Incidental Mutation 'R0629:Dscaml1'
ID 57759
Institutional Source Beutler Lab
Gene Symbol Dscaml1
Ensembl Gene ENSMUSG00000032087
Gene Name DS cell adhesion molecule like 1
Synonyms 4921507G06Rik, 4930435C18Rik
MMRRC Submission 038818-MU
Accession Numbers
Essential gene? Possibly essential (E-score: 0.674) question?
Stock # R0629 (G1)
Quality Score 210
Status Validated
Chromosome 9
Chromosomal Location 45426628-45753712 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to G at 45721418 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 1194 (D1194G)
Ref Sequence ENSEMBL: ENSMUSP00000034592 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000034592]
AlphaFold Q4VA61
Predicted Effect probably damaging
Transcript: ENSMUST00000034592
AA Change: D1194G

PolyPhen 2 Score 0.983 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000034592
Gene: ENSMUSG00000032087
AA Change: D1194G

DomainStartEndE-ValueType
low complexity region 3 17 N/A INTRINSIC
low complexity region 28 55 N/A INTRINSIC
IG_like 96 168 1.22e0 SMART
IG 189 277 1.15e-3 SMART
IGc2 296 359 2.54e-14 SMART
IGc2 385 451 8.12e-13 SMART
IGc2 478 550 9.55e-10 SMART
IGc2 575 640 9.78e-7 SMART
IGc2 666 734 5.93e-6 SMART
IGc2 760 832 6.75e-10 SMART
IG 853 943 1e-3 SMART
FN3 945 1029 6.64e-7 SMART
FN3 1045 1133 9.46e-12 SMART
FN3 1148 1234 3.2e-9 SMART
FN3 1249 1332 3.48e-10 SMART
IGc2 1363 1428 1.49e-11 SMART
FN3 1442 1522 3.42e-9 SMART
FN3 1537 1618 2.14e-1 SMART
low complexity region 1671 1683 N/A INTRINSIC
low complexity region 2018 2026 N/A INTRINSIC
low complexity region 2035 2069 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000216685
AA Change: D223G
Meta Mutation Damage Score 0.2014 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.9%
  • 10x: 97.6%
  • 20x: 95.6%
Validation Efficiency 100% (66/66)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the Ig superfamily of cell adhesion molecules and is involved in neuronal differentiation. The encoded membrane-bound protein localizes to the cell surface, where it forms aggregates that repel neuronal processes of the same cell type. [provided by RefSeq, Sep 2016]
PHENOTYPE: Mice homozygous for a gene trapped allele exhibit impaired self-avoidance in multiple cell types in the retina. [provided by MGI curators]
Allele List at MGI

All alleles(4) : Gene trapped(4)

Other mutations in this stock
Total: 64 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aars2 A T 17: 45,507,547 (GRCm38) D86V probably damaging Het
Adamts14 G A 10: 61,211,624 (GRCm38) Q733* probably null Het
Adcy10 A G 1: 165,543,105 (GRCm38) D651G probably damaging Het
Apcdd1 T A 18: 62,933,970 (GRCm38) C52S probably damaging Het
Bclaf1 T C 10: 20,333,426 (GRCm38) S463P probably damaging Het
Cabcoco1 T C 10: 68,516,278 (GRCm38) Y68C probably damaging Het
Cacna1f G A X: 7,620,434 (GRCm38) S888N probably damaging Het
Cacna1g A G 11: 94,409,543 (GRCm38) C2134R possibly damaging Het
Cdc37 A C 9: 21,140,768 (GRCm38) M325R possibly damaging Het
Clca2 T A 3: 145,072,239 (GRCm38) M762L probably benign Het
Cntn3 C T 6: 102,203,976 (GRCm38) V753M probably damaging Het
Col6a6 A T 9: 105,727,165 (GRCm38) probably benign Het
Egfr G A 11: 16,869,333 (GRCm38) G288S probably damaging Het
Fbxl17 G T 17: 63,471,414 (GRCm38) N19K probably damaging Het
Fmo3 A G 1: 162,958,227 (GRCm38) probably benign Het
