660 (GRCm39) |
V464D |
probably benign |
Het |
| Klhl36 |
G |
A |
8: 120,596,914 (GRCm39) |
W205* |
probably null |
Het |
| Krt17 |
A |
G |
11: 100,149,291 (GRCm39) |
Y260H |
probably damaging |
Het |
| Lats1 |
C |
T |
10: 7,588,706 (GRCm39) |
Q1108* |
probably null |
Het |
| Lrch1 |
G |
A |
14: 74,994,477 (GRCm39) |
T709I |
possibly damaging |
Het |
| Lrrc58 |
C |
A |
16: 37,689,053 (GRCm39) |
Q66K |
probably benign |
Het |
| Mei1 |
G |
A |
15: 81,999,682 (GRCm39) |
A664T |
|
Het |
| Mtmr6 |
C |
T |
14: 60,537,753 (GRCm39) |
T546M |
probably benign |
Het |
| Ncoa3 |
T |
A |
2: 165,910,449 (GRCm39) |
F1288L |
probably damaging |
Het |
| Nwd1 |
G |
T |
8: 73,434,458 (GRCm39) |
V1352L |
probably benign |
Het |
| Or4k77 |
T |
A |
2: 111,199,707 (GRCm39) |
H243Q |
probably damaging |
Het |
| Or5ac17 |
A |
T |
16: 59,036,761 (GRCm39) |
C72S |
probably benign |
Het |
| Ovol3 |
C |
T |
7: 29,934,646 (GRCm39) |
|
probably null |
Het |
| Palb2 |
C |
A |
7: 121,716,554 (GRCm39) |
V843L |
probably damaging |
Het |
| Pds5a |
T |
A |
5: 65,809,878 (GRCm39) |
|
probably null |
Het |
| Per1 |
A |
G |
11: 68,995,561 (GRCm39) |
S714G |
possibly damaging |
Het |
| Plch2 |
G |
A |
4: 155,084,917 (GRCm39) |
R442C |
probably damaging |
Het |
| Pon2 |
A |
T |
6: 5,289,080 (GRCm39) |
S26R |
probably benign |
Het |
| Ppp1r9a |
A |
T |
6: 5,115,378 (GRCm39) |
N834Y |
probably damaging |
Het |
| Pramel22 |
T |
C |
4: 143,382,130 (GRCm39) |
I189V |
probably damaging |
Het |
| Rbm46 |
C |
T |
3: 82,749,795 (GRCm39) |
W483* |
probably null |
Het |
| Rnd1 |
A |
T |
15: 98,571,782 (GRCm39) |
V88E |
probably damaging |
Het |
| Sbno2 |
T |
A |
10: 79,905,409 (GRCm39) |
T142S |
unknown |
Het |
| Scn9a |
C |
T |
2: 66,377,531 (GRCm39) |
V384M |
possibly damaging |
Het |
| Sertad4 |
T |
A |
1: 192,529,018 (GRCm39) |
H266L |
possibly damaging |
Het |
| Setd5 |
T |
A |
6: 113,092,043 (GRCm39) |
M288K |
possibly damaging |
Het |
| Sfxn4 |
T |
A |
19: 60,845,799 (GRCm39) |
N66Y |
probably damaging |
Het |
| Sinhcaf |
A |
G |
6: 148,834,600 (GRCm39) |
Y10H |
probably benign |
Het |
| Skint6 |
T |
A |
4: 113,095,425 (GRCm39) |
N78I |
probably damaging |
Het |
| Sltm |
G |
T |
9: 70,480,748 (GRCm39) |
G200V |
unknown |
Het |
| Smg1 |
A |
G |
7: 117,795,116 (GRCm39) |
I477T |
unknown |
Het |
| Supv3l1 |
C |
T |
10: 62,266,249 (GRCm39) |
|
probably null |
Het |
| Syne2 |
A |
G |
12: 76,062,337 (GRCm39) |
R4220G |
probably benign |
Het |
| Tbr1 |
A |
T |
2: 61,635,161 (GRCm39) |
H37L |
possibly damaging |
Het |
| Tet3 |
TGGCCCAGGCCCAGGC |
TGGCCCAGGCCCAGGCCCAGGC |
6: 83,345,211 (GRCm39) |
|
probably benign |
Het |
| Tmem231 |
G |
T |
8: 112,645,040 (GRCm39) |
S155R |
probably damaging |
Het |
| Trem3 |
A |
G |
17: 48,565,498 (GRCm39) |
*184W |
probably null |
Het |
| Trim33 |
T |
A |
3: 103,253,956 (GRCm39) |
|
probably benign |
Het |
| Tsen2 |
G |
A |
6: 115,536,943 (GRCm39) |
W233* |
probably null |
Het |
| Ttc21a |
T |
A |
9: 119,774,605 (GRCm39) |
N286K |
probably damaging |
Het |
| Tulp4 |
A |
T |
17: 6,248,983 (GRCm39) |
M194L |
probably benign |
Het |
| Ube3b |
C |
A |
5: 114,553,345 (GRCm39) |
R906S |
possibly damaging |
Het |
| Ube3b |
A |
C |
5: 114,556,687 (GRCm39) |
D1006A |
probably damaging |
Het |
| Vipas39 |
A |
T |
12: 87,288,705 (GRCm39) |
|
probably null |
Het |
| Wdr35 |
T |
A |
12: 9,072,785 (GRCm39) |
Y920N |
probably damaging |
Het |
| Zan |
T |
G |
5: 137,423,824 (GRCm39) |
I2692L |
unknown |
Het |
| Zfp142 |
C |
A |
1: 74,624,679 (GRCm39) |
E48D |
probably benign |
Het |
| Zfp598 |
T |
C |
17: 24,896,504 (GRCm39) |
Y194H |
probably damaging |
Het |
| Zfp85 |
T |
C |
13: 67,897,064 (GRCm39) |
N336S |
probably benign |
Het |
| Zfyve27 |
A |
T |
19: 42,177,959 (GRCm39) |
|
probably null |
Het |
| Zp3 |
T |
C |
5: 136,011,559 (GRCm39) |
S126P |
probably damaging |
Het |
|
| Other mutations in Kif21a |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00539:Kif21a
|
APN |
15 |
90,821,504 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01476:Kif21a
|
APN |
15 |
90,828,067 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
