Mutagenetix > Incidental Mutation

Incidental Mutation 'R0629:Cacna1g'

57772

Institutional Source

Beutler Lab

Gene Symbol

Cacna1g

Ensembl Gene

ENSMUSG00000020866

Gene Name

calcium channel, voltage-dependent, T type, alpha 1G subunit

Synonyms

a1G, Cav3.1d

MMRRC Submission

038818-MU

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.378) question?

Stock #

R0629 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

94408391-94474198 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 94409543 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Arginine at position 2134 (C2134R)

Ref Sequence

ENSEMBL: ENSMUSP00000103419 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000021234] [ENSMUST00000100561] [ENSMUST00000103166] [ENSMUST00000107785] [ENSMUST00000107786] [ENSMUST00000107788] [ENSMUST00000107789] [ENSMUST00000107790] [ENSMUST00000107791] [ENSMUST00000107792] [ENSMUST00000107793]

AlphaFold

Q5SUF7

Predicted Effect

possibly damaging
Transcript: ENSMUST00000021234
AA Change: C2141R

PolyPhen 2 Score 0.638 (Sensitivity: 0.87; Specificity: 0.91)

SMART Domains

Protein: ENSMUSP00000021234
Gene: ENSMUSG00000020866
AA Change: C2141R

Domain	Start	End	E-Value	Type
low complexity region	2	12	N/A	INTRINSIC
Pfam:Ion_trans	119	394	9.2e-66	PFAM
low complexity region	483	507	N/A	INTRINSIC
low complexity region	535	547	N/A	INTRINSIC
Pfam:Ion_trans	777	963	7.9e-46	PFAM
low complexity region	1040	1051	N/A	INTRINSIC
low complexity region	1063	1090	N/A	INTRINSIC
low complexity region	1111	1127	N/A	INTRINSIC
low complexity region	1193	1204	N/A	INTRINSIC
Pfam:Ion_trans	1290	1514	3e-55	PFAM
coiled coil region	1519	1559	N/A	INTRINSIC
low complexity region	1562	1573	N/A	INTRINSIC
Pfam:Ion_trans	1630	1835	3e-49	PFAM
Pfam:PKD_channel	1688	1842	7.8e-11	PFAM
low complexity region	2180	2211	N/A	INTRINSIC
low complexity region	2230	2246	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000100561
AA Change: C2164R

PolyPhen 2 Score 0.082 (Sensitivity: 0.93; Specificity: 0.85)

SMART Domains

Protein: ENSMUSP00000098127
Gene: ENSMUSG00000020866
AA Change: C2164R

Domain	Start	End	E-Value	Type
low complexity region	2	12	N/A	INTRINSIC
Pfam:Ion_trans	119	394	1.9e-65	PFAM
low complexity region	483	507	N/A	INTRINSIC
low complexity region	535	547	N/A	INTRINSIC
Pfam:Ion_trans	777	963	1.6e-45	PFAM
low complexity region	1063	1074	N/A	INTRINSIC
low complexity region	1086	1113	N/A	INTRINSIC
low complexity region	1134	1150	N/A	INTRINSIC
low complexity region	1216	1227	N/A	INTRINSIC
Pfam:Ion_trans	1313	1537	6.1e-55	PFAM
coiled coil region	1542	1582	N/A	INTRINSIC
low complexity region	1585	1596	N/A	INTRINSIC
Pfam:Ion_trans	1653	1858	6.2e-49	PFAM
Pfam:PKD_channel	1711	1865	1.4e-10	PFAM
low complexity region	2203	2234	N/A	INTRINSIC
low complexity region	2253	2269	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000103166
AA Change: C2157R

PolyPhen 2 Score 0.082 (Sensitivity: 0.93; Specificity: 0.85)

