Mutagenetix > Incidental Mutation

Incidental Mutation 'R7445:Svep1'

577212

Institutional Source

Beutler Lab

Gene Symbol

Svep1

Ensembl Gene

ENSMUSG00000028369

Gene Name

sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1

Synonyms

D430029O09Rik, 4833413O10Rik, Polydom, 1110021D17Rik

MMRRC Submission

045521-MU

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R7445 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

58042442-58206859 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 58094122 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Lysine at position 1505 (N1505K)

Ref Sequence

ENSEMBL: ENSMUSP00000045856 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000042850]

AlphaFold

no structure available at present

Predicted Effect

possibly damaging
Transcript: ENSMUST00000042850
AA Change: N1505K

PolyPhen 2 Score 0.847 (Sensitivity: 0.83; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000045856
Gene: ENSMUSG00000028369
AA Change: N1505K

Domain	Start	End	E-Value	Type
signal peptide	1	17	N/A	INTRINSIC
low complexity region	51	60	N/A	INTRINSIC
VWA	82	261	2.18e-32	SMART
Pfam:GCC2_GCC3	311	361	3.4e-14	PFAM
CCP	379	434	3.62e-8	SMART
CCP	439	494	1.78e-16	SMART
CCP	499	559	2.13e-5	SMART
Pfam:HYR	560	642	1.7e-20	PFAM
Pfam:HYR	643	722	4.6e-15	PFAM
CCP	727	787	3.59e-1	SMART
low complexity region	862	873	N/A	INTRINSIC
Pfam:GCC2_GCC3	1004	1051	3.2e-16	PFAM
Pfam:GCC2_GCC3	1058	1105	5.4e-19	PFAM
Pfam:GCC2_GCC3	1112	1159	7.7e-19	PFAM
EGF	1195	1228	3.12e-7	SMART
EGF_CA	1230	1266	3.93e-13	SMART
EGF_CA	1268	1304	8.3e-12	SMART
EGF_CA	1306	1342	4.59e-14	SMART
EGF_CA	1344	1380	8.69e-15	SMART
EGF_CA	1382	1418	3.42e-13	SMART
Pfam:Pentaxin	1429	1622	1.8e-28	PFAM
Pfam:Laminin_G_3	1432	1589	1.1e-20	PFAM
CCP	1630	1684	1.71e-9	SMART
CCP	1689	1742	2.31e-15	SMART
EGF_CA	1744	1783	5.23e-9	SMART
CCP	1788	1841	4.62e-15	SMART
CCP	1846	1899	8.29e-17	SMART
CCP	1904	1957	1.1e-12	SMART
CCP	1962	2015	5.6e-14	SMART
CCP	2020	2077	4.15e-8	SMART
CCP	2082	2140	8.11e-11	SMART
CCP	2145	2198	4.38e-16	SMART
CCP	2203	2258	1.69e-8	SMART
CCP	2263	2317	1.42e-15	SMART
CCP	2322	2375	3.1e-7	SMART
CCP	2380	2434	4.55e-14	SMART
CCP	2439	2492	6.95e-10	SMART
CCP	2497	2550	8.88e-17	SMART
CCP	2555	2607	1.7e-13	SMART
CCP	2651	2709	1.02e-7	SMART
CCP	2714	2767	9.6e-13	SMART
CCP	2772	2825	3.64e-13	SMART
CCP	2830	2883	6.63e-16	SMART
CCP	2888	2941	2.76e-13	SMART
CCP	2946	2999	4.41e-12	SMART
CCP	3004	3055	4.25e-5	SMART
CCP	3060	3113	5.15e-13	SMART
CCP	3118	3172	2.11e-9	SMART
CCP	3177	3232	1.02e-7	SMART
CCP	3237	3290	6.19e-16	SMART
CCP	3295	3348	5.35e-11	SMART
CCP	3353	3407	8.43e-9	SMART
CCP	3412	3464	2.44e-14	SMART
EGF	3467	3496	1.28e-3	SMART
EGF	3499	3528	1.15e-5	SMART
EGF	3531	3560	2.85e-1	SMART

Meta Mutation Damage Score

0.4026

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.8%
20x: 99.2%

Validation Efficiency

100% (67/67)

