Mutagenetix > Incidental Mutation

Incidental Mutation 'R7449:Birc6'

577608

Institutional Source

Beutler Lab

Gene Symbol

Birc6

Ensembl Gene

ENSMUSG00000024073

Gene Name

baculoviral IAP repeat-containing 6

Synonyms

D630005A10Rik, A430032G04Rik, apollon, Bruce, A430040A19Rik

MMRRC Submission

045524-MU

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R7449 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

74835290-75010351 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 75009336 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Lysine at position 4869 (N4869K)

Ref Sequence

ENSEMBL: ENSMUSP00000138333 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000180037] [ENSMUST00000182133] [ENSMUST00000182597] [ENSMUST00000182944] [ENSMUST00000183224]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000180037
AA Change: N4860K

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000136329
Gene: ENSMUSG00000024073
AA Change: N4860K

Domain	Start	End	E-Value	Type
low complexity region	24	54	N/A	INTRINSIC
BIR	287	363	2.87e-24	SMART
low complexity region	472	493	N/A	INTRINSIC
low complexity region	624	635	N/A	INTRINSIC
low complexity region	674	685	N/A	INTRINSIC
low complexity region	769	781	N/A	INTRINSIC
low complexity region	1054	1071	N/A	INTRINSIC
low complexity region	1369	1380	N/A	INTRINSIC
coiled coil region	1620	1675	N/A	INTRINSIC
low complexity region	1709	1726	N/A	INTRINSIC
low complexity region	1993	1998	N/A	INTRINSIC
low complexity region	2044	2059	N/A	INTRINSIC
low complexity region	2142	2163	N/A	INTRINSIC
low complexity region	2253	2266	N/A	INTRINSIC
low complexity region	2491	2505	N/A	INTRINSIC
low complexity region	2671	2688	N/A	INTRINSIC
low complexity region	2893	2905	N/A	INTRINSIC
low complexity region	2958	2970	N/A	INTRINSIC
Pfam:DUF3643	3477	3632	1e-69	PFAM
low complexity region	3747	3772	N/A	INTRINSIC
low complexity region	3900	3919	N/A	INTRINSIC
low complexity region	3940	3958	N/A	INTRINSIC
low complexity region	3963	3972	N/A	INTRINSIC
low complexity region	4146	4157	N/A	INTRINSIC
low complexity region	4307	4318	N/A	INTRINSIC
low complexity region	4433	4444	N/A	INTRINSIC
UBCc	4592	4756	1.04e-25	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000182133
AA Change: N4854K

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000138693
Gene: ENSMUSG00000024073
AA Change: N4854K

Domain	Start	End	E-Value	Type
low complexity region	24	54	N/A	INTRINSIC
BIR	287	363	2.87e-24	SMART
low complexity region	472	493	N/A	INTRINSIC
low complexity region	624	635	N/A	INTRINSIC
low complexity region	674	685	N/A	INTRINSIC
low complexity region	769	781	N/A	INTRINSIC
low complexity region	1054	1071	N/A	INTRINSIC
low complexity region	1369	1380	N/A	INTRINSIC
coiled coil region	1620	1675	N/A	INTRINSIC
low complexity region	1709	1726	N/A	INTRINSIC
low complexity region	1993	1998	N/A	INTRINSIC
low complexity region	2044	2055	N/A	INTRINSIC
low complexity region	2136	2157	N/A	INTRINSIC
low complexity region	2247	2260	N/A	INTRINSIC
low complexity region	2485	2499	N/A	INTRINSIC
low complexity region	2665	2682	N/A	INTRINSIC
low complexity region	2887	2899	N/A	INTRINSIC
low complexity region	2952	2964	N/A	INTRINSIC
Pfam:DUF3643	3470	3626	2.1e-71	PFAM
low complexity region	3741	3766	N/A	INTRINSIC
low complexity region	3894	3913	N/A	INTRINSIC
low complexity region	3934	3952	N/A	INTRINSIC
low complexity region	3957	3966	N/A	INTRINSIC
low complexity region	4140	4151	N/A	INTRINSIC
low complexity region	4301	4312	N/A	INTRINSIC
low complexity region	4427	4438	N/A	INTRINSIC
UBCc	4586	4750	1.04e-25	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000182597
AA Change: N4869K

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000138333
Gene: ENSMUSG00000024073
AA Change: N4869K

Domain	Start	End	E-Value	Type
low complexity region	24	54	N/A	INTRINSIC
BIR	287	363	2.87e-24	SMART
low complexity region	472	493	N/A	INTRINSIC
low complexity region	624	635	N/A	INTRINSIC
low complexity region	674	685	N/A	INTRINSIC
low complexity region	769	781	N/A	INTRINSIC
low complexity region	1054	1071	N/A	INTRINSIC
low complexity region	1369	1380	N/A	INTRINSIC
coiled coil region	1620	1675	N/A	INTRINSIC
low complexity region	1709	1726	N/A	INTRINSIC
low complexity region	1993	1998	N/A	INTRINSIC
low complexity region	2044	2059	N/A	INTRINSIC
low complexity region	2142	2163	N/A	INTRINSIC
low complexity region	2262	2275	N/A	INTRINSIC
low complexity region	2500	2514	N/A	INTRINSIC
low complexity region	2680	2697	N/A	INTRINSIC
low complexity region	2902	2914	N/A	INTRINSIC
low complexity region	2967	2979	N/A	INTRINSIC
Pfam:DUF3643	3485	3641	2.2e-71	PFAM
low complexity region	3756	3781	N/A	INTRINSIC
low complexity region	3909	3928	N/A	INTRINSIC
low complexity region	3949	3967	N/A	INTRINSIC
low complexity region	3972	3981	N/A	INTRINSIC
low complexity region	4155	4166	N/A	INTRINSIC
low complexity region	4316	4327	N/A	INTRINSIC
low complexity region	4442	4453	N/A	INTRINSIC
UBCc	4601	4765	1.04e-25	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000182944
AA Change: N4856K

