Incidental Mutation 'R7461:Tradd'
ID 578450
Institutional Source Beutler Lab
Gene Symbol Tradd
Ensembl Gene ENSMUSG00000031887
Gene Name TNFRSF1A-associated via death domain
Synonyms 9130005N23Rik
MMRRC Submission 045535-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.212) question?
Stock # R7461 (G1)
Quality Score 225.009
Status Validated
Chromosome 8
Chromosomal Location 105985207-105991226 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 105987196 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Glutamic Acid at position 37 (K37E)
Ref Sequence ENSEMBL: ENSMUSP00000034359 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000034359] [ENSMUST00000036221] [ENSMUST00000126923] [ENSMUST00000144762]
AlphaFold Q3U0V2
Predicted Effect possibly damaging
Transcript: ENSMUST00000034359
AA Change: K37E

PolyPhen 2 Score 0.528 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000034359
Gene: ENSMUSG00000031887
AA Change: K37E

DomainStartEndE-ValueType
Pfam:TRADD_N 51 161 2.9e-49 PFAM
DEATH 203 303 1.14e-17 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000036221
SMART Domains Protein: ENSMUSP00000038638
Gene: ENSMUSG00000033313

DomainStartEndE-ValueType
FBOX 8 48 2.72e-6 SMART
low complexity region 102 113 N/A INTRINSIC
low complexity region 252 263 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000126923
SMART Domains Protein: ENSMUSP00000115366
Gene: ENSMUSG00000033313

DomainStartEndE-ValueType
FBOX 8 48 2.72e-6 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000144762
AA Change: K37E

PolyPhen 2 Score 0.659 (Sensitivity: 0.86; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000119174
Gene: ENSMUSG00000031887
AA Change: K37E

