Incidental Mutation 'R7464:Nav1'
| ID |
578602 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Nav1
|
| Ensembl Gene |
ENSMUSG00000009418 |
| Gene Name |
neuron navigator 1 |
| Synonyms |
9930003A20Rik, unc53H1, steerin-1, POMFIL3, C230080M11Rik |
| MMRRC Submission |
045538-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.944)
|
| Stock # |
R7464 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
1 |
| Chromosomal Location |
135362318-135615843 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 135512647 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Leucine
at position 138
(M138L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000140322
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000040599]
[ENSMUST00000067414]
[ENSMUST00000190298]
|
| AlphaFold |
Q8CH77 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000040599
AA Change: M138L
PolyPhen 2
Score 0.333 (Sensitivity: 0.90; Specificity: 0.89)
|
| SMART Domains |
Protein: ENSMUSP00000043803
Gene: ENSMUSG00000009418
AA Change: M138L
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
16 |
33 |
N/A |
INTRINSIC |
|
low complexity region
|
48 |
65 |
N/A |
INTRINSIC |
|
low complexity region
|
119 |
132 |
N/A |
INTRINSIC |
|
low complexity region
|
303 |
318 |
N/A |
INTRINSIC |
|
low complexity region
|
414 |
428 |
N/A |
INTRINSIC |
|
low complexity region
|
436 |
456 |
N/A |
INTRINSIC |
|
low complexity region
|
739 |
749 |
N/A |
INTRINSIC |
|
low complexity region
|
807 |
818 |
N/A |
INTRINSIC |
|
low complexity region
|
892 |
913 |
N/A |
INTRINSIC |
|
low complexity region
|
975 |
989 |
N/A |
INTRINSIC |
|
coiled coil region
|
1070 |
1105 |
N/A |
INTRINSIC |
|
low complexity region
|
1179 |
1210 |
N/A |
INTRINSIC |
|
low complexity region
|
1260 |
1281 |
N/A |
INTRINSIC |
|
low complexity region
|
1296 |
1304 |
N/A |
INTRINSIC |
|
coiled coil region
|
1328 |
1360 |
N/A |
INTRINSIC |
|
AAA
|
1548 |
1702 |
3.16e-5 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000067414
AA Change: M138L
PolyPhen 2
Score 0.333 (Sensitivity: 0.90; Specificity: 0.89)
|
| SMART Domains |
Protein: ENSMUSP00000067241
Gene: ENSMUSG00000009418
AA Change: M138L
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
16 |
33 |
N/A |
INTRINSIC |
|
low complexity region
|
48 |
65 |
N/A |
INTRINSIC |
|
low complexity region
|
119 |
132 |
N/A |
INTRINSIC |
|
low complexity region
|
303 |
318 |
N/A |
INTRINSIC |
|
low complexity region
|
414 |
428 |
N/A |
INTRINSIC |
|
low complexity region
|
436 |
456 |
N/A |
INTRINSIC |
|
low complexity region
|
739 |
749 |
N/A |
INTRINSIC |
|
low complexity region
|
807 |
818 |
N/A |
INTRINSIC |
|
low complexity region
|
892 |
913 |
N/A |
INTRINSIC |
|
low complexity region
|
975 |
989 |
N/A |
INTRINSIC |
|
coiled coil region
|
1070 |
1105 |
N/A |
INTRINSIC |
|
low complexity region
|
1179 |
1210 |
N/A |
INTRINSIC |
|
low complexity region
|
1260 |
1281 |
N/A |
INTRINSIC |
|
low complexity region
|
1296 |
1304 |
N/A |
INTRINSIC |
|
coiled coil region
|
1328 |
1360 |
N/A |
INTRINSIC |
|
AAA
|
1548 |
1702 |
3.16e-5 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000190298
AA Change: M138L
PolyPhen 2
Score 0.034 (Sensitivity: 0.95; Specificity: 0.82)
|
| SMART Domains |
Protein: ENSMUSP00000140322
Gene: ENSMUSG00000009418
AA Change: M138L
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
16 |
33 |
N/A |
INTRINSIC |
|
low complexity region
|
48 |
65 |
N/A |
INTRINSIC |
|
low complexity region
|
119 |
132 |
N/A |
INTRINSIC |
|
low complexity region
|
303 |
318 |
N/A |
INTRINSIC |
|
low complexity region
|
414 |
428 |
N/A |
INTRINSIC |
|
low complexity region
|
436 |
456 |
N/A |
INTRINSIC |
|
low complexity region
|
739 |
749 |
N/A |
INTRINSIC |
|
low complexity region
|
807 |
818 |
N/A |
INTRINSIC |
|
low complexity region
|
892 |
913 |
N/A |
INTRINSIC |
|
low complexity region
|
975 |
989 |
N/A |
INTRINSIC |
|
coiled coil region
|
1013 |
1048 |
N/A |
INTRINSIC |
|
low complexity region
|
1122 |
1153 |
N/A |
INTRINSIC |
|
low complexity region
|
1200 |
1221 |
N/A |
INTRINSIC |
|
low complexity region
|
1236 |
1244 |
N/A |
INTRINSIC |