IGL01617:Kif21a
|
APN |
15 |
90,879,840 (GRCm39) |
splice site |
probably benign |
|
|
IGL01736:Kif21a
|
APN |
15 |
90,843,948 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
IGL01923:Kif21a
|
APN |
15 |
90,840,633 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL01985:Kif21a
|
APN |
15 |
90,875,970 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02304:Kif21a
|
APN |
15 |
90,849,738 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02589:Kif21a
|
APN |
15 |
90,869,489 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03115:Kif21a
|
APN |
15 |
90,869,598 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03211:Kif21a
|
APN |
15 |
90,882,166 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
IGL03372:Kif21a
|
APN |
15 |
90,840,579 (GRCm39) |
missense |
probably benign |
0.38 |
|
reflex
|
UTSW |
15 |
90,852,561 (GRCm39) |
missense |
probably null |
1.00 |
|
R0052:Kif21a
|
UTSW |
15 |
90,855,060 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0052:Kif21a
|
UTSW |
15 |
90,855,060 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0304:Kif21a
|
UTSW |
15 |
90,860,724 (GRCm39) |
splice site |
probably null |
|
|
R0378:Kif21a
|
UTSW |
15 |
90,853,977 (GRCm39) |
splice site |
probably null |
|
|
R0420:Kif21a
|
UTSW |
15 |
90,852,257 (GRCm39) |
unclassified |
probably benign |
|
|
R0536:Kif21a
|
UTSW |
15 |
90,843,886 (GRCm39) |
splice site |
probably benign |
|
|
R0826:Kif21a
|
UTSW |
15 |
90,881,744 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0971:Kif21a
|
UTSW |
15 |
90,824,784 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R1052:Kif21a
|
UTSW |
15 |
90,819,853 (GRCm39) |
missense |
probably benign |
0.17 |
|
R1168:Kif21a
|
UTSW |
15 |
90,877,956 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1324:Kif21a
|
UTSW |
15 |
90,832,525 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1471:Kif21a
|
UTSW |
15 |
90,840,622 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1625:Kif21a
|
UTSW |
15 |
90,826,378 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1636:Kif21a
|
UTSW |
15 |
90,869,008 (GRCm39) |
splice site |
probably benign |
|
|
R1647:Kif21a
|
UTSW |
15 |
90,878,570 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1648:Kif21a
|
UTSW |
15 |
90,878,570 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1699:Kif21a
|
UTSW |
15 |
90,843,946 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1703:Kif21a
|
UTSW |
15 |
90,833,250 (GRCm39) |
splice site |
probably null |
|
|
R1795:Kif21a
|
UTSW |
15 |
90,856,930 (GRCm39) |
splice site |
probably null |
|
|
R1812:Kif21a
|
UTSW |
15 |
90,855,969 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R1959:Kif21a
|
UTSW |
15 |
90,855,051 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1960:Kif21a
|
UTSW |
15 |
90,855,051 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1961:Kif21a
|
UTSW |
15 |
90,855,051 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1996:Kif21a
|
UTSW |
15 |
90,878,574 (GRCm39) |
nonsense |
probably null |
|
|
R2230:Kif21a
|
UTSW |
15 |
90,869,565 (GRCm39) |
nonsense |
probably null |
|
|
R2231:Kif21a
|
UTSW |
15 |
90,869,565 (GRCm39) |
nonsense |
probably null |
|
|
R2232:Kif21a
|
UTSW |
15 |
90,869,565 (GRCm39) |
nonsense |
probably null |
|
|
R2424:Kif21a
|
UTSW |
15 |
90,855,399 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2429:Kif21a
|
UTSW |
15 |
90,882,208 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2513:Kif21a
|
UTSW |
15 |
90,878,594 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R2846:Kif21a
|
UTSW |
15 |
90,818,667 (GRCm39) |
missense |
probably benign |
|
|
R3027:Kif21a
|
UTSW |
15 |
90,856,845 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3624:Kif21a
|
UTSW |
15 |
90,849,798 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3820:Kif21a
|
UTSW |
15 |
90,852,277 (GRCm39) |
missense |
probably benign |
0.17 |
|
R3923:Kif21a
|
UTSW |
15 |
90,821,497 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R3962:Kif21a
|
UTSW |
15 |
90,869,612 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4355:Kif21a
|
UTSW |
15 |
