Mutagenetix > Incidental Mutation

Incidental Mutation 'R0629:Gm7461'

57750

Institutional Source

Beutler Lab

Gene Symbol

Gm7461

Ensembl Gene

ENSMUSG00000048484

Gene Name

predicted gene 7461

Synonyms

MMRRC Submission

038818-MU

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.265) question?

Stock #

R0629 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

4677539-4678365 bp(-) (GRCm38)

Type of Mutation

unclassified

DNA Base Change (assembly)

C to T at 4677769 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Gene Model

predicted gene model for transcript(s):

AlphaFold

no structure available at present

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000058918

SMART Domains

Protein: ENSMUSP00000052460
Gene: ENSMUSG00000048484

Domain	Start	End	E-Value	Type
low complexity region	99	115	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000181337

Meta Mutation Damage Score

0.0869

Coding Region Coverage

1x: 99.4%
3x: 98.9%
10x: 97.6%
20x: 95.6%

Validation Efficiency

100% (66/66)

Allele List at MGI

Other mutations in this stock

Total: 64 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aars2	A	T	17: 45,507,547 (GRCm38)	D86V	probably damaging	Het
Adamts14	G	A	10: 61,211,624 (GRCm38)	Q733*	probably null	Het
Adcy10	A	G	1: 165,543,105 (GRCm38)	D651G	probably damaging	Het
Apcdd1	T	A	18: 62,933,970 (GRCm38)	C52S	probably damaging	Het
Bclaf1	T	C	10: 20,333,426 (GRCm38)	S463P	probably damaging	Het
Cabcoco1	T	C	10: 68,516,278 (GRCm38)	Y68C	probably damaging	Het
Cacna1f	G	A	X: 7,620,434 (GRCm38)	S888N	probably damaging	Het
Cacna1g	A	G	11: 94,409,543 (GRCm38)	C2134R	possibly damaging	Het
Cdc37	A	C	9: 21,140,768 (GRCm38)	M325R	possibly damaging	Het
Clca2	T	A	3: 145,072,239 (GRCm38)	M762L	probably benign	Het
Cntn3	C	T	6: 102,203,976 (GRCm38)	V753M	probably damaging	Het
Col6a6	A	T	9: 105,727,165 (GRCm38)		probably benign	Het
Dscaml1	A	G	9: 45,721,418 (GRCm38)	D1194G	probably damaging	Het
Egfr	G	A	11: 16,869,333 (GRCm38)	G288S	probably damaging	Het
Fbxl17	G	T	17: 63,471,414 (GRCm38)	N19K	probably damaging	Het
Fmo3	A	G	1: 162,958,227 (GRCm38)		probably benign	Het
Frmd6	T	C	12: 70,883,762 (GRCm38)	Y219H	probably damaging	Het
Fuca1	T	C	4: 135,925,644 (GRCm38)	V193A	possibly damaging	Het
Gm1141	G	C	X: 71,938,773 (GRCm38)	R296P	possibly damaging	Het
Gpc5	T	A	14: 115,552,239 (GRCm38)	N508K	possibly damaging	Het
Iqch	A	T	9: 63,425,382 (GRCm38)	D1019E	probably benign	Het
Isyna1	A	G	8: 70,594,708 (GRCm38)	Y27C	probably damaging	Het
Itgb8	T	G	12: 119,202,481 (GRCm38)	H105P	probably benign	Het
Kbtbd11	C	T	8: 15,027,572 (GRCm38)	P57L	probably benign	Het
Kcns3	A	C	12: 11,092,558 (GRCm38)	C47G	probably damaging	Het
