Incidental Mutation 'R7443:Zfp827'
ID 577097
Institutional Source Beutler Lab
Gene Symbol Zfp827
Ensembl Gene ENSMUSG00000071064
Gene Name zinc finger protein 827
Synonyms D630040G17Rik, 2810449M09Rik
MMRRC Submission 045519-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.920) question?
Stock # R7443 (G1)
Quality Score 225.009
Status Not validated
Chromosome 8
Chromosomal Location 79755066-79920395 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 79917047 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Glycine at position 541 (S541G)
Gene Model predicted gene model for transcript(s): [ENSMUST00000098614] [ENSMUST00000119254] [ENSMUST00000148713]
AlphaFold Q505G8
Predicted Effect probably benign
Transcript: ENSMUST00000098614
SMART Domains Protein: ENSMUSP00000096214
Gene: ENSMUSG00000071064

DomainStartEndE-ValueType
low complexity region 102 128 N/A INTRINSIC
low complexity region 226 256 N/A INTRINSIC
low complexity region 271 298 N/A INTRINSIC
low complexity region 306 342 N/A INTRINSIC
low complexity region 343 348 N/A INTRINSIC
ZnF_C2H2 371 393 6.78e-3 SMART
ZnF_C2H2 399 421 2.99e-4 SMART
ZnF_C2H2 430 452 5.42e-2 SMART
internal_repeat_2 561 585 3.31e-7 PROSPERO
low complexity region 613 627 N/A INTRINSIC
internal_repeat_2 719 743 3.31e-7 PROSPERO
ZnF_C2H2 814 836 2.4e-3 SMART
ZnF_C2H2 842 864 4.72e-2 SMART
ZnF_C2H2 894 916 1.64e-1 SMART
ZnF_C2H2 926 949 7.89e0 SMART
low complexity region 956 974 N/A INTRINSIC
ZnF_C2H2 1016 1038 1.26e-2 SMART
ZnF_C2H2 1044 1066 3.07e-1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000119254
SMART Domains Protein: ENSMUSP00000113199
Gene: ENSMUSG00000071064

DomainStartEndE-ValueType
low complexity region 102 128 N/A INTRINSIC
low complexity region 226 256 N/A INTRINSIC
low complexity region 271 298 N/A INTRINSIC
low complexity region 306 342 N/A INTRINSIC
low complexity region 343 348 N/A INTRINSIC
ZnF_C2H2 371 393 6.78e-3 SMART
ZnF_C2H2 399 421 2.99e-4 SMART
ZnF_C2H2 430 452 5.42e-2 SMART
internal_repeat_2 561 585 3.25e-7 PROSPERO
low complexity region 613 627 N/A INTRINSIC
internal_repeat_2 719 743 3.25e-7 PROSPERO
ZnF_C2H2 814 836 2.4e-3 SMART
ZnF_C2H2 842 864 4.72e-2 SMART
ZnF_C2H2 894 916 1.64e-1 SMART
ZnF_C2H2 926 949 7.89e0 SMART
low complexity region 956 974 N/A INTRINSIC
ZnF_C2H2 1016 1038 1.26e-2 SMART
ZnF_C2H2 1044 1066 3.07e-1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000129613
SMART Domains Protein: ENSMUSP00000119511
Gene: ENSMUSG00000071064

DomainStartEndE-ValueType
ZnF_C2H2 35 57 1.64e-1 SMART
ZnF_C2H2 67 90 7.89e0 SMART
low complexity region 97 115 N/A INTRINSIC
ZnF_C2H2 157 179 1.26e-2 SMART
ZnF_C2H2 185 207 3.07e-1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000145827
SMART Domains Protein: ENSMUSP00000114208
Gene: ENSMUSG00000071064

DomainStartEndE-ValueType
ZnF_C2H2 77 99 2.4e-3 SMART
ZnF_C2H2 111 133 4.72e-2 SMART
ZnF_C2H2 163 185 1.64e-1 SMART
ZnF_C2H2 195 218 7.89e0 SMART
low complexity region 225 243 N/A INTRINSIC
ZnF_C2H2 285 307 1.26e-2 SMART
ZnF_C2H2 313 335 3.07e-1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000148713
SMART Domains Protein: ENSMUSP00000120913
Gene: ENSMUSG00000071064

DomainStartEndE-ValueType
ZnF_C2H2 106 128 2.4e-3 SMART
ZnF_C2H2 134 156 4.72e-2 SMART
ZnF_C2H2 186 208 1.64e-1 SMART
ZnF_C2H2 218 241 7.89e0 SMART
low complexity region 248 266 N/A INTRINSIC
ZnF_C2H2 308 330 1.26e-2 SMART
ZnF_C2H2 336 358 3.07e-1 SMART
Predicted Effect
SMART Domains Protein: ENSMUSP00000120562
Gene: ENSMUSG00000071064
AA Change: S541G

