Incidental Mutation 'R7454:Tpp2'
| ID |
577952 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Tpp2
|
| Ensembl Gene |
ENSMUSG00000041763 |
| Gene Name |
tripeptidyl peptidase II |
| Synonyms |
TppII |
| MMRRC Submission |
045528-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly essential
(E-score: 0.589)
|
| Stock # |
R7454 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
1 |
| Chromosomal Location |
43973130-44042160 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 43993819 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Proline
at position 235
(S235P)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000085244
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000087933]
[ENSMUST00000188302]
[ENSMUST00000188313]
[ENSMUST00000189388]
|
| AlphaFold |
Q64514 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000087933
AA Change: S235P
PolyPhen 2
Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
|
| SMART Domains |
Protein: ENSMUSP00000085244
Gene: ENSMUSG00000041763
AA Change: S235P
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Peptidase_S8
|
35 |
500 |
1.4e-96 |
PFAM |
|
low complexity region
|
674 |
685 |
N/A |
INTRINSIC |
|
Pfam:TPPII
|
777 |
964 |
2.4e-80 |
PFAM |
|
low complexity region
|
1017 |
1033 |
N/A |
INTRINSIC |
|
PDB:3LXU|X
|
1034 |
1262 |
1e-20 |
PDB |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000188302
AA Change: S235P
PolyPhen 2
Score 0.983 (Sensitivity: 0.75; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000140474
Gene: ENSMUSG00000041763
AA Change: S235P
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Peptidase_S8
|
39 |
509 |
4.3e-84 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000188313
AA Change: S235P
PolyPhen 2
Score 0.988 (Sensitivity: 0.73; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000139918
Gene: ENSMUSG00000041763
AA Change: S235P
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Peptidase_S8
|
39 |
509 |
5.1e-83 |
PFAM |
|
low complexity region
|
674 |
685 |
N/A |
INTRINSIC |
|
Pfam:TPPII
|
773 |
966 |
2.7e-93 |
PFAM |
|
low complexity region
|
1004 |
1020 |
N/A |
INTRINSIC |
|
PDB:3LXU|X
|
1021 |
1249 |
1e-20 |
PDB |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000189388
AA Change: S235P
PolyPhen 2
Score 0.027 (Sensitivity: 0.95; Specificity: 0.81)
|
| SMART Domains |
Protein: ENSMUSP00000140562
Gene: ENSMUSG00000041763
AA Change: S235P
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Peptidase_S8
|
39 |
509 |
2.3e-81 |
PFAM |
|
low complexity region
|
674 |
685 |
N/A |
INTRINSIC |
|
Pfam:TPPII
|
773 |
880 |
7.8e-49 |
PFAM |
|
| Meta Mutation Damage Score |
0.1163 |
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 99.1%
|
| Validation Efficiency |
100% (90/90) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a mammalian peptidase that, at neutral pH, removes tripeptides from the N terminus of longer peptides. The protein has a specialized function that is essential for some MHC class I antigen presentation. The protein is a high molecular mass serine exopeptidase; the amino acid sequence surrounding the serine residue at the active site is similar to the peptidases of the subtilisin class rather than the trypsin class. [provided by RefSeq, Jul 2008]
PHENOTYPE: Engineered mutations of this gene result in decreased lifespan and symptoms of immunohematopoietic senescence. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 89 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2510002D24Rik |
A |
G |
16: 18,655,601 (GRCm39) |
E57G |
possibly damaging |
Het |
| 4932414N04Rik |
C |
A |
2: 68,518,648 (GRCm39) |
T159K |
unknown |
Het |
| Adamts10 |
T |
A |
17: 33,763,979 (GRCm39) |
F616L |
possibly damaging |
Het |
| Adtrp |
G |
