Mutagenetix > Incidental Mutation

Incidental Mutation 'R0629:Cdc37'

57757

Institutional Source

Beutler Lab

Gene Symbol

Cdc37

Ensembl Gene

ENSMUSG00000019471

Gene Name

cell division cycle 37

Synonyms

p50Cdc37

MMRRC Submission

038818-MU

Accession Numbers

Essential gene?

Probably essential (E-score: 0.948) question?

Stock #

R0629 (G1)

Quality Score

153

Status

Validated

Chromosome

Chromosomal Location

21133222-21149982 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to C at 21140768 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Arginine at position 325 (M325R)

Ref Sequence

ENSEMBL: ENSMUSP00000019615 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000019615] [ENSMUST00000215296]

AlphaFold

Q61081

Predicted Effect

possibly damaging
Transcript: ENSMUST00000019615
AA Change: M325R

PolyPhen 2 Score 0.716 (Sensitivity: 0.86; Specificity: 0.92)

SMART Domains

Protein: ENSMUSP00000019615
Gene: ENSMUSG00000019471
AA Change: M325R

Domain	Start	End	E-Value	Type
CDC37_N	1	128	1.07e-69	SMART
CDC37_M	121	283	4.37e-84	SMART
CDC37_C	287	379	1.25e-43	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000215296

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000215866

Meta Mutation Damage Score

0.7990

Coding Region Coverage

1x: 99.4%
3x: 98.9%
10x: 97.6%
20x: 95.6%

Validation Efficiency

100% (66/66)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is highly similar to Cdc 37, a cell division cycle control protein of Sacchromyces cerevisiae. This protein is a molecular chaperone with specific function in cell signal transduction. It has been shown to form complex with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. It is thought to play a critical role in directing Hsp90 to its target kinases. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 64 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aars2	A	T	17: 45,507,547 (GRCm38)	D86V	probably damaging	Het
Adamts14	G	A	10: 61,211,624 (GRCm38)	Q733*	probably null	Het
Adcy10	A	G	1: 165,543,105 (GRCm38)	D651G	probably damaging	Het
Apcdd1	T	A	18: 62,933,970 (GRCm38)	C52S	probably damaging	Het
Bclaf1	T	C	10: 20,333,426 (GRCm38)	S463P	probably damaging	Het
Cabcoco1	T	C	10: 68,516,278 (GRCm38)	Y68C	probably damaging	Het
Cacna1f	G	A	X: 7,620,434 (GRCm38)	S888N	probably damaging	Het
Cacna1g	A	G	11: 94,409,543 (GRCm38)	C2134R	possibly damaging	Het
Clca2	T	A	3: 145,072,239 (GRCm38)	M762L	probably benign	Het
Cntn3	C	T	6: 102,203,976 (GRCm38)	V753M	probably damaging	Het
Col6a6	A	T	9: 105,727,165 (GRCm38)		probably benign	Het
Dscaml1	A	G	9: 45,721,418 (GRCm38)	D1194G	probably damaging	Het
Egfr	G	A	11: 16,869,333 (GRCm38)	G288S	probably damaging	Het
Fbxl17	G	T	17: 63,471,414 (GRCm38)	N19K	probably damaging	Het
Fmo3	A	G	1: 162,958,227 (GRCm38)		probably benign	Het
Frmd6	T	C	12: 70,883,762 (GRCm38)	Y219H	probably damaging	Het
Fuca1	T	C	4: 135,925,644 (GRCm38)	V193A	possibly damaging	Het
Gm7461	C	T	8: 4,677,769 (GRCm38)		noncoding transcript	Het
Gpc5	T	A	14: 115,552,239 (GRCm38)	N508K	possibly damaging	Het
Iqch	A	T	9: 63,425,382 (GRCm38)	D1019E	probably benign	Het
Isyna1	A	G	8: 70,594,708 (GRCm38)	Y27C	probably damaging	Het
Itgb8	T	G	12: 119,202,481 (GRCm38)	H105P	probably benign	Het
Kbtbd11	C	T	8: 15,027,572 (GRCm38)	P57L	probably benign	Het
Kcns3	A	C	12: 11,092,558 (GRCm38)	C47G	probably damaging	Het
Kif21b	A	T	1: 136,172,157 (GRCm38)		probably null	Het
Lama3	A	T	18: 12,419,245 (GRCm38)	H418L	possibly damaging	Het
Lrit3	A	G	3: 129,788,302 (GRCm38)	Y679H	probably damaging	Het
Lrrc19	T	A	4: 94,638,252 (GRCm38)	D356V	probably damaging	Het
Morc2b	A	G	17: 33,135,807 (GRCm38)	M997T	probably benign	Het
Mroh9	T	C	1: 163,060,636 (GRCm38)	H290R	possibly damaging	Het
Mtcl1	A	T	17: 66,338,142 (GRCm38)	S1886T	possibly damaging	Het
Muc20	T	C	16: 32,793,421 (GRCm38)	T529A	possibly damaging	Het
Myo7a	A	C	7: 98,085,466 (GRCm38)	L607R	probably damaging	Het
Myom2	T	A	8: 15,069,783 (GRCm38)	F180I	probably damaging	Het
Myt1l	G	A	12: 29,811,485 (GRCm38)	E89K	unknown	Het
Nek2	A	G	1: 191,831,317 (GRCm38)	N431S	probably benign	Het
Oprm1	A	T	10: 6,832,604 (GRCm38)		probably null	Het
Or2aj4	A	T	16: 19,565,980 (GRCm38)	V301E	possibly damaging	Het
Or5t7	T	A	2: 86,676,529 (GRCm38)	H268L	possibly damaging	Het
Oxsr1	A	G	9: 119,241,784 (GRCm38)		probably benign	Het
Pasd1	G	C	X: 71,938,773 (GRCm38)	R296P	possibly damaging	Het
Pdgfrb	G	A	18: 61,078,648 (GRCm38)		probably null	Het
Proser1	C	A	3: 53,479,064 (GRCm38)	P789Q	probably benign	Het
Ptgs2	A	G	1: 150,101,037 (GRCm38)	Q7R	probably benign	Het
Rab3d	A	G	9: 21,914,686 (GRCm38)	V144A	probably benign	Het
Ralgapb	T	A	2: 158,439,547 (GRCm38)	L167H	probably damaging	Het
Ranbp3	A	G	17: 56,708,200 (GRCm38)	T301A	possibly damaging	Het
Rasgrf1	G	A	9: 89,984,269 (GRCm38)	V587M	probably damaging	Het
Sec16b	A	G	1: 157,564,863 (GRCm38)		probably benign	Het
Sin3b	T	C	8: 72,753,536 (GRCm38)		probably benign	Het
Slc10a2	T	C	8: 5,098,562 (GRCm38)	S128G	probably benign	Het
Tbl1xr1	G	A	3: 22,210,401 (GRCm38)	V507I	probably benign	Het
Tmem8b	T	G	4: 43,669,896 (GRCm38)		probably null	Het
Trak1	A	T	9: 121,367,167 (GRCm38)	T22S	probably benign	Het
Trim30d	A	G	7: 104,487,655 (GRCm38)	I114T	probably damaging	Het
Ttc13	A	T	8: 124,674,366 (GRCm38)	S624T	probably damaging	Het
Ttn	T	C	2: 76,828,130 (GRCm38)		probably benign	Het
Vipr1	T	A	9: 121,660,171 (GRCm38)	Y99*	probably null	Het
Vmn1r210	T	C	13: 22,827,874 (GRCm38)	K81E	probably damaging	Het
Wwc1	T	C	11: 35,853,472 (GRCm38)	Y841C	probably benign	Het
Xrcc4	A	G	13: 90,000,905 (GRCm38)		probably benign	Het
Zdhhc22	A	T	12: 86,988,297 (GRCm38)	I127N	probably damaging	Het
Zdhhc7	A	G	8: 120,088,046 (GRCm38)	L8P	possibly damaging	Het
Zfp664	C	A	5: 124,885,595 (GRCm38)	L18I	probably damaging	Het