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000138732
Gene: ENSMUSG00000024073
AA Change: N4856K

Domain	Start	End	E-Value	Type
low complexity region	24	54	N/A	INTRINSIC
BIR	287	363	2.87e-24	SMART
low complexity region	472	493	N/A	INTRINSIC
low complexity region	624	635	N/A	INTRINSIC
low complexity region	674	685	N/A	INTRINSIC
low complexity region	769	781	N/A	INTRINSIC
low complexity region	1054	1071	N/A	INTRINSIC
low complexity region	1369	1380	N/A	INTRINSIC
coiled coil region	1616	1671	N/A	INTRINSIC
low complexity region	1705	1722	N/A	INTRINSIC
low complexity region	1989	1994	N/A	INTRINSIC
low complexity region	2040	2055	N/A	INTRINSIC
low complexity region	2138	2159	N/A	INTRINSIC
low complexity region	2249	2262	N/A	INTRINSIC
low complexity region	2487	2501	N/A	INTRINSIC
low complexity region	2667	2684	N/A	INTRINSIC
low complexity region	2889	2901	N/A	INTRINSIC
low complexity region	2954	2966	N/A	INTRINSIC
Pfam:DUF3643	3472	3628	3.2e-71	PFAM
low complexity region	3743	3768	N/A	INTRINSIC
low complexity region	3896	3915	N/A	INTRINSIC
low complexity region	3936	3954	N/A	INTRINSIC
low complexity region	3959	3968	N/A	INTRINSIC
low complexity region	4142	4153	N/A	INTRINSIC
low complexity region	4303	4314	N/A	INTRINSIC
low complexity region	4429	4440	N/A	INTRINSIC
UBCc	4588	4752	1.04e-25	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000183224
AA Change: N4840K

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000138270
Gene: ENSMUSG00000024073
AA Change: N4840K

Domain	Start	End	E-Value	Type
low complexity region	2	26	N/A	INTRINSIC
BIR	259	335	2.87e-24	SMART
low complexity region	444	465	N/A	INTRINSIC
low complexity region	596	607	N/A	INTRINSIC
low complexity region	646	657	N/A	INTRINSIC
low complexity region	741	753	N/A	INTRINSIC
low complexity region	1026	1043	N/A	INTRINSIC
low complexity region	1355	1366	N/A	INTRINSIC
coiled coil region	1606	1661	N/A	INTRINSIC
low complexity region	1695	1712	N/A	INTRINSIC
low complexity region	1979	1984	N/A	INTRINSIC
low complexity region	2030	2041	N/A	INTRINSIC
low complexity region	2122	2143	N/A	INTRINSIC
low complexity region	2233	2246	N/A	INTRINSIC
low complexity region	2471	2485	N/A	INTRINSIC
low complexity region	2651	2668	N/A	INTRINSIC
low complexity region	2873	2885	N/A	INTRINSIC
low complexity region	2938	2950	N/A	INTRINSIC
Pfam:DUF3643	3456	3612	3.2e-71	PFAM
low complexity region	3727	3752	N/A	INTRINSIC
low complexity region	3880	3899	N/A	INTRINSIC
low complexity region	3920	3938	N/A	INTRINSIC
low complexity region	3943	3952	N/A	INTRINSIC
low complexity region	4126	4137	N/A	INTRINSIC
low complexity region	4287	4298	N/A	INTRINSIC
low complexity region	4413	4424	N/A	INTRINSIC
UBCc	4572	4736	1.04e-25	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000183249