90,855,036 (GRCm39) |
missense |
probably benign |
0.17 |
|
R4516:Kif21a
|
UTSW |
15 |
90,855,345 (GRCm39) |
missense |
probably benign |
0.38 |
|
R4530:Kif21a
|
UTSW |
15 |
90,852,292 (GRCm39) |
splice site |
probably null |
|
|
R4612:Kif21a
|
UTSW |
15 |
90,852,426 (GRCm39) |
splice site |
probably null |
|
|
R4674:Kif21a
|
UTSW |
15 |
90,824,748 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R4675:Kif21a
|
UTSW |
15 |
90,824,748 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R4698:Kif21a
|
UTSW |
15 |
90,840,508 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R4712:Kif21a
|
UTSW |
15 |
90,868,958 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4955:Kif21a
|
UTSW |
15 |
90,821,393 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4974:Kif21a
|
UTSW |
15 |
90,833,213 (GRCm39) |
missense |
probably benign |
0.16 |
|
R5034:Kif21a
|
UTSW |
15 |
90,852,561 (GRCm39) |
missense |
probably null |
1.00 |
|
R5165:Kif21a
|
UTSW |
15 |
90,840,579 (GRCm39) |
missense |
probably benign |
0.38 |
|
R5464:Kif21a
|
UTSW |
15 |
90,878,058 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5541:Kif21a
|
UTSW |
15 |
90,852,316 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5757:Kif21a
|
UTSW |
15 |
90,835,548 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5936:Kif21a
|
UTSW |
15 |
90,819,850 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5976:Kif21a
|
UTSW |
15 |
90,820,015 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6074:Kif21a
|
UTSW |
15 |
90,865,095 (GRCm39) |
missense |
probably benign |
|
|
R6638:Kif21a
|
UTSW |
15 |
90,850,610 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6723:Kif21a
|
UTSW |
15 |
90,824,649 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6785:Kif21a
|
UTSW |
15 |
90,819,933 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6977:Kif21a
|
UTSW |
15 |
90,865,040 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7058:Kif21a
|
UTSW |
15 |
90,833,106 (GRCm39) |
splice site |
probably null |
|
|
R7147:Kif21a
|
UTSW |
15 |
90,865,086 (GRCm39) |
missense |
probably benign |
0.13 |
|
R7290:Kif21a
|
UTSW |
15 |
90,851,432 (GRCm39) |
nonsense |
probably null |
|
|
R7593:Kif21a
|
UTSW |
15 |
90,828,064 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7661:Kif21a
|
UTSW |
15 |
90,865,122 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R7891:Kif21a
|
UTSW |
15 |
90,840,517 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8137:Kif21a
|
UTSW |
15 |
90,852,645 (GRCm39) |
missense |
probably benign |
|
|
R8182:Kif21a
|
UTSW |
15 |
90,819,964 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R8303:Kif21a
|
UTSW |
15 |
90,855,399 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8388:Kif21a
|
UTSW |
15 |
90,843,327 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R8867:Kif21a
|
UTSW |
15 |
90,852,382 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8921:Kif21a
|
UTSW |
15 |
90,855,930 (GRCm39) |
missense |
probably benign |
0.04 |
|
R8984:Kif21a
|
UTSW |
15 |
90,840,559 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9024:Kif21a
|
UTSW |
15 |
90,821,399 (GRCm39) |
nonsense |
probably null |
|
|
R9254:Kif21a
|
UTSW |
15 |
90,854,030 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9366:Kif21a
|
UTSW |
15 |
90,843,951 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9379:Kif21a
|
UTSW |
15 |
90,854,030 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9393:Kif21a
|
UTSW |
15 |
90,853,981 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9518:Kif21a
|
UTSW |
15 |
90,840,676 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9712:Kif21a
|
UTSW |
15 |
90,879,715 (GRCm39) |
missense |
probably benign |
0.13 |
|
R9712:Kif21a
|
UTSW |
15 |
90,869,528 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9721:Kif21a
|
UTSW |
15 |
90,855,330 (GRCm39) |
missense |
probably damaging |
0.99 |
|
| Predicted Primers |
PCR Primer
(F):5'- AGACAGTGAGGATTTCCATGAG -3'
(R):5'- GTTTCTCCAGCTGTGCAAGG -3'
Sequencing Primer
(F):5'- AGGCGAGCCTGCACTACTTAATG -3'
(R):5'- CTGTGCAAGGGGGCAGATG -3'
|
| Posted On |
2019-10-07 |
Incidental Mutation