Frmd6 T C 12: 70,883,762 (GRCm38) Y219H probably damaging Het
Fuca1 T C 4: 135,925,644 (GRCm38) V193A possibly damaging Het
Gm1141 G C X: 71,938,773 (GRCm38) R296P possibly damaging Het
Gm7461 C T 8: 4,677,769 (GRCm38) noncoding transcript Het
Gpc5 T A 14: 115,552,239 (GRCm38) N508K possibly damaging Het
Iqch A T 9: 63,425,382 (GRCm38) D1019E probably benign Het
Isyna1 A G 8: 70,594,708 (GRCm38) Y27C probably damaging Het
Itgb8 T G 12: 119,202,481 (GRCm38) H105P probably benign Het
Kbtbd11 C T 8: 15,027,572 (GRCm38) P57L probably benign Het
Kcns3 A C 12: 11,092,558 (GRCm38) C47G probably damaging Het
Kif21b A T 1: 136,172,157 (GRCm38) probably null Het
Lama3 A T 18: 12,419,245 (GRCm38) H418L possibly damaging Het
Lrit3 A G 3: 129,788,302 (GRCm38) Y679H probably damaging Het
Lrrc19 T A 4: 94,638,252 (GRCm38) D356V probably damaging Het
Morc2b A G 17: 33,135,807 (GRCm38) M997T probably benign Het
Mroh9 T C 1: 163,060,636 (GRCm38) H290R possibly damaging Het
Mtcl1 A T 17: 66,338,142 (GRCm38) S1886T possibly damaging Het
Muc20 T C 16: 32,793,421 (GRCm38) T529A possibly damaging Het
Myo7a A C 7: 98,085,466 (GRCm38) L607R probably damaging Het
Myom2 T A 8: 15,069,783 (GRCm38) F180I probably damaging Het
Myt1l G A 12: 29,811,485 (GRCm38) E89K unknown Het
Nek2 A G 1: 191,831,317 (GRCm38) N431S probably benign Het
Olfr1086 T A 2: 86,676,529 (GRCm38) H268L possibly damaging Het
Olfr169 A T 16: 19,565,980 (GRCm38) V301E possibly damaging Het
Oprm1 A T 10: 6,832,604 (GRCm38) probably null Het
Oxsr1 A G 9: 119,241,784 (GRCm38) probably benign Het
Pdgfrb G A 18: 61,078,648 (GRCm38) probably null Het
Proser1 C A 3: 53,479,064 (GRCm38) P789Q probably benign Het
Ptgs2 A G 1: 150,101,037 (GRCm38) Q7R probably benign Het
Rab3d A G 9: 21,914,686 (GRCm38) V144A probably benign Het
Ralgapb T A 2: 158,439,547 (GRCm38) L167H probably damaging Het
Ranbp3 A G 17: 56,708,200 (GRCm38) T301A possibly damaging Het
Rasgrf1 G A 9: 89,984,269 (GRCm38) V587M probably damaging Het
Sec16b A G 1: 157,564,863 (GRCm38) probably benign Het
Sin3b T C 8: 72,753,536 (GRCm38) probably benign Het
Slc10a2 T C 8: 5,098,562 (GRCm38) S128G probably benign Het
Tbl1xr1 G A 3: 22,210,401 (GRCm38) V507I probably benign Het
Tmem8b T G 4: 43,669,896 (GRCm38) probably null Het
Trak1 A T 9: 121,367,167 (GRCm38) T22S probably benign Het
Trim30d A G 7: 104,487,655 (GRCm38) I114T probably damaging Het
Ttc13 A T 8: 124,674,366 (GRCm38) S624T probably damaging Het
Ttn T C 2: 76,828,130 (GRCm38) probably benign Het
Vipr1 T A 9: 121,660,171 (GRCm38) Y99* probably null Het
Vmn1r210 T C 13: 22,827,874 (GRCm38) K81E probably damaging Het
Wwc1 T C 11: 35,853,472 (GRCm38) Y841C probably benign Het
Xrcc4 A G 13: 90,000,905 (GRCm38) probably benign Het
Zdhhc22 A T 12: 86,988,297 (GRCm38) I127N probably damaging Het
Zdhhc7 A G 8: 120,088,046 (GRCm38) L8P possibly damaging Het
Zfp664 C A 5: 124,885,595 (GRCm38) L18I probably damaging Het
Other mutations in Dscaml1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00418:Dscaml1 APN 9 45,670,200 (GRCm38) nonsense probably null
IGL00497:Dscaml1 APN 9 45,752,238 (GRCm38) missense probably damaging 1.00
IGL00895:Dscaml1 APN 9 45,751,253 (GRCm38) missense probably damaging 0.99
IGL01011:Dscaml1 APN 9 45,683,672 (GRCm38) missense possibly damaging 0.76