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.7%
20x: 99.0%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. This protein inhibits apoptosis by facilitating the degradation of apoptotic proteins by ubiquitination. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous mice exhibit perinatal lethality and exhibit placental defects. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 73 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca16	T	A	7: 120,035,131 (GRCm39)	Y306N	possibly damaging	Het
Adgrv1	A	T	13: 81,647,192 (GRCm39)	V3116D	probably damaging	Het
Adss1	A	T	12: 112,600,585 (GRCm39)	T185S	probably damaging	Het
Ago2	G	A	15: 73,018,348 (GRCm39)	P30L	probably damaging	Het
Arb2a	A	G	13: 77,907,561 (GRCm39)	I41V	probably damaging	Het
Atp5pf	C	T	16: 84,628,251 (GRCm39)	V44M	probably benign	Het
Atp7b	T	A	8: 22,501,865 (GRCm39)	I833F	probably damaging	Het
Cacna1c	C	T	6: 118,579,310 (GRCm39)	D1796N		Het
Ccng2	C	G	5: 93,421,202 (GRCm39)	S237R	probably benign	Het
Cnga1	A	G	5: 72,762,647 (GRCm39)	I289T	probably benign	Het
Crybg1	C	A	10: 43,880,515 (GRCm39)	E224D	probably benign	Het
Dysf	T	C	6: 84,114,362 (GRCm39)	L1217P	possibly damaging	Het
Ebf2	T	A	14: 67,647,469 (GRCm39)	N339K	probably damaging	Het
Eva1c	T	C	16: 90,673,081 (GRCm39)		probably null	Het
Fam184a	T	C	10: 53,574,730 (GRCm39)	E293G	probably damaging	Het
Folh1	G	A	7: 86,380,956 (GRCm39)	P506S	probably benign	Het
Ftcd	A	T	10: 76,415,997 (GRCm39)	K210N	probably benign	Het
Gdf6	T	A	4: 9,844,494 (GRCm39)	V6D	possibly damaging	Het
Ghitm	C	A	14: 36,853,538 (GRCm39)	G101C	probably damaging	Het
Gimap5	T	A	6: 48,729,838 (GRCm39)	V136D	probably damaging	Het
Grm4	C	T	17: 27,654,345 (GRCm39)	G535D	probably damaging	Het
Gse1	T	C	8: 120,956,450 (GRCm39)	S314P	unknown	Het
Hnrnpdl	A	G	5: 100,185,014 (GRCm39)	I279T	probably damaging	Het
Idi2l	T	A	13: 8,993,340 (GRCm39)	H51L	probably damaging	Het
Itpr1	T	C	6: 108,366,345 (GRCm39)	S923P	probably damaging	Het
Krt39	C	A	11: 99,408,887 (GRCm39)	C303F	probably benign	Het
Lrrn1	T	C	6: 107,545,482 (GRCm39)	S427P	possibly damaging	Het
Lrrn3	T	A	12: 41,503,487 (GRCm39)	R277W	probably damaging	Het
Ltb4r1	T	C	14: 56,005,375 (GRCm39)	L226P	probably damaging	Het
Map1b	C	T	13: 99,644,648 (GRCm39)	R85Q	probably damaging	Het
Mcoln1	T	C	8: 3,557,285 (GRCm39)	L125P	probably damaging	Het
Nid1	T	G	13: 13,656,636 (GRCm39)	V589G	probably damaging	Het
Nlrp5	T	G	7: 23,116,951 (GRCm39)	F225C	probably benign	Het
Notch3	C	T	17: 32,376,940 (GRCm39)	A322T	probably damaging	Het
Or14c43	A	G	7: 86,115,063 (GRCm39)	H148R	probably benign	Het
Or52a5b	G	T	7: 103,417,026 (GRCm39)	Q193K	probably benign	Het
Or7g34	T	A	9: 19,478,162 (GRCm39)	T173S	probably benign	Het
Otogl	A	G	10: 107,639,524 (GRCm39)	C1363R	probably damaging	Het
Ovol1	T	A	19: 5,603,625 (GRCm39)	D92V	probably benign	Het
Pigt	T	C	2: 164,344,419 (GRCm39)	L356P	probably damaging	Het
Plekhg3	A	G	12: 76,612,996 (GRCm39)	Q434R	probably damaging	Het
Plekhh1	T	C	12: 79,126,326 (GRCm39)	F1344L	probably benign	Het
Polr1has	A	G	17: 37,275,275 (GRCm39)	D16G	probably damaging	Het
Psmd3	T	A	11: 98,586,377 (GRCm39)	L515Q	probably damaging	Het
Pus1	A	G	5: 110,922,452 (GRCm39)	L405P	probably damaging	Het
Qtrt2	T	A	16: 43,701,395 (GRCm39)	H55L	probably benign	Het
Rasgrp1	T	C	2: 117,118,424 (GRCm39)	I522V	probably damaging	Het
Raver2	T	A	4: 100,959,860 (GRCm39)	H113Q	probably damaging	Het
Recql4	T	C	15: 76,589,765 (GRCm39)	D760G	unknown	Het
Rhobtb3	C	T	13: 76,058,860 (GRCm39)	V313M	probably benign	Het
Rhox4d	G	A	X: 36,700,645 (GRCm39)	G191E	unknown	Het
Rictor	C	T	15: 6,801,635 (GRCm39)	S441L	probably benign	Het
Rnf185	T	C	11: 3,376,578 (GRCm39)	Q135R	probably benign	Het
Sema3f	T	C	9: 107,561,235 (GRCm39)	S584G	probably damaging	Het
Sh3pxd2a	T	A	19: 47,256,091 (GRCm39)	T904S	probably benign	Het
Slc4a10	T	C	2: 62,134,290 (GRCm39)	V1002A	probably benign	Het
Taf1b	T	C	12: 24,554,992 (GRCm39)	I55T	probably benign	Het
Tchh	CTCCGCCGGGAGCAAGAGCTCCGCCGGGAGCAAGAGTTCCGCCGGGAGCAAGAGCTCCGCCGGGAGCAAGAGTTCCGCCGGGAGCAAGAGCTCCGCC	CTCCGCCGGGAGCAAGAGCTCCGCCGGGAGCAAGAGTTCCGCCGGGAGCAAGAGCTCCGCC	3: 93,354,015 (GRCm39)		probably benign	Het
Tenm4	A	T	7: 96,523,420 (GRCm39)	D1654V	possibly damaging	Het
Tgfb1	G	A	7: 25,404,263 (GRCm39)	V357M	probably damaging	Het
Tnxb	C	T	17: 34,922,335 (GRCm39)	P2383S	possibly damaging	Het
Trpm1	A	T	7: 63,858,723 (GRCm39)	M382L	probably benign	Het
Trrap	A	G	5: 144,788,019 (GRCm39)	Y3516C	probably damaging	Het
Txnrd1	T	A	10: 82,721,067 (GRCm39)	Y494*	probably null	Het
Ubr2	C	T	17: 47,275,714 (GRCm39)	E811K	probably damaging	Het
Ubxn4	T	A	1: 128,172,280 (GRCm39)	F25I	possibly damaging	Het
Vmn2r117	A	G	17: 23,678,869 (GRCm39)	M785T	probably damaging	Het
Vmn2r99	G	A	17: 19,599,407 (GRCm39)	D364N	probably benign	Het
Vps45	C	A	3: 95,954,448 (GRCm39)		probably null	Het
Wdr25	A	C	12: 108,992,367 (GRCm39)	H426P	probably damaging	Het
Wdr83	A	T	8: 85,806,310 (GRCm39)	W136R	probably damaging	Het
Xylt1	A	C	7: 117,191,232 (GRCm39)	I343L	possibly damaging	Het
Zscan4b	T	C	7: 10,637,985 (GRCm39)	Q53R	possibly damaging	Het

