Incidental Mutation 'R7460:Olfr559'
ID578385
Institutional Source Beutler Lab
Gene Symbol Olfr559
Ensembl Gene ENSMUSG00000066272
Gene Nameolfactory receptor 559
SynonymsGA_x6K02T2PBJ9-5441154-5440198, MOR11-1
MMRRC Submission
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.089) question?
Stock #R7460 (G1)
Quality Score225.009
Status Validated
Chromosome7
Chromosomal Location102723207-102727491 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 102723821 bp
ZygosityHeterozygous
Amino Acid Change Methionine to Lysine at position 223 (M223K)
Ref Sequence ENSEMBL: ENSMUSP00000151100 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000084816] [ENSMUST00000215657] [ENSMUST00000216312]
Predicted Effect probably benign
Transcript: ENSMUST00000084816
AA Change: M223K

PolyPhen 2 Score 0.094 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000095820
Gene: ENSMUSG00000066272
AA Change: M223K

DomainStartEndE-ValueType
Pfam:7tm_4 37 317 1.1e-117 PFAM
Pfam:7TM_GPCR_Srsx 41 215 1e-10 PFAM
Pfam:7tm_1 47 299 3e-18 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000215657
AA Change: M223K

PolyPhen 2 Score 0.094 (Sensitivity: 0.93; Specificity: 0.85)
Predicted Effect probably benign
Transcript: ENSMUST00000216312
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency 100% (64/64)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 63 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1300017J02Rik T C 9: 103,254,648 N625D probably benign Het
Abi2 T A 1: 60,434,307 V61D probably damaging Het
Agrn C A 4: 156,174,424 V915L probably damaging Het
Arhgap24 T C 5: 102,892,346 V476A probably benign Het
Arhgef15 A G 11: 68,947,035 L720P probably damaging Het
Atad2b C A 12: 4,952,660 R343S probably benign Het
Atxn3 T A 12: 101,926,517 T313S probably benign Het
BC037034 G A 5: 138,262,729 T218M probably benign Het
BC051665 T C 13: 60,784,643 E76G probably benign Het
Birc2 A T 9: 7,818,761 F610I probably damaging Het
Cdh16 A T 8: 104,622,291 V58D possibly damaging Het
Cenpf T C 1: 189,654,050 D2011G probably damaging Het
Ddb1 T C 19: 10,607,911 probably null Het
Ddx1 A G 12: 13,231,439 probably null Het
Disp2 A G 2: 118,789,780 H331R probably damaging Het
Dmxl1 A G 18: 49,878,612 T1279A probably benign Het
Dync1i2 T C 2: 71,250,886 I473T probably damaging Het
Fam114a1 T G 5: 65,038,707 V520G possibly damaging Het
Fan1 T A 7: 64,372,486 N340Y probably damaging Het
Fat2 T A 11: 55,278,963 D2990V probably damaging Het
Fbxo18 C T 2: 11,756,685 G597D probably benign Het
Fdxr A C 11: 115,276,854 S12A probably benign Het
Fgf14 T A 14: 124,676,693 R9W possibly damaging Het
Gnat3 A T 5: 17,999,658 D103V Het
Hepacam2 G A 6: 3,487,199 P53S probably benign Het
Jmjd1c A G 10: 67,217,036 T21A probably benign Het
Lama1 T C 17: 67,767,018 C930R Het
Lrp1b T C 2: 40,598,466 T4536A Het
Lrrc27 T A 7: 139,223,658 V166E probably damaging Het
Mapk10 C T 5: 103,038,577 V90I probably benign Het
Mfsd14b C T 13: 65,072,023 G339D probably damaging Het
Mkl2 G T 16: 13,400,976 Q495H probably benign Het
Mnt T A 11: 74,843,283 M580K unknown Het
