Incidental Mutation 'R7454:Dennd4a'
| ID |
578008 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Dennd4a
|
| Ensembl Gene |
ENSMUSG00000053641 |
| Gene Name |
DENN/MADD domain containing 4A |
| Synonyms |
F730015K02Rik |
| MMRRC Submission |
045528-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.432)
|
| Stock # |
R7454 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
9 |
| Chromosomal Location |
64811340-64919667 bp(+) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to C
at 64852570 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Histidine to Proline
at position 319
(H319P)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000037915
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000038890]
|
| AlphaFold |
E9Q8V6 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000038890
AA Change: H319P
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000037915
Gene: ENSMUSG00000053641
AA Change: H319P
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
45 |
93 |
3.26e-5 |
PROSPERO |
|
uDENN
|
169 |
276 |
1.71e-28 |
SMART |
|
DENN
|
309 |
493 |
2.4e-73 |
SMART |
|
dDENN
|
559 |
633 |
4.15e-27 |
SMART |
|
low complexity region
|
724 |
735 |
N/A |
INTRINSIC |
|
low complexity region
|
936 |
950 |
N/A |
INTRINSIC |
|
low complexity region
|
1176 |
1191 |
N/A |
INTRINSIC |
|
low complexity region
|
1249 |
1262 |
N/A |
INTRINSIC |
|
low complexity region
|
1402 |
1417 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 99.1%
|
| Validation Efficiency |
100% (90/90) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a DENN domain-containing protein that may function as a guanine nucleotide exchange factor that specifically activates ras-related protein Rab-10. This protein also contains a interferon stimulated response element-binding domain and may be involved in regulating the v-myc avian myelocytomatosis viral (MYC) oncogene. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 8. [provided by RefSeq, Mar 2016]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 89 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2510002D24Rik |
A |
G |
16: 18,836,851 (GRCm38) |
E57G |
possibly damaging |
Het |
| 4932414N04Rik |
C |
A |
2: 68,688,304 (GRCm38) |
T159K |
unknown |
Het |
| Adamts10 |
T |
A |
17: 33,545,005 (GRCm38) |
F616L |
possibly damaging |
Het |
| Adtrp |
G |
A |
13: 41,828,315 (GRCm38) |
S26L |
unknown |
Het |
| Alpk3 |
A |
C |
7: 81,078,562 (GRCm38) |
E480A |
probably benign |
Het |
| Anks6 |
T |
C |
4: 47,038,919 (GRCm38) |
T529A |
unknown |
Het |
| Arl4d |
A |
G |
11: 101,666,660 (GRCm38) |
H4R |
probably benign |
Het |
| Ash1l |
A |
G |
3: 88,983,865 (GRCm38) |
H1017R |
probably benign |
Het |
| Bbs12 |
T |
C |
3: 37,320,953 (GRCm38) |
S517P |
possibly damaging |
Het |
| Bcl11b |
C |
A |
12: 107,916,208 (GRCm38) |
R616L |
possibly damaging |
Het |
| Bean1 |
G |
A |
8: 104,211,026 (GRCm38) |
G79D |
probably damaging |
Het |
| Bicra |
C |
G |
7: 15,972,134 (GRCm38) |
G1461R |
probably benign |
Het |
| Bptf |
T |
C |