Other mutations in Birc6

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00402:Birc6	APN	17	74,880,558 (GRCm39)	splice site	probably benign
IGL00542:Birc6	APN	17	74,930,766 (GRCm39)	splice site	probably null
IGL00659:Birc6	APN	17	74,967,648 (GRCm39)	missense	probably damaging	1.00
IGL00710:Birc6	APN	17	74,916,084 (GRCm39)	missense	probably benign	0.37
IGL00806:Birc6	APN	17	74,918,524 (GRCm39)	missense	possibly damaging	0.85
IGL00848:Birc6	APN	17	75,003,388 (GRCm39)	nonsense	probably null
IGL01071:Birc6	APN	17	74,873,127 (GRCm39)	missense	possibly damaging	0.84
IGL01071:Birc6	APN	17	74,938,696 (GRCm39)	missense	probably damaging	1.00
IGL01121:Birc6	APN	17	74,938,033 (GRCm39)	missense	probably benign	0.08
IGL01132:Birc6	APN	17	74,910,055 (GRCm39)	missense	probably damaging	1.00
IGL01323:Birc6	APN	17	74,929,920 (GRCm39)	missense	probably damaging	1.00
IGL01444:Birc6	APN	17	74,938,682 (GRCm39)	missense	probably damaging	1.00
IGL01511:Birc6	APN	17	74,933,998 (GRCm39)	nonsense	probably null
IGL01576:Birc6	APN	17	74,984,365 (GRCm39)	missense	possibly damaging	0.80
IGL01578:Birc6	APN	17	74,955,192 (GRCm39)	missense	probably benign	0.08
IGL01649:Birc6	APN	17	74,911,541 (GRCm39)	missense	probably benign	0.03
IGL01657:Birc6	APN	17	74,967,606 (GRCm39)	missense	probably damaging	1.00
IGL01739:Birc6	APN	17	74,966,216 (GRCm39)	missense	probably benign
IGL01756:Birc6	APN	17	74,947,203 (GRCm39)	missense	probably benign	0.00
IGL01807:Birc6	APN	17	74,938,032 (GRCm39)	missense	probably benign
IGL01885:Birc6	APN	17	74,911,511 (GRCm39)	missense	possibly damaging	0.51
IGL01906:Birc6	APN	17	74,945,353 (GRCm39)	missense	probably damaging	1.00
IGL01915:Birc6	APN	17	74,938,715 (GRCm39)	missense	probably benign	0.34
IGL01998:Birc6	APN	17	74,886,880 (GRCm39)	missense	probably benign	0.06
IGL02084:Birc6	APN	17	74,915,277 (GRCm39)	missense	probably benign	0.45
IGL02086:Birc6	APN	17	74,946,822 (GRCm39)	missense	probably damaging	1.00
IGL02161:Birc6	APN	17	74,855,832 (GRCm39)	missense	probably damaging	0.99
IGL02195:Birc6	APN	17	75,004,376 (GRCm39)	splice site	probably benign
IGL02283:Birc6	APN	17	74,906,935 (GRCm39)	missense	probably benign
IGL02476:Birc6	APN	17	75,003,386 (GRCm39)	missense	possibly damaging	0.81
IGL02493:Birc6	APN	17	74,959,054 (GRCm39)	unclassified	probably benign
IGL02547:Birc6	APN	17	74,886,640 (GRCm39)	missense	probably benign	0.21
IGL02678:Birc6	APN	17	74,956,898 (GRCm39)	missense	probably damaging	1.00
IGL02713:Birc6	APN	17	74,886,319 (GRCm39)	missense	probably benign
IGL02851:Birc6	APN	17	74,916,184 (GRCm39)	missense	probably damaging	1.00
IGL02875:Birc6	APN	17	74,896,713 (GRCm39)	missense	probably damaging	1.00
IGL02985:Birc6	APN	17	74,947,185 (GRCm39)	missense	probably benign	0.00
IGL03004:Birc6	APN	17	74,919,180 (GRCm39)	missense	probably benign	0.10
IGL03053:Birc6	APN	17	74,872,967 (GRCm39)	missense	probably damaging	1.00
IGL03085:Birc6	APN	17	74,903,945 (GRCm39)	missense	probably damaging	0.97
IGL03109:Birc6	APN	17	74,886,329 (GRCm39)	missense	possibly damaging	0.71
IGL03143:Birc6	APN	17	74,905,994 (GRCm39)	missense	possibly damaging	0.89
IGL03180:Birc6	APN	17	74,966,226 (GRCm39)	missense	probably benign
IGL03221:Birc6	APN	17	74,934,002 (GRCm39)	missense	probably benign	0.00
IGL03230:Birc6	APN	17	74,918,065 (GRCm39)	missense	probably damaging	1.00
IGL03294:Birc6	APN	17	74,956,881 (GRCm39)	missense	probably benign	0.02
IGL03399:Birc6	APN	17	74,901,368 (GRCm39)	missense	probably benign	0.01
Badlands	UTSW	17	74,910,031 (GRCm39)	missense	probably damaging	1.00
Big_sky	UTSW	17	74,835,533 (GRCm39)	missense	probably null	0.33
bitterroot	UTSW	17	74,956,691 (GRCm39)	missense	probably damaging	1.00
Black_hills	UTSW	17	74,999,327 (GRCm39)	missense	probably damaging	1.00
bottomlands	UTSW	17	74,916,654 (GRCm39)	missense	probably damaging	1.00
Chai	UTSW	17	74,977,369 (GRCm39)	missense	probably damaging	1.00
