|Institutional Source||Beutler Lab|
|Gene Name||cell division cycle 37|
|Is this an essential gene?||Probably essential (E-score: 0.951)|
|Stock #||R0629 (G1)|
|Chromosomal Location||21133222-21149982 bp(-) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||A to C at 21140768 bp|
|Amino Acid Change||Methionine to Arginine at position 325 (M325R)|
|Ref Sequence||ENSEMBL: ENSMUSP00000019615 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000019615] [ENSMUST00000215296]|
|Predicted Effect||possibly damaging
AA Change: M325R
PolyPhen 2 Score 0.716 (Sensitivity: 0.86; Specificity: 0.92)
AA Change: M325R
|Predicted Effect||probably benign
|Predicted Effect||noncoding transcript
|Meta Mutation Damage Score||0.7990|
|Coding Region Coverage||
|Validation Efficiency||100% (66/66)|
|MGI Phenotype||FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is highly similar to Cdc 37, a cell division cycle control protein of Sacchromyces cerevisiae. This protein is a molecular chaperone with specific function in cell signal transduction. It has been shown to form complex with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. It is thought to play a critical role in directing Hsp90 to its target kinases. [provided by RefSeq, Jul 2008]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Cdc37||
(F):5'- TGTCGTTCTCAGACAGGGTCTCAC -3'
(R):5'- CACCAGTACATGGAGGGCTTCAAG -3'
(F):5'- ctgaattgctctggctcatcttaac -3'
(R):5'- CTTCAAGTATGAACTGGAAGCC -3'