Mutagenetix > Incidental Mutation

Incidental Mutation 'R7446:Or4d10'

577329

Institutional Source

Beutler Lab

Gene Symbol

Or4d10

Ensembl Gene

ENSMUSG00000067526

Gene Name

olfactory receptor family 4 subfamily D member 10

Synonyms

MOR239-7, GA_x6K02T2RE5P-2433425-2432490, Olfr1425

MMRRC Submission

045522-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.076) question?

Stock #

R7446 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

12051059-12051994 bp(-) (GRCm39)

Type of Mutation

makesense

DNA Base Change (assembly)

A to G at 12051061 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Stop codon to Glutamine at position 312 (*312Q)

Ref Sequence

ENSEMBL: ENSMUSP00000151154 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000087828] [ENSMUST00000214918]

AlphaFold

K7N659

Predicted Effect

probably null
Transcript: ENSMUST00000087828
AA Change: *313Q

SMART Domains

Protein: ENSMUSP00000085130
Gene: ENSMUSG00000067526
AA Change: *313Q

Domain	Start	End	E-Value	Type
Pfam:7tm_4	30	303	9.3e-48	PFAM
Pfam:7tm_1	40	286	8.8e-22	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000214918
AA Change: *312Q

Meta Mutation Damage Score

0.9755

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.7%
20x: 99.1%

Validation Efficiency

100% (67/67)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 66 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930407I10Rik	A	G	15: 81,950,441 (GRCm39)	D1446G	probably benign	Het
Adgrg1	A	G	8: 95,738,412 (GRCm39)	Y635C	probably damaging	Het
Akr1cl	G	A	1: 65,055,837 (GRCm39)	R222W	probably damaging	Het
C2	G	A	17: 35,094,986 (GRCm39)	R250C	probably damaging	Het
Cdk15	A	G	1: 59,328,854 (GRCm39)	Y254C	probably damaging	Het
Celsr1	T	C	15: 85,791,874 (GRCm39)	T2576A	possibly damaging	Het
Cfap61	C	T	2: 145,995,758 (GRCm39)	R1108C	probably benign	Het
Clca3a1	A	G	3: 144,733,188 (GRCm39)	S107P	possibly damaging	Het
Cplane1	A	G	15: 8,261,564 (GRCm39)	D2460G	probably damaging	Het
Cpsf1	A	G	15: 76,485,950 (GRCm39)	S407P	probably benign	Het
Crisp4	T	C	1: 18,192,962 (GRCm39)	T252A	probably damaging	Het
Ctbs	A	G	3: 146,164,573 (GRCm39)	Y242C	probably damaging	Het
Cul4a	A	G	8: 13,186,874 (GRCm39)	T537A	probably benign	Het
D930020B18Rik	T	C	10: 121,503,650 (GRCm39)	I275T	possibly damaging	Het
Dcaf7	T	C	11: 105,944,561 (GRCm39)	V248A	probably benign	Het
Def8	T	C	8: 124,181,061 (GRCm39)	C153R	probably damaging	Het
Dennd1a	A	T	2: 37,706,991 (GRCm39)	V505D	possibly damaging	Het
Dpysl5	A	C	5: 30,936,231 (GRCm39)	D207A	probably benign	Het
Dync2h1	A	T	9: 7,041,720 (GRCm39)	S3307R	probably benign	Het
Enpp5	G	A	17: 44,396,155 (GRCm39)	G356S	probably damaging	Het
Erf	A	T	7: 24,945,556 (GRCm39)	C72S	probably damaging	Het
Fastkd3	A	T	13: 68,740,079 (GRCm39)	H47L	unknown	Het
Gm5591	C	T	7: 38,218,933 (GRCm39)	E647K	probably benign	Het
Gng12	TGTCCAGCAAG	TG	6: 66,992,736 (GRCm39)		probably benign	Het
Guk1	T	C	11: 59,076,850 (GRCm39)	T78A	probably benign	Het
Hephl1	T	C	9: 15,009,347 (GRCm39)	T82A	probably damaging	Het
Htra4	A	G	8: 25,527,181 (GRCm39)	S205P	probably benign	Het
Jakmip2	T	C	18: 43,710,390 (GRCm39)	D271G	probably damaging	Het
Krt16	CAGTATCTG	C	11: 100,137,610 (GRCm39)		probably null	Het
Lrp1b	T	A	2: 41,561,069 (GRCm39)	E286V		Het
Lrp2	C	A	2: 69,262,557 (GRCm39)	G4415W	probably damaging	Het
Lrp2	C	T	2: 69,290,018 (GRCm39)	R3607H	probably damaging	Het
Mcph1	A	G	8: 18,721,109 (GRCm39)	K646E	probably benign	Het
Mgam	T	C	6: 40,723,266 (GRCm39)	L457P	probably damaging	Het
Mink1	T	A	11: 70,500,455 (GRCm39)	S802T	probably benign	Het
Mrgprb5	C	T	7: 47,818,252 (GRCm39)	G161E	possibly damaging	Het
Mroh1	G	A	15: 76,336,472 (GRCm39)	G1565D	possibly damaging	Het
Mynn	A	G	3: 30,661,201 (GRCm39)	K51R	probably benign	Het
Myo1b	A	G	1: 51,803,065 (GRCm39)	F872S	possibly damaging	Het
Nbas	A	T	12: 13,443,499 (GRCm39)	T1185S	probably benign	Het
Oas1d	A	T	5: 121,058,054 (GRCm39)	I333L	probably benign	Het
Or10ak9	A	T	4: 118,726,019 (GRCm39)	I14F	possibly damaging	Het
P2ry12	A	G	3: 59,124,632 (GRCm39)	*348Q	probably null	Het
Pik3cb	A	T	9: 98,928,711 (GRCm39)	V848E	probably damaging	Het
Plcz1	A	C	6: 139,959,312 (GRCm39)	S282A	possibly damaging	Het
Prss46	A	G	9: 110,679,189 (GRCm39)	D130G	probably damaging	Het
Pygl	T	C	12: 70,243,784 (GRCm39)	I644V	probably benign	Het
Ralgds	T	A	2: 28,435,901 (GRCm39)	S509T	probably damaging	Het
Rdh16f2	A	G	10: 127,712,767 (GRCm39)	D255G	probably benign	Het
Scaf4	T	C	16: 90,055,658 (GRCm39)	D133G	unknown	Het
Sdk1	G	A	5: 142,130,731 (GRCm39)	S1630N	probably damaging	Het
Sema5b	C	T	16: 35,467,573 (GRCm39)	T279I	probably damaging	Het
Slc24a3	T	A	2: 145,422,902 (GRCm39)	L207H	probably damaging	Het
Speer2	A	T	16: 69,654,965 (GRCm39)	S167T	possibly damaging	Het
Spock1	A	G	13: 57,583,898 (GRCm39)	I339T	unknown	Het
Srsf6	T	A	2: 162,776,636 (GRCm39)	S327T	unknown	Het
Syne1	T	A	10: 5,172,266 (GRCm39)	E5058D	probably benign	Het
Tcf19	A	G	17: 35,825,428 (GRCm39)	V243A	probably benign	Het
Tspan15	T	C	10: 62,029,734 (GRCm39)	D122G	probably benign	Het
Ttc17	C	T	2: 94,205,495 (GRCm39)	V284M	probably damaging	Het
Usp29	A	C	7: 6,964,219 (GRCm39)	T21P	possibly damaging	Het
Uspl1	T	A	5: 149,141,082 (GRCm39)	C360*	probably null	Het
Vmn1r181	A	C	7: 23,684,356 (GRCm39)	S274R	probably benign	Het
Xrcc5	T	C	1: 72,433,132 (GRCm39)		probably null	Het
Zfp277	C	T	12: 40,378,729 (GRCm39)	R376H	probably damaging	Het
Zfp629	T	C	7: 127,210,201 (GRCm39)	E536G	probably benign	Het

