Incidental Mutation 'R7441:Lrrc63'
ID 576978
Institutional Source Beutler Lab
Gene Symbol Lrrc63
Ensembl Gene ENSMUSG00000021997
Gene Name leucine rich repeat containing 63
Synonyms 4921509B22Rik
MMRRC Submission 045517-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.106) question?
Stock # R7441 (G1)
Quality Score 225.009
Status Not validated
Chromosome 14
Chromosomal Location 75321743-75368321 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 75363697 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 145 (S145P)
Ref Sequence ENSEMBL: ENSMUSP00000022574 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000022574] [ENSMUST00000134114] [ENSMUST00000143539]
AlphaFold no structure available at present
Predicted Effect possibly damaging
Transcript: ENSMUST00000022574
AA Change: S145P

PolyPhen 2 Score 0.838 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000022574
Gene: ENSMUSG00000021997
AA Change: S145P

DomainStartEndE-ValueType
low complexity region 15 37 N/A INTRINSIC
low complexity region 139 152 N/A INTRINSIC
low complexity region 276 310 N/A INTRINSIC
LRR 412 434 2.82e0 SMART
LRR 435 458 1.45e1 SMART
LRR 481 504 1.53e-1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000134114
SMART Domains Protein: ENSMUSP00000121376
Gene: ENSMUSG00000021998

DomainStartEndE-ValueType
EFh 13 41 6.91e-5 SMART
EFh 53 81 7.7e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000143539
SMART Domains Protein: ENSMUSP00000118721
Gene: ENSMUSG00000021998