Dakota	UTSW	17	74,932,099 (GRCm39)	critical splice acceptor site	probably null
Sempervirens	UTSW	17	74,949,499 (GRCm39)	missense	probably damaging	1.00
E0370:Birc6	UTSW	17	74,984,352 (GRCm39)	missense	probably damaging	1.00
G1citation:Birc6	UTSW	17	74,905,039 (GRCm39)	missense	probably damaging	1.00
G1citation:Birc6	UTSW	17	74,887,377 (GRCm39)	missense	possibly damaging	0.82
PIT4494001:Birc6	UTSW	17	74,933,975 (GRCm39)	missense	probably damaging	1.00
R0081:Birc6	UTSW	17	74,950,436 (GRCm39)	missense	probably benign	0.01
R0086:Birc6	UTSW	17	74,900,161 (GRCm39)	missense	possibly damaging	0.54
R0089:Birc6	UTSW	17	74,945,371 (GRCm39)	missense	possibly damaging	0.90
R0116:Birc6	UTSW	17	74,930,741 (GRCm39)	splice site	probably benign
R0129:Birc6	UTSW	17	74,835,755 (GRCm39)	missense	probably benign	0.05
R0196:Birc6	UTSW	17	74,887,282 (GRCm39)	missense	possibly damaging	0.57
R0201:Birc6	UTSW	17	74,916,322 (GRCm39)	missense	possibly damaging	0.92
R0207:Birc6	UTSW	17	74,969,827 (GRCm39)	splice site	probably benign
R0295:Birc6	UTSW	17	74,920,357 (GRCm39)	intron	probably benign
R0386:Birc6	UTSW	17	74,906,335 (GRCm39)	missense	probably damaging	0.99
R0423:Birc6	UTSW	17	75,003,292 (GRCm39)	missense	probably damaging	1.00
R0449:Birc6	UTSW	17	74,999,290 (GRCm39)	missense	probably damaging	1.00
R0453:Birc6	UTSW	17	74,956,749 (GRCm39)	missense	probably damaging	1.00
R0457:Birc6	UTSW	17	74,969,620 (GRCm39)	missense	probably damaging	1.00
R0457:Birc6	UTSW	17	74,959,023 (GRCm39)	missense	probably benign
R0564:Birc6	UTSW	17	74,932,238 (GRCm39)	splice site	probably benign
R0575:Birc6	UTSW	17	74,996,232 (GRCm39)	missense	probably damaging	1.00
R0582:Birc6	UTSW	17	74,950,332 (GRCm39)	missense	probably damaging	1.00
R0624:Birc6	UTSW	17	74,887,344 (GRCm39)	missense	probably benign	0.20
R0973:Birc6	UTSW	17	74,872,856 (GRCm39)	missense	probably damaging	0.99
R1061:Birc6	UTSW	17	74,996,307 (GRCm39)	missense	probably damaging	1.00
R1378:Birc6	UTSW	17	74,967,450 (GRCm39)	missense	probably damaging	1.00
R1402:Birc6	UTSW	17	75,004,528 (GRCm39)	splice site	probably benign
R1436:Birc6	UTSW	17	74,959,700 (GRCm39)	missense	probably damaging	1.00
R1456:Birc6	UTSW	17	74,916,285 (GRCm39)	missense	probably benign	0.35
R1465:Birc6	UTSW	17	74,930,853 (GRCm39)	missense	probably benign	0.03
R1465:Birc6	UTSW	17	74,930,853 (GRCm39)	missense	probably benign	0.03
R1474:Birc6	UTSW	17	74,886,673 (GRCm39)	missense	probably damaging	0.98
R1479:Birc6	UTSW	17	74,941,848 (GRCm39)	missense	probably damaging	1.00
R1486:Birc6	UTSW	17	74,946,815 (GRCm39)	missense	probably damaging	1.00
R1499:Birc6	UTSW	17	74,919,314 (GRCm39)	missense	probably damaging	1.00
R1515:Birc6	UTSW	17	74,835,631 (GRCm39)	nonsense	probably null
R1549:Birc6	UTSW	17	74,969,737 (GRCm39)	missense	probably damaging	1.00
R1559:Birc6	UTSW	17	74,999,232 (GRCm39)	missense	probably damaging	1.00
R1573:Birc6	UTSW	17	74,967,685 (GRCm39)	splice site	probably benign
R1615:Birc6	UTSW	17	74,916,404 (GRCm39)	splice site	probably null
R1621:Birc6	UTSW	17	74,977,245 (GRCm39)	missense	probably benign
R1680:Birc6	UTSW	17	74,855,741 (GRCm39)	missense	probably benign	0.01
R1743:Birc6	UTSW	17	74,886,751 (GRCm39)	missense	possibly damaging	0.95
R1774:Birc6	UTSW	17	74,947,008 (GRCm39)	missense	probably damaging	1.00
R1775:Birc6	UTSW	17	74,919,281 (GRCm39)	missense	probably damaging	1.00
R1818:Birc6	UTSW	17	74,956,844 (GRCm39)	missense	probably damaging	1.00
R1836:Birc6	UTSW	17	74,921,385 (GRCm39)	missense	probably benign	0.41
R1931:Birc6	UTSW	17	74,872,977 (GRCm39)	missense	probably damaging	0.99
R1939:Birc6	UTSW	17	74,977,332 (GRCm39)	missense	probably damaging	1.00
R1964:Birc6	UTSW	17	74,941,880 (GRCm39)	missense	possibly damaging	0.94
R1994:Birc6	UTSW	17	74,905,057 (GRCm39)	missense	probably benign	0.01
R2000:Birc6	UTSW	17	74,911,614 (GRCm39)	missense	possibly damaging	0.46