MGI Phenotype

PHENOTYPE: Mice homozygous for a knock-out allele exhibit complete preweaning lethality, edema, abnormal skin coloration, thick epidermis, acanthosis, and tail/limb abnormalities. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 65 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
0610040J01Rik	T	A	5: 63,898,619 (GRCm38)	S233T	probably damaging	Het
1700034E13Rik	T	A	18: 52,660,481 (GRCm38)	C29S	probably damaging	Het
1700061G19Rik	G	A	17: 56,882,973 (GRCm38)	R333Q	possibly damaging	Het
9130409I23Rik	A	G	1: 181,055,012 (GRCm38)	N113S	possibly damaging	Het
Ank3	A	G	10: 69,992,124 (GRCm38)	T2208A		Het
Ap4s1	T	C	12: 51,738,641 (GRCm38)	L132P	probably damaging	Het
Ascl4	C	T	10: 85,928,500 (GRCm38)	R4C	probably benign	Het
Brd7	A	T	8: 88,361,708 (GRCm38)	Y18N	probably damaging	Het
Cacna2d3	A	G	14: 29,058,618 (GRCm38)	S648P	possibly damaging	Het
Camta1	C	T	4: 151,144,291 (GRCm38)	E695K	possibly damaging	Het
Ccdc28b	A	G	4: 129,622,607 (GRCm38)	F53L	probably benign	Het
Chaf1a	A	G	17: 56,062,170 (GRCm38)	D467G	possibly damaging	Het
Cnnm1	G	A	19: 43,440,821 (GRCm38)	R126H	possibly damaging	Het
Cog5	T	G	12: 31,919,672 (GRCm38)	S730R	possibly damaging	Het
Col11a1	A	T	3: 114,193,929 (GRCm38)	E1374D	unknown	Het
Csmd1	A	G	8: 16,158,254 (GRCm38)	I1229T	possibly damaging	Het
Dnajc30	T	C	5: 135,064,378 (GRCm38)	L43P	probably damaging	Het
Eif3f	C	T	7: 108,934,658 (GRCm38)	T76M	unknown	Het
Ermap	G	A	4: 119,188,710 (GRCm38)	T42I	unknown	Het
Gpd1l	C	T	9: 114,920,674 (GRCm38)	G25S	probably damaging	Het
Heatr1	G	T	13: 12,431,038 (GRCm38)	W1632L	possibly damaging	Het
Ice1	T	C	13: 70,596,167 (GRCm38)	D29G		Het
Ipo8	T	C	6: 148,789,817 (GRCm38)	D685G	probably benign	Het
Klra10	T	C	6: 130,275,856 (GRCm38)	T152A	probably benign	Het
Lmntd1	T	A	6: 145,429,967 (GRCm38)	S82C	probably damaging	Het
Maip1	T	C	1: 57,407,031 (GRCm38)	S87P	possibly damaging	Het
Mapkapk2	A	G	1: 131,097,519 (GRCm38)	S3P	unknown	Het
Mei4	A	G	9: 81,890,239 (GRCm38)	Y35C	possibly damaging	Het
Ms4a14	T	G	19: 11,302,972 (GRCm38)	K741Q	probably benign	Het
Naip2	A	C	13: 100,161,782 (GRCm38)	I582S	probably benign	Het
