Incidental Mutation 'R7440:Vmn1r83'
ID 576888
Institutional Source Beutler Lab
Gene Symbol Vmn1r83
Ensembl Gene ENSMUSG00000066804
Gene Name vomeronasal 1 receptor 83
Synonyms V1rg8
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.057) question?
Stock # R7440 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 12319707-12329481 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to C at 12321629 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 167 (Y167C)
Ref Sequence ENSEMBL: ENSMUSP00000083406 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000086229] [ENSMUST00000226701]
AlphaFold Q8R287
Predicted Effect probably damaging
Transcript: ENSMUST00000086229
AA Change: Y167C

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000083406
Gene: ENSMUSG00000066804
AA Change: Y167C

DomainStartEndE-ValueType
Pfam:TAS2R 1 303 1.3e-8 PFAM
Pfam:V1R 26 299 1.7e-28 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000226701
AA Change: Y167C

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency 100% (69/69)
Allele List at MGI
Other mutations in this stock
Total: 69 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110032A03Rik A G 9: 50,764,913 V35A probably benign Het
9230104L09Rik A C 2: 148,846,991 C109W probably damaging Het
Acadm G A 3: 153,922,989 T403I probably damaging Het
Adat1 A T 8: 111,989,898 M64K probably damaging Het
Adcy2 C T 13: 68,796,667 V199M probably damaging Het
Ankrd13a T C 5: 114,803,575 S508P possibly damaging Het
Ap1g1 T A 8: 109,802,724 probably null Het
Bicral C T 17: 46,825,784 G167R probably damaging Het
Ccser2 T C 14: 36,898,217 K727E possibly damaging Het
Cep350 T G 1: 155,940,772 K332N probably damaging Het
Chd5 A G 4: 152,384,651 N1811S probably benign Het
Chpf A T 1: 75,475,601 V565D probably damaging Het
Clcn6 A T 4: 148,014,195 L489H probably damaging Het
Cntln C A 4: 85,063,216 T877K possibly damaging Het
Cog4 T C 8: 110,879,706 V630A probably benign Het
Col6a5 G T 9: 105,881,431 S2192* probably null Het
Cry2 G A 2: 92,413,638 R397W probably damaging Het
Cyp1b1 T C 17: 79,713,557 N252S probably damaging Het
Dhx9 T C 1: 153,481,231 I91V probably benign Het
Dnajb6 G A 5: 29,757,859 A256T possibly damaging Het
Epm2a T G 10: 11,390,875 Y121* probably null Het
Erlec1 T C 11: 30,950,818 I117V possibly damaging Het
Exoc8 T C 8: 124,895,781 M616V probably benign Het
Fmn1 A T 2: 113,441,611 Q108L unknown Het
Fuz T C 7: 44,896,572 L46P probably damaging Het
Gm15319 C T 8: 20,356,948 S254N unknown Het
Insc T C 7: 114,845,043 S422P possibly damaging Het
Intu A G 3: 40,697,551 I813V probably benign Het
Jak3 T A 8: 71,680,718 S352T probably benign Het
Klf11 T C 12: 24,655,491 S315P probably benign Het
Lrrc63 T C 14: 75,121,013 N400D possibly damaging Het
Lrrk1 T C 7: 66,290,854 D760G probably damaging Het
Macf1 A T 4: 123,455,446 L3976* probably null Het
Map7 C T 10: 20,261,859 A259V probably damaging Het
Meioc T A 11: 102,674,237 D170E possibly damaging Het
Mgat5b T A 11: 116,968,445 Y34* probably null Het
Mgst1 A G 6: 138,150,844 K68R probably benign Het
