Incidental Mutation 'R7447:Arhgap39'
ID 577395
Institutional Source Beutler Lab
Gene Symbol Arhgap39
Ensembl Gene ENSMUSG00000033697
Gene Name Rho GTPase activating protein 39
Synonyms D15Wsu169e
Accession Numbers
Essential gene? Probably non essential (E-score: 0.219) question?
Stock # R7447 (G1)
Quality Score 225.009
Status Not validated
Chromosome 15
Chromosomal Location 76608183-76702366 bp(-) (GRCm39)
Type of Mutation start gained
DNA Base Change (assembly) G to A at 76649797 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000135896 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000036176] [ENSMUST00000077821] [ENSMUST00000175843] [ENSMUST00000176219] [ENSMUST00000176736] [ENSMUST00000176855] [ENSMUST00000177026]
AlphaFold P59281
Predicted Effect probably benign
Transcript: ENSMUST00000036176
SMART Domains Protein: ENSMUSP00000036697
Gene: ENSMUSG00000033697

DomainStartEndE-ValueType
WW 27 60 1.64e0 SMART
WW 66 99 5.41e-1 SMART
low complexity region 125 138 N/A INTRINSIC
low complexity region 304 318 N/A INTRINSIC
Pfam:MyTH4 759 904 2.3e-32 PFAM
RhoGAP 932 1105 5.9e-28 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000077821
SMART Domains Protein: ENSMUSP00000076993
Gene: ENSMUSG00000033697

DomainStartEndE-ValueType
WW 27 60 1.64e0 SMART
WW 66 99 5.41e-1 SMART
low complexity region 125 138 N/A INTRINSIC
low complexity region 304 318 N/A INTRINSIC
Pfam:MyTH4 756 874 3.3e-25 PFAM
RhoGAP 901 1074 5.9e-28 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000175843
Predicted Effect probably benign
Transcript: ENSMUST00000176219
Predicted Effect probably benign
Transcript: ENSMUST00000176736
Predicted Effect probably benign
Transcript: ENSMUST00000176855
SMART Domains Protein: ENSMUSP00000135043
Gene: ENSMUSG00000033697

DomainStartEndE-ValueType
WW 27 60 1.64e0 SMART
WW 66 99 5.41e-1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000177026
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.4%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 88 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adck5 A T 15: 76,479,396 (GRCm39) I484F possibly damaging Het
Ago2 A T 15: 73,009,881 (GRCm39) N100K probably benign Het
Appl1 T A 14: 26,681,409 (GRCm39) K130* probably null Het
Axdnd1 A G 1: 156,245,802 (GRCm39) probably null Het
Camta1 A T 4: 151,168,327 (GRCm39) V1332E probably benign Het
Cd3g A G 9: 44,884,857 (GRCm39) L129P probably damaging Het
Cd80 T G 16: 38,294,251 (GRCm39) S45A probably benign Het
Cdk12 A T 11: 98,136,106 (GRCm39) Q1120L unknown Het
Clip1 G A 5: 123,791,696 (GRCm39) S158F probably benign Het
Cntn3 C A 6: 102,255,416 (GRCm39) E161* probably null Het
Cyp3a59 A C 5: 146,024,215 (GRCm39) K67T probably benign Het
Dmxl1 T C 18: 49,997,681 (GRCm39) L623P probably damaging Het
Drd3 T A 16: 43,637,426 (GRCm39) Y208* probably null Het