11: 107,044,640 (GRCm38) |
T124A |
probably benign |
Het |
| Btnl4 |
A |
T |
17: 34,472,374 (GRCm38) |
V312E |
probably benign |
Het |
| Ccdc7a |
A |
G |
8: 128,944,516 (GRCm38) |
M503T |
unknown |
Het |
| Celf5 |
T |
C |
10: 81,482,523 (GRCm38) |
E28G |
probably damaging |
Het |
| Cilp2 |
G |
A |
8: 69,883,390 (GRCm38) |
L350F |
probably damaging |
Het |
| Clec4a2 |
T |
C |
6: 123,142,452 (GRCm38) |
I245T |
probably damaging |
Het |
| Ctnnal1 |
A |
T |
4: 56,844,544 (GRCm38) |
V140D |
probably damaging |
Het |
| Dlgap3 |
G |
T |
4: 127,235,059 (GRCm38) |
L857F |
probably null |
Het |
| Dnah6 |
T |
A |
6: 73,212,492 (GRCm38) |
T58S |
probably damaging |
Het |
| Dnah7a |
T |
A |
1: 53,518,764 (GRCm38) |
M2164L |
probably benign |
Het |
| Dspp |
T |
A |
5: 104,175,610 (GRCm38) |
H206Q |
probably benign |
Het |
| Dzip1l |
G |
A |
9: 99,659,674 (GRCm38) |
V443M |
possibly damaging |
Het |
| Erc2 |
A |
G |
14: 28,302,991 (GRCm38) |
H939R |
possibly damaging |
Het |
| Fam149a |
G |
T |
8: 45,348,546 (GRCm38) |
H513N |
probably benign |
Het |
| Fam171a2 |
T |
C |
11: 102,439,717 (GRCm38) |
T280A |
possibly damaging |
Het |
| Fam208b |
A |
G |
13: 3,585,332 (GRCm38) |
S492P |
probably benign |
Het |
| Fkbp5 |
A |
C |
17: 28,416,025 (GRCm38) |
V170G |
probably damaging |
Het |
| Fnbp4 |
ACCACCTCCACCTCCACCTCC |
ACCACCTCCACCTCCACCTCCACCTCC |
2: 90,777,815 (GRCm38) |
|
probably benign |
Het |
| Fzd2 |
T |
C |
11: 102,605,129 (GRCm38) |
F133S |
probably damaging |
Het |
| Galm |
A |
G |
17: 80,138,121 (GRCm38) |
N100S |
possibly damaging |
Het |
| Gbp2b |
T |
A |
3: 142,598,159 (GRCm38) |
I5N |
possibly damaging |
Het |
| Gga2 |
T |
C |
7: 122,002,146 (GRCm38) |
R245G |
probably benign |
Het |
| Gm10053 |
A |
G |
19: 24,875,900 (GRCm38) |
T50A |
probably benign |
Het |
| Gm1110 |
T |
C |
9: 26,920,649 (GRCm38) |
T69A |
probably benign |
Het |
| Gm15922 |
T |
G |
7: 3,735,510 (GRCm38) |
E622D |
probably benign |
Het |
| Heatr5a |
T |
C |
12: 51,961,543 (GRCm38) |
S6G |
probably benign |
Het |
| Hmcn1 |
A |
G |
1: 150,563,604 (GRCm38) |
S5610P |
probably damaging |
Het |
| Hmgb4 |
A |
G |
4: 128,260,406 (GRCm38) |
V123A |
probably damaging |
Het |
| Itgal |
C |
A |
7: 127,327,764 (GRCm38) |
Q943K |
probably benign |
Het |
| Jakmip1 |
C |
A |
5: 37,175,154 (GRCm38) |
D1059E |
probably damaging |
Het |
| Jazf1 |
T |
C |
6: 52,893,944 (GRCm38) |
|
probably null |
Het |
| Kat6a |
A |
G |
8: 22,935,772 (GRCm38) |
E1111G |
possibly damaging |
Het |
| Kdm4b |
C |
A |
17: 56,389,639 (GRCm38) |
P452T |
probably benign |
Het |
| Krit1 |
T |
C |
5: 3,812,474 (GRCm38) |
Y210H |
probably damaging |
Het |
| Krtap6-2 |
A |
T |
16: 89,419,912 (GRCm38) |
Y56N |
unknown |
Het |
| Lig1 |
A |
T |
7: 13,288,721 (GRCm38) |
D158V |
probably damaging |
Het |
| Lmo1 |
A |
T |
7: 109,140,666 (GRCm38) |
L94Q |
probably benign |
Het |
| Lrrc30 |
A |
T |
17: 67,632,243 (GRCm38) |
L114H |
probably damaging |
Het |
| Ltn1 |
T |
C |
16: 87,397,812 (GRCm38) |
I1400V |
probably benign |
Het |
| Mark3 |