Ncapg2	A	G	12: 116,419,268 (GRCm38)	I240V	possibly damaging	Het
Ncbp1	T	A	4: 46,149,914 (GRCm38)	M145K	probably damaging	Het
Nmur2	A	G	11: 56,032,940 (GRCm38)	F263L	probably damaging	Het
Ntrk2	A	G	13: 58,846,762 (GRCm38)	E164G	probably benign	Het
Olfr48	T	A	2: 89,844,272 (GRCm38)	T234S	probably damaging	Het
Olfr705	A	G	7: 106,873,342 (GRCm38)	L301S	possibly damaging	Het
Olfr785	A	T	10: 129,409,885 (GRCm38)	D173V	probably benign	Het
P3h2	T	A	16: 25,985,065 (GRCm38)	Y317F	probably damaging	Het
Pcmtd1	C	T	1: 7,120,420 (GRCm38)	R38C	probably damaging	Het
Pcyox1	T	C	6: 86,391,679 (GRCm38)	T286A	possibly damaging	Het
Pdxk	T	C	10: 78,447,967 (GRCm38)	D131G	probably benign	Het
Ppl	T	C	16: 5,089,068 (GRCm38)	D1121G	probably damaging	Het
Prkra	T	C	2: 76,633,598 (GRCm38)	D240G	probably benign	Het
Ptgs1	C	A	2: 36,245,210 (GRCm38)	N395K	probably benign	Het
Ptprq	A	T	10: 107,590,959 (GRCm38)	Y1572N	probably damaging	Het
Pyroxd1	A	T	6: 142,358,501 (GRCm38)	H326L	probably benign	Het
Rapgef5	A	G	12: 117,755,969 (GRCm38)	D778G	probably benign	Het
Rbm46	T	A	3: 82,864,210 (GRCm38)	E366V	probably damaging	Het
Rnd1	G	T	15: 98,670,669 (GRCm38)	H209Q	probably benign	Het
Rnf122	A	T	8: 31,118,500 (GRCm38)	D32V	possibly damaging	Het
Samd4b	G	A	7: 28,406,456 (GRCm38)	P446S	probably benign	Het
Slco1a5	C	A	6: 142,259,008 (GRCm38)	A187S	possibly damaging	Het
Smarca4	G	A	9: 21,686,247 (GRCm38)	V1436M	probably damaging	Het
Smok2a	G	A	17: 13,226,639 (GRCm38)	G368R	possibly damaging	Het
Smok3c	T	A	5: 138,064,495 (GRCm38)	H81Q	probably damaging	Het
Soga3	T	C	10: 29,197,003 (GRCm38)	S764P	possibly damaging	Het
Stk16	T	C	1: 75,213,652 (GRCm38)	V245A	probably damaging	Het
Tigd4	G	A	3: 84,595,164 (GRCm38)	A463T	probably benign	Het
Tmem117	T	C	15: 94,714,918 (GRCm38)	F112L	probably benign	Het
Tmem72	A	G	6: 116,698,330 (GRCm38)	I67T	probably benign	Het
Tnik	A	G	3: 28,663,909 (GRCm38)		probably null	Het
Trav14-2	A	G	14: 53,641,058 (GRCm38)	Q66R	probably damaging	Het
Trpv6	T	A	6: 41,621,342 (GRCm38)	D677V	probably damaging	Het
Vgll4	C	T	6: 114,862,196 (GRCm38)	S278N	unknown	Het
Wdfy4	C	T	14: 33,070,618 (GRCm38)	W2157*	probably null	Het