A |
13: 41,981,791 (GRCm39) |
S26L |
unknown |
Het |
| Alpk3 |
A |
C |
7: 80,728,310 (GRCm39) |
E480A |
probably benign |
Het |
| Anks6 |
T |
C |
4: 47,038,919 (GRCm39) |
T529A |
unknown |
Het |
| Arl4d |
A |
G |
11: 101,557,486 (GRCm39) |
H4R |
probably benign |
Het |
| Ash1l |
A |
G |
3: 88,891,172 (GRCm39) |
H1017R |
probably benign |
Het |
| Bbs12 |
T |
C |
3: 37,375,102 (GRCm39) |
S517P |
possibly damaging |
Het |
| Bcl11b |
C |
A |
12: 107,882,467 (GRCm39) |
R616L |
possibly damaging |
Het |
| Bean1 |
G |
A |
8: 104,937,658 (GRCm39) |
G79D |
probably damaging |
Het |
| Bicra |
C |
G |
7: 15,706,059 (GRCm39) |
G1461R |
probably benign |
Het |
| Bptf |
T |
C |
11: 106,935,466 (GRCm39) |
T124A |
probably benign |
Het |
| Btnl4 |
A |
T |
17: 34,691,348 (GRCm39) |
V312E |
probably benign |
Het |
| Ccdc7a |
A |
G |
8: 129,670,997 (GRCm39) |
M503T |
unknown |
Het |
| Celf5 |
T |
C |
10: 81,318,357 (GRCm39) |
E28G |
probably damaging |
Het |
| Cilp2 |
G |
A |
8: 70,336,040 (GRCm39) |
L350F |
probably damaging |
Het |
| Clec4a2 |
T |
C |
6: 123,119,411 (GRCm39) |
I245T |
probably damaging |
Het |
| Ctnnal1 |
A |
T |
4: 56,844,544 (GRCm39) |
V140D |
probably damaging |
Het |
| Dennd4a |
A |
C |
9: 64,759,852 (GRCm39) |
H319P |
probably damaging |
Het |
| Dlgap3 |
G |
T |
4: 127,128,852 (GRCm39) |
L857F |
probably null |
Het |
| Dnah6 |
T |
A |
6: 73,189,475 (GRCm39) |
T58S |
probably damaging |
Het |
| Dnah7a |
T |
A |
1: 53,557,923 (GRCm39) |
M2164L |
probably benign |
Het |
| Dspp |
T |
A |
5: 104,323,476 (GRCm39) |
H206Q |
probably benign |
Het |
| Dzip1l |
G |
A |
9: 99,541,727 (GRCm39) |
V443M |
possibly damaging |
Het |
| Erc2 |
A |
G |
14: 28,024,948 (GRCm39) |
H939R |
possibly damaging |
Het |
| Fam149a |
G |
T |
8: 45,801,583 (GRCm39) |
H513N |
probably benign |
Het |
| Fam171a2 |
T |
C |
11: 102,330,543 (GRCm39) |
T280A |
possibly damaging |
Het |
| Fkbp5 |
A |
C |
17: 28,634,999 (GRCm39) |
V170G |
probably damaging |
Het |
| Fnbp4 |
ACCACCTCCACCTCCACCTCC |
ACCACCTCCACCTCCACCTCCACCTCC |
2: 90,608,159 (GRCm39) |
|
probably benign |
Het |
| Fzd2 |
T |
C |
11: 102,495,955 (GRCm39) |
F133S |
probably damaging |
Het |
| Galm |
A |
G |
17: 80,445,550 (GRCm39) |
N100S |
possibly damaging |
Het |
| Gbp2b |
T |
A |
3: 142,303,920 (GRCm39) |
I5N |
possibly damaging |
Het |
| Gga2 |
T |
C |
7: 121,601,369 (GRCm39) |
R245G |
probably benign |
Het |
| Gm10053 |
A |
G |
19: 24,853,264 (GRCm39) |
T50A |
probably benign |
Het |
| Gm1110 |
T |
C |
9: 26,831,945 (GRCm39) |
T69A |
probably benign |
Het |
| Heatr5a |
T |
C |
12: 52,008,326 (GRCm39) |
S6G |
probably benign |
Het |
| Hmcn1 |
A |
G |
1: 150,439,355 (GRCm39) |
S5610P |
probably damaging |
Het |
| Hmgb4 |
A |
G |
4: 128,154,199 (GRCm39) |
V123A |
probably damaging |
Het |
| Itgal |
C |
A |
7: 126,926,936 (GRCm39) |
Q943K |
probably benign |
Het |
| Jakmip1 |
C |
A |
5: 37,332,498 (GRCm39) |
D1059E |
probably damaging |
Het |
| Jazf1 |
T |
C |
6: 52,870,929 (GRCm39) |
|
probably null |
Het |
| Kat6a |
A |
G |
8: 23,425,788 (GRCm39) |
E1111G |
possibly damaging |
Het |
| Kdm4b |
C |
A |
17: 56,696,639 (GRCm39) |
P452T |
probably benign |
Het |
| Krit1 |
T |
C |
5: 3,862,474 (GRCm39) |
Y210H |
probably damaging |
Het |
| Krtap6-2 |
A |
T |
16: 89,216,800 (GRCm39) |
Y56N |
unknown |
Het |
| Lig1 |
A |
T |
7: 13,022,647 (GRCm39) |
D158V |
probably damaging |
Het |
| Lmo1 |
A |
T |
7: 108,739,873 (GRCm39) |
L94Q |
probably benign |
Het |
| Lrrc30 |
A |
T |
17: 67,939,238 (GRCm39) |
L114H |
probably damaging |
Het |
| Ltn1 |
T |
C |
16: 87,194,700 (GRCm39) |
I1400V |
probably benign |
Het |
| Mark3 |
T |
C |
12: 111,570,961 (GRCm39) |
I87T |
probably damaging |
Het |
| Mfrp |
G |
T |
9: 44,016,480 (GRCm39) |