T |
C |
12: 111,604,527 (GRCm38) |
I87T |
probably damaging |
Het |
| Mfrp |
G |
T |
9: 44,105,183 (GRCm38) |
V392F |
possibly damaging |
Het |
| Mrgprg |
A |
G |
7: 143,765,135 (GRCm38) |
L80P |
probably damaging |
Het |
| Ndufaf3 |
A |
T |
9: 108,566,926 (GRCm38) |
M1K |
probably null |
Het |
| Nme7 |
T |
A |
1: 164,380,648 (GRCm38) |
L295* |
probably null |
Het |
| Noct |
G |
T |
3: 51,249,730 (GRCm38) |
C163F |
probably damaging |
Het |
| Olfr1270 |
T |
A |
2: 90,149,419 (GRCm38) |
I196F |
possibly damaging |
Het |
| Olfr229 |
A |
G |
9: 39,909,904 (GRCm38) |
I34V |
probably benign |
Het |
| Olfr541 |
A |
T |
7: 140,704,634 (GRCm38) |
I128F |
probably damaging |
Het |
| Olfr747 |
T |
A |
14: 50,680,824 (GRCm38) |
Q270L |
possibly damaging |
Het |
| Olfr772 |
T |
A |
10: 129,174,455 (GRCm38) |
T189S |
probably damaging |
Het |
| Olfr992 |
T |
A |
2: 85,399,611 (GRCm38) |
K307N |
probably damaging |
Het |
| Patz1 |
C |
T |
11: 3,298,297 (GRCm38) |
|
probably benign |
Het |
| Per3 |
A |
G |
4: 151,012,728 (GRCm38) |
L780P |
probably benign |
Het |
| Pla2g4a |
T |
C |
1: 149,872,690 (GRCm38) |
M256V |
possibly damaging |
Het |
| Pnliprp1 |
A |
G |
19: 58,741,100 (GRCm38) |
K395R |
probably benign |
Het |
| Poc5 |
G |
T |
13: 96,400,832 (GRCm38) |
G242V |
possibly damaging |
Het |
| Ppfia4 |
A |
G |
1: 134,324,135 (GRCm38) |
S434P |
possibly damaging |
Het |
| Prss42 |
A |
G |
9: 110,798,829 (GRCm38) |
N110S |
probably benign |
Het |
| Ralgapb |
T |
A |
2: 158,432,902 (GRCm38) |
I241N |
possibly damaging |
Het |
| Rbak |
A |
C |
5: 143,173,773 (GRCm38) |
Y508* |
probably null |
Het |
| S1pr2 |
G |
T |
9: 20,967,549 (GRCm38) |
R328S |
possibly damaging |
Het |
| Sap130 |
T |
C |
18: 31,650,512 (GRCm38) |
M214T |
probably benign |
Het |
| Slc46a1 |
T |
A |
11: 78,466,511 (GRCm38) |
V130E |
probably damaging |
Het |
| Smc4 |
A |
T |
3: 69,018,124 (GRCm38) |
H343L |
probably benign |
Het |
| Tarbp1 |
C |
A |
8: 126,457,677 (GRCm38) |
R500L |
probably benign |
Het |
| Tgfbr3 |
A |
T |
5: 107,215,028 (GRCm38) |
H39Q |
probably damaging |
Het |
| Tpp2 |
T |
C |
1: 43,954,659 (GRCm38) |
S235P |
probably benign |
Het |
| Trbc2 |
G |
T |
6: 41,546,829 (GRCm38) |
R33M |
|
Het |
| Trim3 |
C |
T |
7: 105,619,558 (GRCm38) |
R63Q |
probably damaging |
Het |
| Ttc28 |
T |
C |
5: 111,285,484 (GRCm38) |
V2128A |
probably benign |
Het |
| Ttn |
T |
A |
2: 76,944,139 (GRCm38) |
Q2187L |
unknown |
Het |
| Ttn |
C |
T |
2: 76,725,818 (GRCm38) |
R30281H |
probably damaging |
Het |
| Ttyh3 |
T |
C |
5: 140,629,425 (GRCm38) |
S403G |
possibly damaging |
Het |
| Vmn2r112 |
A |
T |
17: 22,603,307 (GRCm38) |
D322V |
probably benign |
Het |
| Wdr38 |
C |
T |
2: 38,998,340 (GRCm38) |
|
probably benign |
Het |
| Xrn1 |
T |
A |
9: 96,048,358 (GRCm38) |
S1543R |
probably benign |
Het |
| Zbtb8b |
G |
A |
4: 129,432,769 (GRCm38) |
T201I |
possibly damaging |
Het |
|
| Other mutations in Dennd4a |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00476:Dennd4a
|
APN |
9 |
