Incidental Mutation 'R7457:Vmn1r49'
ID 578198
Institutional Source Beutler Lab
Gene Symbol Vmn1r49
Ensembl Gene ENSMUSG00000095932
Gene Name vomeronasal 1, receptor 49
Synonyms V1rb2, VRi2, V1r5
MMRRC Submission 045531-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.086) question?
Stock # R7457 (G1)
Quality Score 225.009
Status Not validated
Chromosome 6
Chromosomal Location 90049068-90050000 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 90049534 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 156 (V156A)
Ref Sequence ENSEMBL: ENSMUSP00000154456 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071865] [ENSMUST00000203791] [ENSMUST00000226368]
AlphaFold Q9WUF1
Predicted Effect probably benign
Transcript: ENSMUST00000071865
AA Change: V156A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000071762
Gene: ENSMUSG00000095932
AA Change: V156A

DomainStartEndE-ValueType
transmembrane domain 15 37 N/A INTRINSIC
Pfam:V1R 38 302 5e-165 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000203791
AA Change: V156A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000145107
Gene: ENSMUSG00000095932
AA Change: V156A

DomainStartEndE-ValueType
transmembrane domain 15 37 N/A INTRINSIC
Pfam:V1R 38 302 5e-165 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000226368
AA Change: V156A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency 100% (61/61)
MGI Phenotype PHENOTYPE: Mice homozygous for a non-functional knock-in allele display abnormal patterns of axonal projections in the accessory olfactory bulb. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam32 A T 8: 25,374,635 (GRCm39) H452Q probably damaging Het
Adcy8 A T 15: 64,792,529 (GRCm39) N142K possibly damaging Het
Alkbh8 T A 9: 3,343,056 (GRCm39) S57R probably damaging Het
Atp4a A G 7: 30,420,192 (GRCm39) T780A probably benign Het
Atp9b A T 18: 80,960,833 (GRCm39) probably null Het
Cdyl2 A T 8: 117,305,935 (GRCm39) V442E probably damaging Het
Ces2a C T 8: 105,464,021 (GRCm39) R218C possibly damaging Het
Cfap57 A T 4: 118,446,198 (GRCm39) V688E probably damaging Het
Clec11a T C 7: 43,955,379 (GRCm39) T139A probably benign Het
Clstn1 A T 4: 149,719,373 (GRCm39) T411S probably benign Het
Commd5 A T 15: 76,784,824 (GRCm39) S74C probably damaging Het
Cyp3a59 C A 5: 146,041,560 (GRCm39) P368Q probably damaging Het
Dennd4b A G 3: 90,176,622 (GRCm39) M309V probably benign Het
Dhrs9 T A 2: 69,231,611 (GRCm39) V257E probably benign Het
Dhx16 T C 17: 36,201,952 (GRCm39) V993A probably damaging Het
Dok5 A T 2: 170,712,735 (GRCm39) Q247L probably benign Het
E330034G19Rik A T 14: 24,359,582 (GRCm39) E331V unknown Het
Efs A G 14: 55,157,451 (GRCm39) S287P probably benign Het
Fbn1 T C 2: 125,193,667 (GRCm39) N1384S possibly damaging Het
Flt4 A G 11: 49,521,155 (GRCm39) E388G possibly damaging Het
Fmn2 T A 1: 174,331,303 (GRCm39) probably null Het
Fmo4 T C 1: 162,621,672 (GRCm39) Y513C probably benign Het
Gbp4 T C 5: 105,267,419 (GRCm39) E500G probably damaging Het
Gm29106 T C 1: 118,126,982 (GRCm39) S225P probably damaging Het
Gstt2 G A 10: 75,668,354 (GRCm39) R134W probably damaging Het
Gucy1b2 T C 14: 62,630,401 (GRCm39) T782A probably benign Het
Gzf1 G T 2: 148,532,002 (GRCm39) R543L probably damaging Het
H2-Eb2 G A 17: 34,553,321 (GRCm39) G169E probably damaging Het
Hdhd3 T A 4: 62,418,027 (GRCm39) R50W probably damaging Het
Hdlbp T C 1: 93,355,944 (GRCm39) K407E probably benign Het
Isl2 A G 9: 55,452,240 (GRCm39) T271A probably benign Het
Kbtbd7 GTCTCTC GTC 14: 79,665,364 (GRCm39) probably null Het
Kdm4b T A 17: 56,703,319 (GRCm39) N671K probably damaging Het
