|Institutional Source||Beutler Lab|
|Gene Name||protein tyrosine phosphatase, non-receptor type 4|
|Synonyms||TEP/mPTPMEG, PTPMEG, TEP, testis-enriched phosphatase, hPTP-MEG, protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)|
|Is this an essential gene?||Possibly non essential (E-score: 0.259)|
|Stock #||R7459 (G1)|
|Chromosomal Location||119652467-119837613 bp(-) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||T to A at 119659834 bp|
|Amino Acid Change||Lysine to Asparagine at position 926 (K926N)|
|Ref Sequence||ENSEMBL: ENSMUSP00000067614 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000064091] [ENSMUST00000166624]|
|Predicted Effect||probably damaging
AA Change: K926N
PolyPhen 2 Score 0.987 (Sensitivity: 0.73; Specificity: 0.96)
AA Change: K926N
|Predicted Effect||probably benign
|Coding Region Coverage||
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. This PTP has been shown to interact with glutamate receptor delta 2 and epsilon subunits, and is thought to play a role in signalling downstream of the glutamate receptors through tyrosine dephosphorylation. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a null allele exhibit impaired coordination, abnormal eye blink conditioning behavior, and reduced long term depression. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Ptpn4||
(F):5'- TCGTCGTTCAGAGCAAAGC -3'
(R):5'- GGTAAAACTTCTAACTCCGTTCTG -3'
(F):5'- TGGTCAACCATGTGAGTAATAGG -3'
(R):5'- AACTCCGTTCTGTTTCATGTTTTAAG -3'