Incidental Mutation 'R7441:Kifc3'
ID 576954
Institutional Source Beutler Lab
Gene Symbol Kifc3
Ensembl Gene ENSMUSG00000031788
Gene Name kinesin family member C3
Synonyms
MMRRC Submission 045517-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R7441 (G1)
Quality Score 225.009
Status Not validated
Chromosome 8
Chromosomal Location 95826456-95929440 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 95864615 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Valine at position 32 (M32V)
Ref Sequence ENSEMBL: ENSMUSP00000034240 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000034240] [ENSMUST00000169748] [ENSMUST00000212076] [ENSMUST00000212424] [ENSMUST00000212554] [ENSMUST00000212786] [ENSMUST00000212842]
AlphaFold O35231
Predicted Effect probably benign
Transcript: ENSMUST00000034240
AA Change: M32V

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000034240
Gene: ENSMUSG00000031788
AA Change: M32V

DomainStartEndE-ValueType
low complexity region 33 46 N/A INTRINSIC
coiled coil region 100 360 N/A INTRINSIC
coiled coil region 393 430 N/A INTRINSIC
KISc 441 774 3.15e-158 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000169748
SMART Domains Protein: ENSMUSP00000126784
Gene: ENSMUSG00000031788

DomainStartEndE-ValueType
coiled coil region 34 324 N/A INTRINSIC
coiled coil region 357 394 N/A INTRINSIC
KISc 405 728 3.11e-148 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000212076
Predicted Effect probably benign
Transcript: ENSMUST00000212424
AA Change: M32V

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
Predicted Effect probably benign
Transcript: ENSMUST00000212554
AA Change: M32V

PolyPhen 2 Score 0.014 (Sensitivity: 0.96; Specificity: 0.79)
Predicted Effect probably benign
Transcript: ENSMUST00000212786
Predicted Effect probably benign
Transcript: ENSMUST00000212842
AA Change: M32V