R2042:Birc6	UTSW	17	74,916,654 (GRCm39)	missense	probably damaging	1.00
R2090:Birc6	UTSW	17	74,969,791 (GRCm39)	missense	probably benign
R2130:Birc6	UTSW	17	74,966,149 (GRCm39)	splice site	probably benign
R2144:Birc6	UTSW	17	74,967,408 (GRCm39)	missense	possibly damaging	0.71
R2145:Birc6	UTSW	17	74,967,408 (GRCm39)	missense	possibly damaging	0.71
R2166:Birc6	UTSW	17	74,942,790 (GRCm39)	missense	probably benign	0.02
R2180:Birc6	UTSW	17	74,919,146 (GRCm39)	missense	probably benign	0.03
R2271:Birc6	UTSW	17	74,909,966 (GRCm39)	missense	probably benign	0.06
R2272:Birc6	UTSW	17	74,909,966 (GRCm39)	missense	probably benign	0.06
R2416:Birc6	UTSW	17	74,915,214 (GRCm39)	missense	possibly damaging	0.83
R2420:Birc6	UTSW	17	74,967,609 (GRCm39)	missense	probably damaging	1.00
R2421:Birc6	UTSW	17	74,967,609 (GRCm39)	missense	probably damaging	1.00
R2422:Birc6	UTSW	17	74,967,609 (GRCm39)	missense	probably damaging	1.00
R2513:Birc6	UTSW	17	74,954,724 (GRCm39)	missense	probably damaging	0.97
R2912:Birc6	UTSW	17	74,999,201 (GRCm39)	missense	probably damaging	1.00
R3024:Birc6	UTSW	17	74,915,214 (GRCm39)	missense	possibly damaging	0.83
R3771:Birc6	UTSW	17	74,925,424 (GRCm39)	splice site	probably benign
R3772:Birc6	UTSW	17	74,925,424 (GRCm39)	splice site	probably benign
R3829:Birc6	UTSW	17	74,962,173 (GRCm39)	missense	probably damaging	1.00
R3913:Birc6	UTSW	17	74,880,608 (GRCm39)	nonsense	probably null
R3915:Birc6	UTSW	17	74,886,603 (GRCm39)	missense	probably benign	0.12
R3921:Birc6	UTSW	17	74,934,014 (GRCm39)	missense	probably damaging	0.98
R3928:Birc6	UTSW	17	74,945,404 (GRCm39)	missense	probably damaging	1.00
R3928:Birc6	UTSW	17	74,918,170 (GRCm39)	missense	possibly damaging	0.91
R4111:Birc6	UTSW	17	74,873,010 (GRCm39)	missense	probably damaging	1.00
R4155:Birc6	UTSW	17	74,903,934 (GRCm39)	missense	probably benign	0.00
R4163:Birc6	UTSW	17	74,933,975 (GRCm39)	missense	probably damaging	1.00
R4226:Birc6	UTSW	17	74,926,835 (GRCm39)	critical splice donor site	probably null
R4227:Birc6	UTSW	17	74,926,835 (GRCm39)	critical splice donor site	probably null
R4358:Birc6	UTSW	17	74,926,663 (GRCm39)	splice site	probably null
R4524:Birc6	UTSW	17	74,948,772 (GRCm39)	missense	probably damaging	1.00
R4605:Birc6	UTSW	17	74,946,929 (GRCm39)	missense	probably damaging	1.00
R4619:Birc6	UTSW	17	74,947,145 (GRCm39)	missense	probably benign	0.18
R4620:Birc6	UTSW	17	74,947,145 (GRCm39)	missense	probably benign	0.18
R4762:Birc6	UTSW	17	74,936,484 (GRCm39)	missense	probably damaging	1.00
R4814:Birc6	UTSW	17	74,956,667 (GRCm39)	missense	probably damaging	1.00
R4849:Birc6	UTSW	17	74,954,383 (GRCm39)	missense	probably damaging	0.99
R4869:Birc6	UTSW	17	74,893,007 (GRCm39)	missense	probably benign	0.05
R4912:Birc6	UTSW	17	74,872,900 (GRCm39)	missense	probably damaging	1.00
R4921:Birc6	UTSW	17	74,957,094 (GRCm39)	missense	probably damaging	1.00
R4942:Birc6	UTSW	17	74,930,045 (GRCm39)	missense	probably damaging	1.00
R4954:Birc6	UTSW	17	74,919,026 (GRCm39)	missense	probably damaging	1.00
R4992:Birc6	UTSW	17	74,996,251 (GRCm39)	missense	probably benign	0.44
R4994:Birc6	UTSW	17	74,901,319 (GRCm39)	intron	probably benign
R5018:Birc6	UTSW	17	74,947,054 (GRCm39)	missense	probably damaging	1.00
R5022:Birc6	UTSW	17	74,999,327 (GRCm39)	missense	probably damaging	1.00
R5054:Birc6	UTSW	17	74,962,320 (GRCm39)	missense	probably damaging	1.00
R5068:Birc6	UTSW	17	74,872,967 (GRCm39)	missense	probably damaging	1.00
R5069:Birc6	UTSW	17	74,872,967 (GRCm39)	missense	probably damaging	1.00
R5070:Birc6	UTSW	17	74,872,967 (GRCm39)	missense	probably damaging	1.00
R5196:Birc6	UTSW	17	74,913,136 (GRCm39)	splice site	probably benign
R5209:Birc6	UTSW	17	74,977,369 (GRCm39)	missense	probably damaging	1.00
R5212:Birc6	UTSW	17	74,977,369 (GRCm39)	missense	probably damaging	1.00
R5216:Birc6	UTSW	17	74,920,465 (GRCm39)	missense	probably damaging	1.00