Other mutations in Or4d10

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01936:Or4d10	APN	19	12,051,421 (GRCm39)	missense	probably benign	0.00
IGL02508:Or4d10	APN	19	12,051,251 (GRCm39)	missense	possibly damaging	0.90
IGL03183:Or4d10	APN	19	12,051,392 (GRCm39)	missense	probably damaging	0.98
R1164:Or4d10	UTSW	19	12,051,605 (GRCm39)	nonsense	probably null
R1866:Or4d10	UTSW	19	12,051,183 (GRCm39)	missense	probably benign	0.03
R3745:Or4d10	UTSW	19	12,051,744 (GRCm39)	missense	probably damaging	1.00
R4364:Or4d10	UTSW	19	12,051,861 (GRCm39)	missense	probably benign	0.13
R4888:Or4d10	UTSW	19	12,051,679 (GRCm39)	missense	probably damaging	1.00
R4962:Or4d10	UTSW	19	12,051,639 (GRCm39)	missense	probably damaging	1.00
R5954:Or4d10	UTSW	19	12,051,447 (GRCm39)	missense	possibly damaging	0.96
R6383:Or4d10	UTSW	19	12,051,727 (GRCm39)	missense	probably damaging	1.00
R6409:Or4d10	UTSW	19	12,052,111 (GRCm39)	start gained	probably benign
R6417:Or4d10	UTSW	19	12,051,324 (GRCm39)	missense	probably benign	0.18
R6420:Or4d10	UTSW	19	12,051,324 (GRCm39)	missense	probably benign	0.18
R7109:Or4d10	UTSW	19	12,051,576 (GRCm39)	missense	probably benign
R7505:Or4d10	UTSW	19	12,051,969 (GRCm39)	missense	possibly damaging	0.88
R9689:Or4d10	UTSW	19	12,051,567 (GRCm39)	missense	possibly damaging	0.90
Z1176:Or4d10	UTSW	19	12,051,274 (GRCm39)	missense	probably damaging	1.00
Z1176:Or4d10	UTSW	19	12,051,204 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- GTCTCAGTTGTTAAGACATGAGTTC -3'
(R):5'- TGCTGAAGTCTCAATCAGGAG -3'

Sequencing Primer
(F):5'- CCATTTGACAGCTTATTGGT -3'
(R):5'- CTGCATCTATGTCTATGCCAGG -3'

Posted On

2019-10-07