Other mutations in Svep1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00475:Svep1	APN	4	58,176,077 (GRCm38)	missense	probably damaging	0.98
IGL00489:Svep1	APN	4	58,068,988 (GRCm38)	missense	possibly damaging	0.71
IGL00496:Svep1	APN	4	58,069,001 (GRCm38)	missense	possibly damaging	0.95
IGL00864:Svep1	APN	4	58,068,533 (GRCm38)	nonsense	probably null
IGL00904:Svep1	APN	4	58,097,398 (GRCm38)	missense	probably benign	0.00
IGL00935:Svep1	APN	4	58,090,664 (GRCm38)	missense	possibly damaging	0.71
IGL00963:Svep1	APN	4	58,072,791 (GRCm38)	nonsense	probably null
IGL01077:Svep1	APN	4	58,068,760 (GRCm38)	missense	possibly damaging	0.71
IGL01084:Svep1	APN	4	58,111,419 (GRCm38)	missense	possibly damaging	0.71
IGL01150:Svep1	APN	4	58,070,302 (GRCm38)	missense	probably benign	0.04
IGL01161:Svep1	APN	4	58,146,569 (GRCm38)	missense	probably damaging	0.96
IGL01360:Svep1	APN	4	58,116,554 (GRCm38)	missense	possibly damaging	0.73
IGL01365:Svep1	APN	4	58,100,878 (GRCm38)	critical splice acceptor site	probably null
IGL01396:Svep1	APN	4	58,068,552 (GRCm38)	missense	possibly damaging	0.85
IGL01601:Svep1	APN	4	58,084,872 (GRCm38)	missense	probably damaging	1.00
IGL01636:Svep1	APN	4	58,116,622 (GRCm38)	missense	possibly damaging	0.96
IGL01838:Svep1	APN	4	58,121,910 (GRCm38)	missense	possibly damaging	0.72
IGL01949:Svep1	APN	4	58,176,006 (GRCm38)	missense	probably damaging	1.00
IGL01984:Svep1	APN	4	58,068,877 (GRCm38)	missense	possibly damaging	0.93
IGL02005:Svep1	APN	4	58,069,056 (GRCm38)	missense	possibly damaging	0.93
IGL02036:Svep1	APN	4	58,088,245 (GRCm38)	missense	possibly damaging	0.85
IGL02039:Svep1	APN	4	58,123,980 (GRCm38)	critical splice donor site	probably null
IGL02043:Svep1	APN	4	58,068,556 (GRCm38)	missense	probably benign	0.19
IGL02073:Svep1	APN	4	58,070,104 (GRCm38)	missense	probably benign	0.06
IGL02188:Svep1	APN	4	58,068,382 (GRCm38)	missense	possibly damaging	0.71
IGL02256:Svep1	APN	4	58,070,311 (GRCm38)	missense	possibly damaging	0.71
IGL02284:Svep1	APN	4	58,072,819 (GRCm38)	missense	probably benign	0.32
IGL02323:Svep1	APN	4	58,070,236 (GRCm38)	nonsense	probably null
IGL02440:Svep1	APN	4	58,145,293 (GRCm38)	missense	probably benign	0.06
IGL02449:Svep1	APN	4	58,070,296 (GRCm38)	missense	possibly damaging	0.71
IGL02501:Svep1	APN	4	58,145,341 (GRCm38)	splice site	probably benign
IGL02568:Svep1	APN	4	58,135,441 (GRCm38)	missense	probably benign	0.42
IGL02625:Svep1	APN	4	58,115,807 (GRCm38)	missense	possibly damaging	0.53
IGL02795:Svep1	APN	4	58,123,223 (GRCm38)	missense	probably damaging	1.00
IGL02818:Svep1	APN	4	58,069,804 (GRCm38)	missense	possibly damaging	0.71
IGL02871:Svep1	APN	4	58,100,871 (GRCm38)	missense	probably benign
IGL02875:Svep1	APN	4	58,082,821 (GRCm38)	splice site	probably benign
IGL02887:Svep1	APN	4	58,145,301 (GRCm38)	missense	probably damaging	1.00
IGL03240:Svep1	APN	4	58,048,188 (GRCm38)	missense	possibly damaging	0.73
IGL03243:Svep1	APN	4	58,133,387 (GRCm38)	missense	probably benign	0.06
IGL03264:Svep1	APN	4	58,066,422 (GRCm38)	splice site	probably benign
IGL03288:Svep1	APN	4	58,116,532 (GRCm38)	missense	probably benign	0.01
IGL03340:Svep1	APN	4	58,111,451 (GRCm38)	missense	possibly damaging	0.96