DomainStartEndE-ValueType
ZnF_C2H2 31 53 2.4e-3 SMART
ZnF_C2H2 59 81 4.72e-2 SMART
ZnF_C2H2 111 133 1.64e-1 SMART
ZnF_C2H2 143 166 7.89e0 SMART
low complexity region 173 191 N/A INTRINSIC
ZnF_C2H2 233 255 1.26e-2 SMART
ZnF_C2H2 261 283 3.07e-1 SMART
ZnF_C2H2 290 312 9.44e-2 SMART
ZnF_C2H2 317 339 4.34e-1 SMART
ZnF_C2H2 345 367 7.9e-4 SMART
ZnF_C2H2 373 396 2.53e-2 SMART
ZnF_C2H2 402 424 2.45e0 SMART
low complexity region 444 466 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.2%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 72 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abl2 T C 1: 156,452,951 (GRCm39) I162T probably damaging Het
Acaca G A 11: 84,206,619 (GRCm39) S1493N probably benign Het
Arf2 T A 11: 103,859,976 (GRCm39) M18K probably benign Het
Bag5 A G 12: 111,677,161 (GRCm39) S221P probably damaging Het
Bcr T C 10: 74,978,968 (GRCm39) probably null Het
Btg2 T A 1: 134,005,433 (GRCm39) K51* probably null Het
Chrne A G 11: 70,509,092 (GRCm39) V130A probably benign Het
Cracd T C 5: 77,004,485 (GRCm39) V282A unknown Het
Cubn T A 2: 13,460,320 (GRCm39) D714V probably damaging Het
Cyp4a29 A T 4: 115,105,756 (GRCm39) I153F probably damaging Het
Dph7 C A 2: 24,852,505 (GRCm39) H5Q probably benign Het
Epha6 T C 16: 59,595,988 (GRCm39) N901S possibly damaging Het
Exosc9 C A 3: 36,607,990 (GRCm39) P66Q probably damaging Het
Foxn3 T C 12: 99,355,038 (GRCm39) D42G possibly damaging Het
Gbp11 A G 5: 105,478,816 (GRCm39) probably null Het
Gm3264 A T 14: 16,058,304 (GRCm39) Y37F probably damaging Het
H2-M10.2 T A 17: 36,596,945 (GRCm39) I44F probably benign Het
Hemgn A T 4: 46,396,145 (GRCm39) F364I probably damaging Het
Hnf4a A G 2: 163,400,932 (GRCm39) I184V probably benign Het
Ighe G T 12: 113,235,785 (GRCm39) C180* probably null Het
Iigp1c A T 18: 60,379,122 (GRCm39) N219I probably benign Het
Klk1b22 T A 7: 43,765,534 (GRCm39) I162K probably benign Het
Lmo3 C T 6: 138,354,220 (GRCm39) A104T probably damaging Het
Lsm14a A G 7: 34,053,263 (GRCm39) V263A probably benign Het
Ltbp1 T C 17: 75,671,432 (GRCm39) Y1538H probably damaging Het
Ly6g6g T C 15: 74,647,249 (GRCm39) E32G Het
Map9 A G 3: 82,278,663 (GRCm39) E221G possibly damaging Het
Mccc2 G A 13: 100,130,144 (GRCm39) A71V possibly damaging Het
Mdc1 T A 17: 36,161,712 (GRCm39) V875E probably damaging Het
Mier2 A T 10: 79,376,289 (GRCm39) I212N unknown Het
Mitd1 T C 1: 37,920,117 (GRCm39) T164A probably benign Het
Myh1 T C 11: 67,111,331 (GRCm39) I1590T probably benign Het
Mylk2 T G 2: 152,753,346 (GRCm39) probably benign Het
Ncapg T A 5: 45,829,652 (GRCm39) V118E probably benign Het
Nynrin G A 14: 56,108,873 (GRCm39) V1327I probably benign Het
Oas1c C A 5: 120,943,484 (GRCm39) K218N probably damaging Het
Or11g24 A G 14: 50,662,507 (GRCm39) D177G probably damaging Het
Or13a18 A G 7: 140,190,961 (GRCm39) N286S probably damaging Het
Or1e23 A T 11: 73,407,674 (GRCm39) V117D possibly damaging Het
Or4a80 T A 2: 89,582,285 (GRCm39) M296L probably benign Het
Or5g26 T A 2: 85,493,912 (GRCm39) I289F probably damaging Het
Or5h17 T A 16: 58,820,353 (GRCm39) F102I probably damaging Het
