Mutagenetix > Incidental Mutation

Incidental Mutation 'R7460:Lama1'

578423

Institutional Source

Beutler Lab

Gene Symbol

Lama1

Ensembl Gene

ENSMUSG00000032796

Gene Name

laminin, alpha 1

Synonyms

Lama

MMRRC Submission

045534-MU

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R7460 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

68004254-68129642 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 68074013 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Arginine at position 930 (C930R)

Ref Sequence

ENSEMBL: ENSMUSP00000043957 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000035471]

AlphaFold

no structure available at present

Predicted Effect

SMART Domains

Protein: ENSMUSP00000043957
Gene: ENSMUSG00000032796
AA Change: C930R

Domain	Start	End	E-Value	Type
low complexity region	3	22	N/A	INTRINSIC
LamNT	23	275	1.2e-131	SMART
EGF_Lam	277	331	1e-5	SMART
EGF_Lam	334	401	6.6e-6	SMART
EGF_Lam	404	458	9.11e-9	SMART
EGF_Lam	461	507	8.12e-6	SMART
LamB	570	702	2.09e-57	SMART
EGF_like	715	746	3.36e0	SMART
EGF_Lam	749	795	7.01e-10	SMART
EGF_Lam	798	853	3.59e-7	SMART
EGF_Lam	856	906	1.53e-10	SMART
EGF_Lam	909	955	1.13e-13	SMART
EGF_Lam	958	1002	1.36e-7	SMART
EGF_Lam	1005	1048	7.29e-8	SMART
EGF_like	1034	1082	4.83e1	SMART
EGF_Lam	1051	1094	1.67e-7	SMART
EGF_Lam	1097	1154	1.32e-5	SMART
LamB	1220	1352	8.7e-46	SMART
Pfam:Laminin_EGF	1367	1397	1.7e-6	PFAM
EGF_Lam	1410	1456	7.12e-11	SMART
EGF_Lam	1459	1513	3.25e-5	SMART
EGF_like	1497	1547	6.41e1	SMART
EGF_Lam	1516	1560	1.71e-13	SMART
Pfam:Laminin_I	1574	1838	1.7e-91	PFAM
low complexity region	2012	2031	N/A	INTRINSIC
low complexity region	2087	2098	N/A	INTRINSIC
LamG	2145	2287	3.66e-30	SMART
LamG	2332	2473	5.98e-35	SMART
LamG	2513	2661	1.11e-29	SMART
low complexity region	2695	2708	N/A	INTRINSIC
LamG	2743	2877	9.72e-35	SMART
LamG	2920	3056	4.63e-41	SMART