SMART Domains

Protein: ENSMUSP00000099455
Gene: ENSMUSG00000020866
AA Change: C2157R

Domain	Start	End	E-Value	Type
low complexity region	2	12	N/A	INTRINSIC
Pfam:Ion_trans	119	394	1.9e-65	PFAM
low complexity region	483	507	N/A	INTRINSIC
low complexity region	535	547	N/A	INTRINSIC
Pfam:Ion_trans	777	963	1.6e-45	PFAM
low complexity region	1063	1074	N/A	INTRINSIC
low complexity region	1086	1113	N/A	INTRINSIC
low complexity region	1134	1150	N/A	INTRINSIC
low complexity region	1216	1227	N/A	INTRINSIC
Pfam:Ion_trans	1313	1537	6.1e-55	PFAM
SCOP:d1g2qa_	1545	1589	6e-3	SMART
Pfam:Ion_trans	1646	1851	6.2e-49	PFAM
Pfam:PKD_channel	1704	1858	1.4e-10	PFAM
low complexity region	2196	2227	N/A	INTRINSIC
low complexity region	2246	2262	N/A	INTRINSIC

Predicted Effect

possibly damaging
Transcript: ENSMUST00000107785
AA Change: C2045R

PolyPhen 2 Score 0.734 (Sensitivity: 0.85; Specificity: 0.92)

SMART Domains

Protein: ENSMUSP00000103414
Gene: ENSMUSG00000020866
AA Change: C2045R

Domain	Start	End	E-Value	Type
low complexity region	2	12	N/A	INTRINSIC
Pfam:Ion_trans	119	394	1.8e-65	PFAM
low complexity region	483	507	N/A	INTRINSIC
low complexity region	535	547	N/A	INTRINSIC
Pfam:Ion_trans	777	963	1.5e-45	PFAM
low complexity region	1040	1051	N/A	INTRINSIC
low complexity region	1063	1090	N/A	INTRINSIC
low complexity region	1111	1127	N/A	INTRINSIC
low complexity region	1193	1204	N/A	INTRINSIC
Pfam:Ion_trans	1290	1514	5.7e-55	PFAM
coiled coil region	1519	1558	N/A	INTRINSIC
Pfam:Ion_trans	1612	1817	5.8e-49	PFAM
Pfam:PKD_channel	1670	1824	1.4e-10	PFAM
low complexity region	2027	2042	N/A	INTRINSIC
low complexity region	2084	2115	N/A	INTRINSIC
low complexity region	2134	2150	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000107786
AA Change: C2117R

PolyPhen 2 Score 0.021 (Sensitivity: 0.95; Specificity: 0.80)

SMART Domains

Protein: ENSMUSP00000103415
Gene: ENSMUSG00000020866
AA Change: C2117R

Domain	Start	End	E-Value	Type
low complexity region	2	12	N/A	INTRINSIC
Pfam:Ion_trans	119	383	4e-60	PFAM
low complexity region	466	490	N/A	INTRINSIC
low complexity region	518	530	N/A	INTRINSIC
Pfam:Ion_trans	760	946	1.6e-45	PFAM
low complexity region	1023	1034	N/A	INTRINSIC
low complexity region	1046	1073	N/A	INTRINSIC
low complexity region	1094	1110	N/A	INTRINSIC
low complexity region	1176	1187	N/A	INTRINSIC
Pfam:Ion_trans	1273	1497	5.9e-55	PFAM
SCOP:d1g2qa_	1505	1549	6e-3	SMART
Pfam:Ion_trans	1606	1811	6e-49	PFAM
Pfam:PKD_channel	1664	1818	1.4e-10	PFAM
low complexity region	2156	2187	N/A	INTRINSIC
low complexity region	2206	2222	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000107788
AA Change: C2139R

PolyPhen 2 Score 0.157 (Sensitivity: 0.92; Specificity: 0.87)