Miga1 T A 3: 152,338,046 probably null Het
Mrps33 G A 6: 39,802,479 P94L probably damaging Het
Ncapg2 G T 12: 116,450,413 G1068C possibly damaging Het
Ndufaf7 C T 17: 78,942,117 H148Y probably damaging Het
Nkx6-3 A T 8: 23,153,754 D57V probably damaging Het
Nlrp1a T C 11: 71,092,324 D1272G probably damaging Het
Oit3 T C 10: 59,429,570 N291S probably damaging Het
Olfr362 A T 2: 37,105,169 H160Q possibly damaging Het
Pld1 T G 3: 28,041,270 S251A probably benign Het
Ppfibp1 T C 6: 147,019,503 S580P probably benign Het
Prdx6b A T 2: 80,293,216 D123V probably damaging Het
Ptprs A G 17: 56,424,256 L1050P possibly damaging Het
Rcc1 A C 4: 132,337,799 S138A probably damaging Het
Rimbp3 G T 16: 17,213,201 R1496S possibly damaging Het
Sacs T C 14: 61,191,605 V371A probably benign Het
Sfxn4 A G 19: 60,842,204 L260P possibly damaging Het
Slc17a1 G A 13: 23,878,483 S211N possibly damaging Het
Slc39a11 C T 11: 113,562,092 V8M probably damaging Het
Smpd2 A G 10: 41,489,016 I78T probably benign Het
Steap3 A C 1: 120,241,518 F350V probably benign Het
Syt17 A T 7: 118,381,884 V462E probably damaging Het
Tlr11 T A 14: 50,361,344 D262E probably benign Het
Tnfrsf9 T C 4: 150,929,874 V10A probably benign Het
Trpv3 C A 11: 73,277,974 Q87K probably benign Het
Ugt1a5 T C 1: 88,166,559 Y170H probably benign Het
Urb1 A G 16: 90,787,408 L562P probably damaging Het
Usp3 G T 9: 66,530,255 N299K probably benign Het
Vmn2r117 T A 17: 23,475,565 Y436F probably benign Het
Vps13d A G 4: 145,128,411 I2220T Het
Zfp936 T A 7: 43,187,261 V32D probably damaging Het
Znrd1 T A 17: 36,957,844 L75F probably benign Het
Zswim2 A G 2: 83,920,719 C259R probably damaging Het
Other mutations in Vmn1r83
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01371:Vmn1r83 APN 7 12321233 missense probably benign 0.10
IGL01447:Vmn1r83 APN 7 12321497 missense probably benign
IGL01793:Vmn1r83 APN 7 12321577 missense probably benign 0.02
IGL02137:Vmn1r83 APN 7 12321834 missense probably damaging 1.00
IGL03155:Vmn1r83 APN 7 12321690 missense probably benign
IGL03182:Vmn1r83 APN 7 12321690 missense probably benign
R0627:Vmn1r83 UTSW 7 12321992 missense probably damaging 0.99
R1511:Vmn1r83 UTSW 7 12321270 missense possibly damaging 0.87
R3882:Vmn1r83 UTSW 7 12321402 missense probably damaging 1.00
R4613:Vmn1r83 UTSW 7 12321768 missense probably benign 0.00
R4678:Vmn1r83 UTSW 7 12321770 missense possibly damaging 0.67
R5580:Vmn1r83 UTSW 7 12321873 missense probably benign 0.01
R6982:Vmn1r83 UTSW 7 12321836 missense probably damaging 1.00
R7476:Vmn1r83 UTSW 7 12321615 missense possibly damaging 0.93
R7522:Vmn1r83 UTSW 7 12321578 missense possibly damaging 0.61
R7759:Vmn1r83 UTSW 7 12321433 missense probably benign 0.06
R8886:Vmn1r83 UTSW 7 12321916 missense probably benign 0.10
R9077:Vmn1r83 UTSW 7 12321644 missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGTCCTCAGGCAAGACTTTC -3'
(R):5'- GCCATGTGCCTATTGAGTTG -3'

Sequencing Primer
(F):5'- TGTCCTCAGGCAAGACTTTCAAAAG -3'
(R):5'- GCCTATTGAGTTGCTTCCAAG -3'
Posted On 2019-10-07