Incidental Mutation 'R0629:Sin3b'
ID 57754
Institutional Source Beutler Lab
Gene Symbol Sin3b
Ensembl Gene ENSMUSG00000031622
Gene Name transcriptional regulator, SIN3B (yeast)
Synonyms 2810430C10Rik
MMRRC Submission 038818-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R0629 (G1)
Quality Score 211
Status Validated
Chromosome 8
Chromosomal Location 73449913-73484829 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) T to C at 73480164 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000004494 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000004494]
AlphaFold Q62141
PDB Structure STRUCTURE OF THE COMPLEX OF THE MAD1-SIN3B INTERACTION DOMAINS [SOLUTION NMR]
Extended SID of Mad1 bound to the PAH2 domain of mSin3B [SOLUTION NMR]
Solution structure of the first PAH domain of the mouse transcriptional repressor SIN3B [SOLUTION NMR]
Solution structure of the NRSF/REST-mSin3B PAH1 complex [SOLUTION NMR]
Solution structure of free PAH2 domain of mSin3B [SOLUTION NMR]
Predicted Effect probably benign
Transcript: ENSMUST00000004494
SMART Domains Protein: ENSMUSP00000004494
Gene: ENSMUSG00000031622

DomainStartEndE-ValueType
low complexity region 5 26 N/A INTRINSIC
Pfam:PAH 53 97 2.5e-19 PFAM
Pfam:PAH 173 227 4.4e-20 PFAM
Pfam:PAH 313 357 1.6e-8 PFAM
HDAC_interact 384 484 2.75e-58 SMART
low complexity region 667 688 N/A INTRINSIC
Pfam:Sin3a_C 712 1011 7.2e-81 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000212256
Predicted Effect noncoding transcript
Transcript: ENSMUST00000212677
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.9%
  • 10x: 97.6%
  • 20x: 95.6%
Validation Efficiency 100% (66/66)
MGI Phenotype PHENOTYPE: Homozygous null mice fail to survive past P1 and exhibit pallor, fetal growth retardation, impaired terminal differentiation of erythrocytes and granulocytes, a pale liver and reduced ossification of the long bones in the hindlimb. Mutant MEFs show impaired G0 arrest upon serum deprivation. [provided by MGI curators]
Allele List at MGI

All alleles(8) : Targeted, knock-out(1) Targeted, other(4) Gene trapped(3)

Other mutations in this stock
Total: 64 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aars2 A T 17: 45,818,473 (GRCm39) D86V probably damaging Het
Adamts14 G A 10: 61,047,403 (GRCm39) Q733* probably null Het
Adcy10 A G 1: 165,370,674 (GRCm39) D651G probably damaging Het
Apcdd1 T A 18: 63,067,041 (GRCm39) C52S probably damaging Het
Bclaf1 T C 10: 20,209,172 (GRCm39) S463P probably damaging Het
Cabcoco1 T C 10: 68,352,108 (GRCm39) Y68C probably damaging Het
Cacna1f G A X: 7,486,673 (GRCm39) S888N probably damaging Het
Cacna1g A G 11: 94,300,369 (GRCm39) C2134R possibly damaging Het
Cdc37 A C 9: 21,052,064 (GRCm39) M325R possibly damaging Het
Clca3a2 T A 3: 144,778,000 (GRCm39) M762L probably benign Het
Cntn3 C T 6: 102,180,937 (GRCm39) V753M probably damaging Het
Col6a6 A T 9: 105,604,364 (GRCm39) probably benign Het
Dscaml1 A G 9: 45,632,716 (GRCm39) D1194G probably damaging Het
Egfr G A 11: 16,819,333 (GRCm39) G288S probably damaging Het
Fbxl17 G T 17: 63,778,409 (GRCm39) N19K probably damaging Het
Fmo3 A G 1: 162,785,796 (GRCm39) probably benign Het
Frmd6 T C 12: 70,930,536 (GRCm39) Y219H probably damaging Het
Fuca1 T C 4: 135,652,955 (GRCm39) V193A possibly damaging Het
Gm7461 C T 8: 4,727,769 (GRCm39) noncoding transcript Het
Gpc5 T A 14: 115,789,651 (GRCm39) N508K possibly damaging Het
Iqch A T 9: 63,332,664 (GRCm39) D1019E probably benign Het
