|Institutional Source||Beutler Lab|
|Gene Name||non-SMC condensin II complex, subunit G2|
|Synonyms||Luzp5, 5830426I05Rik, mCAP-G2, Mtb|
|Is this an essential gene?||Essential (E-score: 1.000)|
|Stock #||R7445 (G1)|
|Chromosomal Location||116405402-116463731 bp(+) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||A to G at 116419268 bp (GRCm38)|
|Amino Acid Change||Isoleucine to Valine at position 240 (I240V)|
|Ref Sequence||ENSEMBL: ENSMUSP00000081889 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000084828]|
AA Change: I240V
PolyPhen 2 Score 0.502 (Sensitivity: 0.88; Specificity: 0.90)
AA Change: I240V
|Coding Region Coverage||
|Validation Efficiency||100% (67/67)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that belongs to the Condensin2nSMC family of proteins. The encoded protein is a regulatory subunit of the condensin II complex which, along with the condensin I complex, plays a role in chromosome assembly and segregation during mitosis. A similar protein in mouse is required for early development of the embryo. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
PHENOTYPE: Homozygous null embryos exhibit impaired inner cell mass expansion and die shortly after implantation and prior to gastrulation and blood cell development. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Ncapg2||
(F):5'- AAGTGATACTGACTTGGGCTTC -3'
(R):5'- AGACTGGAGATCAACCTGGG -3'
(F):5'- GGGCTTCATTTTTATAAATAGCTGAC -3'
(R):5'- GGGCTACATATCAAGACCTTGTC -3'