DomainStartEndE-ValueType
EFh 13 41 6.91e-5 SMART
EFh 53 76 4.45e1 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4921509C19Rik A C 2: 151,314,845 (GRCm39) S278A possibly damaging Het
Adamts20 T C 15: 94,251,554 (GRCm39) D411G probably damaging Het
Adgrl3 A G 5: 81,871,987 (GRCm39) I894V possibly damaging Het
Adprhl1 C T 8: 13,273,069 (GRCm39) V1230I probably benign Het
Agpat1 T A 17: 34,829,883 (GRCm39) Y77N probably damaging Het
Anpep A G 7: 79,477,392 (GRCm39) V725A possibly damaging Het
Apc T A 18: 34,445,126 (GRCm39) I674K probably damaging Het
Arhgef2 A G 3: 88,551,262 (GRCm39) R808G probably damaging Het
Asap1 A G 15: 64,002,105 (GRCm39) V402A probably damaging Het
Aspg T C 12: 112,091,255 (GRCm39) V479A possibly damaging Het
B3galnt2 G A 13: 14,169,070 (GRCm39) V368M probably benign Het
Bahcc1 T C 11: 120,177,132 (GRCm39) S2007P probably damaging Het
Cyfip2 A T 11: 46,087,254 (GRCm39) I1212N possibly damaging Het
Dnajc16 A T 4: 141,491,124 (GRCm39) D675E probably damaging Het
Dram2 T C 3: 106,462,503 (GRCm39) F4L probably damaging Het
Dsp A G 13: 38,379,425 (GRCm39) T2057A probably benign Het
Dync1h1 T G 12: 110,602,887 (GRCm39) L2176R probably damaging Het
Efhb A T 17: 53,708,549 (GRCm39) I707N possibly damaging Het
Eif2ak4 A G 2: 118,302,377 (GRCm39) T1555A probably benign Het
Erc1 G A 6: 119,801,912 (GRCm39) T35I possibly damaging Het
Esr2 C A 12: 76,188,168 (GRCm39) M363I probably benign Het
Etl4 A T 2: 20,749,000 (GRCm39) N446I possibly damaging Het
Evpl T A 11: 116,113,782 (GRCm39) K1303* probably null Het
Fam135b A T 15: 71,335,529 (GRCm39) V555E probably damaging Het
Fam186b A G 15: 99,177,970 (GRCm39) L452P probably benign Het
Fmn1 A T 2: 113,271,956 (GRCm39) Q108L unknown Het
Gcc2 A G 10: 58,092,723 (GRCm39) T48A probably benign Het
Gm6619 T G 6: 131,467,354 (GRCm39) I73S possibly damaging Het
Gm8267 T A 14: 44,960,397 (GRCm39) D116V probably damaging Het
Gtf3c3 G A 1: 54,459,607 (GRCm39) T385M probably benign Het
Iqgap2 C A 13: 95,764,584 (GRCm39) M1553I probably benign Het
Kcnk1 G T 8: 126,722,307 (GRCm39) G37C probably damaging Het
Kifc3 T C 8: 95,864,615 (GRCm39) M32V probably benign Het
Krt81 C A 15: 101,359,251 (GRCm39) K222N possibly damaging Het
Mybbp1a T A 11: 72,342,101 (GRCm39) V1279E probably benign Het
Niban3 A G 8: 72,052,808 (GRCm39) D94G probably benign Het
Or11g26 A T 14: 50,752,853 (GRCm39) Y64F probably damaging Het
Or8u9 T A 2: 86,001,354 (GRCm39) D269V probably damaging Het
Pierce1 TCTCTGGGGCAGGCTTAGCCTTGGGCTCCCCCGGCTCCGGCTCCTCTGGGGCAGGCTTAGCCTTGGGCTCCCCCGGCTCCGGCTCCTCTGGGGCGGGCTTAGCCTTGGGCTCCCCCGGCTCCGGCTCCTC TCTCTGGGGCAGGCTTAGCCTTGGGCTCCCCCGGCTCCGGCTCCTCTGGGGCGGGCTTAGCCTTGGGCTCCCCCGGCTCCGGCTCCTC 2: 28,356,122 (GRCm39) probably benign Het
Pramel12 A G 4: 143,145,410 (GRCm39) Y293C probably benign Het
Ptpn18 T C 1: 34,512,416 (GRCm39) V407A probably benign Het
Ptpn9 T A 9: 56,934,717 (GRCm39) Y160* probably null Het
Ptprj T C 2: 90,280,163 (GRCm39) K1045R possibly damaging Het
Rundc3a G T 11: 102,290,872 (GRCm39) probably null Het
Scn11a C T 9: 119,587,692 (GRCm39) V1351I probably benign Het
Slc26a9 A G 1: 131,690,556 (GRCm39) Y520C probably damaging Het
Spata20 G A 11: 94,374,867 (GRCm39) A245V probably benign Het
Steap3 A C 1: 120,169,248 (GRCm39) F350V probably benign Het
Swt1 A T 1: 151,286,815 (GRCm39) F226I probably benign Het
Taar7f A G 10: 23,925,885 (GRCm39) T160A possibly damaging Het