Other mutations in Cdc37

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01943:Cdc37	APN	9	21,143,113 (GRCm38)	missense	probably benign	0.00
IGL02448:Cdc37	APN	9	21,139,851 (GRCm38)	missense	possibly damaging	0.55
IGL02547:Cdc37	APN	9	21,139,966 (GRCm38)	unclassified	probably benign
R0137:Cdc37	UTSW	9	21,142,130 (GRCm38)	missense	possibly damaging	0.74
R0195:Cdc37	UTSW	9	21,142,280 (GRCm38)	missense	probably benign	0.01
R0523:Cdc37	UTSW	9	21,142,996 (GRCm38)	missense	probably damaging	1.00
R0611:Cdc37	UTSW	9	21,142,241 (GRCm38)	missense	probably damaging	1.00
R0755:Cdc37	UTSW	9	21,139,864 (GRCm38)	missense	probably damaging	1.00
R1512:Cdc37	UTSW	9	21,142,416 (GRCm38)	splice site	probably benign
R2127:Cdc37	UTSW	9	21,149,847 (GRCm38)	missense	probably damaging	1.00
R2238:Cdc37	UTSW	9	21,142,533 (GRCm38)	nonsense	probably null
R2239:Cdc37	UTSW	9	21,142,533 (GRCm38)	nonsense	probably null
R3031:Cdc37	UTSW	9	21,143,191 (GRCm38)	missense	possibly damaging	0.88
R5068:Cdc37	UTSW	9	21,149,803 (GRCm38)	missense	probably damaging	0.98
R5169:Cdc37	UTSW	9	21,141,117 (GRCm38)	missense	probably benign	0.00
R5308:Cdc37	UTSW	9	21,140,764 (GRCm38)	missense	probably benign	0.00
R5333:Cdc37	UTSW	9	21,143,161 (GRCm38)	missense	possibly damaging	0.69
R5595:Cdc37	UTSW	9	21,143,213 (GRCm38)	missense	probably damaging	1.00
R7040:Cdc37	UTSW	9	21,142,223 (GRCm38)	missense	probably damaging	1.00
R7819:Cdc37	UTSW	9	21,140,964 (GRCm38)	missense	probably damaging	0.97
R8066:Cdc37	UTSW	9	21,143,141 (GRCm38)	missense	probably benign	0.01
R8500:Cdc37	UTSW	9	21,140,801 (GRCm38)	missense	probably damaging	0.99

Predicted Primers

PCR Primer
(F):5'- TGTCGTTCTCAGACAGGGTCTCAC -3'
(R):5'- CACCAGTACATGGAGGGCTTCAAG -3'

Sequencing Primer
(F):5'- ctgaattgctctggctcatcttaac -3'
(R):5'- CTTCAAGTATGAACTGGAAGCC -3'

Posted On

2013-07-11