64,911,762 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01610:Dennd4a
|
APN |
9 |
64,906,884 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL01788:Dennd4a
|
APN |
9 |
64,842,621 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL01827:Dennd4a
|
APN |
9 |
64,842,561 (GRCm38) |
nonsense |
probably null |
|
|
IGL01828:Dennd4a
|
APN |
9 |
64,842,561 (GRCm38) |
nonsense |
probably null |
|
|
IGL01829:Dennd4a
|
APN |
9 |
64,842,561 (GRCm38) |
nonsense |
probably null |
|
|
IGL01979:Dennd4a
|
APN |
9 |
64,894,409 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL02100:Dennd4a
|
APN |
9 |
64,909,706 (GRCm38) |
splice site |
probably benign |
|
|
IGL02339:Dennd4a
|
APN |
9 |
64,842,561 (GRCm38) |
nonsense |
probably null |
|
|
IGL02341:Dennd4a
|
APN |
9 |
64,842,561 (GRCm38) |
nonsense |
probably null |
|
|
IGL02584:Dennd4a
|
APN |
9 |
64,851,298 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02607:Dennd4a
|
APN |
9 |
64,862,327 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL02654:Dennd4a
|
APN |
9 |
64,910,191 (GRCm38) |
splice site |
probably benign |
|
|
IGL02701:Dennd4a
|
APN |
9 |
64,897,353 (GRCm38) |
missense |
possibly damaging |
0.50 |
|
IGL03051:Dennd4a
|
APN |
9 |
64,862,414 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03257:Dennd4a
|
APN |
9 |
64,871,874 (GRCm38) |
missense |
possibly damaging |
0.93 |
|
IGL03346:Dennd4a
|
APN |
9 |
64,888,526 (GRCm38) |
missense |
possibly damaging |
0.47 |
|
IGL03349:Dennd4a
|
APN |
9 |
64,888,974 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03398:Dennd4a
|
APN |
9 |
64,871,882 (GRCm38) |
missense |
probably benign |
0.32 |
|
R0010:Dennd4a
|
UTSW |
9 |
64,896,715 (GRCm38) |
missense |
probably benign |
0.00 |
|
R0010:Dennd4a
|
UTSW |
9 |
64,896,715 (GRCm38) |
missense |
probably benign |
0.00 |
|
R0129:Dennd4a
|
UTSW |
9 |
64,893,294 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0220:Dennd4a
|
UTSW |
9 |
64,852,445 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0396:Dennd4a
|
UTSW |
9 |
64,862,391 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0881:Dennd4a
|
UTSW |
9 |
64,851,383 (GRCm38) |
critical splice donor site |
probably null |
|
|
R1225:Dennd4a
|
UTSW |
9 |
64,911,675 (GRCm38) |
missense |
probably benign |
0.03 |
|
R1311:Dennd4a
|
UTSW |
9 |
64,910,004 (GRCm38) |
missense |
probably benign |
0.34 |
|
R1448:Dennd4a
|
UTSW |
9 |
64,906,045 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R1450:Dennd4a
|
UTSW |
9 |
64,911,665 (GRCm38) |
missense |
probably benign |
0.03 |
|
R1630:Dennd4a
|
UTSW |
9 |
64,871,882 (GRCm38) |
missense |
probably benign |
0.32 |
|
R1709:Dennd4a
|
UTSW |
9 |
64,889,605 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
R1824:Dennd4a
|
UTSW |
9 |
64,859,358 (GRCm38) |
critical splice donor site |
probably null |
|
|
R1851:Dennd4a
|
UTSW |
9 |
64,862,030 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1870:Dennd4a
|
UTSW |
9 |
64,897,234 (GRCm38) |
missense |
probably benign |
0.00 |
|
R1900:Dennd4a
|
UTSW |
9 |