R5279:Birc6	UTSW	17	74,957,042 (GRCm39)	missense	probably damaging	0.98
R5286:Birc6	UTSW	17	74,977,242 (GRCm39)	missense	probably damaging	1.00
R5399:Birc6	UTSW	17	74,911,573 (GRCm39)	missense	possibly damaging	0.75
R5482:Birc6	UTSW	17	74,969,685 (GRCm39)	missense	probably damaging	1.00
R5482:Birc6	UTSW	17	74,948,777 (GRCm39)	missense	possibly damaging	0.86
R5492:Birc6	UTSW	17	74,977,369 (GRCm39)	missense	probably damaging	1.00
R5504:Birc6	UTSW	17	74,962,208 (GRCm39)	missense	probably damaging	1.00
R5519:Birc6	UTSW	17	74,887,173 (GRCm39)	missense	probably benign
R5544:Birc6	UTSW	17	74,977,369 (GRCm39)	missense	probably damaging	1.00
R5608:Birc6	UTSW	17	74,920,539 (GRCm39)	missense	probably damaging	0.99
R5623:Birc6	UTSW	17	74,835,651 (GRCm39)	missense	probably damaging	0.99
R5701:Birc6	UTSW	17	75,004,420 (GRCm39)	missense	possibly damaging	0.59
R5707:Birc6	UTSW	17	75,003,399 (GRCm39)	missense	probably damaging	1.00
R5715:Birc6	UTSW	17	74,938,615 (GRCm39)	missense	probably damaging	1.00
R5734:Birc6	UTSW	17	74,925,419 (GRCm39)	splice site	probably benign
R5792:Birc6	UTSW	17	74,938,048 (GRCm39)	missense	probably benign	0.05
R5809:Birc6	UTSW	17	74,977,369 (GRCm39)	missense	probably damaging	1.00
R5810:Birc6	UTSW	17	74,977,369 (GRCm39)	missense	probably damaging	1.00
R5813:Birc6	UTSW	17	74,953,497 (GRCm39)	missense	probably damaging	1.00
R5933:Birc6	UTSW	17	74,906,232 (GRCm39)	missense	probably damaging	1.00
R5933:Birc6	UTSW	17	74,906,233 (GRCm39)	missense	probably damaging	0.98
R5960:Birc6	UTSW	17	74,835,760 (GRCm39)	missense	probably damaging	0.97
R5961:Birc6	UTSW	17	74,953,596 (GRCm39)	missense	probably damaging	1.00
R5967:Birc6	UTSW	17	74,967,434 (GRCm39)	missense	probably damaging	0.99
R5970:Birc6	UTSW	17	74,925,497 (GRCm39)	missense	possibly damaging	0.95
R5977:Birc6	UTSW	17	74,910,031 (GRCm39)	missense	probably damaging	1.00
R5982:Birc6	UTSW	17	74,955,153 (GRCm39)	missense	probably benign
R6023:Birc6	UTSW	17	74,961,372 (GRCm39)	missense	probably benign	0.24
R6034:Birc6	UTSW	17	74,922,278 (GRCm39)	missense	probably damaging	1.00
R6034:Birc6	UTSW	17	74,922,278 (GRCm39)	missense	probably damaging	1.00
R6243:Birc6	UTSW	17	74,916,382 (GRCm39)	missense	probably damaging	0.96
R6294:Birc6	UTSW	17	74,996,252 (GRCm39)	missense	probably benign	0.00
R6327:Birc6	UTSW	17	74,969,774 (GRCm39)	missense	probably damaging	1.00
R6501:Birc6	UTSW	17	74,886,276 (GRCm39)	missense	probably damaging	1.00
R6810:Birc6	UTSW	17	74,919,215 (GRCm39)	missense	possibly damaging	0.63
R6822:Birc6	UTSW	17	74,905,039 (GRCm39)	missense	probably damaging	1.00
R6822:Birc6	UTSW	17	74,887,377 (GRCm39)	missense	possibly damaging	0.82
R6835:Birc6	UTSW	17	74,949,499 (GRCm39)	missense	probably damaging	1.00
R6945:Birc6	UTSW	17	74,886,526 (GRCm39)	missense	probably benign	0.04
R6957:Birc6	UTSW	17	74,886,486 (GRCm39)	missense	probably benign
R6989:Birc6	UTSW	17	74,937,984 (GRCm39)	missense	probably benign	0.18
R6991:Birc6	UTSW	17	74,869,090 (GRCm39)	missense	probably damaging	1.00
R7019:Birc6	UTSW	17	74,916,340 (GRCm39)	missense	probably benign	0.01
R7092:Birc6	UTSW	17	74,953,740 (GRCm39)	missense	probably damaging	1.00
R7158:Birc6	UTSW	17	74,901,371 (GRCm39)	missense	probably benign	0.25
R7204:Birc6	UTSW	17	74,947,103 (GRCm39)	missense	probably damaging	1.00
R7267:Birc6	UTSW	17	74,892,980 (GRCm39)	missense	probably benign	0.00
R7316:Birc6	UTSW	17	74,911,489 (GRCm39)	missense	probably damaging	0.99
R7341:Birc6	UTSW	17	74,919,069 (GRCm39)	missense	probably damaging	1.00
R7404:Birc6	UTSW	17	74,946,789 (GRCm39)	missense	possibly damaging	0.73
R7498:Birc6	UTSW	17	74,967,465 (GRCm39)	missense	probably damaging	1.00
R7539:Birc6	UTSW	17	74,956,691 (GRCm39)	missense	probably damaging	1.00
R7569:Birc6	UTSW	17	74,905,077 (GRCm39)	missense	possibly damaging	0.71
R7574:Birc6	UTSW	17	74,886,879 (GRCm39)	missense	probably benign
R7611:Birc6	UTSW	17	74,969,713 (GRCm39)	missense	probably damaging	0.98
