Incidental Mutation 'R0628:Vmn2r11'
| ID |
57693 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r11
|
| Ensembl Gene |
ENSMUSG00000091450 |
| Gene Name |
vomeronasal 2, receptor 11 |
| Synonyms |
EG384219 |
| MMRRC Submission |
038817-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.069)
|
| Stock # |
R0628 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
5 |
| Chromosomal Location |
109194739-109207318 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 109195597 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Leucine to Phenylalanine
at position 576
(L576F)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000133218
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000164875]
|
| AlphaFold |
E9Q4X4 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000164875
AA Change: L576F
PolyPhen 2
Score 0.882 (Sensitivity: 0.82; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000133218
Gene: ENSMUSG00000091450
AA Change: L576F
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
21 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
167 |
475 |
1.6e-29 |
PFAM |
|
Pfam:NCD3G
|
520 |
574 |
9.1e-19 |
PFAM |
|
Pfam:7tm_3
|
607 |
842 |
4.6e-55 |
PFAM |
|
| Meta Mutation Damage Score |
0.1795 |
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.8%
- 10x: 97.3%
- 20x: 94.6%
|
| Validation Efficiency |
98% (58/59) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 56 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Alpk2 |
A |
C |
18: 65,440,367 (GRCm39) |
V809G |
possibly damaging |
Het |
| Bank1 |
T |
A |
3: 135,772,151 (GRCm39) |
D493V |
probably damaging |
Het |
| Camk2d |
T |
C |
3: 126,604,273 (GRCm39) |
|
probably benign |
Het |
| Ccdc17 |
T |
A |
4: 116,455,745 (GRCm39) |
L292H |
probably damaging |
Het |
| Ccdc7b |
A |
G |
8: 129,837,498 (GRCm39) |
|
probably benign |
Het |
| Cd34 |
C |
A |
1: 194,641,525 (GRCm39) |
T317K |
probably damaging |
Het |
| Col6a5 |
C |
G |
9: 105,789,649 (GRCm39) |
|
probably null |
Het |
| Colgalt2 |
G |
T |
1: 152,384,312 (GRCm39) |
A551S |
possibly damaging |
Het |
| Copa |
T |
C |
1: 171,918,592 (GRCm39) |
|
probably benign |
Het |
| Coq7 |
T |
C |
7: 118,128,867 (GRCm39) |
D56G |
probably damaging |
Het |
| Dlg4 |
C |
T |
11: 69,922,610 (GRCm39) |
T201I |
probably damaging |
Het |
| Dnah7a |
T |
A |
1: 53,536,264 (GRCm39) |
D2593V |
probably benign |
Het |
| Ect2l |
T |
A |
10: 18,018,788 (GRCm39) |
E536V |
probably damaging |
Het |
| Emilin3 |
A |
G |
2: 160,752,799 (GRCm39) |
|
probably benign |
Het |
| Eml2 |
T |
C |
7: 18,935,479 (GRCm39) |
|
probably benign |
Het |
| Fam135b |
C |
T |
15: 71,320,505 (GRCm39) |
|
probably benign |
Het |
| Fhip2b |
T |
C |
14: 70,825,161 (GRCm39) |
T392A |
possibly damaging |
Het |
| Gart |
C |
T |
16: 91,430,790 (GRCm39) |
R424H |
probably benign |
Het |
| Gramd1a |
A |
G |
7: 30,842,049 (GRCm39) |
L80P |
probably damaging |
Het |
| Herc1 |
A |
G |
9: 66,358,163 (GRCm39) |
K2415E |
probably benign |
Het |
| Ica1 |
C |
T |
6: 8,644,256 (GRCm39) |
|
probably benign |
Het |
| Idi2l |
T |
A |
13: 8,990,958 (GRCm39) |
|
probably benign |
Het |
| Iyd |
A |
T |
10: 3,497,127 (GRCm39) |
M161L |
probably damaging |
Het |
| Kdm5a |
T |
C |
6: 120,392,200 (GRCm39) |
L974S |
probably damaging |
Het |
| Kif1a |
T |
C |
1: 92,947,605 (GRCm39) |
D1619G |
probably damaging |
Het |
| Lypd8 |
C |
T |
11: 58,275,499 (GRCm39) |
T78M |
probably damaging |
Het |
| Marchf10 |
T |
A |
11: 105,280,986 (GRCm39) |
H433L |
probably benign |
Het |
| Mbp |
A |
G |
18: 82,572,742 (GRCm39) |
Y13C |
probably damaging |
Het |
| Mertk |
A |
T |
2: 128,580,233 (GRCm39) |
N229I |
probably damaging |
Het |
| Msrb2 |
T |
A |
2: 19,398,091 (GRCm39) |
D116E |
probably damaging |
Het |
| Nfix |
G |
A |
8: 85,453,155 (GRCm39) |
R300C |
probably damaging |
Het |
| Otoa |
G |
A |
7: 120,744,873 (GRCm39) |
|
probably benign |
Het |
| Pclo |
A |
G |
5: 14,719,552 (GRCm39) |
T1230A |
unknown |
Het |
| Polrmt |
T |
C |
10: 79,574,979 (GRCm39) |
T851A |
