|Institutional Source||Beutler Lab|
|Gene Name||transcriptional adaptor 2A|
|Is this an essential gene?||Probably essential (E-score: 0.827)|
|Stock #||R7439 (G1)|
|Chromosomal Location||84078920-84129600 bp(-) (GRCm38)|
|Type of Mutation||critical splice donor site (2 bp from exon)|
|DNA Base Change (assembly)||A to T at 84126986 bp|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000018795 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000018795] [ENSMUST00000133811]|
|Predicted Effect||probably null
|Predicted Effect||probably benign
|Coding Region Coverage||
|MGI Phenotype||FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Many DNA-binding transcriptional activator proteins enhance the initiation rate of RNA polymerase II-mediated gene transcription by interacting functionally with the general transcription machinery bound at the basal promoter. Adaptor proteins are usually required for this activation, possibly to acetylate and destabilize nucleosomes, thereby relieving chromatin constraints at the promoter. The protein encoded by this gene is a transcriptional activator adaptor and has been found to be part of the PCAF histone acetylase complex. Several alternatively spliced transcript variants encoding different isoforms of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Oct 2009]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Tada2a||
(F):5'- ATGAAGCTGTGCCACATTCAG -3'
(R):5'- GAGGCTGCACTTCACATTCTG -3'
(F):5'- TGTGCCACATTCAGTAGGC -3'
(R):5'- ACCACACAGTTGCCGTGTC -3'