Meta Mutation Damage Score

0.9676

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.8%
20x: 99.3%

Validation Efficiency

100% (64/64)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes one of the alpha 1 subunits of laminin. The laminins are a family of extracellular matrix glycoproteins that have a heterotrimeric structure consisting of an alpha, beta and gamma chain. These proteins make up a major component of the basement membrane and have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Mutations in this gene may be associated with Poretti-Boltshauser syndrome. [provided by RefSeq, Sep 2014]
PHENOTYPE: Homozygous null mice display embryonic lethality before somite formation with impaired formation of Reichert's membrane. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 63 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abi2	T	A	1: 60,473,466 (GRCm39)	V61D	probably damaging	Het
Agrn	C	A	4: 156,258,881 (GRCm39)	V915L	probably damaging	Het
Arhgap24	T	C	5: 103,040,212 (GRCm39)	V476A	probably benign	Het
Arhgef15	A	G	11: 68,837,861 (GRCm39)	L720P	probably damaging	Het
Atad2b	C	A	12: 5,002,660 (GRCm39)	R343S	probably benign	Het
Atxn3	T	A	12: 101,892,776 (GRCm39)	T313S	probably benign	Het
BC051665	T	C	13: 60,932,457 (GRCm39)	E76G	probably benign	Het
Birc2	A	T	9: 7,818,762 (GRCm39)	F610I	probably damaging	Het
Cdh16	A	T	8: 105,348,923 (GRCm39)	V58D	possibly damaging	Het
Cenpf	T	C	1: 189,386,247 (GRCm39)	D2011G	probably damaging	Het
Ddb1	T	C	19: 10,585,275 (GRCm39)		probably null	Het
Ddx1	A	G	12: 13,281,440 (GRCm39)		probably null	Het
Disp2	A	G	2: 118,620,261 (GRCm39)	H331R	probably damaging	Het
Dmxl1	A	G	18: 50,011,679 (GRCm39)	T1279A	probably benign	Het
Dync1i2	T	C	2: 71,081,230 (GRCm39)	I473T	probably damaging	Het
Fam114a1	T	G	5: 65,196,050 (GRCm39)	V520G	possibly damaging	Het
Fan1	T	A	7: 64,022,234 (GRCm39)	N340Y	probably damaging	Het
Fat2	T	A	11: 55,169,789 (GRCm39)	D2990V	probably damaging	Het
Fbh1	C	T	2: 11,761,496 (GRCm39)	G597D	probably benign	Het
Fdxr	A	C	11: 115,167,680 (GRCm39)	S12A	probably benign	Het
Fgf14	T	A	14: 124,914,105 (GRCm39)	R9W	possibly damaging	Het
Gnat3	A	T	5: 18,204,656 (GRCm39)	D103V		Het
Hepacam2	G	A	6: 3,487,199 (GRCm39)	P53S	probably benign	Het
Inhca	T	C	9: 103,131,847 (GRCm39)	N625D	probably benign	Het
Jmjd1c	A	G	10: 67,052,815 (GRCm39)	T21A	probably benign	Het
Lrp1b	T	C	2: 40,488,478 (GRCm39)	T4536A		Het
Lrrc27	T	A	7: 138,803,574 (GRCm39)	V166E	probably damaging	Het
Mapk10	C	T	5: 103,186,443 (GRCm39)	V90I	probably benign	Het
Mfsd14b	C	T	13: 65,219,837 (GRCm39)	G339D	probably damaging	Het
Mnt	T	A	11: 74,734,109 (GRCm39)	M580K	unknown	Het
Mrc1	T	C	2: 14,253,680 (GRCm39)	S234P	probably damaging	Het
Mrps5	G	A	2: 127,433,811 (GRCm39)	V75I	not run	Het
Mrtfb	G	T	16: 13,218,840 (GRCm39)	Q495H	probably benign	Het
Myo10	A	G	15: 25,807,913 (GRCm39)	D1845G	probably damaging	Het
Or3a1c	A	T	11: 74,046,672 (GRCm39)	I231F	probably damaging	Het
Or51a25	A	T	7: 102,373,028 (GRCm39)	M223K	probably benign	Het
Or7a40	C	A	16: 16,491,030 (GRCm39)	A272S	possibly damaging	Het
Or8b3	T	C	9: 38,314,649 (GRCm39)	S160P	possibly damaging	Het
Pdhx	G	A	2: 102,877,124 (GRCm39)	T95M	probably damaging	Het
Pigb	C	T	9: 72,945,957 (GRCm39)	V72I	probably damaging	Het
Prr7	C	A	13: 55,620,166 (GRCm39)	P110Q	unknown	Het
Psg22	A	G	7: 18,458,329 (GRCm39)	D340G	probably benign	Het
Ptprn2	T	C	12: 117,212,301 (GRCm39)	S908P	probably benign	Het
Ros1	T	C	10: 51,994,299 (GRCm39)	Y1348C	probably damaging	Het
Rspry1	T	C	8: 95,376,963 (GRCm39)	I506T	probably benign	Het
Ryr2	T	A	13: 11,720,596 (GRCm39)	Y2684F	probably benign	Het
Sdr16c6	A	G	4: 4,076,575 (GRCm39)		probably null	Het
Senp7	A	G	16: 55,993,545 (GRCm39)	T743A	possibly damaging	Het
Slc6a20b	T	C	9: 123,434,014 (GRCm39)	I275V	probably benign	Het
Slc6a7	A	G	18: 61,134,674 (GRCm39)	I467T	probably benign	Het
Tacc2	A	G	7: 130,226,363 (GRCm39)	D1016G	probably benign	Het
Thsd7a	A	G	6: 12,554,933 (GRCm39)	V317A		Het
Tle3	A	G	9: 61,320,366 (GRCm39)	H598R	probably damaging	Het
Tmem102	A	G	11: 69,694,949 (GRCm39)	L341P	probably damaging	Het
Tmem94	G	T	11: 115,677,082 (GRCm39)	R118L	possibly damaging	Het
Trappc14	G	A	5: 138,260,991 (GRCm39)	T218M	probably benign	Het
Trhde	T	A	10: 114,249,168 (GRCm39)	D866V	probably damaging	Het
Ttn	A	G	2: 76,581,617 (GRCm39)	I23092T	probably damaging	Het
U2surp	C	A	9: 95,344,877 (GRCm39)	V944L	unknown	Het
Urgcp	T	C	11: 5,666,622 (GRCm39)	H615R	possibly damaging	Het
Vps45	T	A	3: 95,955,699 (GRCm39)	Y97F	probably benign	Het
Zc3h12c	T	C	9: 52,055,402 (GRCm39)	T136A	probably benign	Het
Zfp948	A	T	17: 21,808,677 (GRCm39)	H623L	probably damaging	Het