possibly damaging |
Het |
| Prpf6 |
C |
T |
2: 181,277,841 (GRCm39) |
P401L |
probably damaging |
Het |
| Rasgrp4 |
A |
G |
7: 28,839,635 (GRCm39) |
|
probably benign |
Het |
| Rc3h2 |
A |
T |
2: 37,272,064 (GRCm39) |
|
probably benign |
Het |
| Reps1 |
A |
G |
10: 17,996,841 (GRCm39) |
T588A |
probably damaging |
Het |
| Rtel1 |
A |
C |
2: 180,993,674 (GRCm39) |
S782R |
probably benign |
Het |
| Sacm1l |
A |
G |
9: 123,378,060 (GRCm39) |
|
probably benign |
Het |
| Skic3 |
G |
C |
13: 76,298,848 (GRCm39) |
V1185L |
possibly damaging |
Het |
| Skint5 |
A |
T |
4: 113,588,266 (GRCm39) |
L728* |
probably null |
Het |
| Slc9b2 |
T |
A |
3: 135,029,536 (GRCm39) |
|
probably benign |
Het |
| Snapc3 |
A |
T |
4: 83,368,397 (GRCm39) |
H298L |
probably benign |
Het |
| Tex9 |
A |
T |
9: 72,399,233 (GRCm39) |
M1K |
probably null |
Het |
| Trappc13 |
C |
T |
13: 104,291,424 (GRCm39) |
|
probably benign |
Het |
| Usp3 |
C |
T |
9: 66,425,726 (GRCm39) |
R467H |
probably benign |
Het |
| Wnk4 |
T |
C |
11: 101,165,849 (GRCm39) |
F792S |
probably benign |
Het |
| Zfp1007 |
T |
C |
5: 109,826,442 (GRCm39) |
|
probably null |
Het |
| Zfp280d |
T |
C |
9: 72,269,230 (GRCm39) |
V764A |
probably benign |
Het |
| Zfp69 |
G |
A |
4: 120,806,622 (GRCm39) |
Q4* |
probably null |
Het |
| Zfp692 |
T |
G |
11: 58,200,449 (GRCm39) |
L206R |
probably damaging |
Het |
| Zic2 |
CCCACCACCACCATCACCACCACCACC |
CCCACCATCACCACCACCACC |
14: 122,713,776 (GRCm39) |
|
probably benign |
Het |
| Zic4 |
T |
A |
9: 91,266,170 (GRCm39) |
Y264* |
probably null |
Het |
| Zic4 |
T |
A |
9: 91,266,172 (GRCm39) |
M272K |
probably benign |
Het |
| Zscan4b |
A |
T |
7: 10,635,390 (GRCm39) |
N284K |
probably damaging |
Het |
|
| Other mutations in Vmn2r11 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00925:Vmn2r11
|
APN |
5 |
109,194,885 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01677:Vmn2r11
|
APN |
5 |
109,201,823 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
IGL02048:Vmn2r11
|
APN |
5 |
109,202,658 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02559:Vmn2r11
|
APN |
5 |
109,200,046 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02879:Vmn2r11
|
APN |
5 |
109,201,704 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL03084:Vmn2r11
|
APN |
5 |
109,207,209 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03163:Vmn2r11
|
APN |
5 |
109,201,692 (GRCm39) |
missense |
probably benign |
0.41 |
|
IGL03289:Vmn2r11
|
APN |
5 |
109,196,788 (GRCm39) |
splice site |
probably benign |
|
|
IGL03294:Vmn2r11
|
APN |
5 |
109,201,935 (GRCm39) |
missense |
probably benign |
0.22 |
|
R0233:Vmn2r11
|
UTSW |
5 |
109,201,968 (GRCm39) |
missense |
probably benign |
0.16 |
|
R0233:Vmn2r11
|
UTSW |
5 |
109,201,968 (GRCm39) |
missense |
probably benign |
0.16 |
|
R0421:Vmn2r11
|
UTSW |
5 |
109,207,294 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0549:Vmn2r11
|
UTSW |
5 |
109,199,963 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R1523:Vmn2r11
|
UTSW |
5 |
109,201,707 (GRCm39) |
missense |
probably benign |
0.25 |
|
R1660:Vmn2r11
|
UTSW |
5 |
109,201,724 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R1827:Vmn2r11
|
UTSW |
5 |
109,199,938 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1913:Vmn2r11
|
UTSW |
5 |
109,202,654 (GRCm39) |
missense |
probably benign |
|
|
R2260:Vmn2r11
|
UTSW |
5 |
109,201,657 (GRCm39) |
nonsense |
probably null |
|
|
R2400:Vmn2r11
|
UTSW |
5 |
109,199,928 (GRCm39) |
missense |
probably benign |
0.03 |
|
R3933:Vmn2r11
|
UTSW |
5 |
109,201,260 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4091:Vmn2r11
|
UTSW |
5 |
109,202,616 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4624:Vmn2r11
|
UTSW |
5 |
109,200,101 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4762:Vmn2r11
|
UTSW |
5 |
109,195,436 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5256:Vmn2r11
|
UTSW |
5 |
109,202,658 (GRCm39) |
missense |
probably benign |
0.26 |
|
R5370:Vmn2r11
|
UTSW |
5 |