Dusp10 A T 1: 183,801,153 (GRCm39) M307L probably benign Het
Dync2li1 A T 17: 84,955,141 (GRCm39) I267L possibly damaging Het
Dynlt2b T A 16: 32,244,089 (GRCm39) V95E probably damaging Het
Edn3 C A 2: 174,603,544 (GRCm39) C97* probably null Het
Ehbp1l1 T A 19: 5,769,456 (GRCm39) T616S possibly damaging Het
Eif2a C T 3: 58,452,963 (GRCm39) T246I probably damaging Het
Enpp5 G A 17: 44,396,155 (GRCm39) G356S probably damaging Het
Errfi1 A G 4: 150,951,108 (GRCm39) T179A probably damaging Het
Esyt3 G A 9: 99,203,615 (GRCm39) L450F probably damaging Het
Evx2 A G 2: 74,489,448 (GRCm39) S106P probably benign Het
Fam83a T G 15: 57,873,086 (GRCm39) V305G probably benign Het
Fem1al T C 11: 29,774,122 (GRCm39) D445G probably benign Het
Gpr171 T A 3: 59,005,860 (GRCm39) probably null Het
Grip1 A G 10: 119,922,871 (GRCm39) T1106A probably benign Het
Hecw1 A G 13: 14,531,789 (GRCm39) Y162H probably damaging Het
Hephl1 C T 9: 15,009,178 (GRCm39) probably null Het
Hsp90aa1 A G 12: 110,658,562 (GRCm39) I693T possibly damaging Het
Ifit1bl2 T A 19: 34,596,974 (GRCm39) D214V probably damaging Het
Igsf10 T C 3: 59,239,222 (GRCm39) M320V probably benign Het
Kcnq2 A G 2: 180,754,887 (GRCm39) L220P probably damaging Het
Kpna1 C A 16: 35,850,009 (GRCm39) Q372K probably damaging Het
Lilrb4a T G 10: 51,367,149 (GRCm39) probably null Het
Ly75 C A 2: 60,164,818 (GRCm39) E787* probably null Het
Magi1 T G 6: 93,722,562 (GRCm39) S666R possibly damaging Het
Mif C A 10: 75,695,687 (GRCm39) A39S possibly damaging Het
Mob4 G A 1: 55,170,625 (GRCm39) probably benign Het
Mtmr4 G T 11: 87,502,727 (GRCm39) C927F probably damaging Het
Myh1 A G 11: 67,110,006 (GRCm39) K1398R probably benign Het
Myo3a T C 2: 22,436,464 (GRCm39) V873A probably benign Het
Naip5 T C 13: 100,356,204 (GRCm39) Q1137R probably benign Het
Naip5 G T 13: 100,356,205 (GRCm39) Q1137K not run Het
Nckap5l G A 15: 99,325,357 (GRCm39) P382L probably damaging Het
Ngly1 T C 14: 16,290,844 (GRCm38) I442T probably damaging Het
Nhsl3 C A 4: 129,115,835 (GRCm39) R988L possibly damaging Het
Nlrp1a T C 11: 70,983,237 (GRCm39) Y1243C probably damaging Het
Or8k53 T A 2: 86,177,150 (GRCm39) H320L possibly damaging Het
Pcsk5 C T 19: 17,487,600 (GRCm39) G1027D probably benign Het
Pla2g2c T A 4: 138,458,927 (GRCm39) I11N probably benign Het
Polr3d A G 14: 70,677,240 (GRCm39) I331T probably damaging Het
Ppp4r4 A G 12: 103,551,985 (GRCm39) I293M possibly damaging Het
Prkce G T 17: 86,866,687 (GRCm39) V516F probably damaging Het
Prss27 T A 17: 24,264,683 (GRCm39) L282Q probably damaging Het
Pxdn A G 12: 30,034,926 (GRCm39) Y261C probably damaging Het
R3hcc1l T C 19: 42,551,101 (GRCm39) S33P probably benign Het
Rab11fip3 G C 17: 26,287,848 (GRCm39) R102G possibly damaging Het
Rabggta A T 14: 55,956,773 (GRCm39) N310K probably null Het