Other mutations in Lama1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00157:Lama1	APN	17	68,122,923 (GRCm39)	missense	probably benign
IGL00336:Lama1	APN	17	68,120,943 (GRCm39)	missense	probably benign	0.07
IGL01066:Lama1	APN	17	68,050,321 (GRCm39)	missense	probably damaging	1.00
IGL01140:Lama1	APN	17	68,109,928 (GRCm39)	missense	probably benign	0.14
IGL01291:Lama1	APN	17	68,045,865 (GRCm39)	missense	probably damaging	1.00
IGL01296:Lama1	APN	17	68,052,046 (GRCm39)	missense	probably benign	0.27
IGL01317:Lama1	APN	17	68,125,696 (GRCm39)	missense	probably damaging	1.00
IGL01490:Lama1	APN	17	68,057,579 (GRCm39)	missense	possibly damaging	0.54
IGL01506:Lama1	APN	17	68,092,065 (GRCm39)	missense	probably benign	0.01
IGL01508:Lama1	APN	17	68,116,356 (GRCm39)	splice site	probably benign
IGL01522:Lama1	APN	17	68,059,769 (GRCm39)	splice site	probably benign
IGL01530:Lama1	APN	17	68,103,785 (GRCm39)	missense	probably benign	0.02
IGL01541:Lama1	APN	17	68,092,065 (GRCm39)	missense	probably benign	0.01
IGL01677:Lama1	APN	17	68,086,143 (GRCm39)	missense	probably benign	0.15
IGL01886:Lama1	APN	17	68,114,792 (GRCm39)	missense	probably benign	0.36
IGL01994:Lama1	APN	17	68,059,434 (GRCm39)	missense	probably benign	0.05
IGL02017:Lama1	APN	17	68,071,720 (GRCm39)	missense	probably benign	0.00
IGL02021:Lama1	APN	17	68,128,621 (GRCm39)	missense	probably damaging	1.00
IGL02026:Lama1	APN	17	68,116,287 (GRCm39)	missense	possibly damaging	0.82
IGL02044:Lama1	APN	17	68,118,485 (GRCm39)	missense	probably benign	0.01
IGL02120:Lama1	APN	17	68,023,784 (GRCm39)	missense	probably damaging	1.00
IGL02425:Lama1	APN	17	68,118,480 (GRCm39)	missense	probably benign	0.45
IGL02549:Lama1	APN	17	68,097,830 (GRCm39)	missense	possibly damaging	0.93
IGL02642:Lama1	APN	17	68,119,361 (GRCm39)	missense	probably benign	0.00
IGL02795:Lama1	APN	17	68,045,889 (GRCm39)	splice site	probably null
IGL02798:Lama1	APN	17	68,102,186 (GRCm39)	splice site	probably benign
IGL02863:Lama1	APN	17	68,111,531 (GRCm39)	missense	probably damaging	0.99
IGL02870:Lama1	APN	17	68,111,531 (GRCm39)	missense	probably damaging	0.99
IGL02876:Lama1	APN	17	68,057,687 (GRCm39)	critical splice donor site	probably null
IGL02885:Lama1	APN	17	68,111,531 (GRCm39)	missense	probably damaging	0.99
IGL02891:Lama1	APN	17	68,111,531 (GRCm39)	missense	probably damaging	0.99
IGL02978:Lama1	APN	17	68,093,076 (GRCm39)	nonsense	probably null
IGL03064:Lama1	APN	17	68,086,099 (GRCm39)	missense	probably benign	0.01
IGL03076:Lama1	APN	17	68,023,794 (GRCm39)	missense	possibly damaging	0.95
IGL03110:Lama1	APN	17	68,105,981 (GRCm39)	missense	probably benign	0.04
