Incidental Mutation 'R7446:Or10ak9'
ID 577281
Institutional Source Beutler Lab
Gene Symbol Or10ak9
Ensembl Gene ENSMUSG00000073769
Gene Name olfactory receptor family 10 subfamily AK member 9
Synonyms MOR259-3P, GA_x6K02T2QD9B-18670866-18669913, Olfr1331
MMRRC Submission 045522-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.054) question?
Stock # R7446 (G1)
Quality Score 225.009
Status Validated
Chromosome 4
Chromosomal Location 118725980-118726933 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 118726019 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 14 (I14F)
Ref Sequence ENSEMBL: ENSMUSP00000101967 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000094831] [ENSMUST00000106360] [ENSMUST00000216589]
AlphaFold K7N684
Predicted Effect possibly damaging
Transcript: ENSMUST00000094831
AA Change: I14F

PolyPhen 2 Score 0.827 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000092426
Gene: ENSMUSG00000073769
AA Change: I14F

DomainStartEndE-ValueType
Pfam:7tm_4 32 308 2.1e-53 PFAM
Pfam:7tm_1 42 291 3.9e-22 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000106360
AA Change: I14F

PolyPhen 2 Score 0.827 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000101967
Gene: ENSMUSG00000073769
AA Change: I14F

DomainStartEndE-ValueType
Pfam:7tm_1 41 290 1.2e-28 PFAM
Pfam:7tm_4 139 283 2.8e-45 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000216589
AA Change: I13F