IGL01086:Dscaml1 APN 9 45,702,662 (GRCm38) splice site probably benign
IGL01125:Dscaml1 APN 9 45,749,632 (GRCm38) critical splice acceptor site probably null
IGL01132:Dscaml1 APN 9 45,752,328 (GRCm38) nonsense probably null
IGL01356:Dscaml1 APN 9 45,746,857 (GRCm38) missense probably benign 0.03
IGL01459:Dscaml1 APN 9 45,742,683 (GRCm38) nonsense probably null
IGL01552:Dscaml1 APN 9 45,447,908 (GRCm38) missense probably damaging 1.00
IGL02033:Dscaml1 APN 9 45,683,782 (GRCm38) missense probably damaging 1.00
IGL02044:Dscaml1 APN 9 45,746,943 (GRCm38) nonsense probably null
IGL02095:Dscaml1 APN 9 45,447,703 (GRCm38) missense probably damaging 1.00
IGL02166:Dscaml1 APN 9 45,683,701 (GRCm38) missense probably damaging 0.98
IGL02262:Dscaml1 APN 9 45,732,080 (GRCm38) missense probably benign 0.44
IGL02262:Dscaml1 APN 9 45,745,116 (GRCm38) missense probably benign
IGL02340:Dscaml1 APN 9 45,670,176 (GRCm38) missense possibly damaging 0.66
IGL02604:Dscaml1 APN 9 45,744,328 (GRCm38) unclassified probably benign
IGL02619:Dscaml1 APN 9 45,447,796 (GRCm38) missense probably damaging 1.00
IGL02805:Dscaml1 APN 9 45,447,897 (GRCm38) missense probably damaging 0.98
IGL03409:Dscaml1 APN 9 45,670,103 (GRCm38) missense probably damaging 1.00
D3080:Dscaml1 UTSW 9 45,684,325 (GRCm38) missense probably benign 0.44
IGL03050:Dscaml1 UTSW 9 45,742,999 (GRCm38) missense probably damaging 1.00
R0149:Dscaml1 UTSW 9 45,742,680 (GRCm38) nonsense probably null
R0582:Dscaml1 UTSW 9 45,668,264 (GRCm38) missense possibly damaging 0.77
R0632:Dscaml1 UTSW 9 45,732,134 (GRCm38) missense probably benign 0.06
R0815:Dscaml1 UTSW 9 45,745,074 (GRCm38) missense probably benign 0.00
R1162:Dscaml1 UTSW 9 45,752,349 (GRCm38) splice site probably benign
R1449:Dscaml1 UTSW 9 45,742,223 (GRCm38) missense possibly damaging 0.95
R1474:Dscaml1 UTSW 9 45,685,221 (GRCm38) missense probably damaging 1.00
R1481:Dscaml1 UTSW 9 45,672,643 (GRCm38) missense probably benign 0.01
R1533:Dscaml1 UTSW 9 45,450,584 (GRCm38) missense probably damaging 0.99
R1542:Dscaml1 UTSW 9 45,749,440 (GRCm38) missense possibly damaging 0.84
R1572:Dscaml1 UTSW 9 45,721,333 (GRCm38) missense probably benign 0.00
R1627:Dscaml1 UTSW 9 45,753,147 (GRCm38) missense probably damaging 1.00
R1634:Dscaml1 UTSW 9 45,672,749 (GRCm38) missense probably damaging 1.00
R1713:Dscaml1 UTSW 9 45,752,690 (GRCm38) missense possibly damaging 0.49
R1777:Dscaml1 UTSW 9 45,683,756 (GRCm38) missense possibly damaging 0.58
R1812:Dscaml1 UTSW 9 45,751,286 (GRCm38) critical splice donor site probably null
R1834:Dscaml1 UTSW 9 45,683,632 (GRCm38) missense probably benign 0.00
R1907:Dscaml1 UTSW 9 45,740,480 (GRCm38) missense probably damaging 1.00
R1953:Dscaml1 UTSW 9 45,670,224 (GRCm38) missense probably benign 0.01
R2056:Dscaml1 UTSW 9 45,750,132 (GRCm38) missense probably damaging 0.99
R2193:Dscaml1 UTSW 9 45,685,234 (GRCm38) missense probably benign 0.21
R2497:Dscaml1 UTSW 9 45,745,078 (GRCm38) missense probably benign 0.00
R3768:Dscaml1 UTSW 9 45,732,137 (GRCm38) missense possibly damaging 0.94
R3891:Dscaml1 UTSW 9 45,717,484 (GRCm38) missense possibly damaging 0.84
R4110:Dscaml1 UTSW 9 45,732,068 (GRCm38) missense probably benign 0.07
R4706:Dscaml1 UTSW 9 45,450,580 (GRCm38) missense probably damaging 1.00
R4716:Dscaml1 UTSW 9 45,450,592 (GRCm38) missense probably damaging 1.00