V392F |
possibly damaging |
Het |
| Mrgprg |
A |
G |
7: 143,318,872 (GRCm39) |
L80P |
probably damaging |
Het |
| Ndufaf3 |
A |
T |
9: 108,444,125 (GRCm39) |
M1K |
probably null |
Het |
| Nme7 |
T |
A |
1: 164,208,217 (GRCm39) |
L295* |
probably null |
Het |
| Noct |
G |
T |
3: 51,157,151 (GRCm39) |
C163F |
probably damaging |
Het |
| Or11h4b |
T |
A |
14: 50,918,281 (GRCm39) |
Q270L |
possibly damaging |
Het |
| Or13a26 |
A |
T |
7: 140,284,547 (GRCm39) |
I128F |
probably damaging |
Het |
| Or4b1 |
T |
A |
2: 89,979,763 (GRCm39) |
I196F |
possibly damaging |
Het |
| Or5ak22 |
T |
A |
2: 85,229,955 (GRCm39) |
K307N |
probably damaging |
Het |
| Or6c203 |
T |
A |
10: 129,010,324 (GRCm39) |
T189S |
probably damaging |
Het |
| Or8g2 |
A |
G |
9: 39,821,200 (GRCm39) |
I34V |
probably benign |
Het |
| Patz1 |
C |
T |
11: 3,248,297 (GRCm39) |
|
probably benign |
Het |
| Per3 |
A |
G |
4: 151,097,185 (GRCm39) |
L780P |
probably benign |
Het |
| Pira1 |
T |
G |
7: 3,738,509 (GRCm39) |
E622D |
probably benign |
Het |
| Pla2g4a |
T |
C |
1: 149,748,441 (GRCm39) |
M256V |
possibly damaging |
Het |
| Pnliprp1 |
A |
G |
19: 58,729,532 (GRCm39) |
K395R |
probably benign |
Het |
| Poc5 |
G |
T |
13: 96,537,340 (GRCm39) |
G242V |
possibly damaging |
Het |
| Ppfia4 |
A |
G |
1: 134,251,873 (GRCm39) |
S434P |
possibly damaging |
Het |
| Prss42 |
A |
G |
9: 110,627,897 (GRCm39) |
N110S |
probably benign |
Het |
| Ralgapb |
T |
A |
2: 158,274,822 (GRCm39) |
I241N |
possibly damaging |
Het |
| Rbak |
A |
C |
5: 143,159,528 (GRCm39) |
Y508* |
probably null |
Het |
| S1pr2 |
G |
T |
9: 20,878,845 (GRCm39) |
R328S |
possibly damaging |
Het |
| Sap130 |
T |
C |
18: 31,783,565 (GRCm39) |
M214T |
probably benign |
Het |
| Slc46a1 |
T |
A |
11: 78,357,337 (GRCm39) |
V130E |
probably damaging |
Het |
| Smc4 |
A |
T |
3: 68,925,457 (GRCm39) |
H343L |
probably benign |
Het |
| Tarbp1 |
C |
A |
8: 127,184,416 (GRCm39) |
R500L |
probably benign |
Het |
| Tasor2 |
A |
G |
13: 3,635,332 (GRCm39) |
S492P |
probably benign |
Het |
| Tgfbr3 |
A |
T |
5: 107,362,894 (GRCm39) |
H39Q |
probably damaging |
Het |
| Trbc2 |
G |
T |
6: 41,523,763 (GRCm39) |
R33M |
|
Het |
| Trim3 |
C |
T |
7: 105,268,765 (GRCm39) |
R63Q |
probably damaging |
Het |
| Ttc28 |
T |
C |
5: 111,433,350 (GRCm39) |
V2128A |
probably benign |
Het |
| Ttn |
C |
T |
2: 76,556,162 (GRCm39) |
R30281H |
probably damaging |
Het |
| Ttn |
T |
A |
2: 76,774,483 (GRCm39) |
Q2187L |
unknown |
Het |
| Ttyh3 |
T |
C |
5: 140,615,180 (GRCm39) |
S403G |
possibly damaging |
Het |
| Vmn2r112 |
A |
T |
17: 22,822,288 (GRCm39) |
D322V |
probably benign |
Het |
| Wdr38 |
C |
T |
2: 38,888,352 (GRCm39) |
|
probably benign |
Het |
| Xrn1 |
T |
A |
9: 95,930,411 (GRCm39) |
S1543R |
probably benign |
Het |
| Zbtb8b |
G |
A |
4: 129,326,562 (GRCm39) |
T201I |
possibly damaging |
Het |
|
| Other mutations in Tpp2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00977:Tpp2
|
APN |
1 |
44,022,451 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL01021:Tpp2
|
APN |
1 |
43,973,347 (GRCm39) |
nonsense |
probably null |
|
|
IGL01096:Tpp2
|
APN |
1 |
44,000,048 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01344:Tpp2
|
APN |
1 |
44,022,422 (GRCm39) |
missense |
probably benign |
0.04 |
|
IGL01642:Tpp2
|
APN |
1 |
43,993,813 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02719:Tpp2
|
APN |
1 |
43,979,391 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL02890:Tpp2
|
APN |
1 |
44,038,850 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03102:Tpp2
|
APN |
1 |
43,995,649 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03175:Tpp2
|
APN |
1 |
44,012,671 (GRCm39) |
missense |
probably benign |
0.35 |
|
beaver
|
UTSW |
1 |
44,010,875 (GRCm39) |