PolyPhen 2 Score 0.892 (Sensitivity: 0.82; Specificity: 0.94)
Meta Mutation Damage Score 0.0839 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency 100% (67/67)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 66 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930407I10Rik A G 15: 81,950,441 (GRCm39) D1446G probably benign Het
Adgrg1 A G 8: 95,738,412 (GRCm39) Y635C probably damaging Het
Akr1cl G A 1: 65,055,837 (GRCm39) R222W probably damaging Het
C2 G A 17: 35,094,986 (GRCm39) R250C probably damaging Het
Cdk15 A G 1: 59,328,854 (GRCm39) Y254C probably damaging Het
Celsr1 T C 15: 85,791,874 (GRCm39) T2576A possibly damaging Het
Cfap61 C T 2: 145,995,758 (GRCm39) R1108C probably benign Het
Clca3a1 A G 3: 144,733,188 (GRCm39) S107P possibly damaging Het
Cplane1 A G 15: 8,261,564 (GRCm39) D2460G probably damaging Het
Cpsf1 A G 15: 76,485,950 (GRCm39) S407P probably benign Het
Crisp4 T C 1: 18,192,962 (GRCm39) T252A probably damaging Het
Ctbs A G 3: 146,164,573 (GRCm39) Y242C probably damaging Het
Cul4a A G 8: 13,186,874 (GRCm39) T537A probably benign Het
D930020B18Rik T C 10: 121,503,650 (GRCm39) I275T possibly damaging Het
Dcaf7 T C 11: 105,944,561 (GRCm39) V248A probably benign Het
Def8 T C 8: 124,181,061 (GRCm39) C153R probably damaging Het
Dennd1a A T 2: 37,706,991 (GRCm39) V505D possibly damaging Het
Dpysl5 A C 5: 30,936,231 (GRCm39) D207A probably benign Het
Dync2h1 A T 9: 7,041,720 (GRCm39) S3307R probably benign Het
Enpp5 G A 17: 44,396,155 (GRCm39) G356S probably damaging Het
Erf A T 7: 24,945,556 (GRCm39) C72S probably damaging Het
Fastkd3 A T 13: 68,740,079 (GRCm39) H47L unknown Het
Gm5591 C T 7: 38,218,933 (GRCm39) E647K probably benign Het
Gng12 TGTCCAGCAAG TG 6: 66,992,736 (GRCm39) probably benign Het
Guk1 T C 11: 59,076,850 (GRCm39) T78A probably benign Het
Hephl1 T C 9: 15,009,347 (GRCm39) T82A probably damaging Het
Htra4 A G 8: 25,527,181 (GRCm39) S205P probably benign Het
Jakmip2 T C 18: 43,710,390 (GRCm39) D271G probably damaging Het
Krt16 CAGTATCTG C 11: 100,137,610 (GRCm39) probably null Het
Lrp1b T A 2: 41,561,069 (GRCm39) E286V Het
Lrp2 C A 2: 69,262,557 (GRCm39) G4415W probably damaging Het
Lrp2 C T 2: 69,290,018 (GRCm39) R3607H probably damaging Het
Mcph1 A G 8: 18,721,109 (GRCm39) K646E probably benign Het
Mgam T C 6: 40,723,266 (GRCm39) L457P probably damaging Het
Mink1 T A 11: 70,500,455 (GRCm39) S802T probably benign Het
Mrgprb5 C T 7: 47,818,252 (GRCm39) G161E possibly damaging Het
Mroh1 G A 15: 76,336,472 (GRCm39) G1565D possibly damaging Het
Mynn A G 3: 30,661,201 (GRCm39) K51R probably benign Het
Myo1b A G 1: 51,803,065 (GRCm39) F872S possibly damaging Het
Nbas A T 12: 13,443,499 (GRCm39) T1185S probably benign Het
Oas1d A T 5: 121,058,054 (GRCm39) I333L probably benign Het
Or4d10 A G 19: 12,051,061 (GRCm39) *312Q probably null Het
P2ry12 A G 3: 59,124,632 (GRCm39) *348Q probably null Het
Pik3cb A T 9: 98,928,711 (GRCm39) V848E probably damaging Het
Plcz1 A C 6: 139,959,312 (GRCm39) S282A possibly damaging Het
Prss46 A G 9: 110,679,189 (GRCm39) D130G probably damaging Het
Pygl T C 12: 70,243,784 (GRCm39) I644V probably benign Het
Ralgds T A 2: 28,435,901 (GRCm39) S509T probably damaging Het
Rdh16f2 A G 10: 127,712,767 (GRCm39) D255G probably benign Het
Scaf4 T C 16: 90,055,658 (GRCm39) D133G unknown Het
Sdk1 G A 5: 142,130,731 (GRCm39) S1630N probably damaging Het
Sema5b C T 16: 35,467,573 (GRCm39) T279I probably damaging Het
Slc24a3 T A 2: 145,422,902 (GRCm39) L207H probably damaging Het
Speer2 A T 16: 69,654,965 (GRCm39) S167T possibly damaging Het
Spock1 A G 13: 57,583,898 (GRCm39) I339T unknown Het
Srsf6 T A 2: 162,776,636 (GRCm39) S327T unknown Het
Syne1 T A 10: 5,172,266 (GRCm39) E5058D probably benign Het
Tcf19 A G 17: 35,825,428 (GRCm39) V243A probably benign Het
Tspan15 T C 10: 62,029,734 (GRCm39) D122G probably benign Het
Ttc17 C T 2: 94,205,495 (GRCm39) V284M probably damaging Het
Usp29 A C 7: 6,964,219 (GRCm39) T21P possibly damaging Het
Uspl1 T A 5: 149,141,082 (GRCm39) C360* probably null Het
Vmn1r181 A C 7: 23,684,356 (GRCm39) S274R probably benign Het
Xrcc5 T C 1: 72,433,132 (GRCm39) probably null Het
Zfp277 C T 12: 40,378,729 (GRCm39) R376H probably damaging Het
Zfp629 T C 7: 127,210,201 (GRCm39) E536G probably benign Het
Other mutations in Or10ak9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00090:Or10ak9 APN 4 118,726,484 (GRCm39) missense probably damaging 1.00
IGL01314:Or10ak9 APN 4 118,726,328 (GRCm39) missense probably benign 0.26
IGL02025:Or10ak9 APN 4 118,726,362 (GRCm39) missense probably damaging 1.00
IGL02458:Or10ak9 APN 4 118,726,497 (GRCm39) missense possibly damaging 0.83
IGL02793:Or10ak9 APN 4 118,726,794 (GRCm39) missense probably damaging 1.00
IGL02827:Or10ak9 APN 4 118,726,157 (GRCm39) missense probably damaging 0.99
IGL02863:Or10ak9 APN 4 118,726,083 (GRCm39) missense possibly damaging 0.52
IGL03125:Or10ak9 APN 4 118,726,118 (GRCm39) missense possibly damaging 0.95
R0078:Or10ak9 UTSW 4 118,726,424 (GRCm39) missense probably benign
R0152:Or10ak9 UTSW 4 118,726,083 (GRCm39) missense possibly damaging 0.89
R0299:Or10ak9 UTSW 4 118,726,613 (GRCm39) missense probably benign 0.00
R3881:Or10ak9 UTSW 4 118,726,550 (GRCm39) missense probably benign 0.00
R3928:Or10ak9 UTSW 4 118,726,179 (GRCm39) missense probably damaging 1.00
R3929:Or10ak9 UTSW 4 118,726,179 (GRCm39) missense probably damaging 1.00
R5288:Or10ak9 UTSW 4 118,726,772 (GRCm39) missense probably damaging 1.00
R5552:Or10ak9 UTSW 4 118,726,665 (GRCm39) missense probably damaging 1.00
R5672:Or10ak9 UTSW 4 118,726,379 (GRCm39) missense possibly damaging 0.83
R5773:Or10ak9 UTSW 4 118,726,718 (GRCm39) missense probably damaging 0.97
R6117:Or10ak9 UTSW 4 118,726,341 (GRCm39) missense probably benign 0.39
R6910:Or10ak9 UTSW 4 118,726,335 (GRCm39) missense probably damaging 1.00
R6911:Or10ak9 UTSW 4 118,726,335 (GRCm39) missense probably damaging 1.00
R6912:Or10ak9 UTSW 4 118,726,335 (GRCm39) missense probably damaging 1.00
R7164:Or10ak9 UTSW 4 118,726,922 (GRCm39) missense probably benign 0.30
R9747:Or10ak9 UTSW 4 118,726,217 (GRCm39) missense probably damaging 1.00
T0975:Or10ak9 UTSW 4 118,726,500 (GRCm39) missense probably benign 0.02
Predicted Primers PCR Primer
(F):5'- TACAATGCGTTATGAGGTGTTTCC -3'
(R):5'- ACAAAGGTCATATCCAACAGGG -3'

Sequencing Primer
(F):5'- CCCCGTTTTACAGATGAAGAGACTG -3'
(R):5'- TCCAACAGGGAGAGGGTAG -3'
Posted On 2019-10-07