R4719:Dscaml1 UTSW 9 45,672,695 (GRCm38) missense probably benign 0.13
R4770:Dscaml1 UTSW 9 45,670,106 (GRCm38) missense probably damaging 1.00
R4924:Dscaml1 UTSW 9 45,745,189 (GRCm38) missense probably damaging 1.00
R5167:Dscaml1 UTSW 9 45,717,432 (GRCm38) missense probably damaging 1.00
R5346:Dscaml1 UTSW 9 45,450,559 (GRCm38) missense possibly damaging 0.63
R5737:Dscaml1 UTSW 9 45,745,185 (GRCm38) missense probably damaging 0.99
R5977:Dscaml1 UTSW 9 45,721,298 (GRCm38) missense probably benign 0.19
R6073:Dscaml1 UTSW 9 45,450,583 (GRCm38) missense probably benign 0.22
R6276:Dscaml1 UTSW 9 45,668,160 (GRCm38) missense possibly damaging 0.62
R6415:Dscaml1 UTSW 9 45,683,677 (GRCm38) nonsense probably null
R6527:Dscaml1 UTSW 9 45,712,184 (GRCm38) nonsense probably null
R6582:Dscaml1 UTSW 9 45,752,806 (GRCm38) missense probably benign 0.00
R6655:Dscaml1 UTSW 9 45,746,937 (GRCm38) missense probably benign 0.00
R6772:Dscaml1 UTSW 9 45,710,311 (GRCm38) missense probably damaging 1.00
R6799:Dscaml1 UTSW 9 45,450,583 (GRCm38) missense probably benign 0.22
R6892:Dscaml1 UTSW 9 45,683,830 (GRCm38) missense probably damaging 0.99
R6918:Dscaml1 UTSW 9 45,430,507 (GRCm38) missense probably benign
R6967:Dscaml1 UTSW 9 45,674,523 (GRCm38) missense probably damaging 0.97
R7214:Dscaml1 UTSW 9 45,670,139 (GRCm38) missense probably benign 0.01
R7286:Dscaml1 UTSW 9 45,742,746 (GRCm38) critical splice donor site probably null
R7315:Dscaml1 UTSW 9 45,745,125 (GRCm38) missense probably benign 0.00
R7338:Dscaml1 UTSW 9 45,674,504 (GRCm38) missense probably benign 0.12
R7343:Dscaml1 UTSW 9 45,752,916 (GRCm38) missense probably benign
R7395:Dscaml1 UTSW 9 45,702,405 (GRCm38) missense possibly damaging 0.73
R7439:Dscaml1 UTSW 9 45,710,326 (GRCm38) missense possibly damaging 0.94
R7484:Dscaml1 UTSW 9 45,749,446 (GRCm38) splice site probably null
R7545:Dscaml1 UTSW 9 45,685,383 (GRCm38) missense probably benign 0.11
R7979:Dscaml1 UTSW 9 45,683,731 (GRCm38) missense probably damaging 1.00
R8005:Dscaml1 UTSW 9 45,717,510 (GRCm38) missense probably damaging 1.00
R8181:Dscaml1 UTSW 9 45,746,842 (GRCm38) missense possibly damaging 0.86
R8262:Dscaml1 UTSW 9 45,747,140 (GRCm38) intron probably benign
R8428:Dscaml1 UTSW 9 45,742,586 (GRCm38) missense probably benign 0.00
R8725:Dscaml1 UTSW 9 45,430,461 (GRCm38) missense probably benign 0.00
R8727:Dscaml1 UTSW 9 45,430,461 (GRCm38) missense probably benign 0.00
R8796:Dscaml1 UTSW 9 45,447,728 (GRCm38) missense probably damaging 0.99
R8840:Dscaml1 UTSW 9 45,723,420 (GRCm38) missense probably damaging 0.99
R9291:Dscaml1 UTSW 9 45,447,953 (GRCm38) missense probably damaging 1.00
R9394:Dscaml1 UTSW 9 45,750,056 (GRCm38) missense possibly damaging 0.64
R9610:Dscaml1 UTSW 9 45,668,224 (GRCm38) missense possibly damaging 0.95
R9611:Dscaml1 UTSW 9 45,668,224 (GRCm38) missense possibly damaging 0.95
R9653:Dscaml1 UTSW 9 45,732,168 (GRCm38) critical splice donor site probably null
R9699:Dscaml1 UTSW 9 45,743,017 (GRCm38) missense probably damaging 0.97
X0058:Dscaml1 UTSW 9 45,752,128 (GRCm38) missense probably benign 0.00
Z1177:Dscaml1 UTSW 9 45,672,791 (GRCm38) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- GGCTGTCTCTCATACCCTAACTGACTG -3'
(R):5'- GTGCAAATGGACCCCGATCTACAC -3'

Sequencing Primer
(F):5'- ATACCCTAACTGACTGTTGATTTCC -3'
(R):5'- atctgcctgcctctgcc -3'
Posted On 2013-07-11