SMART Domains

Protein: ENSMUSP00000103417
Gene: ENSMUSG00000020866
AA Change: C2139R

Domain	Start	End	E-Value	Type
low complexity region	2	12	N/A	INTRINSIC
Pfam:Ion_trans	119	394	1.9e-65	PFAM
low complexity region	483	507	N/A	INTRINSIC
low complexity region	535	547	N/A	INTRINSIC
Pfam:Ion_trans	777	963	1.6e-45	PFAM
low complexity region	1063	1074	N/A	INTRINSIC
low complexity region	1086	1113	N/A	INTRINSIC
low complexity region	1134	1150	N/A	INTRINSIC
low complexity region	1216	1227	N/A	INTRINSIC
Pfam:Ion_trans	1313	1537	6e-55	PFAM
coiled coil region	1542	1574	N/A	INTRINSIC
Pfam:Ion_trans	1628	1833	6.1e-49	PFAM
Pfam:PKD_channel	1686	1840	1.4e-10	PFAM
low complexity region	2178	2209	N/A	INTRINSIC
low complexity region	2228	2244	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000107789
AA Change: C2250R

PolyPhen 2 Score 0.082 (Sensitivity: 0.93; Specificity: 0.85)

SMART Domains

Protein: ENSMUSP00000103418
Gene: ENSMUSG00000020866
AA Change: C2250R

Domain	Start	End	E-Value	Type
low complexity region	2	12	N/A	INTRINSIC
Pfam:Ion_trans	80	406	1.6e-76	PFAM
low complexity region	483	507	N/A	INTRINSIC
low complexity region	535	547	N/A	INTRINSIC
Pfam:Ion_trans	742	972	3.4e-56	PFAM
low complexity region	1063	1074	N/A	INTRINSIC
low complexity region	1086	1113	N/A	INTRINSIC
low complexity region	1134	1150	N/A	INTRINSIC
low complexity region	1216	1227	N/A	INTRINSIC
Pfam:Ion_trans	1276	1549	1.5e-61	PFAM
low complexity region	1578	1589	N/A	INTRINSIC
Pfam:Ion_trans	1611	1863	2.1e-56	PFAM
Pfam:PKD_channel	1703	1858	3.4e-9	PFAM
low complexity region	2289	2320	N/A	INTRINSIC
low complexity region	2339	2355	N/A	INTRINSIC

Predicted Effect

possibly damaging
Transcript: ENSMUST00000107790
AA Change: C2134R

PolyPhen 2 Score 0.926 (Sensitivity: 0.81; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000103419
Gene: ENSMUSG00000020866
AA Change: C2134R

Domain	Start	End	E-Value	Type
low complexity region	2	12	N/A	INTRINSIC
Pfam:Ion_trans	119	394	1.9e-65	PFAM
low complexity region	483	507	N/A	INTRINSIC
low complexity region	535	547	N/A	INTRINSIC
Pfam:Ion_trans	777	963	1.6e-45	PFAM
low complexity region	1040	1051	N/A	INTRINSIC
low complexity region	1063	1090	N/A	INTRINSIC
low complexity region	1111	1127	N/A	INTRINSIC
low complexity region	1193	1204	N/A	INTRINSIC
Pfam:Ion_trans	1290	1514	6e-55	PFAM
SCOP:d1g2qa_	1522	1566	6e-3	SMART
Pfam:Ion_trans	1623	1828	6.1e-49	PFAM
Pfam:PKD_channel	1681	1835	1.4e-10	PFAM
low complexity region	2173	2204	N/A	INTRINSIC
low complexity region	2223	2239	N/A	INTRINSIC

Predicted Effect

possibly damaging
Transcript: ENSMUST00000107791
AA Change: C2123R

PolyPhen 2 Score 0.911 (Sensitivity: 0.81; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000103420
Gene: ENSMUSG00000020866
AA Change: C2123R