missense |
probably benign |
0.08 |
|
billingsly
|
UTSW |
1 |
44,022,712 (GRCm39) |
missense |
probably damaging |
1.00 |
|
cleaver
|
UTSW |
1 |
44,017,668 (GRCm39) |
nonsense |
probably null |
|
|
dow
|
UTSW |
1 |
44,009,552 (GRCm39) |
splice site |
probably benign |
|
|
Eddie
|
UTSW |
1 |
44,008,148 (GRCm39) |
missense |
probably damaging |
1.00 |
|
jerry
|
UTSW |
1 |
44,017,897 (GRCm39) |
missense |
probably benign |
0.04 |
|
June
|
UTSW |
1 |
43,993,870 (GRCm39) |
missense |
probably damaging |
1.00 |
|
landers
|
UTSW |
1 |
44,016,415 (GRCm39) |
missense |
probably damaging |
1.00 |
|
mathers
|
UTSW |
1 |
44,031,428 (GRCm39) |
missense |
probably damaging |
1.00 |
|
recurrentis
|
UTSW |
1 |
44,031,553 (GRCm39) |
missense |
probably null |
0.29 |
|
state
|
UTSW |
1 |
44,017,598 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
wally
|
UTSW |
1 |
44,031,556 (GRCm39) |
critical splice donor site |
probably null |
|
|
Ward
|
UTSW |
1 |
43,993,896 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
wilson
|
UTSW |
1 |
44,011,849 (GRCm39) |
critical splice donor site |
probably null |
|
|
BB010:Tpp2
|
UTSW |
1 |
44,000,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
BB020:Tpp2
|
UTSW |
1 |
44,000,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0001:Tpp2
|
UTSW |
1 |
44,010,886 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0003:Tpp2
|
UTSW |
1 |
43,999,299 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R0066:Tpp2
|
UTSW |
1 |
44,020,908 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R0110:Tpp2
|
UTSW |
1 |
44,017,664 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0110:Tpp2
|
UTSW |
1 |
44,038,853 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0167:Tpp2
|
UTSW |
1 |
44,009,648 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0441:Tpp2
|
UTSW |
1 |
44,029,722 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R0520:Tpp2
|
UTSW |
1 |
44,029,690 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0639:Tpp2
|
UTSW |
1 |
44,014,607 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1118:Tpp2
|
UTSW |
1 |
44,031,556 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1119:Tpp2
|
UTSW |
1 |
44,031,556 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1593:Tpp2
|
UTSW |
1 |
44,014,593 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1702:Tpp2
|
UTSW |
1 |
44,029,708 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1756:Tpp2
|
UTSW |
1 |
44,017,885 (GRCm39) |
splice site |
probably null |
|
|
R2066:Tpp2
|
UTSW |
1 |
44,017,598 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R2171:Tpp2
|
UTSW |
1 |
43,996,606 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2378:Tpp2
|
UTSW |
1 |
44,038,925 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2394:Tpp2
|
UTSW |
1 |
44,022,346 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R2507:Tpp2
|
UTSW |
1 |
44,040,609 (GRCm39) |
missense |
probably benign |
0.31 |
|
R2879:Tpp2
|
UTSW |
1 |
44,010,783 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3436:Tpp2
|
UTSW |
1 |
43,979,304 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4106:Tpp2
|
UTSW |
1 |
44,040,617 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R4658:Tpp2
|
UTSW |
1 |
43,993,870 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4760:Tpp2
|
UTSW |
1 |
44,010,875 (GRCm39) |
missense |
probably benign |
0.08 |
|
R4963:Tpp2
|
UTSW |
1 |
44,031,428 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5049:Tpp2
|
UTSW |
1 |
44,040,633 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R5073:Tpp2
|
UTSW |
1 |
43,993,896 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R6010:Tpp2
|
UTSW |
1 |
43,990,373 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6118:Tpp2