Kif21b	A	T	1: 136,172,157 (GRCm38)		probably null	Het
Lama3	A	T	18: 12,419,245 (GRCm38)	H418L	possibly damaging	Het
Lrit3	A	G	3: 129,788,302 (GRCm38)	Y679H	probably damaging	Het
Lrrc19	T	A	4: 94,638,252 (GRCm38)	D356V	probably damaging	Het
Morc2b	A	G	17: 33,135,807 (GRCm38)	M997T	probably benign	Het
Mroh9	T	C	1: 163,060,636 (GRCm38)	H290R	possibly damaging	Het
Mtcl1	A	T	17: 66,338,142 (GRCm38)	S1886T	possibly damaging	Het
Muc20	T	C	16: 32,793,421 (GRCm38)	T529A	possibly damaging	Het
Myo7a	A	C	7: 98,085,466 (GRCm38)	L607R	probably damaging	Het
Myom2	T	A	8: 15,069,783 (GRCm38)	F180I	probably damaging	Het
Myt1l	G	A	12: 29,811,485 (GRCm38)	E89K	unknown	Het
Nek2	A	G	1: 191,831,317 (GRCm38)	N431S	probably benign	Het
Olfr1086	T	A	2: 86,676,529 (GRCm38)	H268L	possibly damaging	Het
Olfr169	A	T	16: 19,565,980 (GRCm38)	V301E	possibly damaging	Het
Oprm1	A	T	10: 6,832,604 (GRCm38)		probably null	Het
Oxsr1	A	G	9: 119,241,784 (GRCm38)		probably benign	Het
Pdgfrb	G	A	18: 61,078,648 (GRCm38)		probably null	Het
Proser1	C	A	3: 53,479,064 (GRCm38)	P789Q	probably benign	Het
Ptgs2	A	G	1: 150,101,037 (GRCm38)	Q7R	probably benign	Het
Rab3d	A	G	9: 21,914,686 (GRCm38)	V144A	probably benign	Het
Ralgapb	T	A	2: 158,439,547 (GRCm38)	L167H	probably damaging	Het
Ranbp3	A	G	17: 56,708,200 (GRCm38)	T301A	possibly damaging	Het
Rasgrf1	G	A	9: 89,984,269 (GRCm38)	V587M	probably damaging	Het
Sec16b	A	G	1: 157,564,863 (GRCm38)		probably benign	Het
Sin3b	T	C	8: 72,753,536 (GRCm38)		probably benign	Het
Slc10a2	T	C	8: 5,098,562 (GRCm38)	S128G	probably benign	Het
Tbl1xr1	G	A	3: 22,210,401 (GRCm38)	V507I	probably benign	Het
Tmem8b	T	G	4: 43,669,896 (GRCm38)		probably null	Het
Trak1	A	T	9: 121,367,167 (GRCm38)	T22S	probably benign	Het
Trim30d	A	G	7: 104,487,655 (GRCm38)	I114T	probably damaging	Het
Ttc13	A	T	8: 124,674,366 (GRCm38)	S624T	probably damaging	Het
Ttn	T	C	2: 76,828,130 (GRCm38)		probably benign	Het
Vipr1	T	A	9: 121,660,171 (GRCm38)	Y99*	probably null	Het
Vmn1r210	T	C	13: 22,827,874 (GRCm38)	K81E	probably damaging	Het
Wwc1	T	C	11: 35,853,472 (GRCm38)	Y841C	probably benign	Het
Xrcc4	A	G	13: 90,000,905 (GRCm38)		probably benign	Het
Zdhhc22	A	T	12: 86,988,297 (GRCm38)	I127N	probably damaging	Het
Zdhhc7	A	G	8: 120,088,046 (GRCm38)	L8P	possibly damaging	Het
Zfp664	C	A	5: 124,885,595 (GRCm38)	L18I	probably damaging	Het

Other mutations in Gm7461

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02975:Gm7461	APN	8	4,677,847 (GRCm38)	unclassified	noncoding transcript

Predicted Primers

PCR Primer
(F):5'- TCAATGACCGGGGATTGGAAACC -3'
(R):5'- ACAAACGCAGTGATGTAGCCGC -3'

Sequencing Primer
(F):5'- ACCATCTCATGTCAGTGCAG -3'
(R):5'- TGTGCTCGCCAATCAGAG -3'

Posted On

2013-07-11