Domain	Start	End	E-Value	Type
low complexity region	2	12	N/A	INTRINSIC
Pfam:Ion_trans	119	394	1.8e-65	PFAM
low complexity region	483	507	N/A	INTRINSIC
low complexity region	535	547	N/A	INTRINSIC
Pfam:Ion_trans	777	963	1.6e-45	PFAM
low complexity region	1040	1051	N/A	INTRINSIC
low complexity region	1063	1090	N/A	INTRINSIC
low complexity region	1111	1127	N/A	INTRINSIC
low complexity region	1193	1204	N/A	INTRINSIC
Pfam:Ion_trans	1290	1514	6e-55	PFAM
coiled coil region	1519	1558	N/A	INTRINSIC
Pfam:Ion_trans	1612	1817	6e-49	PFAM
Pfam:PKD_channel	1670	1824	1.4e-10	PFAM
low complexity region	2162	2193	N/A	INTRINSIC
low complexity region	2212	2228	N/A	INTRINSIC

Predicted Effect

possibly damaging
Transcript: ENSMUST00000107792
AA Change: C2116R

PolyPhen 2 Score 0.781 (Sensitivity: 0.85; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000103421
Gene: ENSMUSG00000020866
AA Change: C2116R

Domain	Start	End	E-Value	Type
low complexity region	2	12	N/A	INTRINSIC
Pfam:Ion_trans	119	394	1.8e-65	PFAM
low complexity region	483	507	N/A	INTRINSIC
low complexity region	535	547	N/A	INTRINSIC
Pfam:Ion_trans	777	963	1.6e-45	PFAM
low complexity region	1040	1051	N/A	INTRINSIC
low complexity region	1063	1090	N/A	INTRINSIC
low complexity region	1111	1127	N/A	INTRINSIC
low complexity region	1193	1204	N/A	INTRINSIC
Pfam:Ion_trans	1290	1514	5.9e-55	PFAM
coiled coil region	1519	1551	N/A	INTRINSIC
Pfam:Ion_trans	1605	1810	6e-49	PFAM
Pfam:PKD_channel	1663	1817	1.4e-10	PFAM
low complexity region	2155	2186	N/A	INTRINSIC
low complexity region	2205	2221	N/A	INTRINSIC

Predicted Effect

possibly damaging
Transcript: ENSMUST00000107793
AA Change: C2146R

PolyPhen 2 Score 0.857 (Sensitivity: 0.83; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000103422
Gene: ENSMUSG00000020866
AA Change: C2146R

Domain	Start	End	E-Value	Type
low complexity region	2	12	N/A	INTRINSIC
Pfam:Ion_trans	119	394	1.9e-65	PFAM
low complexity region	483	507	N/A	INTRINSIC
low complexity region	535	547	N/A	INTRINSIC
Pfam:Ion_trans	777	963	1.6e-45	PFAM
low complexity region	1063	1074	N/A	INTRINSIC
low complexity region	1086	1113	N/A	INTRINSIC
low complexity region	1134	1150	N/A	INTRINSIC
low complexity region	1216	1227	N/A	INTRINSIC
Pfam:Ion_trans	1313	1537	6e-55	PFAM
coiled coil region	1542	1581	N/A	INTRINSIC
Pfam:Ion_trans	1635	1840	6.1e-49	PFAM
Pfam:PKD_channel	1693	1847	1.4e-10	PFAM
low complexity region	2185	2216	N/A	INTRINSIC
low complexity region	2235	2251	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000133331

