|Institutional Source||Beutler Lab|
|Gene Name||TNF receptor-associated factor 5|
|Essential gene?||Non essential (E-score: 0.000)|
|Stock #||R7452 (G1)|
|Chromosomal Location||191997205-192092559 bp(-) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||T to A at 191999831 bp (GRCm38)|
|Amino Acid Change||Isoleucine to Phenylalanine at position 47 (I47F)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000085573]|
AA Change: I350F
PolyPhen 2 Score 0.895 (Sensitivity: 0.82; Specificity: 0.94)
AA Change: I350F
|Meta Mutation Damage Score||0.0613|
|Coding Region Coverage||
|Validation Efficiency||100% (75/75)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The scaffold protein encoded by this gene is a member of the tumor necrosis factor receptor-associated factor (TRAF) protein family and contains a meprin and TRAF homology (MATH) domain, a RING-type zinc finger, and two TRAF-type zinc fingers. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. This protein is one of the components of a multiple protein complex which binds to tumor necrosis factor (TNF) receptor cytoplasmic domains and mediates TNF-induced activation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]
PHENOTYPE: Homozygous null mice show defects in lymphocyte activation but are otherwise viable and develop normally. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Traf5||
(F):5'- AGCTAGAATCTCATGCTGCTTC -3'
(R):5'- CGCTACAAATCCGATGTCTCG -3'
(F):5'- TGCTGCTTCACAAACAGGATTCAG -3'
(R):5'- AAATCCGATGTCTCGTTTCCAAGAC -3'