64,897,336 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R1911:Dennd4a
|
UTSW |
9 |
64,889,086 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1938:Dennd4a
|
UTSW |
9 |
64,842,490 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1954:Dennd4a
|
UTSW |
9 |
64,852,467 (GRCm38) |
missense |
probably benign |
0.02 |
|
R1955:Dennd4a
|
UTSW |
9 |
64,852,467 (GRCm38) |
missense |
probably benign |
0.02 |
|
R2049:Dennd4a
|
UTSW |
9 |
64,889,605 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
R2129:Dennd4a
|
UTSW |
9 |
64,905,974 (GRCm38) |
splice site |
probably null |
|
|
R2138:Dennd4a
|
UTSW |
9 |
64,889,337 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2929:Dennd4a
|
UTSW |
9 |
64,852,417 (GRCm38) |
missense |
possibly damaging |
0.85 |
|
R3083:Dennd4a
|
UTSW |
9 |
64,906,081 (GRCm38) |
missense |
probably benign |
0.03 |
|
R3108:Dennd4a
|
UTSW |
9 |
64,912,387 (GRCm38) |
missense |
probably benign |
0.23 |
|
R3176:Dennd4a
|
UTSW |
9 |
64,888,993 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3177:Dennd4a
|
UTSW |
9 |
64,888,993 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3276:Dennd4a
|
UTSW |
9 |
64,888,993 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3277:Dennd4a
|
UTSW |
9 |
64,888,993 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3890:Dennd4a
|
UTSW |
9 |
64,872,028 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3953:Dennd4a
|
UTSW |
9 |
64,852,575 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3963:Dennd4a
|
UTSW |
9 |
64,862,331 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4059:Dennd4a
|
UTSW |
9 |
64,911,892 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
R4499:Dennd4a
|
UTSW |
9 |
64,910,123 (GRCm38) |
missense |
possibly damaging |
0.78 |
|
R4500:Dennd4a
|
UTSW |
9 |
64,910,123 (GRCm38) |
missense |
possibly damaging |
0.78 |
|
R4501:Dennd4a
|
UTSW |
9 |
64,910,123 (GRCm38) |
missense |
possibly damaging |
0.78 |
|
R4671:Dennd4a
|
UTSW |
9 |
64,894,407 (GRCm38) |
missense |
probably benign |
|
|
R4701:Dennd4a
|
UTSW |
9 |
64,897,357 (GRCm38) |
missense |
possibly damaging |
0.91 |
|
R4821:Dennd4a
|
UTSW |
9 |
64,897,249 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
R4829:Dennd4a
|
UTSW |
9 |
64,889,056 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4876:Dennd4a
|
UTSW |
9 |
64,896,590 (GRCm38) |
missense |
probably benign |
|
|
R4881:Dennd4a
|
UTSW |
9 |
64,838,844 (GRCm38) |
missense |
possibly damaging |
0.77 |
|
R4962:Dennd4a
|
UTSW |
9 |
64,906,003 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5225:Dennd4a
|
UTSW |
9 |
64,888,928 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R5557:Dennd4a
|
UTSW |
9 |
64,904,227 (GRCm38) |
missense |
probably benign |
0.07 |
|
R5649:Dennd4a
|
UTSW |
9 |
64,851,209 (GRCm38) |
splice site |
probably null |
|
|
R5868:Dennd4a
|
UTSW |
9 |
64,896,729 (GRCm38) |
missense |
probably benign |
0.02 |
|
R5876:Dennd4a
|
UTSW |
9 |
64,911,755 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6052:Dennd4a
|
UTSW |
9 |