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000146160

Meta Mutation Damage Score

0.0621

Coding Region Coverage

1x: 99.4%
3x: 98.9%
10x: 97.6%
20x: 95.6%

Validation Efficiency

100% (66/66)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Voltage-sensitive calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division, and cell death. This gene encodes a T-type, low-voltage activated calcium channel. The T-type channels generate currents that are both transient, owing to fast inactivation, and tiny, owing to small conductance. T-type channels are thought to be involved in pacemaker activity, low-threshold calcium spikes, neuronal oscillations and resonance, and rebound burst firing. Many alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Sep 2011]
PHENOTYPE: Homozygote null mice display disrupted sleeping patterns, altered amounts of activity, abnormal action potentials in the brain, prolonged electrical conductance in the heart, and resistance to diet-induced obesity. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 64 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aars2	A	T	17: 45,507,547	D86V	probably damaging	Het
Adamts14	G	A	10: 61,211,624	Q733*	probably null	Het
Adcy10	A	G	1: 165,543,105	D651G	probably damaging	Het
Apcdd1	T	A	18: 62,933,970	C52S	probably damaging	Het
Bclaf1	T	C	10: 20,333,426	S463P	probably damaging	Het
Cabcoco1	T	C	10: 68,516,278	Y68C	probably damaging	Het
Cacna1f	G	A	X: 7,620,434	S888N	probably damaging	Het
Cdc37	A	C	9: 21,140,768	M325R	possibly damaging	Het
Clca2	T	A	3: 145,072,239	M762L	probably benign	Het
Cntn3	C	T	6: 102,203,976	V753M	probably damaging	Het
Col6a6	A	T	9: 105,727,165		probably benign	Het
Dscaml1	A	G	9: 45,721,418	D1194G	probably damaging	Het
Egfr	G	A	11: 16,869,333	G288S	probably damaging	Het
Fbxl17	G	T	17: 63,471,414	N19K	probably damaging	Het
Fmo3	A	G	1: 162,958,227		probably benign	Het
Frmd6	T	C	12: 70,883,762	Y219H	probably damaging	Het
Fuca1	T	C	4: 135,925,644	V193A	possibly damaging	Het
Gm1141	G	C	X: 71,938,773	R296P	possibly damaging	Het
Gm7461	C	T	8: 4,677,769		noncoding transcript	Het
Gpc5	T	A	14: 115,552,239	N508K	possibly damaging	Het
Iqch	A	T	9: 63,425,382	D1019E	probably benign	Het
Isyna1	A	G	8: 70,594,708	Y27C	probably damaging	Het
Itgb8	T	G	12: 119,202,481	H105P	probably benign	Het
Kbtbd11	C	T	8: 15,027,572	P57L	probably benign	Het
Kcns3	A	C	12: 11,092,558	C47G	probably damaging	Het
Kif21b	A	T	1: 136,172,157		probably null	Het
Lama3	A	T	18: 12,419,245	H418L	possibly damaging	Het
Lrit3	A	G	3: 129,788,302	Y679H	probably damaging	Het
Lrrc19	T	A	4: 94,638,252	D356V	probably damaging	Het
Morc2b	A	G	17: 33,135,807	M997T	probably benign	Het
Mroh9	T	C	1: 163,060,636	H290R	possibly damaging	Het
Mtcl1	A	T	17: 66,338,142	S1886T	possibly damaging	Het
Muc20	T	C	16: 32,793,421	T529A	possibly damaging	Het
Myo7a	A	C	7: 98,085,466	L607R	probably damaging	Het
Myom2	T	A	8: 15,069,783	F180I	probably damaging	Het
Myt1l	G	A	12: 29,811,485	E89K	unknown	Het
Nek2	A	G	1: 191,831,317	N431S	probably benign	Het
Olfr1086	T	A	2: 86,676,529	H268L	possibly damaging	Het
Olfr169	A	T	16: 19,565,980	V301E	possibly damaging	Het
Oprm1	A	T	10: 6,832,604		probably null	Het
Oxsr1	A	G	9: 119,241,784		probably benign	Het
Pdgfrb	G	A	18: 61,078,648		probably null	Het
Proser1	C	A	3: 53,479,064	P789Q	probably benign	Het
Ptgs2	A	G	1: 150,101,037	Q7R	probably benign	Het
Rab3d	A	G	9: 21,914,686	V144A	probably benign	Het
Ralgapb	T	A	2: 158,439,547	L167H	probably damaging	Het
Ranbp3	A	G	17: 56,708,200	T301A	possibly damaging	Het
Rasgrf1	G	A	9: 89,984,269	V587M	probably damaging	Het
Sec16b	A	G	1: 157,564,863		probably benign	Het
Sin3b	T	C	8: 72,753,536		probably benign	Het
Slc10a2	T	C	8: 5,098,562	S128G	probably benign	Het
Tbl1xr1	G	A	3: 22,210,401	V507I	probably benign	Het
Tmem8b	T	G	4: 43,669,896		probably null	Het
Trak1	A	T	9: 121,367,167	T22S	probably benign	Het
Trim30d	A	G	7: 104,487,655	I114T	probably damaging	Het
Ttc13	A	T	8: 124,674,366	S624T	probably damaging	Het
Ttn	T	C	2: 76,828,130		probably benign	Het
Vipr1	T	A	9: 121,660,171	Y99*	probably null	Het
Vmn1r210	T	C	13: 22,827,874	K81E	probably damaging	Het
Wwc1	T	C	11: 35,853,472	Y841C	probably benign	Het
Xrcc4	A	G	13: 90,000,905		probably benign	Het
Zdhhc22	A	T	12: 86,988,297	I127N	probably damaging	Het
Zdhhc7	A	G	8: 120,088,046	L8P	possibly damaging	Het
Zfp664	C	A	5: 124,885,595	L18I	probably damaging	Het