Isyna1 A G 8: 71,047,358 (GRCm39) Y27C probably damaging Het
Itgb8 T G 12: 119,166,216 (GRCm39) H105P probably benign Het
Kbtbd11 C T 8: 15,077,572 (GRCm39) P57L probably benign Het
Kcns3 A C 12: 11,142,559 (GRCm39) C47G probably damaging Het
Kif21b A T 1: 136,099,895 (GRCm39) probably null Het
Lama3 A T 18: 12,552,302 (GRCm39) H418L possibly damaging Het
Lrit3 A G 3: 129,581,951 (GRCm39) Y679H probably damaging Het
Lrrc19 T A 4: 94,526,489 (GRCm39) D356V probably damaging Het
Morc2b A G 17: 33,354,781 (GRCm39) M997T probably benign Het
Mroh9 T C 1: 162,888,205 (GRCm39) H290R possibly damaging Het
Mtcl1 A T 17: 66,645,137 (GRCm39) S1886T possibly damaging Het
Muc20 T C 16: 32,613,791 (GRCm39) T529A possibly damaging Het
Myo7a A C 7: 97,734,673 (GRCm39) L607R probably damaging Het
Myom2 T A 8: 15,119,783 (GRCm39) F180I probably damaging Het
Myt1l G A 12: 29,861,484 (GRCm39) E89K unknown Het
Nek2 A G 1: 191,563,429 (GRCm39) N431S probably benign Het
Oprm1 A T 10: 6,782,604 (GRCm39) probably null Het
Or2aj4 A T 16: 19,384,730 (GRCm39) V301E possibly damaging Het
Or5t7 T A 2: 86,506,873 (GRCm39) H268L possibly damaging Het
Oxsr1 A G 9: 119,070,850 (GRCm39) probably benign Het
Pasd1 G C X: 70,982,379 (GRCm39) R296P possibly damaging Het
Pdgfrb G A 18: 61,211,720 (GRCm39) probably null Het
Proser1 C A 3: 53,386,485 (GRCm39) P789Q probably benign Het
Ptgs2 A G 1: 149,976,788 (GRCm39) Q7R probably benign Het
Rab3d A G 9: 21,825,982 (GRCm39) V144A probably benign Het
Ralgapb T A 2: 158,281,467 (GRCm39) L167H probably damaging Het
Ranbp3 A G 17: 57,015,200 (GRCm39) T301A possibly damaging Het
Rasgrf1 G A 9: 89,866,322 (GRCm39) V587M probably damaging Het
Sec16b A G 1: 157,392,433 (GRCm39) probably benign Het
Slc10a2 T C 8: 5,148,562 (GRCm39) S128G probably benign Het
Tbl1xr1 G A 3: 22,264,565 (GRCm39) V507I probably benign Het
Tmem8b T G 4: 43,669,896 (GRCm39) probably null Het
Trak1 A T 9: 121,196,233 (GRCm39) T22S probably benign Het
Trim30d A G 7: 104,136,862 (GRCm39) I114T probably damaging Het
Ttc13 A T 8: 125,401,105 (GRCm39) S624T probably damaging Het
Ttn T C 2: 76,658,474 (GRCm39) probably benign Het
Vipr1 T A 9: 121,489,237 (GRCm39) Y99* probably null Het
Vmn1r210 T C 13: 23,012,044 (GRCm39) K81E probably damaging Het
Wwc1 T C 11: 35,744,299 (GRCm39) Y841C probably benign Het
Xrcc4 A G 13: 90,149,024 (GRCm39) probably benign Het
Zdhhc22 A T 12: 87,035,071 (GRCm39) I127N probably damaging Het
Zdhhc7 A G 8: 120,814,785 (GRCm39) L8P possibly damaging Het
Zfp664 C A 5: 124,962,659 (GRCm39) L18I probably damaging Het
Other mutations in Sin3b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00586:Sin3b APN 8 73,483,628 (GRCm39) missense probably benign 0.22
IGL01107:Sin3b APN 8 73,457,733 (GRCm39) missense possibly damaging 0.74
IGL01114:Sin3b APN 8 73,471,133 (GRCm39) missense probably benign 0.06
IGL01603:Sin3b APN 8 73,476,692 (GRCm39) missense probably damaging 1.00
IGL01763:Sin3b APN 8 73,473,236 (GRCm39) missense probably damaging 1.00
IGL02078:Sin3b APN 8 73,480,208 (GRCm39) missense possibly damaging 0.49
IGL02572:Sin3b APN 8 73,471,109 (GRCm39) missense probably benign 0.15
IGL02732:Sin3b APN 8 73,460,081 (GRCm39) missense possibly damaging 0.72
IGL02831:Sin3b APN 8 73,471,190 (GRCm39) missense probably damaging 1.00
IGL03064:Sin3b APN 8 73,483,686 (GRCm39) unclassified probably benign
IGL03107:Sin3b APN 8 73,480,213 (GRCm39) missense probably damaging 0.99