109,195,421 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5419:Vmn2r11
|
UTSW |
5 |
109,207,224 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R5516:Vmn2r11
|
UTSW |
5 |
109,195,032 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5643:Vmn2r11
|
UTSW |
5 |
109,194,869 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5671:Vmn2r11
|
UTSW |
5 |
109,202,772 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5679:Vmn2r11
|
UTSW |
5 |
109,202,708 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5739:Vmn2r11
|
UTSW |
5 |
109,207,114 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5746:Vmn2r11
|
UTSW |
5 |
109,201,560 (GRCm39) |
missense |
probably benign |
0.41 |
|
R5995:Vmn2r11
|
UTSW |
5 |
109,194,921 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6147:Vmn2r11
|
UTSW |
5 |
109,202,700 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6220:Vmn2r11
|
UTSW |
5 |
109,201,434 (GRCm39) |
missense |
probably benign |
0.09 |
|
R6374:Vmn2r11
|
UTSW |
5 |
109,201,679 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R6491:Vmn2r11
|
UTSW |
5 |
109,196,800 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R6804:Vmn2r11
|
UTSW |
5 |
109,201,350 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6814:Vmn2r11
|
UTSW |
5 |
109,194,976 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R6872:Vmn2r11
|
UTSW |
5 |
109,194,976 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R7014:Vmn2r11
|
UTSW |
5 |
109,201,289 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7041:Vmn2r11
|
UTSW |
5 |
109,202,816 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7043:Vmn2r11
|
UTSW |
5 |
109,200,098 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7050:Vmn2r11
|
UTSW |
5 |
109,202,657 (GRCm39) |
missense |
probably benign |
0.05 |
|
R7184:Vmn2r11
|
UTSW |
5 |
109,201,281 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7388:Vmn2r11
|
UTSW |
5 |
109,202,742 (GRCm39) |
missense |
probably benign |
0.05 |
|
R7477:Vmn2r11
|
UTSW |
5 |
109,207,214 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R7524:Vmn2r11
|
UTSW |
5 |
109,201,848 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7682:Vmn2r11
|
UTSW |
5 |
109,195,481 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7715:Vmn2r11
|
UTSW |
5 |
109,195,307 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7869:Vmn2r11
|
UTSW |
5 |
109,199,986 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8094:Vmn2r11
|
UTSW |
5 |
109,201,626 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8277:Vmn2r11
|
UTSW |
5 |
109,202,833 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8506:Vmn2r11
|
UTSW |
5 |
109,207,270 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8676:Vmn2r11
|
UTSW |
5 |
109,201,626 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8701:Vmn2r11
|
UTSW |
5 |
109,195,556 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8749:Vmn2r11
|
UTSW |
5 |
109,195,319 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9046:Vmn2r11
|
UTSW |
5 |
109,202,850 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9138:Vmn2r11
|
UTSW |
5 |
109,201,904 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9267:Vmn2r11
|
UTSW |
5 |
109,199,929 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R9306:Vmn2r11
|
UTSW |
5 |
109,196,831 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9384:Vmn2r11
|
UTSW |
5 |
109,201,266 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9443:Vmn2r11
|
UTSW |
5 |
109,195,159 (GRCm39) |
nonsense |
probably null |
|
|
R9520:Vmn2r11
|
UTSW |
5 |
109,201,455 (GRCm39) |
missense |
probably benign |
0.35 |
|
R9596:Vmn2r11
|
UTSW |
5 |
109,201,563 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R9677:Vmn2r11
|
UTSW |
5 |
109,201,332 (GRCm39) |
missense |
|
|
|
| Predicted Primers |
PCR Primer
(F):5'- TGAGAATGCGGTTATTGGCCTTCAC -3'
(R):5'- GATCTTCCCACAATGAGAGGGATATGC -3'
Sequencing Primer
(F):5'- GGCCTTCACAATGGGAGTATC -3'
(R):5'- taaataatttttGCTGTTCCATTCCC -3'
|
| Posted On |
2013-07-11 |
Incidental Mutation