IGL03143:Lama1	APN	17	68,111,531 (GRCm39)	missense	probably damaging	0.99
IGL03159:Lama1	APN	17	68,111,531 (GRCm39)	missense	probably damaging	0.99
IGL03268:Lama1	APN	17	68,111,531 (GRCm39)	missense	probably damaging	0.99
ANU05:Lama1	UTSW	17	68,045,865 (GRCm39)	missense	probably damaging	1.00
PIT4472001:Lama1	UTSW	17	68,071,699 (GRCm39)	missense
R0047:Lama1	UTSW	17	68,102,181 (GRCm39)	splice site	probably benign
R0047:Lama1	UTSW	17	68,102,181 (GRCm39)	splice site	probably benign
R0050:Lama1	UTSW	17	68,089,051 (GRCm39)	missense	possibly damaging	0.66
R0096:Lama1	UTSW	17	68,112,408 (GRCm39)	missense	probably benign	0.12
R0096:Lama1	UTSW	17	68,112,408 (GRCm39)	missense	probably benign	0.12
R0111:Lama1	UTSW	17	68,044,493 (GRCm39)	missense	probably damaging	0.98
R0116:Lama1	UTSW	17	68,083,918 (GRCm39)	missense	probably benign	0.10
R0121:Lama1	UTSW	17	68,105,508 (GRCm39)	splice site	probably benign
R0278:Lama1	UTSW	17	68,117,178 (GRCm39)	missense	probably null	0.98
R0281:Lama1	UTSW	17	68,124,564 (GRCm39)	missense	probably damaging	1.00
R0312:Lama1	UTSW	17	68,082,846 (GRCm39)	missense	possibly damaging	0.45
R0419:Lama1	UTSW	17	68,098,605 (GRCm39)	critical splice donor site	probably null
R0512:Lama1	UTSW	17	68,086,129 (GRCm39)	missense	possibly damaging	0.67
R0514:Lama1	UTSW	17	68,071,693 (GRCm39)	missense	probably benign	0.40
R0562:Lama1	UTSW	17	68,122,954 (GRCm39)	missense	probably damaging	1.00
R0632:Lama1	UTSW	17	68,059,363 (GRCm39)	splice site	probably benign
R0645:Lama1	UTSW	17	68,080,707 (GRCm39)	missense	probably benign	0.01
R0712:Lama1	UTSW	17	68,086,037 (GRCm39)	splice site	probably null
R0763:Lama1	UTSW	17	68,079,813 (GRCm39)	missense	probably damaging	0.97
R0941:Lama1	UTSW	17	68,082,860 (GRCm39)	missense	probably benign	0.10
R1025:Lama1	UTSW	17	68,059,893 (GRCm39)	missense	probably benign	0.00
R1084:Lama1	UTSW	17	68,111,464 (GRCm39)	missense	probably benign	0.12
R1103:Lama1	UTSW	17	68,097,942 (GRCm39)	missense	probably damaging	0.98
R1420:Lama1	UTSW	17	68,097,942 (GRCm39)	missense	probably damaging	0.98
R1430:Lama1	UTSW	17	68,089,150 (GRCm39)	missense	possibly damaging	0.95
R1569:Lama1	UTSW	17	68,087,613 (GRCm39)	splice site	probably null
R1575:Lama1	UTSW	17	68,117,404 (GRCm39)	missense	possibly damaging	0.96
R1613:Lama1	UTSW	17	68,114,918 (GRCm39)	missense	probably benign	0.42
R1620:Lama1	UTSW	17	68,074,028 (GRCm39)	missense	probably benign	0.01
R1629:Lama1	UTSW	17	68,112,423 (GRCm39)	missense	probably benign	0.00
R1645:Lama1	UTSW	17	68,044,677 (GRCm39)	missense	probably benign	0.14
R1652:Lama1	UTSW	17	68,114,841 (GRCm39)	missense	probably damaging	0.97
R1674:Lama1	UTSW	17	68,098,239 (GRCm39)	missense	probably benign
