Incidental Mutation 'R7457:Cdyl2'
ID578205
Institutional Source Beutler Lab
Gene Symbol Cdyl2
Ensembl Gene ENSMUSG00000031758
Gene Namechromodomain protein, Y chromosome-like 2
Synonyms
MMRRC Submission
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.213) question?
Stock #R7457 (G1)
Quality Score225.009
Status Validated
Chromosome8
Chromosomal Location116574400-116732991 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 116579196 bp
ZygosityHeterozygous
Amino Acid Change Valine to Glutamic Acid at position 442 (V442E)
Ref Sequence ENSEMBL: ENSMUSP00000104730 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000109102]
Predicted Effect probably damaging
Transcript: ENSMUST00000109102
AA Change: V442E

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000104730
Gene: ENSMUSG00000031758
AA Change: V442E

DomainStartEndE-ValueType
CHROMO 6 60 1.25e-17 SMART
Pfam:ECH_1 252 499 5e-33 PFAM
Pfam:ECH_2 258 501 1.6e-14 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency 100% (61/61)
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam32 A T 8: 24,884,619 H452Q probably damaging Het
Adcy8 A T 15: 64,920,680 N142K possibly damaging Het
Alkbh8 T A 9: 3,343,056 S57R probably damaging Het
Atp4a A G 7: 30,720,767 T780A probably benign Het
Atp9b A T 18: 80,917,618 probably null Het
Ces2a C T 8: 104,737,389 R218C possibly damaging Het
Cfap57 A T 4: 118,589,001 V688E probably damaging Het
Clec11a T C 7: 44,305,955 T139A probably benign Het
Clstn1 A T 4: 149,634,916 T411S probably benign Het
Commd5 A T 15: 76,900,624 S74C probably damaging Het
Cyp3a59 C A 5: 146,104,750 P368Q probably damaging Het
Dennd4b A G 3: 90,269,315 M309V probably benign Het
Dhrs9 T A 2: 69,401,267 V257E probably benign Het
Dhx16 T C 17: 35,891,060 V993A probably damaging Het
Dok5 A T 2: 170,870,815 Q247L probably benign Het
E330034G19Rik A T 14: 24,309,514 E331V unknown Het
Efs A G 14: 54,919,994 S287P probably benign Het
Fbn1 T C 2: 125,351,747 N1384S possibly damaging Het
Flt4 A G 11: 49,630,328 E388G possibly damaging Het
Fmn2 T A 1: 174,503,737 probably null Het
Fmo4 T C 1: 162,794,103 Y513C probably benign Het
Gbp4 T C 5: 105,119,553 E500G probably damaging Het
Gm29106 T C 1: 118,199,252 S225P probably damaging Het
Gstt2 G A 10: 75,832,520 R134W probably damaging Het
Gucy1b2 T C 14: 62,392,952 T782A probably benign Het
Gzf1 G T 2: 148,690,082 R543L probably damaging Het
H2-Eb2 G A 17: 34,334,347 G169E probably damaging Het
Hdhd3 T A 4: 62,499,790 R50W probably damaging Het
Hdlbp T C 1: 93,428,222 K407E probably benign Het
Isl2 A G 9: 55,544,956 T271A probably benign Het
Kbtbd7 GTCTCTC GTC 14: 79,427,924 probably null Het
Kdm4b T A 17: 56,396,319 N671K probably damaging Het
Lats1 T A 10: 7,710,891 L939H probably damaging Het
Map3k1 A T 13: 111,756,255 M822K probably damaging Het
Mettl18 C A 1: 163,996,761 T217N probably damaging Het
Nav3 A T 10: 109,696,328 Y2083* probably null Het
Nckap1l T C 15: 103,453,806 probably benign Het