PolyPhen 2 Score 0.014 (Sensitivity: 0.96; Specificity: 0.79)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the kinesin-14 family of microtubule motors. Members of this family play a role in the formation, maintenance and remodeling of the bipolar mitotic spindle. The protein encoded by this gene has cytoplasmic functions in the interphase cells. It may also be involved in the final stages of cytokinesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]
PHENOTYPE: Mice homozygous for this targeted mutation are viable, fertile, and appear phenotypically indistinguishable from wild-type littermates. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4921509C19Rik A C 2: 151,314,845 (GRCm39) S278A possibly damaging Het
Adamts20 T C 15: 94,251,554 (GRCm39) D411G probably damaging Het
Adgrl3 A G 5: 81,871,987 (GRCm39) I894V possibly damaging Het
Adprhl1 C T 8: 13,273,069 (GRCm39) V1230I probably benign Het
Agpat1 T A 17: 34,829,883 (GRCm39) Y77N probably damaging Het
Anpep A G 7: 79,477,392 (GRCm39) V725A possibly damaging Het
Apc T A 18: 34,445,126 (GRCm39) I674K probably damaging Het
Arhgef2 A G 3: 88,551,262 (GRCm39) R808G probably damaging Het
Asap1 A G 15: 64,002,105 (GRCm39) V402A probably damaging Het
Aspg T C 12: 112,091,255 (GRCm39) V479A possibly damaging Het
B3galnt2 G A 13: 14,169,070 (GRCm39) V368M probably benign Het
Bahcc1 T C 11: 120,177,132 (GRCm39) S2007P probably damaging Het
Cyfip2 A T 11: 46,087,254 (GRCm39) I1212N possibly damaging Het
Dnajc16 A T 4: 141,491,124 (GRCm39) D675E probably damaging Het
Dram2 T C 3: 106,462,503 (GRCm39) F4L probably damaging Het
Dsp A G 13: 38,379,425 (GRCm39) T2057A probably benign Het
Dync1h1 T G 12: 110,602,887 (GRCm39) L2176R probably damaging Het
Efhb A T 17: 53,708,549 (GRCm39) I707N possibly damaging Het
Eif2ak4 A G 2: 118,302,377 (GRCm39) T1555A probably benign Het
Erc1 G A 6: 119,801,912 (GRCm39) T35I possibly damaging Het
Esr2 C A 12: 76,188,168 (GRCm39) M363I probably benign Het
Etl4 A T 2: 20,749,000 (GRCm39) N446I possibly damaging Het
Evpl T A 11: 116,113,782 (GRCm39) K1303* probably null Het
Fam135b A T 15: 71,335,529 (GRCm39) V555E probably damaging Het
Fam186b A G 15: 99,177,970 (GRCm39) L452P probably benign Het
Fmn1 A T 2: 113,271,956 (GRCm39) Q108L unknown Het
Gcc2 A G 10: 58,092,723 (GRCm39) T48A probably benign Het
Gm6619 T G 6: 131,467,354 (GRCm39) I73S possibly damaging Het
Gm8267 T A 14: 44,960,397 (GRCm39) D116V probably damaging Het
Gtf3c3 G A 1: 54,459,607 (GRCm39) T385M probably benign Het
Iqgap2 C A 13: 95,764,584 (GRCm39) M1553I probably benign Het
Kcnk1 G T 8: 126,722,307 (GRCm39) G37C probably damaging Het
Krt81 C A 15: 101,359,251 (GRCm39) K222N possibly damaging Het
Lrrc63 A G 14: 75,363,697 (GRCm39) S145P possibly damaging Het
Mybbp1a T A 11: 72,342,101 (GRCm39) V1279E probably benign Het
Niban3 A G 8: 72,052,808 (GRCm39) D94G probably benign Het
Or11g26 A T 14: 50,752,853 (GRCm39) Y64F probably damaging Het
Or8u9 T A 2: 86,001,354 (GRCm39) D269V probably damaging Het
Pierce1 TCTCTGGGGCAGGCTTAGCCTTGGGCTCCCCCGGCTCCGGCTCCTCTGGGGCAGGCTTAGCCTTGGGCTCCCCCGGCTCCGGCTCCTCTGGGGCGGGCTTAGCCTTGGGCTCCCCCGGCTCCGGCTCCTC TCTCTGGGGCAGGCTTAGCCTTGGGCTCCCCCGGCTCCGGCTCCTCTGGGGCGGGCTTAGCCTTGGGCTCCCCCGGCTCCGGCTCCTC 2: 28,356,122 (GRCm39) probably benign Het
Pramel12 A G 4: 143,145,410 (GRCm39) Y293C probably benign Het
Ptpn18 T C 1: 34,512,416 (GRCm39) V407A probably benign Het
Ptpn9 T A 9: 56,934,717 (GRCm39) Y160* probably null Het
Ptprj T C 2: 90,280,163 (GRCm39) K1045R possibly damaging Het
Rundc3a G T 11: 102,290,872 (GRCm39) probably null Het
Scn11a C T 9: 119,587,692 (GRCm39) V1351I probably benign Het
Slc26a9 A G 1: 131,690,556 (GRCm39) Y520C probably damaging Het
Spata20 G A 11: 94,374,867 (GRCm39) A245V probably benign Het
Steap3 A C 1: 120,169,248 (GRCm39) F350V probably benign Het
Swt1 A T 1: 151,286,815 (GRCm39) F226I probably benign Het
Taar7f A G 10: 23,925,885 (GRCm39) T160A possibly damaging Het
Timd5 G A 11: 46,419,382 (GRCm39) W66* probably null Het
Upf2 A T 2: 6,023,743 (GRCm39) I698F unknown Het