R1678:Lama1	UTSW	17	68,117,150 (GRCm39)	missense	possibly damaging	0.56
R1710:Lama1	UTSW	17	68,060,786 (GRCm39)	missense	probably benign	0.00
R1712:Lama1	UTSW	17	68,024,181 (GRCm39)	missense	possibly damaging	0.95
R1737:Lama1	UTSW	17	68,109,916 (GRCm39)	missense	probably benign	0.36
R1757:Lama1	UTSW	17	68,004,378 (GRCm39)	missense	unknown
R1757:Lama1	UTSW	17	68,070,831 (GRCm39)	missense	probably benign	0.40
R1813:Lama1	UTSW	17	68,098,218 (GRCm39)	missense	probably benign
R1896:Lama1	UTSW	17	68,098,218 (GRCm39)	missense	probably benign
R1945:Lama1	UTSW	17	68,052,848 (GRCm39)	missense	probably benign	0.14
R2086:Lama1	UTSW	17	68,124,618 (GRCm39)	missense	probably damaging	1.00
R2149:Lama1	UTSW	17	68,080,860 (GRCm39)	missense	possibly damaging	0.95
R2178:Lama1	UTSW	17	68,076,510 (GRCm39)	missense	probably benign	0.07
R2183:Lama1	UTSW	17	68,098,004 (GRCm39)	missense	probably damaging	0.98
R2197:Lama1	UTSW	17	68,059,936 (GRCm39)	missense	probably benign	0.02
R2213:Lama1	UTSW	17	68,084,029 (GRCm39)	nonsense	probably null
R2260:Lama1	UTSW	17	68,044,502 (GRCm39)	missense	probably damaging	0.96
R2356:Lama1	UTSW	17	68,117,109 (GRCm39)	missense	probably damaging	1.00
R2420:Lama1	UTSW	17	68,057,548 (GRCm39)	missense	probably benign	0.00
R2421:Lama1	UTSW	17	68,057,548 (GRCm39)	missense	probably benign	0.00
R2422:Lama1	UTSW	17	68,057,548 (GRCm39)	missense	probably benign	0.00
R2424:Lama1	UTSW	17	68,105,660 (GRCm39)	missense	probably benign	0.09
R2442:Lama1	UTSW	17	68,075,312 (GRCm39)	missense	probably benign	0.04
R3147:Lama1	UTSW	17	68,044,653 (GRCm39)	missense	probably damaging	0.98
R3414:Lama1	UTSW	17	68,044,598 (GRCm39)	missense	probably damaging	1.00
R3683:Lama1	UTSW	17	68,075,328 (GRCm39)	missense	probably benign	0.40
R3820:Lama1	UTSW	17	68,086,041 (GRCm39)	splice site	probably null
R3821:Lama1	UTSW	17	68,086,041 (GRCm39)	splice site	probably null
R3822:Lama1	UTSW	17	68,086,041 (GRCm39)	splice site	probably null
R4012:Lama1	UTSW	17	68,119,368 (GRCm39)	nonsense	probably null
R4113:Lama1	UTSW	17	68,071,698 (GRCm39)	missense	probably benign	0.01
R4133:Lama1	UTSW	17	68,119,481 (GRCm39)	missense	probably damaging	1.00
R4133:Lama1	UTSW	17	68,057,650 (GRCm39)	missense	probably damaging	0.98
R4259:Lama1	UTSW	17	68,059,413 (GRCm39)	missense	possibly damaging	0.95
R4278:Lama1	UTSW	17	68,098,512 (GRCm39)	missense	probably null	0.00
R4321:Lama1	UTSW	17	68,078,078 (GRCm39)	missense	probably benign	0.03
R4374:Lama1	UTSW	17	68,111,513 (GRCm39)	missense	probably benign	0.00
R4386:Lama1	UTSW	17	68,080,707 (GRCm39)	missense	probably benign	0.01