IGL03341:Svep1	APN	4	58,070,308 (GRCm38)	nonsense	probably null
IGL03348:Svep1	APN	4	58,113,635 (GRCm38)	missense	probably damaging	1.00
R0001:Svep1	UTSW	4	58,066,460 (GRCm38)	missense	possibly damaging	0.93
R0042:Svep1	UTSW	4	58,123,192 (GRCm38)	missense	possibly damaging	0.92
R0042:Svep1	UTSW	4	58,123,192 (GRCm38)	missense	possibly damaging	0.92
R0125:Svep1	UTSW	4	58,099,937 (GRCm38)	splice site	probably benign
R0142:Svep1	UTSW	4	58,118,232 (GRCm38)	missense	probably benign	0.33
R0147:Svep1	UTSW	4	58,116,608 (GRCm38)	missense	possibly damaging	0.85
R0148:Svep1	UTSW	4	58,116,608 (GRCm38)	missense	possibly damaging	0.85
R0157:Svep1	UTSW	4	58,069,830 (GRCm38)	missense	possibly damaging	0.72
R0195:Svep1	UTSW	4	58,089,514 (GRCm38)	missense	possibly damaging	0.82
R0197:Svep1	UTSW	4	58,070,851 (GRCm38)	missense	possibly damaging	0.71
R0257:Svep1	UTSW	4	58,179,610 (GRCm38)	missense	possibly damaging	0.71
R0314:Svep1	UTSW	4	58,096,331 (GRCm38)	missense	possibly damaging	0.71
R0316:Svep1	UTSW	4	58,072,737 (GRCm38)	missense	probably damaging	0.98
R0322:Svep1	UTSW	4	58,057,996 (GRCm38)	splice site	probably benign
R0426:Svep1	UTSW	4	58,073,333 (GRCm38)	missense	possibly damaging	0.87
R0446:Svep1	UTSW	4	58,088,280 (GRCm38)	missense	probably damaging	1.00
R0457:Svep1	UTSW	4	58,118,136 (GRCm38)	missense	probably damaging	1.00
R0471:Svep1	UTSW	4	58,054,700 (GRCm38)	missense	possibly damaging	0.85
R0555:Svep1	UTSW	4	58,128,858 (GRCm38)	missense	possibly damaging	0.71
R0634:Svep1	UTSW	4	58,070,661 (GRCm38)	missense	possibly damaging	0.86
R0636:Svep1	UTSW	4	58,073,121 (GRCm38)	nonsense	probably null
R0827:Svep1	UTSW	4	58,053,113 (GRCm38)	splice site	probably benign
R1025:Svep1	UTSW	4	58,087,817 (GRCm38)	missense	possibly damaging	0.86
R1027:Svep1	UTSW	4	58,094,084 (GRCm38)	missense	possibly damaging	0.86
R1069:Svep1	UTSW	4	58,070,239 (GRCm38)	missense	probably damaging	1.00
R1161:Svep1	UTSW	4	58,069,416 (GRCm38)	missense	possibly damaging	0.71
R1245:Svep1	UTSW	4	58,066,427 (GRCm38)	critical splice donor site	probably null
R1282:Svep1	UTSW	4	58,100,032 (GRCm38)	missense	possibly damaging	0.93
R1310:Svep1	UTSW	4	58,069,416 (GRCm38)	missense	possibly damaging	0.71
R1444:Svep1	UTSW	4	58,115,754 (GRCm38)	missense	possibly damaging	0.53
R1460:Svep1	UTSW	4	58,068,740 (GRCm38)	missense	possibly damaging	0.85
R1500:Svep1	UTSW	4	58,070,239 (GRCm38)	missense	probably damaging	1.00
R1628:Svep1	UTSW	4	58,107,561 (GRCm38)	missense	probably benign	0.00
R1712:Svep1	UTSW	4	58,070,629 (GRCm38)	missense	probably benign	0.06
R1774:Svep1	UTSW	4	58,146,562 (GRCm38)	missense	possibly damaging	0.92
R1783:Svep1	UTSW	4	58,073,333 (GRCm38)	missense	probably benign
R1829:Svep1	UTSW	4	58,096,310 (GRCm38)	missense	possibly damaging	0.93
R1978:Svep1	UTSW	4	58,097,292 (GRCm38)	missense	possibly damaging	0.73
R1993:Svep1	UTSW	4	58,064,170 (GRCm38)	critical splice donor site	probably null
R2017:Svep1	UTSW	4	58,070,568 (GRCm38)	missense	probably benign	0.08
R2058:Svep1	UTSW	4	58,084,554 (GRCm38)	missense	possibly damaging	0.92
R2109:Svep1	UTSW	4	58,206,030 (GRCm38)	missense	possibly damaging	0.51