Other mutations in Cacna1g

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01300:Cacna1g	APN	11	94433912	missense	probably benign	0.16
IGL01382:Cacna1g	APN	11	94465858	missense	probably damaging	1.00
IGL01694:Cacna1g	APN	11	94429112	missense	probably damaging	1.00
IGL01866:Cacna1g	APN	11	94457111	missense	probably damaging	0.99
IGL02341:Cacna1g	APN	11	94462152	missense	probably damaging	1.00
IGL02506:Cacna1g	APN	11	94429129	missense	probably damaging	0.99
IGL02706:Cacna1g	APN	11	94456992	missense	probably damaging	1.00
IGL02879:Cacna1g	APN	11	94409605	missense	probably benign	0.12
IGL03366:Cacna1g	APN	11	94457151	missense	probably damaging	1.00
ANU23:Cacna1g	UTSW	11	94466228	critical splice acceptor site	probably benign
IGL03134:Cacna1g	UTSW	11	94459825	missense	probably damaging	1.00
R0092:Cacna1g	UTSW	11	94457264	missense	probably damaging	1.00
R0123:Cacna1g	UTSW	11	94409476	missense	probably damaging	1.00
R0178:Cacna1g	UTSW	11	94463483	missense	probably damaging	1.00
R0375:Cacna1g	UTSW	11	94411054	missense	possibly damaging	0.79
R0389:Cacna1g	UTSW	11	94459697	missense	probably damaging	1.00
R0433:Cacna1g	UTSW	11	94459207	missense	probably benign	0.16
R0458:Cacna1g	UTSW	11	94409440	missense	probably damaging	0.96
R0498:Cacna1g	UTSW	11	94459859	missense	probably damaging	1.00
R0800:Cacna1g	UTSW	11	94426439	missense	probably damaging	1.00
R1341:Cacna1g	UTSW	11	94433756	missense	probably damaging	0.99
R1457:Cacna1g	UTSW	11	94459555	missense	possibly damaging	0.76
R1523:Cacna1g	UTSW	11	94442729	critical splice donor site	probably null
R1532:Cacna1g	UTSW	11	94443331	missense	probably damaging	1.00
R1540:Cacna1g	UTSW	11	94457039	missense	probably damaging	1.00
R1652:Cacna1g	UTSW	11	94427404	missense	probably damaging	1.00
R1688:Cacna1g	UTSW	11	94425953	missense	possibly damaging	0.70
R1750:Cacna1g	UTSW	11	94443292	missense	probably damaging	1.00
R1751:Cacna1g	UTSW	11	94459802	missense	probably benign	0.35
R1767:Cacna1g	UTSW	11	94459802	missense	probably benign	0.35
R1847:Cacna1g	UTSW	11	94466181	missense	probably damaging	1.00
R1924:Cacna1g	UTSW	11	94444054	missense	possibly damaging	0.93
R1973:Cacna1g	UTSW	11	94459777	missense	possibly damaging	0.86
R2050:Cacna1g	UTSW	11	94409474	missense	probably damaging	1.00
R2261:Cacna1g	UTSW	11	94457135	missense	probably benign	0.42
R2273:Cacna1g	UTSW	11	94415936	missense	probably damaging	0.98
R2274:Cacna1g	UTSW	11	94415936	missense	probably damaging	0.98
R2275:Cacna1g	UTSW	11	94415936	missense	probably damaging	0.98