Mrc1 T C 2: 14,248,869 S234P probably damaging Het
Mrps5 G A 2: 127,591,891 V75I not run Het
Myo10 A G 15: 25,807,827 D1845G probably damaging Het
Olfr147 T C 9: 38,403,353 S160P possibly damaging Het
Olfr19 C A 16: 16,673,166 A272S possibly damaging Het
Olfr402 A T 11: 74,155,846 I231F probably damaging Het
Pdhx G A 2: 103,046,779 T95M probably damaging Het
Pigb C T 9: 73,038,675 V72I probably damaging Het
Prr7 C A 13: 55,472,353 P110Q unknown Het
Psg22 A G 7: 18,724,404 D340G probably benign Het
Ptprn2 T C 12: 117,248,681 S908P probably benign Het
Ros1 T C 10: 52,118,203 Y1348C probably damaging Het
Rspry1 T C 8: 94,650,335 I506T probably benign Het
Ryr2 T A 13: 11,705,710 Y2684F probably benign Het
Sdr16c6 A G 4: 4,076,575 probably null Het
Senp7 A G 16: 56,173,182 T743A possibly damaging Het
Slc6a20b T C 9: 123,604,949 I275V probably benign Het
Slc6a7 A G 18: 61,001,602 I467T probably benign Het
Tacc2 A G 7: 130,624,633 D1016G probably benign Het
Thsd7a A G 6: 12,554,934 V317A Het
Tle3 A G 9: 61,413,084 H598R probably damaging Het
Tmem102 A G 11: 69,804,123 L341P probably damaging Het
Tmem94 G T 11: 115,786,256 R118L possibly damaging Het
Trhde T A 10: 114,413,263 D866V probably damaging Het
Ttn A G 2: 76,751,273 I23092T probably damaging Het
U2surp C A 9: 95,462,824 V944L unknown Het
Urgcp T C 11: 5,716,622 H615R possibly damaging Het
Vps45 T A 3: 96,048,387 Y97F probably benign Het
Zc3h12c T C 9: 52,144,102 T136A probably benign Het
Zfp948 A T 17: 21,588,415 H623L probably damaging Het
Other mutations in Olfr559
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02832:Olfr559 APN 7 102723651 missense probably benign 0.01
R0505:Olfr559 UTSW 7 102724029 missense probably damaging 0.97
R1131:Olfr559 UTSW 7 102723680 missense probably damaging 0.99
R1449:Olfr559 UTSW 7 102724190 missense probably damaging 1.00
R3788:Olfr559 UTSW 7 102723487 unclassified probably null
R3915:Olfr559 UTSW 7 102724202 missense possibly damaging 0.95
R3980:Olfr559 UTSW 7 102723752 missense probably damaging 0.98
R4647:Olfr559 UTSW 7 102724092 missense probably damaging 1.00
R5242:Olfr559 UTSW 7 102724276 missense probably benign 0.41
R5404:Olfr559 UTSW 7 102723600 missense possibly damaging 0.95
R5464:Olfr559 UTSW 7 102723917 missense possibly damaging 0.85
R5807:Olfr559 UTSW 7 102724202 missense possibly damaging 0.95
R5965:Olfr559 UTSW 7 102724260 missense probably benign 0.00
R6008:Olfr559 UTSW 7 102724367 missense probably damaging 1.00
R6036:Olfr559 UTSW 7 102724485 missense probably benign
R6036:Olfr559 UTSW 7 102724485 missense probably benign
R6493:Olfr559 UTSW 7 102724080 missense possibly damaging 0.85
R6756:Olfr559 UTSW 7 102724088 missense probably benign 0.03
R7201:Olfr559 UTSW 7 102724485 missense probably benign
R7695:Olfr559 UTSW 7 102723659 missense probably benign 0.37
X0025:Olfr559 UTSW 7 102723815 missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AATGTGAGGCAGGTGCTTTC -3'
(R):5'- ATGTCATCATCAGGATTGGGG -3'

Sequencing Primer
(F):5'- CAGGTGCTTTCCAAAACGATG -3'
(R):5'- ATTGTAGCTCGAGCCACCCTG -3'
Posted On2019-10-07