R2215:Svep1	UTSW	4	58,138,602 (GRCm38)	splice site	probably benign
R2281:Svep1	UTSW	4	58,082,677 (GRCm38)	missense	possibly damaging	0.85
R2504:Svep1	UTSW	4	58,135,628 (GRCm38)	splice site	probably null
R2763:Svep1	UTSW	4	58,084,061 (GRCm38)	missense	possibly damaging	0.86
R3122:Svep1	UTSW	4	58,087,845 (GRCm38)	missense	possibly damaging	0.51
R3605:Svep1	UTSW	4	58,066,542 (GRCm38)	missense	probably benign	0.32
R3763:Svep1	UTSW	4	58,084,833 (GRCm38)	missense	possibly damaging	0.89
R3827:Svep1	UTSW	4	58,096,177 (GRCm38)	missense	probably damaging	0.98
R3829:Svep1	UTSW	4	58,096,177 (GRCm38)	missense	probably damaging	0.98
R3830:Svep1	UTSW	4	58,096,177 (GRCm38)	missense	probably damaging	0.98
R3910:Svep1	UTSW	4	58,145,156 (GRCm38)	critical splice donor site	probably null
R3943:Svep1	UTSW	4	58,084,807 (GRCm38)	splice site	probably null
R3944:Svep1	UTSW	4	58,084,807 (GRCm38)	splice site	probably null
R4153:Svep1	UTSW	4	58,089,426 (GRCm38)	missense	possibly damaging	0.52
R4154:Svep1	UTSW	4	58,069,068 (GRCm38)	missense	possibly damaging	0.71
R4191:Svep1	UTSW	4	58,046,601 (GRCm38)	missense	possibly damaging	0.86
R4355:Svep1	UTSW	4	58,138,695 (GRCm38)	missense	possibly damaging	0.71
R4388:Svep1	UTSW	4	58,069,249 (GRCm38)	missense	possibly damaging	0.93
R4532:Svep1	UTSW	4	58,068,886 (GRCm38)	missense	possibly damaging	0.52
R4584:Svep1	UTSW	4	58,068,526 (GRCm38)	nonsense	probably null
R4592:Svep1	UTSW	4	58,084,028 (GRCm38)	missense	possibly damaging	0.93
R4593:Svep1	UTSW	4	58,091,944 (GRCm38)	missense	possibly damaging	0.71
R4625:Svep1	UTSW	4	58,072,698 (GRCm38)	missense	probably damaging	0.98
R4639:Svep1	UTSW	4	58,082,724 (GRCm38)	missense	probably benign
R4700:Svep1	UTSW	4	58,097,323 (GRCm38)	missense	possibly damaging	0.71
R4720:Svep1	UTSW	4	58,205,869 (GRCm38)	missense	possibly damaging	0.71
R4724:Svep1	UTSW	4	58,070,752 (GRCm38)	missense	possibly damaging	0.71
R4753:Svep1	UTSW	4	58,053,212 (GRCm38)	missense	probably benign	0.06
R4781:Svep1	UTSW	4	58,070,340 (GRCm38)	missense	probably damaging	0.98
R4820:Svep1	UTSW	4	58,082,664 (GRCm38)	missense	probably benign	0.27
R4896:Svep1	UTSW	4	58,087,751 (GRCm38)	missense	probably benign	0.08
R4905:Svep1	UTSW	4	58,069,308 (GRCm38)	missense	probably benign	0.00
R4910:Svep1	UTSW	4	58,096,276 (GRCm38)	missense	possibly damaging	0.71
R4972:Svep1	UTSW	4	58,087,778 (GRCm38)	missense	possibly damaging	0.71
R5004:Svep1	UTSW	4	58,087,751 (GRCm38)	missense	probably benign	0.08
R5088:Svep1	UTSW	4	58,120,648 (GRCm38)	missense	possibly damaging	0.73
R5112:Svep1	UTSW	4	58,068,610 (GRCm38)	nonsense	probably null
R5185:Svep1	UTSW	4	58,084,534 (GRCm38)	missense	probably damaging	0.99
R5302:Svep1	UTSW	4	58,096,183 (GRCm38)	missense	possibly damaging	0.71
R5307:Svep1	UTSW	4	58,072,677 (GRCm38)	missense	possibly damaging	0.71
R5339:Svep1	UTSW	4	58,121,892 (GRCm38)	missense	possibly damaging	0.96
R5379:Svep1	UTSW	4	58,072,991 (GRCm38)	missense	possibly damaging	0.51
R5384:Svep1	UTSW	4	58,104,545 (GRCm38)	missense	possibly damaging	0.71
R5414:Svep1	UTSW	4	58,206,322 (GRCm38)	missense	possibly damaging	0.53
R5514:Svep1	UTSW	4	58,044,054 (GRCm38)	missense	possibly damaging	0.53