Rbbp8 T A 18: 11,793,934 (GRCm39) D15E probably benign Het
Rbm5 T C 9: 107,623,378 (GRCm39) Y486C probably damaging Het
Rptor T A 11: 119,775,805 (GRCm39) F992Y probably benign Het
Slc29a2 T G 19: 5,076,445 (GRCm39) L111R probably damaging Het
Slc39a11 T A 11: 113,452,849 (GRCm39) I31L probably benign Het
Slc6a20a T A 9: 123,485,289 (GRCm39) N311I possibly damaging Het
Slc8a1 A G 17: 81,956,435 (GRCm39) F201S probably damaging Het
Smtn C A 11: 3,480,196 (GRCm39) V342L probably benign Het
Syne2 A G 12: 76,074,853 (GRCm39) T4598A probably benign Het
Tchp A G 5: 114,853,716 (GRCm39) T267A probably benign Het
Tes3-ps A G 13: 49,647,508 (GRCm39) E128G possibly damaging Het
Tigar C T 6: 127,065,129 (GRCm39) G173E probably benign Het
Tmem171 T C 13: 98,824,862 (GRCm39) N256S probably benign Het
Tmem204 A G 17: 25,277,270 (GRCm39) I205T probably damaging Het
Tmem63a A G 1: 180,785,588 (GRCm39) K240R probably benign Het
Tns2 C T 15: 102,019,351 (GRCm39) T446M probably damaging Het
Tnxb A T 17: 34,937,444 (GRCm39) N2931I probably damaging Het
Trrap G T 5: 144,776,284 (GRCm39) R2941L probably damaging Het
Ttc8 A T 12: 98,910,131 (GRCm39) R179S probably damaging Het
Ttll12 G T 15: 83,471,176 (GRCm39) T234N probably damaging Het
Ttn G T 2: 76,577,576 (GRCm39) T24439K probably damaging Het
Ube2z A T 11: 95,946,736 (GRCm39) I246N possibly damaging Het
Usp15 A G 10: 123,011,786 (GRCm39) Y104H probably damaging Het
Usp29 A C 7: 6,964,219 (GRCm39) T21P possibly damaging Het
Usp5 G A 6: 124,798,077 (GRCm39) A436V probably damaging Het
Utp20 A G 10: 88,608,354 (GRCm39) L1561S probably damaging Het
Xrn1 A G 9: 95,927,547 (GRCm39) M1444V probably benign Het
Zfp236 G T 18: 82,651,815 (GRCm39) Q885K probably damaging Het
Zfp831 C A 2: 174,487,896 (GRCm39) P857Q possibly damaging Het
Other mutations in Arhgap39
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01547:Arhgap39 APN 15 76,622,015 (GRCm39) splice site probably benign
IGL01586:Arhgap39 APN 15 76,614,638 (GRCm39) missense probably benign 0.16
IGL01693:Arhgap39 APN 15 76,610,167 (GRCm39) missense probably null 1.00
IGL02017:Arhgap39 APN 15 76,621,237 (GRCm39) missense probably damaging 0.98
IGL02508:Arhgap39 APN 15 76,609,184 (GRCm39) makesense probably null
IGL03333:Arhgap39 APN 15 76,610,932 (GRCm39) missense probably benign 0.05
R0328:Arhgap39 UTSW 15 76,636,152 (GRCm39) splice site probably benign
R0432:Arhgap39 UTSW 15 76,619,086 (GRCm39) missense probably damaging 0.99
R0479:Arhgap39 UTSW 15 76,619,086 (GRCm39) missense probably damaging 0.99
R0549:Arhgap39 UTSW 15 76,619,086 (GRCm39) missense probably damaging 0.99
R0551:Arhgap39 UTSW 15 76,619,086 (GRCm39) missense probably damaging 0.99
R1054:Arhgap39 UTSW 15 76,635,759 (GRCm39) missense probably benign
R1830:Arhgap39 UTSW 15 76,619,383 (GRCm39) missense probably damaging 1.00