Timd5 G A 11: 46,419,382 (GRCm39) W66* probably null Het
Upf2 A T 2: 6,023,743 (GRCm39) I698F unknown Het
Vmn2r84 T C 10: 130,227,982 (GRCm39) T85A possibly damaging Het
Zfp426 T C 9: 20,382,147 (GRCm39) E280G possibly damaging Het
Zfp810 C A 9: 22,190,568 (GRCm39) E78* probably null Het
Zfp937 GTGATAAGGCATTTGCACAAAACAGTCATCTCCTAACACATAAAAGAACACAT G 2: 150,080,630 (GRCm39) probably null Het
Other mutations in Lrrc63
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01688:Lrrc63 APN 14 75,322,422 (GRCm39) missense possibly damaging 0.73
IGL02222:Lrrc63 APN 14 75,323,580 (GRCm39) missense probably damaging 0.99
IGL02385:Lrrc63 APN 14 75,323,640 (GRCm39) missense probably benign
FR4548:Lrrc63 UTSW 14 75,362,622 (GRCm39) small deletion probably benign
FR4589:Lrrc63 UTSW 14 75,362,622 (GRCm39) small deletion probably benign
R0398:Lrrc63 UTSW 14 75,363,910 (GRCm39) missense probably benign 0.06
R0637:Lrrc63 UTSW 14 75,335,660 (GRCm39) splice site probably benign
R0669:Lrrc63 UTSW 14 75,363,550 (GRCm39) missense probably benign 0.27
R1465:Lrrc63 UTSW 14 75,344,829 (GRCm39) missense possibly damaging 0.92
R1465:Lrrc63 UTSW 14 75,344,829 (GRCm39) missense possibly damaging 0.92
R1478:Lrrc63 UTSW 14 75,363,424 (GRCm39) missense probably benign
R1591:Lrrc63 UTSW 14 75,363,332 (GRCm39) missense possibly damaging 0.92
R1753:Lrrc63 UTSW 14 75,323,784 (GRCm39) splice site probably null
R3713:Lrrc63 UTSW 14 75,344,776 (GRCm39) missense probably benign 0.12
R4013:Lrrc63 UTSW 14 75,335,731 (GRCm39) missense probably damaging 0.98
R4793:Lrrc63 UTSW 14 75,363,601 (GRCm39) missense possibly damaging 0.93
R4888:Lrrc63 UTSW 14 75,363,406 (GRCm39) missense probably benign
R4937:Lrrc63 UTSW 14 75,322,389 (GRCm39) missense probably damaging 0.99
R5197:Lrrc63 UTSW 14 75,322,322 (GRCm39) missense possibly damaging 0.68
R5747:Lrrc63 UTSW 14 75,363,904 (GRCm39) missense probably benign
R5861:Lrrc63 UTSW 14 75,344,806 (GRCm39) missense possibly damaging 0.83
R5905:Lrrc63 UTSW 14 75,323,614 (GRCm39) missense possibly damaging 0.92
R6028:Lrrc63 UTSW 14 75,323,614 (GRCm39) missense possibly damaging 0.92
R6661:Lrrc63 UTSW 14 75,362,633 (GRCm39) missense unknown
R6982:Lrrc63 UTSW 14 75,322,211 (GRCm39) missense probably benign 0.33
R7062:Lrrc63 UTSW 14 75,323,737 (GRCm39) missense probably benign 0.00
R7439:Lrrc63 UTSW 14 75,363,697 (GRCm39) missense possibly damaging 0.84
R7440:Lrrc63 UTSW 14 75,358,453 (GRCm39) missense possibly damaging 0.91
R7474:Lrrc63 UTSW 14 75,363,643 (GRCm39) missense possibly damaging 0.83
R7604:Lrrc63 UTSW 14 75,322,409 (GRCm39) missense possibly damaging 0.68
R7703:Lrrc63 UTSW 14 75,360,447 (GRCm39) missense possibly damaging 0.91
R7819:Lrrc63 UTSW 14 75,362,661 (GRCm39) small insertion probably benign
R8519:Lrrc63 UTSW 14 75,363,312 (GRCm39) missense possibly damaging 0.96
R8970:Lrrc63 UTSW 14 75,362,631 (GRCm39) missense unknown
R9025:Lrrc63 UTSW 14 75,322,284 (GRCm39) missense probably benign
R9547:Lrrc63 UTSW 14 75,344,828 (GRCm39) missense probably damaging 0.99
R9589:Lrrc63 UTSW 14 75,322,379 (GRCm39) missense possibly damaging 0.68
R9780:Lrrc63 UTSW 14 75,360,500 (GRCm39) missense probably damaging 0.99
Z1088:Lrrc63 UTSW 14 75,363,430 (GRCm39) missense possibly damaging 0.91
Predicted Primers PCR Primer
(F):5'- CTGAGAAGAGGGAGCTCTTGAC -3'
(R):5'- AGCACTCAAACCATCTGTCTTG -3'

Sequencing Primer
(F):5'- AGGGAGCTCTTGACTATAGCC -3'
(R):5'- GTCTTGACTATGACCATAAGGCACTC -3'
Posted On 2019-10-07