R5538:Svep1	UTSW	4	58,049,282 (GRCm38)	critical splice acceptor site	probably null
R5549:Svep1	UTSW	4	58,057,954 (GRCm38)	missense	probably benign	0.32
R5618:Svep1	UTSW	4	58,070,537 (GRCm38)	missense	probably benign
R5623:Svep1	UTSW	4	58,091,964 (GRCm38)	missense	possibly damaging	0.92
R5686:Svep1	UTSW	4	58,072,826 (GRCm38)	missense	possibly damaging	0.71
R5743:Svep1	UTSW	4	58,096,223 (GRCm38)	missense	possibly damaging	0.71
R5773:Svep1	UTSW	4	58,099,985 (GRCm38)	missense	possibly damaging	0.86
R5809:Svep1	UTSW	4	58,116,524 (GRCm38)	missense	possibly damaging	0.73
R5896:Svep1	UTSW	4	58,084,906 (GRCm38)	missense	possibly damaging	0.71
R5918:Svep1	UTSW	4	58,069,345 (GRCm38)	missense	possibly damaging	0.71
R5969:Svep1	UTSW	4	58,070,977 (GRCm38)	nonsense	probably null
R6010:Svep1	UTSW	4	58,115,832 (GRCm38)	missense	possibly damaging	0.95
R6187:Svep1	UTSW	4	58,072,872 (GRCm38)	missense	probably damaging	1.00
R6192:Svep1	UTSW	4	58,104,536 (GRCm38)	missense	possibly damaging	0.92
R6209:Svep1	UTSW	4	58,128,869 (GRCm38)	missense	probably benign	0.32
R6234:Svep1	UTSW	4	58,113,458 (GRCm38)	splice site	probably null
R6326:Svep1	UTSW	4	58,073,045 (GRCm38)	missense	possibly damaging	0.51
R6400:Svep1	UTSW	4	58,049,169 (GRCm38)	missense	probably damaging	1.00
R6418:Svep1	UTSW	4	58,053,126 (GRCm38)	missense	probably benign	0.01
R6440:Svep1	UTSW	4	58,116,555 (GRCm38)	missense	possibly damaging	0.53
R6489:Svep1	UTSW	4	58,100,066 (GRCm38)	missense	probably damaging	1.00
R6515:Svep1	UTSW	4	58,088,280 (GRCm38)	missense	probably damaging	1.00
R6738:Svep1	UTSW	4	58,123,180 (GRCm38)	missense	possibly damaging	0.71
R6773:Svep1	UTSW	4	58,049,146 (GRCm38)	missense	possibly damaging	0.71
R6796:Svep1	UTSW	4	58,064,275 (GRCm38)	missense	probably benign	0.01
R7055:Svep1	UTSW	4	58,120,642 (GRCm38)	missense	probably benign	0.33
R7055:Svep1	UTSW	4	58,064,275 (GRCm38)	missense	probably benign	0.19
R7111:Svep1	UTSW	4	58,118,207 (GRCm38)	missense	possibly damaging	0.70
R7161:Svep1	UTSW	4	58,128,859 (GRCm38)	missense	possibly damaging	0.93
R7162:Svep1	UTSW	4	58,070,262 (GRCm38)	missense	possibly damaging	0.71
R7182:Svep1	UTSW	4	58,043,991 (GRCm38)	missense	probably benign	0.18
R7292:Svep1	UTSW	4	58,111,395 (GRCm38)	missense	possibly damaging	0.71
R7299:Svep1	UTSW	4	58,046,587 (GRCm38)	nonsense	probably null
R7301:Svep1	UTSW	4	58,046,587 (GRCm38)	nonsense	probably null
R7316:Svep1	UTSW	4	58,068,763 (GRCm38)	missense	possibly damaging	0.71
R7337:Svep1	UTSW	4	58,108,323 (GRCm38)	missense	probably damaging	0.98
R7391:Svep1	UTSW	4	58,145,185 (GRCm38)	missense	probably damaging	0.98
R7402:Svep1	UTSW	4	58,069,699 (GRCm38)	missense	possibly damaging	0.71
R7450:Svep1	UTSW	4	58,064,248 (GRCm38)	missense	possibly damaging	0.71
R7492:Svep1	UTSW	4	58,066,468 (GRCm38)	missense	possibly damaging	0.51
R7505:Svep1	UTSW	4	58,115,862 (GRCm38)	missense	possibly damaging	0.53
R7509:Svep1	UTSW	4	58,090,683 (GRCm38)	missense	probably benign	0.40
R7538:Svep1	UTSW	4	58,053,260 (GRCm38)	missense	possibly damaging	0.71
R7555:Svep1	UTSW	4	58,069,422 (GRCm38)	missense	probably damaging	0.98
R7660:Svep1	UTSW	4	58,087,782 (GRCm38)	missense	probably benign	0.32