Nkx2-3 A G 19: 43,612,547 D16G probably damaging Het
Nlrx1 A G 9: 44,256,510 S697P probably benign Het
Olfr115 T C 17: 37,610,565 K62R possibly damaging Het
Olfr389 G C 11: 73,776,826 S167C probably benign Het
Olfr731 A T 14: 50,238,368 N172K probably damaging Het
Olfr790 T C 10: 129,501,706 V266A probably damaging Het
Pappa A T 4: 65,189,266 D638V probably damaging Het
Pot1a T C 6: 25,771,622 D200G probably benign Het
Ptprs G T 17: 56,419,502 T1366K probably damaging Het
Sass6 A T 3: 116,620,164 R505S probably benign Het
Slc30a6 T C 17: 74,407,238 I84T probably benign Het
Sox10 A T 15: 79,156,139 F400L probably benign Het
Spata31d1b A T 13: 59,716,909 I624F probably damaging Het
Stpg4 A G 17: 87,427,578 probably null Het
Tbc1d9 G T 8: 83,236,680 K340N probably damaging Het
Tspan12 T A 6: 21,772,683 H289L probably benign Het
Ubr1 T A 2: 120,917,828 T809S probably benign Het
Vmn1r43 C T 6: 89,870,190 V105M probably damaging Het
Vmn1r49 A G 6: 90,072,552 V156A probably benign Het
Wnt5a A G 14: 28,518,279 probably null Het
Wwp2 T A 8: 107,517,960 S255T probably benign Het
Zbtb10 A G 3: 9,251,478 T117A possibly damaging Het
Zfp800 C T 6: 28,244,229 V246I probably benign Het
Zfp955a G T 17: 33,244,051 Y35* probably null Het
Other mutations in Cdyl2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00953:Cdyl2 APN 8 116595189 splice site probably benign
IGL01670:Cdyl2 APN 8 116624353 missense probably damaging 1.00
IGL01964:Cdyl2 APN 8 116624029 missense probably benign 0.00
IGL02148:Cdyl2 APN 8 116589244 splice site probably benign
IGL02186:Cdyl2 APN 8 116579286 missense possibly damaging 0.78
R0449:Cdyl2 UTSW 8 116583192 missense probably damaging 1.00
R0630:Cdyl2 UTSW 8 116624035 missense probably benign 0.03
R1430:Cdyl2 UTSW 8 116579317 splice site probably benign
R1883:Cdyl2 UTSW 8 116595163 missense probably damaging 1.00
R2326:Cdyl2 UTSW 8 116623798 missense probably benign
R4194:Cdyl2 UTSW 8 116579164 splice site probably null
R4916:Cdyl2 UTSW 8 116579187 missense probably damaging 1.00
R4977:Cdyl2 UTSW 8 116575269 missense probably damaging 0.99
R5092:Cdyl2 UTSW 8 116623940 missense possibly damaging 0.50
R5320:Cdyl2 UTSW 8 116595055 nonsense probably null
R5727:Cdyl2 UTSW 8 116583168 missense probably damaging 1.00
R5830:Cdyl2 UTSW 8 116595084 missense probably benign 0.23
R6077:Cdyl2 UTSW 8 116589390 missense probably damaging 1.00
R6086:Cdyl2 UTSW 8 116589296 missense probably damaging 1.00
R6145:Cdyl2 UTSW 8 116594978 missense probably damaging 1.00
R6380:Cdyl2 UTSW 8 116583184 missense probably damaging 1.00
R7152:Cdyl2 UTSW 8 116624327 missense probably damaging 1.00
R7193:Cdyl2 UTSW 8 116623994 missense probably benign 0.09
R7244:Cdyl2 UTSW 8 116575260 nonsense probably null
R7394:Cdyl2 UTSW 8 116624051 missense not run
Predicted Primers PCR Primer
(F):5'- TTGGCCTCAGAATTTTATTTGCACG -3'
(R):5'- GACATTGGAGGAGCTCTGTG -3'

Sequencing Primer
(F):5'- CACGTGTATGTGCGCATGC -3'
(R):5'- AGGAGCTCTGTGCCCTCAG -3'
Posted On2019-10-07