R2421:Arhgap39 UTSW 15 76,609,346 (GRCm39) missense probably damaging 1.00
R2497:Arhgap39 UTSW 15 76,609,585 (GRCm39) missense probably damaging 1.00
R3909:Arhgap39 UTSW 15 76,636,088 (GRCm39) missense probably benign 0.03
R4410:Arhgap39 UTSW 15 76,609,712 (GRCm39) unclassified probably benign
R4626:Arhgap39 UTSW 15 76,621,837 (GRCm39) missense possibly damaging 0.92
R4790:Arhgap39 UTSW 15 76,610,931 (GRCm39) missense possibly damaging 0.51
R4792:Arhgap39 UTSW 15 76,625,717 (GRCm39) missense possibly damaging 0.92
R4911:Arhgap39 UTSW 15 76,622,005 (GRCm39) missense probably damaging 1.00
R5225:Arhgap39 UTSW 15 76,609,715 (GRCm39) unclassified probably benign
R5417:Arhgap39 UTSW 15 76,619,301 (GRCm39) missense possibly damaging 0.80
R5443:Arhgap39 UTSW 15 76,682,125 (GRCm39) intron probably benign
R5521:Arhgap39 UTSW 15 76,649,694 (GRCm39) missense possibly damaging 0.66
R5686:Arhgap39 UTSW 15 76,610,833 (GRCm39) missense probably damaging 1.00
R5747:Arhgap39 UTSW 15 76,625,735 (GRCm39) missense possibly damaging 0.68
R5785:Arhgap39 UTSW 15 76,621,618 (GRCm39) missense probably benign
R5879:Arhgap39 UTSW 15 76,636,007 (GRCm39) missense probably damaging 1.00
R6035:Arhgap39 UTSW 15 76,621,424 (GRCm39) nonsense probably null
R6035:Arhgap39 UTSW 15 76,621,424 (GRCm39) nonsense probably null
R6049:Arhgap39 UTSW 15 76,611,601 (GRCm39) critical splice donor site probably null
R6143:Arhgap39 UTSW 15 76,614,606 (GRCm39) nonsense probably null
R6232:Arhgap39 UTSW 15 76,620,712 (GRCm39) missense probably damaging 1.00
R6276:Arhgap39 UTSW 15 76,621,736 (GRCm39) missense probably benign 0.06
R6277:Arhgap39 UTSW 15 76,619,337 (GRCm39) missense probably damaging 1.00
R6305:Arhgap39 UTSW 15 76,621,902 (GRCm39) missense probably benign 0.31
R6587:Arhgap39 UTSW 15 76,621,699 (GRCm39) missense probably damaging 1.00
R7153:Arhgap39 UTSW 15 76,649,691 (GRCm39) missense probably benign 0.09
R7658:Arhgap39 UTSW 15 76,621,617 (GRCm39) missense probably benign 0.03
R8071:Arhgap39 UTSW 15 76,621,702 (GRCm39) missense probably benign
R8269:Arhgap39 UTSW 15 76,635,942 (GRCm39) missense probably benign 0.35
R8368:Arhgap39 UTSW 15 76,619,455 (GRCm39) missense probably damaging 1.00
R9124:Arhgap39 UTSW 15 76,619,467 (GRCm39) missense probably damaging 1.00
R9333:Arhgap39 UTSW 15 76,619,325 (GRCm39) missense probably damaging 1.00
R9438:Arhgap39 UTSW 15 76,636,118 (GRCm39) missense probably damaging 0.96
R9602:Arhgap39 UTSW 15 76,610,954 (GRCm39) missense probably damaging 0.98
R9615:Arhgap39 UTSW 15 76,621,438 (GRCm39) missense probably benign 0.02
R9700:Arhgap39 UTSW 15 76,611,617 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- GACCTTTTCTCTGAACAGTTGC -3'
(R):5'- TCTGTACAAGAGAAGCTGGCC -3'

Sequencing Primer
(F):5'- TGAACAGTTGCTCCCCCAC -3'
(R):5'- TGGCTTCCCCAAGGAGTCTTG -3'
Posted On 2019-10-07