R4463:Lama1	UTSW	17	68,068,695 (GRCm39)	missense	probably damaging	1.00
R4629:Lama1	UTSW	17	68,112,355 (GRCm39)	critical splice acceptor site	probably null
R4630:Lama1	UTSW	17	68,101,295 (GRCm39)	missense	probably benign	0.00
R4633:Lama1	UTSW	17	68,105,579 (GRCm39)	missense	probably damaging	0.96
R4668:Lama1	UTSW	17	68,059,429 (GRCm39)	missense	probably benign	0.27
R4684:Lama1	UTSW	17	68,080,773 (GRCm39)	missense	possibly damaging	0.88
R4745:Lama1	UTSW	17	68,045,775 (GRCm39)	missense	probably damaging	1.00
R4786:Lama1	UTSW	17	68,080,854 (GRCm39)	missense	possibly damaging	0.77
R4797:Lama1	UTSW	17	68,023,770 (GRCm39)	missense	probably benign	0.04
R4803:Lama1	UTSW	17	68,116,266 (GRCm39)	missense	probably damaging	1.00
R4925:Lama1	UTSW	17	68,101,309 (GRCm39)	missense	probably benign	0.02
R4939:Lama1	UTSW	17	68,044,470 (GRCm39)	missense	possibly damaging	0.91
R4952:Lama1	UTSW	17	68,074,561 (GRCm39)	critical splice donor site	probably null
R4975:Lama1	UTSW	17	68,045,829 (GRCm39)	missense	possibly damaging	0.95
R4977:Lama1	UTSW	17	68,044,677 (GRCm39)	missense	probably damaging	1.00
R5039:Lama1	UTSW	17	68,052,888 (GRCm39)	missense	possibly damaging	0.66
R5047:Lama1	UTSW	17	68,050,276 (GRCm39)	nonsense	probably null
R5195:Lama1	UTSW	17	68,071,795 (GRCm39)	missense	probably benign	0.13
R5230:Lama1	UTSW	17	68,052,078 (GRCm39)	nonsense	probably null
R5236:Lama1	UTSW	17	68,111,487 (GRCm39)	missense	probably benign	0.24
R5254:Lama1	UTSW	17	68,063,711 (GRCm39)	missense	probably benign	0.01
R5345:Lama1	UTSW	17	68,124,558 (GRCm39)	missense	probably benign
R5438:Lama1	UTSW	17	68,107,769 (GRCm39)	missense	possibly damaging	0.92
R5521:Lama1	UTSW	17	68,087,889 (GRCm39)	nonsense	probably null
R5568:Lama1	UTSW	17	68,075,293 (GRCm39)	critical splice acceptor site	probably null
R5645:Lama1	UTSW	17	68,109,943 (GRCm39)	missense	probably damaging	1.00
R5665:Lama1	UTSW	17	68,077,982 (GRCm39)	missense	probably damaging	1.00
R5727:Lama1	UTSW	17	68,122,219 (GRCm39)	missense	possibly damaging	0.81
R5757:Lama1	UTSW	17	68,045,782 (GRCm39)	missense	possibly damaging	0.59
R5795:Lama1	UTSW	17	68,103,722 (GRCm39)	missense	probably benign	0.02
R5857:Lama1	UTSW	17	68,114,838 (GRCm39)	missense	probably damaging	0.99
R5894:Lama1	UTSW	17	68,086,042 (GRCm39)	critical splice acceptor site	probably null
R5974:Lama1	UTSW	17	68,080,722 (GRCm39)	missense	probably benign	0.31
R6032:Lama1	UTSW	17	68,057,638 (GRCm39)	missense	probably benign	0.01
R6032:Lama1	UTSW	17	68,057,638 (GRCm39)	missense	probably benign	0.01
R6120:Lama1	UTSW	17	68,087,612 (GRCm39)	critical splice donor site	probably null
R6219:Lama1	UTSW	17	68,097,851 (GRCm39)	missense	probably benign	0.08