R2376:Cacna1g	UTSW	11	94465908	missense	probably damaging	0.99
R3686:Cacna1g	UTSW	11	94459090	splice site	probably null
R3809:Cacna1g	UTSW	11	94416096	missense	probably damaging	1.00
R3875:Cacna1g	UTSW	11	94437923	missense	probably damaging	0.98
R4133:Cacna1g	UTSW	11	94432544	missense	probably damaging	1.00
R4642:Cacna1g	UTSW	11	94418094	missense	probably damaging	1.00
R4732:Cacna1g	UTSW	11	94443215	missense	probably damaging	1.00
R4733:Cacna1g	UTSW	11	94443215	missense	probably damaging	1.00
R4773:Cacna1g	UTSW	11	94411472	missense	possibly damaging	0.78
R4798:Cacna1g	UTSW	11	94433847	missense	probably damaging	1.00
R4839:Cacna1g	UTSW	11	94459607	missense	probably benign	0.16
R4900:Cacna1g	UTSW	11	94459351	missense	possibly damaging	0.78
R4927:Cacna1g	UTSW	11	94429147	missense	probably damaging	1.00
R4930:Cacna1g	UTSW	11	94444073	missense	probably damaging	1.00
R5050:Cacna1g	UTSW	11	94459715	missense	probably damaging	1.00
R5117:Cacna1g	UTSW	11	94432503	missense	probably damaging	1.00
R5186:Cacna1g	UTSW	11	94442848	missense	probably damaging	1.00
R5364:Cacna1g	UTSW	11	94416858	missense	probably benign	0.29
R5512:Cacna1g	UTSW	11	94444142	missense	probably damaging	1.00
R5564:Cacna1g	UTSW	11	94430486	missense	probably damaging	1.00
R5603:Cacna1g	UTSW	11	94439752	missense	possibly damaging	0.76
R5682:Cacna1g	UTSW	11	94459114	missense	probably damaging	1.00
R5818:Cacna1g	UTSW	11	94418120	missense	probably damaging	1.00
R5828:Cacna1g	UTSW	11	94457154	missense	probably damaging	1.00
R5882:Cacna1g	UTSW	11	94459819	missense	probably damaging	1.00
R5884:Cacna1g	UTSW	11	94437867	missense	probably damaging	1.00
R6075:Cacna1g	UTSW	11	94416665	missense	probably damaging	1.00
R6112:Cacna1g	UTSW	11	94409246	missense	probably damaging	0.98
R6122:Cacna1g	UTSW	11	94430171	missense	probably benign	0.11
R6145:Cacna1g	UTSW	11	94462261	missense	probably damaging	1.00
R6362:Cacna1g	UTSW	11	94439707	critical splice donor site	probably null
R6415:Cacna1g	UTSW	11	94463417	missense	probably damaging	1.00
R6468:Cacna1g	UTSW	11	94439722	missense	probably damaging	1.00
R6648:Cacna1g	UTSW	11	94432569	missense	probably damaging	1.00
R6746:Cacna1g	UTSW	11	94409427	nonsense	probably null
R6764:Cacna1g	UTSW	11	94413188	missense	possibly damaging	0.95
R6782:Cacna1g	UTSW	11	94459550	missense	probably damaging	1.00
R6888:Cacna1g	UTSW	11	94459207	missense	probably benign	0.16
R7148:Cacna1g	UTSW	11	94465930	missense	probably benign	0.32