IGL03142:Sin3b APN 8 73,471,196 (GRCm39) missense probably damaging 1.00
3-1:Sin3b UTSW 8 73,479,837 (GRCm39) missense possibly damaging 0.95
R0070:Sin3b UTSW 8 73,452,210 (GRCm39) missense probably damaging 1.00
R0070:Sin3b UTSW 8 73,452,210 (GRCm39) missense probably damaging 1.00
R0226:Sin3b UTSW 8 73,471,136 (GRCm39) missense probably benign 0.44
R1486:Sin3b UTSW 8 73,477,141 (GRCm39) missense probably benign 0.00
R1524:Sin3b UTSW 8 73,479,915 (GRCm39) missense probably benign 0.05
R1653:Sin3b UTSW 8 73,468,147 (GRCm39) missense probably benign 0.30
R2144:Sin3b UTSW 8 73,457,893 (GRCm39) missense probably damaging 1.00
R2180:Sin3b UTSW 8 73,479,923 (GRCm39) nonsense probably null
R2271:Sin3b UTSW 8 73,460,047 (GRCm39) missense probably benign 0.11
R2353:Sin3b UTSW 8 73,450,780 (GRCm39) critical splice donor site probably null
R3945:Sin3b UTSW 8 73,460,067 (GRCm39) missense possibly damaging 0.88
R4412:Sin3b UTSW 8 73,466,407 (GRCm39) missense probably benign 0.16
R4564:Sin3b UTSW 8 73,480,209 (GRCm39) missense probably damaging 1.00
R4782:Sin3b UTSW 8 73,452,271 (GRCm39) missense probably benign 0.04
R4799:Sin3b UTSW 8 73,452,271 (GRCm39) missense probably benign 0.04
R4863:Sin3b UTSW 8 73,471,576 (GRCm39) missense possibly damaging 0.91
R5011:Sin3b UTSW 8 73,471,184 (GRCm39) missense probably benign 0.39
R5237:Sin3b UTSW 8 73,459,971 (GRCm39) critical splice acceptor site probably null
R5325:Sin3b UTSW 8 73,477,154 (GRCm39) missense probably damaging 1.00
R5725:Sin3b UTSW 8 73,452,320 (GRCm39) critical splice donor site probably null
R5927:Sin3b UTSW 8 73,476,506 (GRCm39) missense probably benign 0.00
R5945:Sin3b UTSW 8 73,457,793 (GRCm39) missense probably damaging 0.97
R6492:Sin3b UTSW 8 73,460,118 (GRCm39) critical splice donor site probably null
R7092:Sin3b UTSW 8 73,474,498 (GRCm39) critical splice donor site probably null
R7106:Sin3b UTSW 8 73,450,765 (GRCm39) missense possibly damaging 0.90
R7258:Sin3b UTSW 8 73,476,836 (GRCm39) missense probably benign 0.00
R7472:Sin3b UTSW 8 73,479,853 (GRCm39) missense probably damaging 1.00
R7475:Sin3b UTSW 8 73,476,500 (GRCm39) missense possibly damaging 0.47
R7491:Sin3b UTSW 8 73,473,069 (GRCm39) missense probably damaging 1.00
R7636:Sin3b UTSW 8 73,474,362 (GRCm39) nonsense probably null
R8063:Sin3b UTSW 8 73,452,169 (GRCm39) missense probably damaging 1.00
R8354:Sin3b UTSW 8 73,468,108 (GRCm39) missense probably benign
R8454:Sin3b UTSW 8 73,468,108 (GRCm39) missense probably benign
R8711:Sin3b UTSW 8 73,450,026 (GRCm39) missense probably damaging 0.97
R8719:Sin3b UTSW 8 73,450,139 (GRCm39) missense unknown
R8807:Sin3b UTSW 8 73,476,708 (GRCm39) missense probably benign 0.00
R8857:Sin3b UTSW 8 73,483,523 (GRCm39) missense probably benign
R8924:Sin3b UTSW 8 73,473,131 (GRCm39) missense probably benign 0.05
R9035:Sin3b UTSW 8 73,450,092 (GRCm39) missense unknown
R9127:Sin3b UTSW 8 73,460,034 (GRCm39) missense possibly damaging 0.70
R9272:Sin3b UTSW 8 73,471,168 (GRCm39) missense probably benign 0.02
R9455:Sin3b UTSW 8 73,450,681 (GRCm39) missense possibly damaging 0.56
R9641:Sin3b UTSW 8 73,477,187 (GRCm39) missense probably damaging 1.00
X0017:Sin3b UTSW 8 73,457,793 (GRCm39) missense probably damaging 0.97
Predicted Primers PCR Primer
(F):5'- TGTCCTCCAGATGTGTTCGTGCAG -3'
(R):5'- ATCAGCACAGTTAGGGACGTGACC -3'

Sequencing Primer
(F):5'- ACTGCTTCAAGGTGAGACATTG -3'
(R):5'- GACGTGACCAGGACTGTG -3'
Posted On 2013-07-11