Otoa A T 7: 120,731,633 (GRCm39) M618L probably benign Het
P3r3urf G A 4: 116,030,664 (GRCm39) G23R probably benign Het
Plcg2 A T 8: 118,231,028 (GRCm39) T37S probably benign Het
Plekhg4 T C 8: 106,107,499 (GRCm39) L1010P probably damaging Het
Plxnb1 T C 9: 108,943,675 (GRCm39) F1921L probably damaging Het
Prss47 T A 13: 65,197,303 (GRCm39) K144N probably damaging Het
Rapgef2 T C 3: 78,988,531 (GRCm39) K953E probably damaging Het
Rasip1 T A 7: 45,288,148 (GRCm39) I909N probably damaging Het
Rps5 A G 7: 12,656,922 (GRCm39) T8A probably benign Het
Rsbn1l T C 5: 21,132,621 (GRCm39) K213E possibly damaging Het
Serpinb5 T C 1: 106,809,700 (GRCm39) F369L probably benign Het
Slc4a5 T C 6: 83,241,297 (GRCm39) V306A probably benign Het
Sox13 T C 1: 133,312,369 (GRCm39) Y465C probably damaging Het
Sox13 C A 1: 133,312,311 (GRCm39) K484N probably damaging Het
Stx3 A G 19: 11,769,208 (GRCm39) I39T possibly damaging Het
Tbc1d5 T C 17: 51,273,763 (GRCm39) Y116C probably damaging Het
Tcp11l1 T A 2: 104,514,480 (GRCm39) Q429L probably benign Het
Tns3 G A 11: 8,401,442 (GRCm39) T952I probably benign Het
Trib3 T C 2: 152,181,692 (GRCm39) H176R possibly damaging Het
Trim12a A G 7: 103,950,049 (GRCm39) Y297H probably damaging Het
Unc13a A G 8: 72,083,603 (GRCm39) V1577A probably damaging Het
Vezf1 C A 11: 87,965,489 (GRCm39) P244T probably damaging Het
Vmn1r121 T A 7: 20,831,945 (GRCm39) D165V probably damaging Het
Vmn2r117 T A 17: 23,679,107 (GRCm39) I706F probably benign Het
Vmn2r117 C T 17: 23,679,319 (GRCm39) C635Y probably damaging Het
Vmn2r13 T A 5: 109,339,909 (GRCm39) H22L probably benign Het
Vmn2r87 A T 10: 130,308,588 (GRCm39) M550K probably damaging Het
Wdr6 A G 9: 108,451,489 (GRCm39) L798P probably damaging Het
Wtap C T 17: 13,199,821 (GRCm39) G54D probably benign Het
Zkscan3 A T 13: 21,572,608 (GRCm39) Y341* probably null Het
Other mutations in Zfp827
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01448:Zfp827 APN 8 79,787,362 (GRCm39) missense possibly damaging 0.82
IGL01545:Zfp827 APN 8 79,797,063 (GRCm39) missense probably damaging 1.00
IGL01552:Zfp827 APN 8 79,802,820 (GRCm39) missense probably damaging 1.00
IGL02261:Zfp827 APN 8 79,906,708 (GRCm39) missense probably damaging 0.97
IGL02451:Zfp827 APN 8 79,787,601 (GRCm39) missense probably damaging 1.00
IGL03130:Zfp827 APN 8 79,787,586 (GRCm39) missense probably damaging 1.00
IGL03411:Zfp827 APN 8 79,803,116 (GRCm39) missense probably damaging 0.99
E0354:Zfp827 UTSW 8 79,863,206 (GRCm39) missense probably damaging 1.00
R0502:Zfp827 UTSW 8 79,905,706 (GRCm39) splice site probably null
R0547:Zfp827 UTSW 8 79,786,939 (GRCm39) missense probably damaging 1.00
R0926:Zfp827 UTSW 8 79,844,821 (GRCm39) missense probably benign 0.00
R0975:Zfp827 UTSW 8 79,787,814 (GRCm39) missense probably benign 0.00
R1305:Zfp827 UTSW 8 79,787,523 (GRCm39) missense possibly damaging 0.95
R1462:Zfp827 UTSW 8 79,803,108 (GRCm39) missense probably benign
R1462:Zfp827 UTSW 8 79,803,108 (GRCm39) missense probably benign
R1638:Zfp827 UTSW 8 79,802,975 (GRCm39) missense possibly damaging 0.94
R1714:Zfp827 UTSW 8 79,787,202 (GRCm39) missense probably damaging 1.00