|
UTSW |
1 |
43,979,306 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6155:Tpp2
|
UTSW |
1 |
43,995,649 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6169:Tpp2
|
UTSW |
1 |
44,022,739 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6236:Tpp2
|
UTSW |
1 |
44,016,477 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6695:Tpp2
|
UTSW |
1 |
44,022,436 (GRCm39) |
missense |
probably benign |
|
|
R6845:Tpp2
|
UTSW |
1 |
44,017,668 (GRCm39) |
nonsense |
probably null |
|
|
R7054:Tpp2
|
UTSW |
1 |
44,022,318 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7094:Tpp2
|
UTSW |
1 |
44,008,148 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7223:Tpp2
|
UTSW |
1 |
44,008,048 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7316:Tpp2
|
UTSW |
1 |
44,009,591 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7324:Tpp2
|
UTSW |
1 |
44,017,938 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7363:Tpp2
|
UTSW |
1 |
44,024,582 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7496:Tpp2
|
UTSW |
1 |
44,022,677 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7699:Tpp2
|
UTSW |
1 |
44,009,626 (GRCm39) |
missense |
probably benign |
|
|
R7700:Tpp2
|
UTSW |
1 |
44,009,626 (GRCm39) |
missense |
probably benign |
|
|
R7804:Tpp2
|
UTSW |
1 |
44,022,441 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7933:Tpp2
|
UTSW |
1 |
44,000,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7979:Tpp2
|
UTSW |
1 |
43,979,297 (GRCm39) |
missense |
probably benign |
0.35 |
|
R8032:Tpp2
|
UTSW |
1 |
44,014,628 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R8101:Tpp2
|
UTSW |
1 |
44,009,600 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8245:Tpp2
|
UTSW |
1 |
44,022,712 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8314:Tpp2
|
UTSW |
1 |
43,973,387 (GRCm39) |
missense |
probably benign |
0.10 |
|
R8518:Tpp2
|
UTSW |
1 |
44,019,545 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8519:Tpp2
|
UTSW |
1 |
44,016,365 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R8529:Tpp2
|
UTSW |
1 |
44,022,300 (GRCm39) |
missense |
probably benign |
|
|
R8756:Tpp2
|
UTSW |
1 |
43,999,295 (GRCm39) |
nonsense |
probably null |
|
|
R8765:Tpp2
|
UTSW |
1 |
44,011,849 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8773:Tpp2
|
UTSW |
1 |
44,009,552 (GRCm39) |
splice site |
probably benign |
|
|
R8915:Tpp2
|
UTSW |
1 |
44,016,415 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9049:Tpp2
|
UTSW |
1 |
43,992,502 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R9090:Tpp2
|
UTSW |
1 |
43,993,811 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9176:Tpp2
|
UTSW |
1 |
44,031,553 (GRCm39) |
missense |
probably null |
0.29 |
|
R9214:Tpp2
|
UTSW |
1 |
44,031,514 (GRCm39) |
missense |
probably benign |
|
|
R9271:Tpp2
|
UTSW |
1 |
43,993,811 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9316:Tpp2
|
UTSW |
1 |
44,017,604 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9371:Tpp2
|
UTSW |
1 |
43,999,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9422:Tpp2
|
UTSW |
1 |
44,017,897 (GRCm39) |
missense |
probably benign |
0.04 |
|
R9488:Tpp2
|
UTSW |
1 |
44,041,272 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9513:Tpp2
|
UTSW |
1 |
44,017,648 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9514:Tpp2
|
UTSW |
1 |
44,017,648 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9516:Tpp2
|
UTSW |
1 |
44,017,648 (GRCm39) |
missense |
probably benign |
0.01 |
|
| Predicted Primers |
PCR Primer
(F):5'- GCCTAACTGCTTACTCTGTGAAAC -3'
(R):5'- CACAAAATTTCTAGGCTTCATCCG -3'
Sequencing Primer
(F):5'- CTGCTTACTCTGTGAAACAAAGG -3'
(R):5'- GGCTTCATCCGTCAATAAAAATGTC -3'
|
| Posted On |
2019-10-07 |
Incidental Mutation