Vmn2r84 T C 10: 130,227,982 (GRCm39) T85A possibly damaging Het
Zfp426 T C 9: 20,382,147 (GRCm39) E280G possibly damaging Het
Zfp810 C A 9: 22,190,568 (GRCm39) E78* probably null Het
Zfp937 GTGATAAGGCATTTGCACAAAACAGTCATCTCCTAACACATAAAAGAACACAT G 2: 150,080,630 (GRCm39) probably null Het
Other mutations in Kifc3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00720:Kifc3 APN 8 95,864,644 (GRCm39) missense probably damaging 1.00
IGL01904:Kifc3 APN 8 95,864,585 (GRCm39) missense possibly damaging 0.81
IGL02019:Kifc3 APN 8 95,834,168 (GRCm39) splice site probably benign
IGL02090:Kifc3 APN 8 95,829,108 (GRCm39) missense probably damaging 1.00
IGL02355:Kifc3 APN 8 95,836,507 (GRCm39) missense probably damaging 1.00
IGL02362:Kifc3 APN 8 95,836,507 (GRCm39) missense probably damaging 1.00
IGL02620:Kifc3 APN 8 95,836,582 (GRCm39) missense probably damaging 0.98
IGL02720:Kifc3 APN 8 95,834,993 (GRCm39) missense probably benign 0.00
IGL03030:Kifc3 APN 8 95,829,040 (GRCm39) missense probably damaging 1.00
IGL03327:Kifc3 APN 8 95,835,060 (GRCm39) missense probably damaging 1.00
IGL03390:Kifc3 APN 8 95,835,241 (GRCm39) missense probably damaging 1.00
R0233:Kifc3 UTSW 8 95,828,100 (GRCm39) splice site probably null
R0281:Kifc3 UTSW 8 95,830,088 (GRCm39) missense probably damaging 1.00
R0302:Kifc3 UTSW 8 95,830,098 (GRCm39) missense possibly damaging 0.50
R0619:Kifc3 UTSW 8 95,829,293 (GRCm39) missense probably benign 0.13
R0731:Kifc3 UTSW 8 95,832,361 (GRCm39) missense probably damaging 1.00
R1017:Kifc3 UTSW 8 95,832,413 (GRCm39) missense probably damaging 0.99
R1147:Kifc3 UTSW 8 95,864,546 (GRCm39) missense probably damaging 1.00
R1147:Kifc3 UTSW 8 95,864,546 (GRCm39) missense probably damaging 1.00
R1257:Kifc3 UTSW 8 95,832,400 (GRCm39) missense probably damaging 0.98
R1472:Kifc3 UTSW 8 95,864,541 (GRCm39) critical splice donor site probably null
R1480:Kifc3 UTSW 8 95,836,515 (GRCm39) missense probably damaging 1.00
R1553:Kifc3 UTSW 8 95,833,170 (GRCm39) missense possibly damaging 0.67
R2071:Kifc3 UTSW 8 95,834,981 (GRCm39) critical splice donor site probably null
R2115:Kifc3 UTSW 8 95,835,341 (GRCm39) missense probably damaging 1.00
R3703:Kifc3 UTSW 8 95,830,656 (GRCm39) splice site probably benign
R3704:Kifc3 UTSW 8 95,830,656 (GRCm39) splice site probably benign
R3705:Kifc3 UTSW 8 95,830,656 (GRCm39) splice site probably benign
R4223:Kifc3 UTSW 8 95,836,610 (GRCm39) missense probably damaging 0.96
R4463:Kifc3 UTSW 8 95,828,744 (GRCm39) missense probably damaging 1.00
R4508:Kifc3 UTSW 8 95,834,048 (GRCm39) splice site probably null
R4980:Kifc3 UTSW 8 95,853,177 (GRCm39) missense probably benign
R5032:Kifc3 UTSW 8 95,829,354 (GRCm39) missense probably damaging 1.00
R5068:Kifc3 UTSW 8 95,836,844 (GRCm39) missense possibly damaging 0.54
R5421:Kifc3 UTSW 8 95,836,473 (GRCm39) missense probably damaging 0.99
R5556:Kifc3 UTSW 8 95,835,087 (GRCm39) nonsense probably null
R6845:Kifc3 UTSW 8 95,835,307 (GRCm39) missense probably benign 0.28
R7136:Kifc3 UTSW 8 95,830,077 (GRCm39) missense probably benign 0.10
R7196:Kifc3 UTSW 8 95,833,239 (GRCm39) missense probably benign 0.02
R7404:Kifc3 UTSW 8 95,830,092 (GRCm39) missense probably benign 0.02
R7784:Kifc3 UTSW 8 95,837,320 (GRCm39) critical splice donor site probably null
R7861:Kifc3 UTSW 8 95,834,165 (GRCm39) critical splice acceptor site probably null
R8440:Kifc3 UTSW 8 95,836,422 (GRCm39) missense possibly damaging 0.89
R8754:Kifc3 UTSW 8 95,829,024 (GRCm39) missense probably damaging 1.00
R8983:Kifc3 UTSW 8 95,833,104 (GRCm39) missense probably damaging 1.00
R9035:Kifc3 UTSW 8 95,853,195 (GRCm39) missense possibly damaging 0.52
R9149:Kifc3 UTSW 8 95,853,317 (GRCm39) missense probably benign
R9464:Kifc3 UTSW 8 95,830,622 (GRCm39) missense possibly damaging 0.61
R9589:Kifc3 UTSW 8 95,861,372 (GRCm39) missense possibly damaging 0.87
X0023:Kifc3 UTSW 8 95,835,926 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- CTGTAATTACCTGACAGCTCTGAC -3'
(R):5'- TTTGCAGACCCTTCCAGATGG -3'

Sequencing Primer
(F):5'- CAGCTCTGACTGAGTTTAGGAACC -3'
(R):5'- TGGTACAGCCATGTGGACTAC -3'
Posted On 2019-10-07