R6224:Lama1	UTSW	17	68,109,982 (GRCm39)	missense	possibly damaging	0.56
R6249:Lama1	UTSW	17	68,105,599 (GRCm39)	missense	probably benign
R6265:Lama1	UTSW	17	68,057,650 (GRCm39)	missense	probably damaging	0.98
R6276:Lama1	UTSW	17	68,091,083 (GRCm39)	splice site	probably null
R6284:Lama1	UTSW	17	68,117,091 (GRCm39)	missense	probably damaging	0.99
R6337:Lama1	UTSW	17	68,093,014 (GRCm39)	missense	probably benign	0.27
R6414:Lama1	UTSW	17	68,053,905 (GRCm39)	critical splice donor site	probably null
R6631:Lama1	UTSW	17	68,081,477 (GRCm39)	missense	probably benign	0.21
R6659:Lama1	UTSW	17	68,125,630 (GRCm39)	missense	probably damaging	1.00
R6660:Lama1	UTSW	17	68,111,495 (GRCm39)	missense	probably benign	0.05
R6677:Lama1	UTSW	17	68,102,228 (GRCm39)	missense	probably benign	0.14
R6763:Lama1	UTSW	17	68,053,868 (GRCm39)	missense	unknown
R6787:Lama1	UTSW	17	68,091,020 (GRCm39)	missense	unknown
R6831:Lama1	UTSW	17	68,063,749 (GRCm39)	missense	possibly damaging	0.89
R6855:Lama1	UTSW	17	68,089,150 (GRCm39)	missense	possibly damaging	0.95
R6910:Lama1	UTSW	17	68,098,459 (GRCm39)	missense	possibly damaging	0.60
R6934:Lama1	UTSW	17	68,081,538 (GRCm39)	missense	probably benign	0.04
R6945:Lama1	UTSW	17	68,120,861 (GRCm39)	missense
R6984:Lama1	UTSW	17	68,086,107 (GRCm39)	missense
R6989:Lama1	UTSW	17	68,060,753 (GRCm39)	missense
R6994:Lama1	UTSW	17	68,060,820 (GRCm39)	missense
R6995:Lama1	UTSW	17	68,060,820 (GRCm39)	missense
R7035:Lama1	UTSW	17	68,088,044 (GRCm39)	missense
R7133:Lama1	UTSW	17	68,089,141 (GRCm39)	missense
R7172:Lama1	UTSW	17	68,111,540 (GRCm39)	missense
R7197:Lama1	UTSW	17	68,044,700 (GRCm39)	nonsense	probably null
R7217:Lama1	UTSW	17	68,071,668 (GRCm39)	missense
R7229:Lama1	UTSW	17	68,059,441 (GRCm39)	missense
R7264:Lama1	UTSW	17	68,050,292 (GRCm39)	missense
R7311:Lama1	UTSW	17	68,074,380 (GRCm39)	missense
R7394:Lama1	UTSW	17	68,024,256 (GRCm39)	missense
R7419:Lama1	UTSW	17	68,024,169 (GRCm39)	missense
R7492:Lama1	UTSW	17	68,124,646 (GRCm39)	missense
R7494:Lama1	UTSW	17	68,118,441 (GRCm39)	missense
R7552:Lama1	UTSW	17	68,044,662 (GRCm39)	missense
R7576:Lama1	UTSW	17	68,089,036 (GRCm39)	missense
R7583:Lama1	UTSW	17	68,068,616 (GRCm39)	missense
R7649:Lama1	UTSW	17	68,044,549 (GRCm39)	missense
R7663:Lama1	UTSW	17	68,087,875 (GRCm39)	missense
R7667:Lama1	UTSW	17	68,087,592 (GRCm39)	missense
R7688:Lama1	UTSW	17	68,068,623 (GRCm39)	missense
R7693:Lama1	UTSW	17	68,124,026 (GRCm39)	missense
R7748:Lama1	UTSW	17	68,057,585 (GRCm39)	missense
R7778:Lama1	UTSW	17	68,111,468 (GRCm39)	missense
R7824:Lama1	UTSW	17	68,111,468 (GRCm39)	missense
R7861:Lama1	UTSW	17	68,116,216 (GRCm39)	missense