64,886,945 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6411:Dennd4a
|
UTSW |
9 |
64,871,899 (GRCm38) |
missense |
probably benign |
0.04 |
|
R6596:Dennd4a
|
UTSW |
9 |
64,852,420 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6668:Dennd4a
|
UTSW |
9 |
64,886,965 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6915:Dennd4a
|
UTSW |
9 |
64,852,489 (GRCm38) |
nonsense |
probably null |
|
|
R7056:Dennd4a
|
UTSW |
9 |
64,906,923 (GRCm38) |
missense |
possibly damaging |
0.89 |
|
R7107:Dennd4a
|
UTSW |
9 |
64,894,399 (GRCm38) |
missense |
possibly damaging |
0.79 |
|
R7203:Dennd4a
|
UTSW |
9 |
64,896,474 (GRCm38) |
missense |
probably benign |
0.05 |
|
R7238:Dennd4a
|
UTSW |
9 |
64,861,956 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7373:Dennd4a
|
UTSW |
9 |
64,897,269 (GRCm38) |
missense |
probably benign |
0.01 |
|
R7546:Dennd4a
|
UTSW |
9 |
64,873,044 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7590:Dennd4a
|
UTSW |
9 |
64,888,587 (GRCm38) |
missense |
probably benign |
0.01 |
|
R7662:Dennd4a
|
UTSW |
9 |
64,852,431 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7782:Dennd4a
|
UTSW |
9 |
64,906,920 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R7909:Dennd4a
|
UTSW |
9 |
64,872,993 (GRCm38) |
critical splice acceptor site |
probably null |
|
|
R7976:Dennd4a
|
UTSW |
9 |
64,852,512 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R8026:Dennd4a
|
UTSW |
9 |
64,873,030 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8034:Dennd4a
|
UTSW |
9 |
64,888,568 (GRCm38) |
missense |
probably benign |
0.01 |
|
R8089:Dennd4a
|
UTSW |
9 |
64,849,175 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8298:Dennd4a
|
UTSW |
9 |
64,906,875 (GRCm38) |
missense |
probably benign |
0.00 |
|
R8397:Dennd4a
|
UTSW |
9 |
64,889,109 (GRCm38) |
missense |
probably benign |
|
|
R8425:Dennd4a
|
UTSW |
9 |
64,838,974 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8495:Dennd4a
|
UTSW |
9 |
64,886,879 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8855:Dennd4a
|
UTSW |
9 |
64,912,390 (GRCm38) |
missense |
probably benign |
|
|
R9219:Dennd4a
|
UTSW |
9 |
64,889,094 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R9275:Dennd4a
|
UTSW |
9 |
64,842,624 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9376:Dennd4a
|
UTSW |
9 |
64,912,692 (GRCm38) |
missense |
probably benign |
0.00 |
|
R9485:Dennd4a
|
UTSW |
9 |
64,907,106 (GRCm38) |
nonsense |
probably null |
|
|
R9672:Dennd4a
|
UTSW |
9 |
64,893,358 (GRCm38) |
missense |
probably benign |
|
|
R9746:Dennd4a
|
UTSW |
9 |
64,894,511 (GRCm38) |
missense |
probably benign |
|
|
X0026:Dennd4a
|
UTSW |
9 |
64,897,320 (GRCm38) |
missense |
possibly damaging |
0.67 |
|
Z1088:Dennd4a
|
UTSW |
9 |
64,872,022 (GRCm38) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GCTAAATACTCAGCTGATCATCTG -3'
(R):5'- CATCTTGGATTGTCAATGCTTTCTG -3'
Sequencing Primer
(F):5'- ATACTCAGCTGATCATCTGTTTTG -3'
(R):5'- TGGAACTCACTCTGTAGACCAGG -3'
|
| Posted On |
2019-10-07 |
Incidental Mutation