R7653:Birc6	UTSW	17	74,954,729 (GRCm39)	missense	possibly damaging	0.91
R7716:Birc6	UTSW	17	74,869,056 (GRCm39)	missense	probably damaging	0.99
R7728:Birc6	UTSW	17	74,929,100 (GRCm39)	missense	probably benign	0.01
R7810:Birc6	UTSW	17	74,855,815 (GRCm39)	missense	probably damaging	0.98
R7828:Birc6	UTSW	17	74,886,501 (GRCm39)	missense	probably damaging	0.97
R7881:Birc6	UTSW	17	74,948,666 (GRCm39)	missense	probably damaging	0.99
R7896:Birc6	UTSW	17	74,929,077 (GRCm39)	missense	probably damaging	0.99
R7950:Birc6	UTSW	17	74,900,095 (GRCm39)	missense	probably damaging	1.00
R7988:Birc6	UTSW	17	74,906,368 (GRCm39)	splice site	probably null
R8073:Birc6	UTSW	17	74,910,080 (GRCm39)	missense	probably damaging	1.00
R8128:Birc6	UTSW	17	74,916,253 (GRCm39)	missense	probably damaging	1.00
R8167:Birc6	UTSW	17	74,950,389 (GRCm39)	missense	probably damaging	1.00
R8236:Birc6	UTSW	17	74,918,126 (GRCm39)	missense	probably damaging	1.00
R8237:Birc6	UTSW	17	74,918,126 (GRCm39)	missense	probably damaging	1.00
R8255:Birc6	UTSW	17	74,969,775 (GRCm39)	missense	probably damaging	0.99
R8259:Birc6	UTSW	17	74,905,073 (GRCm39)	missense	probably benign	0.01
R8297:Birc6	UTSW	17	74,932,099 (GRCm39)	critical splice acceptor site	probably null
R8376:Birc6	UTSW	17	74,896,635 (GRCm39)	missense	probably benign	0.18
R8413:Birc6	UTSW	17	74,853,388 (GRCm39)	missense	possibly damaging	0.54
R8503:Birc6	UTSW	17	74,999,239 (GRCm39)	missense	probably damaging	1.00
R8504:Birc6	UTSW	17	74,959,000 (GRCm39)	missense	probably damaging	0.98
R8543:Birc6	UTSW	17	74,872,860 (GRCm39)	missense	probably damaging	1.00
R8550:Birc6	UTSW	17	74,864,949 (GRCm39)	missense	probably benign	0.37
R8551:Birc6	UTSW	17	74,864,949 (GRCm39)	missense	probably benign	0.37
R8556:Birc6	UTSW	17	74,864,949 (GRCm39)	missense	probably benign	0.37
R8683:Birc6	UTSW	17	74,916,114 (GRCm39)	missense	possibly damaging	0.74
R8751:Birc6	UTSW	17	74,955,135 (GRCm39)	missense	probably damaging	0.98
R8803:Birc6	UTSW	17	74,959,033 (GRCm39)	missense	probably damaging	0.99
R8806:Birc6	UTSW	17	74,949,311 (GRCm39)	missense	probably damaging	1.00
R8825:Birc6	UTSW	17	74,920,500 (GRCm39)	missense	probably damaging	0.99
R8888:Birc6	UTSW	17	74,835,533 (GRCm39)	missense	probably null	0.33
R8972:Birc6	UTSW	17	75,009,313 (GRCm39)	missense	probably benign	0.05
R9069:Birc6	UTSW	17	74,868,260 (GRCm39)	splice site	probably benign
R9111:Birc6	UTSW	17	74,966,340 (GRCm39)	missense	probably damaging	0.99
R9130:Birc6	UTSW	17	74,919,146 (GRCm39)	missense
R9352:Birc6	UTSW	17	74,965,347 (GRCm39)	critical splice donor site	probably null
R9354:Birc6	UTSW	17	74,921,401 (GRCm39)	missense	probably benign
R9432:Birc6	UTSW	17	74,966,216 (GRCm39)	missense	probably benign
R9446:Birc6	UTSW	17	74,925,491 (GRCm39)	missense	probably damaging	1.00
R9485:Birc6	UTSW	17	74,945,398 (GRCm39)	missense	probably damaging	1.00
R9499:Birc6	UTSW	17	74,916,064 (GRCm39)	missense	probably benign	0.05
R9551:Birc6	UTSW	17	74,916,064 (GRCm39)	missense	probably benign	0.05
R9552:Birc6	UTSW	17	74,916,064 (GRCm39)	missense	probably benign	0.05
R9585:Birc6	UTSW	17	74,916,265 (GRCm39)	missense	probably damaging	1.00
R9647:Birc6	UTSW	17	74,999,305 (GRCm39)	missense	probably damaging	1.00
R9648:Birc6	UTSW	17	74,938,696 (GRCm39)	missense	probably damaging	1.00
R9667:Birc6	UTSW	17	75,004,420 (GRCm39)	missense	possibly damaging	0.59
R9696:Birc6	UTSW	17	74,947,292 (GRCm39)	missense	probably damaging	0.99
RF016:Birc6	UTSW	17	74,996,319 (GRCm39)	missense	probably damaging	1.00
Z1088:Birc6	UTSW	17	74,918,537 (GRCm39)	missense	probably damaging	0.99
Z1177:Birc6	UTSW	17	74,954,275 (GRCm39)	missense	probably benign	0.10

Predicted Primers

PCR Primer
(F):5'- CAAGTTGTCTCAGTGATAGGCAAG -3'
(R):5'- GATCACCTTGAATTAAACTGGATCTCC -3'

Sequencing Primer
(F):5'- GATAGGCAAGAATCACACTGTTC -3'
(R):5'- ACTGGATCTCCTTAAGGGCATAG -3'

Posted On

2019-10-07