R2044:Zfp827 UTSW 8 79,802,865 (GRCm39) missense probably benign
R2132:Zfp827 UTSW 8 79,912,350 (GRCm39) missense possibly damaging 0.53
R3844:Zfp827 UTSW 8 79,863,248 (GRCm39) missense probably damaging 0.99
R4329:Zfp827 UTSW 8 79,916,463 (GRCm39) utr 3 prime probably benign
R4629:Zfp827 UTSW 8 79,787,011 (GRCm39) missense probably damaging 0.99
R4873:Zfp827 UTSW 8 79,787,403 (GRCm39) missense probably damaging 1.00
R4875:Zfp827 UTSW 8 79,787,403 (GRCm39) missense probably damaging 1.00
R4936:Zfp827 UTSW 8 79,787,812 (GRCm39) missense probably benign
R4965:Zfp827 UTSW 8 79,787,910 (GRCm39) missense probably benign
R5103:Zfp827 UTSW 8 79,797,032 (GRCm39) missense probably damaging 1.00
R5366:Zfp827 UTSW 8 79,912,333 (GRCm39) missense possibly damaging 0.94
R5794:Zfp827 UTSW 8 79,797,071 (GRCm39) missense probably damaging 1.00
R5825:Zfp827 UTSW 8 79,905,645 (GRCm39) missense probably damaging 1.00
R6118:Zfp827 UTSW 8 79,803,067 (GRCm39) missense possibly damaging 0.75
R6236:Zfp827 UTSW 8 79,797,105 (GRCm39) missense probably damaging 1.00
R6263:Zfp827 UTSW 8 79,905,702 (GRCm39) missense probably damaging 1.00
R6306:Zfp827 UTSW 8 79,787,324 (GRCm39) missense probably damaging 1.00
R6490:Zfp827 UTSW 8 79,916,606 (GRCm39) utr 3 prime probably benign
R6497:Zfp827 UTSW 8 79,906,757 (GRCm39) missense probably damaging 1.00
R7250:Zfp827 UTSW 8 79,916,721 (GRCm39) missense
R7290:Zfp827 UTSW 8 79,916,442 (GRCm39) missense possibly damaging 0.86
R7708:Zfp827 UTSW 8 79,902,591 (GRCm39) missense probably damaging 1.00
R7754:Zfp827 UTSW 8 79,916,958 (GRCm39) missense
R7836:Zfp827 UTSW 8 79,912,979 (GRCm39) missense probably damaging 1.00
R7995:Zfp827 UTSW 8 79,844,887 (GRCm39) missense possibly damaging 0.86
R8162:Zfp827 UTSW 8 79,787,206 (GRCm39) nonsense probably null
R8747:Zfp827 UTSW 8 79,755,316 (GRCm39) start codon destroyed probably null
R8798:Zfp827 UTSW 8 79,916,463 (GRCm39) utr 3 prime probably benign
R8980:Zfp827 UTSW 8 79,803,092 (GRCm39) missense probably benign 0.00
R9099:Zfp827 UTSW 8 79,917,107 (GRCm39) missense
R9178:Zfp827 UTSW 8 79,818,564 (GRCm39) missense probably damaging 1.00
R9246:Zfp827 UTSW 8 79,803,132 (GRCm39) missense possibly damaging 0.75
R9277:Zfp827 UTSW 8 79,787,029 (GRCm39) missense probably damaging 0.97
R9318:Zfp827 UTSW 8 79,844,982 (GRCm39) missense possibly damaging 0.75
R9339:Zfp827 UTSW 8 79,844,887 (GRCm39) missense probably benign 0.00
R9425:Zfp827 UTSW 8 79,905,588 (GRCm39) missense probably damaging 1.00
R9499:Zfp827 UTSW 8 79,787,403 (GRCm39) missense probably damaging 1.00
R9544:Zfp827 UTSW 8 79,905,604 (GRCm39) missense probably damaging 1.00
R9551:Zfp827 UTSW 8 79,787,403 (GRCm39) missense probably damaging 1.00
R9552:Zfp827 UTSW 8 79,787,403 (GRCm39) missense probably damaging 1.00
R9588:Zfp827 UTSW 8 79,905,604 (GRCm39) missense probably damaging 1.00
R9665:Zfp827 UTSW 8 79,906,756 (GRCm39) missense possibly damaging 0.89
Predicted Primers PCR Primer
(F):5'- CAAGAAAGGCCTGAGTCCAG -3'
(R):5'- AGCAACATACACCTGCTGG -3'

Sequencing Primer
(F):5'- GGTCATGTCTGCCTCTCAGG -3'
(R):5'- CACCTGCTGGGGTTGTG -3'
Posted On 2019-10-07