R7884:Lama1	UTSW	17	68,076,430 (GRCm39)	missense
R8029:Lama1	UTSW	17	68,124,589 (GRCm39)	missense
R8078:Lama1	UTSW	17	68,098,289 (GRCm39)	missense
R8101:Lama1	UTSW	17	68,052,917 (GRCm39)	missense
R8313:Lama1	UTSW	17	68,057,515 (GRCm39)	missense
R8356:Lama1	UTSW	17	68,044,491 (GRCm39)	missense
R8366:Lama1	UTSW	17	68,125,699 (GRCm39)	missense
R8403:Lama1	UTSW	17	68,052,918 (GRCm39)	missense
R8456:Lama1	UTSW	17	68,044,491 (GRCm39)	missense
R8466:Lama1	UTSW	17	68,120,948 (GRCm39)	missense
R8678:Lama1	UTSW	17	68,124,098 (GRCm39)	missense
R8728:Lama1	UTSW	17	68,125,663 (GRCm39)	missense
R8796:Lama1	UTSW	17	68,117,146 (GRCm39)	missense
R8885:Lama1	UTSW	17	68,080,779 (GRCm39)	missense
R8893:Lama1	UTSW	17	68,112,367 (GRCm39)	missense
R8898:Lama1	UTSW	17	68,128,610 (GRCm39)	missense
R8909:Lama1	UTSW	17	68,079,736 (GRCm39)	missense
R9025:Lama1	UTSW	17	68,119,491 (GRCm39)	missense
R9045:Lama1	UTSW	17	68,060,838 (GRCm39)	missense
R9098:Lama1	UTSW	17	68,111,508 (GRCm39)	missense
R9114:Lama1	UTSW	17	68,128,669 (GRCm39)	missense
R9173:Lama1	UTSW	17	68,076,597 (GRCm39)	missense
R9190:Lama1	UTSW	17	68,111,514 (GRCm39)	missense
R9381:Lama1	UTSW	17	68,044,479 (GRCm39)	missense
R9429:Lama1	UTSW	17	68,118,449 (GRCm39)	missense
R9504:Lama1	UTSW	17	68,128,661 (GRCm39)	missense
R9558:Lama1	UTSW	17	68,124,004 (GRCm39)	missense
R9647:Lama1	UTSW	17	68,024,170 (GRCm39)	missense
R9651:Lama1	UTSW	17	68,101,215 (GRCm39)	missense
R9654:Lama1	UTSW	17	68,101,266 (GRCm39)	missense
R9710:Lama1	UTSW	17	68,129,404 (GRCm39)	missense
R9733:Lama1	UTSW	17	68,116,940 (GRCm39)	missense
RF001:Lama1	UTSW	17	68,059,897 (GRCm39)	missense
RF013:Lama1	UTSW	17	68,088,057 (GRCm39)	missense
V8831:Lama1	UTSW	17	68,059,878 (GRCm39)	missense	probably benign	0.00
X0024:Lama1	UTSW	17	68,045,883 (GRCm39)	missense	probably damaging	1.00
X0028:Lama1	UTSW	17	68,101,305 (GRCm39)	missense	probably benign	0.06
X0028:Lama1	UTSW	17	68,074,417 (GRCm39)	missense	probably benign	0.00
X0066:Lama1	UTSW	17	68,118,561 (GRCm39)	missense	probably damaging	1.00
Z1088:Lama1	UTSW	17	68,117,166 (GRCm39)	missense	probably damaging	1.00
Z1088:Lama1	UTSW	17	68,078,077 (GRCm39)	missense	probably benign	0.25
Z1088:Lama1	UTSW	17	68,059,878 (GRCm39)	missense	probably benign	0.00
Z1176:Lama1	UTSW	17	68,059,878 (GRCm39)	missense	probably benign	0.00
Z1177:Lama1	UTSW	17	68,059,878 (GRCm39)	missense	probably benign	0.00
Z1191:Lama1	UTSW	17	68,105,639 (GRCm39)	missense

Predicted Primers

PCR Primer
(F):5'- TCTTCAGGTCCAGGGTCAAC -3'
(R):5'- TCAGCACATGGTGACCAAG -3'

Sequencing Primer
(F):5'- CTGACGGGGCTCTCATTGTC -3'
(R):5'- CATGGTGACCAAGCCTACGAG -3'

Posted On

2019-10-07