R7670:Svep1	UTSW	4	58,097,424 (GRCm38)	missense	probably damaging	1.00
R7719:Svep1	UTSW	4	58,068,523 (GRCm38)	missense	probably damaging	0.97
R7733:Svep1	UTSW	4	58,049,239 (GRCm38)	missense	probably benign	0.03
R7781:Svep1	UTSW	4	58,069,251 (GRCm38)	missense	possibly damaging	0.71
R7821:Svep1	UTSW	4	58,179,601 (GRCm38)	missense	probably damaging	0.99
R7832:Svep1	UTSW	4	58,054,539 (GRCm38)	missense	probably benign	0.44
R8017:Svep1	UTSW	4	58,146,637 (GRCm38)	missense	probably damaging	0.99
R8019:Svep1	UTSW	4	58,146,637 (GRCm38)	missense	probably damaging	0.99
R8066:Svep1	UTSW	4	58,113,650 (GRCm38)	missense	probably benign	0.33
R8159:Svep1	UTSW	4	58,087,815 (GRCm38)	missense	probably benign	0.01
R8159:Svep1	UTSW	4	58,069,396 (GRCm38)	missense	possibly damaging	0.71
R8170:Svep1	UTSW	4	58,069,378 (GRCm38)	missense	probably benign	0.00
R8246:Svep1	UTSW	4	58,091,889 (GRCm38)	missense	probably damaging	0.96
R8392:Svep1	UTSW	4	58,070,566 (GRCm38)	missense	possibly damaging	0.71
R8436:Svep1	UTSW	4	58,044,053 (GRCm38)	missense	possibly damaging	0.86
R8544:Svep1	UTSW	4	58,206,025 (GRCm38)	missense	probably benign	0.00
R8669:Svep1	UTSW	4	58,070,119 (GRCm38)	missense	possibly damaging	0.95
R8707:Svep1	UTSW	4	58,070,197 (GRCm38)	nonsense	probably null
R8790:Svep1	UTSW	4	58,118,145 (GRCm38)	missense	possibly damaging	0.53
R8804:Svep1	UTSW	4	58,206,043 (GRCm38)	missense	possibly damaging	0.86
R8868:Svep1	UTSW	4	58,135,578 (GRCm38)	missense	possibly damaging	0.77
R8880:Svep1	UTSW	4	58,064,204 (GRCm38)	missense	possibly damaging	0.51
R8949:Svep1	UTSW	4	58,054,604 (GRCm38)	missense	possibly damaging	0.85
R9007:Svep1	UTSW	4	58,091,915 (GRCm38)	missense	possibly damaging	0.86
R9028:Svep1	UTSW	4	58,145,199 (GRCm38)	missense	possibly damaging	0.92
R9131:Svep1	UTSW	4	58,087,778 (GRCm38)	missense	possibly damaging	0.71
R9285:Svep1	UTSW	4	58,084,809 (GRCm38)	critical splice donor site	probably null
R9302:Svep1	UTSW	4	58,120,565 (GRCm38)	missense	possibly damaging	0.53
R9314:Svep1	UTSW	4	58,070,347 (GRCm38)	missense	probably damaging	1.00
R9427:Svep1	UTSW	4	58,069,804 (GRCm38)	missense	possibly damaging	0.71
R9443:Svep1	UTSW	4	58,179,697 (GRCm38)	missense	possibly damaging	0.95
R9473:Svep1	UTSW	4	58,064,243 (GRCm38)	missense	probably benign	0.00
R9487:Svep1	UTSW	4	58,070,517 (GRCm38)	missense	probably benign
R9494:Svep1	UTSW	4	58,070,577 (GRCm38)	missense	possibly damaging	0.51
R9515:Svep1	UTSW	4	58,084,144 (GRCm38)	missense	possibly damaging	0.71
R9681:Svep1	UTSW	4	58,084,959 (GRCm38)	missense	probably damaging	0.98
X0063:Svep1	UTSW	4	58,070,468 (GRCm38)	nonsense	probably null
Z1176:Svep1	UTSW	4	58,133,415 (GRCm38)	missense	possibly damaging	0.51
Z1176:Svep1	UTSW	4	58,115,814 (GRCm38)	missense	possibly damaging	0.93
Z1176:Svep1	UTSW	4	58,111,386 (GRCm38)	missense	probably damaging	0.97
Z1177:Svep1	UTSW	4	58,206,300 (GRCm38)	missense	probably damaging	0.99
Z1177:Svep1	UTSW	4	58,115,841 (GRCm38)	missense	possibly damaging	0.91

Predicted Primers

PCR Primer
(F):5'- AAGCATGACCATCTGCAGAGTC -3'
(R):5'- CCCAAGACTTTTCCTTGATCATCAG -3'

Sequencing Primer
(F):5'- TCTGCAGAGTCTCATACACATG -3'
(R):5'- CCTTGATCATCAGTGTTTACATTGAC -3'

Posted On

2019-10-07