DomainStartEndE-ValueType
PDB:1F2H|A 1 50 7e-23 PDB
SCOP:d1f3va_ 8 50 4e-24 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.2%
Validation Efficiency 100% (53/53)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway. [provided by RefSeq, Jul 2008]
PHENOTYPE: Nullizygous mutations can cause resistance to toxicity induced by TNF, LPS and poly(I:C), resistance to galactosamine and TNF-induced hepatitis, increased susceptibility to bacterial infection, and impaired formation of follicular dendritic cell networksand germinal centers in spleen. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acta2 G A 19: 34,229,931 (GRCm39) T8I probably benign Het
Adgrb2 CTATA CTATATA 4: 129,915,006 (GRCm39) probably benign Het
Akt2 A G 7: 27,336,595 (GRCm39) I448V probably benign Het
Anapc5 G A 5: 122,956,928 (GRCm39) T117M probably damaging Het
Arhgap10 T C 8: 78,115,326 (GRCm39) E358G probably damaging Het
C1qtnf6 T A 15: 78,411,549 (GRCm39) K42N probably benign Het
Cacna1d A T 14: 29,788,120 (GRCm39) D1605E probably benign Het
Cdkl1 T A 12: 69,803,235 (GRCm39) I214L probably benign Het
Celsr2 C T 3: 108,302,956 (GRCm39) G2506R probably damaging Het
Cenpj G A 14: 56,764,501 (GRCm39) R1304* probably null Het
Cfap58 A G 19: 47,970,561 (GRCm39) D593G possibly damaging Het
Crip2 T C 12: 113,107,777 (GRCm39) probably null Het
Crocc2 G T 1: 93,122,311 (GRCm39) A735S possibly damaging Het
Dcc A T 18: 71,439,105 (GRCm39) L1279H probably damaging Het
Dnah2 A G 11: 69,439,816 (GRCm39) probably null Het
Dpp8 C T 9: 64,960,402 (GRCm39) T311M possibly damaging Het
Eps15 T C 4: 109,186,922 (GRCm39) S330P probably damaging Het
Exoc2 C T 13: 31,066,255 (GRCm39) V474I probably benign Het
Fmn1 A G 2: 113,194,416 (GRCm39) T39A unknown Het
Foxn2 T C 17: 88,794,311 (GRCm39) I416T possibly damaging Het
Gbp8 T C 5: 105,178,880 (GRCm39) E145G probably damaging Het
Gjd2 A C 2: 113,841,599 (GRCm39) S293A possibly damaging Het
Gm3676 T A 14: 41,365,233 (GRCm39) I141L probably benign Het
Gm4131 A G 14: 62,718,538 (GRCm39) Y23H possibly damaging Het
Gucy1b1 T A 3: 81,947,054 (GRCm39) D385V possibly damaging Het
Hdac2 T C 10: 36,865,232 (GRCm39) S149P probably damaging Het
Igsf9b A T 9: 27,245,418 (GRCm39) R1128S probably benign Het
Invs A G 4: 48,392,668 (GRCm39) H294R probably damaging Het
Itgbl1 T A 14: 124,065,211 (GRCm39) S122T possibly damaging Het
Kansl3 G A 1: 36,382,876 (GRCm39) S812F probably damaging Het
Kcnt1 A T 2: 25,791,358 (GRCm39) H567L probably benign Het
Klhl30 G T 1: 91,285,130 (GRCm39) V329F possibly damaging Het
Krt33a A G 11: 99,902,765 (GRCm39) I353T probably damaging Het
Lrrc37 G T 11: 103,507,116 (GRCm39) H1617Q unknown Het
Lrrc7 T C 3: 157,892,657 (GRCm39) T331A probably benign Het
Megf10 G T 18: 57,385,925 (GRCm39) V313F probably damaging Het
Myo15a A G 11: 60,395,978 (GRCm39) T1438A Het
Myocd A G 11: 65,109,429 (GRCm39) L114P probably damaging Het
Or5b21 A T 19: 12,839,141 (GRCm39) M1L probably benign Het
Pde4b A G 4: 102,112,503 (GRCm39) E29G probably damaging Het
Por G T 5: 135,758,358 (GRCm39) A112S probably damaging Het
Prkcq T C 2: 11,304,221 (GRCm39) F651S probably damaging Het
Selenoi A G 5: 30,471,926 (GRCm39) I376V possibly damaging Het
Setbp1 A C 18: 78,899,707 (GRCm39) M1320R probably benign Het
Skint6 A T 4: 113,034,243 (GRCm39) probably null Het
Tdrd6 T C 17: 43,938,817 (GRCm39) T744A probably benign Het
Tmem209 C T 6: 30,508,469 (GRCm39) W61* probably null Het
Tmem94 G T 11: 115,677,082 (GRCm39) R118L possibly damaging Het
Top1 A T 2: 160,554,762 (GRCm39) probably null Het
Ttc28 C A 5: 111,371,995 (GRCm39) L846M probably damaging Het
Umodl1 T A 17: 31,207,031 (GRCm39) C807* probably null Het
Upf2 T A 2: 5,978,347 (GRCm39) S404T unknown Het
Wscd1 T C 11: 71,650,799 (GRCm39) L42P possibly damaging Het
Other mutations in Tradd
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01648:Tradd APN 8 105,986,418 (GRCm39) missense probably damaging 0.99
R0240:Tradd UTSW 8 105,985,924 (GRCm39) missense possibly damaging 0.53
R0709:Tradd UTSW 8 105,987,276 (GRCm39) missense possibly damaging 0.82
R0751:Tradd UTSW 8 105,986,403 (GRCm39) missense probably damaging 0.96
R1870:Tradd UTSW 8 105,985,792 (GRCm39) missense possibly damaging 0.77
R2867:Tradd UTSW 8 105,986,145 (GRCm39) missense probably benign
R2867:Tradd UTSW 8 105,986,145 (GRCm39) missense probably benign
R3880:Tradd UTSW 8 105,987,287 (GRCm39) missense possibly damaging 0.82
R4978:Tradd UTSW 8 105,985,900 (GRCm39) missense probably benign 0.32
R5345:Tradd UTSW 8 105,986,556 (GRCm39) missense probably damaging 0.99
R5507:Tradd UTSW 8 105,986,257 (GRCm39) missense possibly damaging 0.94
R5997:Tradd UTSW 8 105,987,277 (GRCm39) missense possibly damaging 0.66
Predicted Primers PCR Primer
(F):5'- CGAGGACACATGTGCAATAAGC -3'
(R):5'- TGCTGGACTACGTGAGACTG -3'

Sequencing Primer
(F):5'- CGGAAGTGCACCCTCTCTC -3'
(R):5'- AGACTGGAGAGTTGTTTCCAAGTC -3'
Posted On 2019-10-07