R7181:Cacna1g	UTSW	11	94415865	missense	probably benign	0.21
R7183:Cacna1g	UTSW	11	94439737	missense	probably benign	0.04
R7193:Cacna1g	UTSW	11	94409231	missense	possibly damaging	0.60
R7237:Cacna1g	UTSW	11	94437879	missense	probably benign	0.21
R7254:Cacna1g	UTSW	11	94432567	nonsense	probably null
R7312:Cacna1g	UTSW	11	94432557	missense	probably damaging	1.00
R7451:Cacna1g	UTSW	11	94429075	missense	probably damaging	1.00
R7470:Cacna1g	UTSW	11	94461939	missense	possibly damaging	0.76
R7534:Cacna1g	UTSW	11	94411078	missense	probably benign	0.00
R7585:Cacna1g	UTSW	11	94473542	missense	probably benign	0.39
R7706:Cacna1g	UTSW	11	94415041	missense	probably benign	0.06
R7812:Cacna1g	UTSW	11	94444054	missense	probably benign	0.03
R7918:Cacna1g	UTSW	11	94444030	missense	probably benign	0.03
R7947:Cacna1g	UTSW	11	94457175	missense	probably benign	0.01
R8013:Cacna1g	UTSW	11	94456970	missense	probably damaging	0.99
R8016:Cacna1g	UTSW	11	94443181	missense	probably benign	0.36
R8029:Cacna1g	UTSW	11	94409738	missense	probably benign	0.01
R8098:Cacna1g	UTSW	11	94416512	missense	probably benign	0.20
R8264:Cacna1g	UTSW	11	94473566	missense	probably benign	0.21
R8478:Cacna1g	UTSW	11	94426452	missense	probably damaging	1.00
R8679:Cacna1g	UTSW	11	94429136	missense	probably damaging	1.00
R8697:Cacna1g	UTSW	11	94416698	missense	probably benign	0.09
R8772:Cacna1g	UTSW	11	94465887	missense	probably benign	0.03
R9011:Cacna1g	UTSW	11	94415837	missense	probably benign	0.21
R9085:Cacna1g	UTSW	11	94443220	missense	probably benign	0.01
R9155:Cacna1g	UTSW	11	94459597	missense
R9243:Cacna1g	UTSW	11	94457067	missense	possibly damaging	0.84
R9288:Cacna1g	UTSW	11	94418071	nonsense	probably null
R9408:Cacna1g	UTSW	11	94430224	missense	probably damaging	1.00
R9496:Cacna1g	UTSW	11	94465885	missense	probably benign	0.03
R9607:Cacna1g	UTSW	11	94465888	missense	probably benign	0.03
R9720:Cacna1g	UTSW	11	94411471	missense	probably benign	0.01
X0001:Cacna1g	UTSW	11	94409645	missense	possibly damaging	0.90
X0019:Cacna1g	UTSW	11	94459253	missense	probably damaging	0.97
X0065:Cacna1g	UTSW	11	94462425	missense	probably damaging	1.00
Z1176:Cacna1g	UTSW	11	94438111	missense	probably benign	0.31
Z1177:Cacna1g	UTSW	11	94459596	missense	probably benign	0.04
Z1177:Cacna1g	UTSW	11	94473590	missense	probably benign	0.21

Predicted Primers

PCR Primer
(F):5'- AGAGACTCAGCGCATCTTTCTTTGG -3'
(R):5'- AGCAATAAGGACTGACTCCCTGGAC -3'

Sequencing Primer
(F):5'- AGCCGTGCTGTCAAGGG -3'
(R):5'- TAGCCGGGAAGACCTGTTG -3'

Posted On

2013-07-11