Lats1 T A 10: 7,586,655 (GRCm39) L939H probably damaging Het
Map3k1 A T 13: 111,892,789 (GRCm39) M822K probably damaging Het
Mettl18 C A 1: 163,824,330 (GRCm39) T217N probably damaging Het
Nav3 A T 10: 109,532,189 (GRCm39) Y2083* probably null Het
Nckap1l T C 15: 103,362,233 (GRCm39) probably benign Het
Nkx2-3 A G 19: 43,600,986 (GRCm39) D16G probably damaging Het
Nlrx1 A G 9: 44,167,807 (GRCm39) S697P probably benign Het
Or14j4 T C 17: 37,921,456 (GRCm39) K62R possibly damaging Het
Or1e29 G C 11: 73,667,652 (GRCm39) S167C probably benign Het
Or4k6 A T 14: 50,475,825 (GRCm39) N172K probably damaging Het
Or6c75 T C 10: 129,337,575 (GRCm39) V266A probably damaging Het
Pappa A T 4: 65,107,503 (GRCm39) D638V probably damaging Het
Pot1a T C 6: 25,771,621 (GRCm39) D200G probably benign Het
Ptprs G T 17: 56,726,502 (GRCm39) T1366K probably damaging Het
Sass6 A T 3: 116,413,813 (GRCm39) R505S probably benign Het
Slc30a6 T C 17: 74,714,233 (GRCm39) I84T probably benign Het
Sox10 A T 15: 79,040,339 (GRCm39) F400L probably benign Het
Spata31d1b A T 13: 59,864,723 (GRCm39) I624F probably damaging Het
Stpg4 A G 17: 87,735,006 (GRCm39) probably null Het
Tbc1d9 G T 8: 83,963,309 (GRCm39) K340N probably damaging Het
Tspan12 T A 6: 21,772,682 (GRCm39) H289L probably benign Het
Ubr1 T A 2: 120,748,309 (GRCm39) T809S probably benign Het
Vmn1r43 C T 6: 89,847,172 (GRCm39) V105M probably damaging Het
Wnt5a A G 14: 28,240,236 (GRCm39) probably null Het
Wwp2 T A 8: 108,244,592 (GRCm39) S255T probably benign Het
Zbtb10 A G 3: 9,316,538 (GRCm39) T117A possibly damaging Het
Zfp800 C T 6: 28,244,228 (GRCm39) V246I probably benign Het
Zfp955a G T 17: 33,463,025 (GRCm39) Y35* probably null Het
Other mutations in Vmn1r49
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01293:Vmn1r49 APN 6 90,049,394 (GRCm39) missense probably damaging 0.99
IGL03230:Vmn1r49 APN 6 90,049,650 (GRCm39) missense probably damaging 1.00
IGL03308:Vmn1r49 APN 6 90,049,341 (GRCm39) missense possibly damaging 0.67
R0517:Vmn1r49 UTSW 6 90,049,720 (GRCm39) missense probably damaging 0.98
R0638:Vmn1r49 UTSW 6 90,049,648 (GRCm39) missense possibly damaging 0.95
R1498:Vmn1r49 UTSW 6 90,049,298 (GRCm39) missense probably damaging 1.00
R1649:Vmn1r49 UTSW 6 90,049,623 (GRCm39) missense possibly damaging 0.66
R1668:Vmn1r49 UTSW 6 90,049,764 (GRCm39) missense probably benign 0.07
R1816:Vmn1r49 UTSW 6 90,049,785 (GRCm39) missense possibly damaging 0.93
R2071:Vmn1r49 UTSW 6 90,049,184 (GRCm39) missense probably benign 0.00
R2155:Vmn1r49 UTSW 6 90,049,441 (GRCm39) missense probably damaging 0.99
R2274:Vmn1r49 UTSW 6 90,049,126 (GRCm39) missense probably benign 0.23
R4222:Vmn1r49 UTSW 6 90,049,228 (GRCm39) missense probably benign 0.06
R4614:Vmn1r49 UTSW 6 90,049,534 (GRCm39) missense probably benign 0.00
R4797:Vmn1r49 UTSW 6 90,049,612 (GRCm39) missense probably benign 0.13
R4978:Vmn1r49 UTSW 6 90,049,872 (GRCm39) missense probably benign 0.30
R5227:Vmn1r49 UTSW 6 90,049,753 (GRCm39) missense probably benign 0.00
R5959:Vmn1r49 UTSW 6 90,049,786 (GRCm39) missense probably damaging 1.00
R6741:Vmn1r49 UTSW 6 90,049,195 (GRCm39) missense probably benign 0.19
R6744:Vmn1r49 UTSW 6 90,049,184 (GRCm39) missense probably benign 0.00
R7173:Vmn1r49 UTSW 6 90,049,250 (GRCm39) missense possibly damaging 0.96
R7573:Vmn1r49 UTSW 6 90,049,843 (GRCm39) missense probably benign 0.06
R8360:Vmn1r49 UTSW 6 90,049,991 (GRCm39) missense probably benign 0.06
R8399:Vmn1r49 UTSW 6 90,049,689 (GRCm39) nonsense probably null
R9560:Vmn1r49 UTSW 6 90,049,382 (GRCm39) missense probably benign 0.03
Predicted Primers
Posted On 2019-10-07