|
coiled coil region
|
1268 |
1300 |
N/A |
INTRINSIC |
|
AAA
|
1488 |
1642 |
3.16e-5 |
SMART |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 98.9%
|
| Validation Efficiency |
96% (79/82) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene belongs to the neuron navigator family and is expressed predominantly in the nervous system. The encoded protein contains coiled-coil domains and a conserved AAA domain characteristic for ATPases associated with a variety of cellular activities. This gene is similar to unc-53, a Caenorhabditis elegans gene involved in axon guidance. The exact function of this gene is not known, but it is thought to play a role in in neuronal development and regeneration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 85 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aass |
C |
T |
6: 23,077,152 (GRCm39) |
G736R |
possibly damaging |
Het |
| Acta2 |
G |
A |
19: 34,229,931 (GRCm39) |
T8I |
probably benign |
Het |
| Ankar |
A |
T |
1: 72,738,053 (GRCm39) |
V43E |
possibly damaging |
Het |
| Apof |
A |
G |
10: 128,105,505 (GRCm39) |
I220V |
probably benign |
Het |
| Asxl1 |
G |
T |
2: 153,239,705 (GRCm39) |
A499S |
probably benign |
Het |
| Baz2a |
T |
A |
10: 127,957,942 (GRCm39) |
D1069E |
possibly damaging |
Het |
| Baz2b |
T |
C |
2: 59,807,792 (GRCm39) |
T156A |
possibly damaging |
Het |
| Bbc3 |
A |
T |
7: 16,051,082 (GRCm39) |
R169W |
unknown |
Het |
| C5ar1 |
T |
A |
7: 15,982,691 (GRCm39) |
I110L |
probably benign |
Het |
| Cd19 |
C |
A |
7: 126,010,975 (GRCm39) |
R323L |
probably damaging |
Het |
| Cdc14b |
A |
T |
13: 64,344,489 (GRCm39) |
C113* |
probably null |
Het |
| Cngb1 |
C |
A |
8: 95,980,811 (GRCm39) |
W914L |
possibly damaging |
Het |
| Colgalt2 |
A |
G |
1: 152,379,895 (GRCm39) |
K445E |
probably damaging |
Het |
| Crebrf |
A |
G |
17: 26,982,461 (GRCm39) |
M608V |
unknown |
Het |
| Csf1 |
T |
A |
3: 107,656,191 (GRCm39) |
H280L |
probably benign |
Het |
| Cyp2j11 |
C |
A |
4: 96,233,357 (GRCm39) |
R113L |
probably damaging |
Het |
| D5Ertd579e |
G |
A |
5: 36,771,129 (GRCm39) |
H1089Y |
probably damaging |
Het |
| Ddx60 |
C |
T |
8: 62,393,708 (GRCm39) |
T48M |
possibly damaging |
Het |
| Defa40 |
T |
A |
8: 21,739,910 (GRCm39) |
S45T |
probably damaging |
Het |
| Dock10 |
T |
C |
1: 80,518,032 (GRCm39) |
D1315G |
probably damaging |
Het |
| Dock2 |
T |
G |
11: 34,586,105 (GRCm39) |
N526H |
probably damaging |
Het |
| Dram2 |
T |
C |
3: 106,480,999 (GRCm39) |
*268Q |
probably null |
Het |
| Emc8 |
A |
G |
8: 121,394,657 (GRCm39) |
Y21H |
possibly damaging |
Het |
| Fam162a |
A |
G |
16: 35,891,863 (GRCm39) |
L4P |
probably damaging |
Het |
| Fan1 |
T |
A |
7: 64,022,234 (GRCm39) |
N340Y |
probably damaging |
Het |
| Fbxw10 |
T |
A |
11: 62,744,124 (GRCm39) |
I307N |
probably benign |
Het |
| Fbxw16 |
A |
G |
9: 109,268,619 (GRCm39) |
V257A |
possibly damaging |
Het |
| Fer1l6 |
T |
A |
15: 58,445,096 (GRCm39) |
|
probably null |
Het |
| Galnt7 |
A |
G |
8: 58,037,054 (GRCm39) |
Y112H |
possibly damaging |
Het |
| Gigyf2 |
T |
C |
1: 87,356,326 (GRCm39) |
I803T |
unknown |
Het |
| Gm28729 |
A |
G |
9: 96,403,288 (GRCm39) |
I44T |
possibly damaging |
Het |
| Gm5447 |
A |
G |
13: 31,158,377 (GRCm39) |
I34V |
not run |
Het |
| H2-M9 |
A |
T |
17: 36,953,303 (GRCm39) |
|
probably null |
Het |
| Helz |
G |
A |
11: 107,527,104 (GRCm39) |
C864Y |
probably damaging |
Het |
| Il25 |
A |
G |
14: 55,170,679 (GRCm39) |
Y84C |
probably null |
Het |
| Itga10 |
T |
A |
3: 96,555,471 (GRCm39) |
C142S |
probably damaging |
Het |
| Kcna10 |
A |
T |
3: 107,101,395 (GRCm39) |
M9L |
probably damaging |
Het |
| Klhl6 |
G |
T |
16: 19,775,863 (GRCm39) |
Q232K |
possibly damaging |
Het |
| Mb21d2 |
T |
G |
16: 28,748,298 (GRCm39) |
I40L |
possibly damaging |
Het |
| Mdm1 |
T |
C |
10: 117,988,171 (GRCm39) |
S334P |
probably benign |
Het |
| Mllt10 |
T |
A |
2: 18,175,090 (GRCm39) |
D549E |
probably benign |
Het |
| Mlxipl |
T |
C |
5: 135,162,482 (GRCm39) |
V648A |
probably benign |
Het |
| Nars2 |
A |
G |
7: 96,689,137 (GRCm39) |
K353R |
probably benign |
Het |
| Neb |
T |
C |
2: 52,083,902 (GRCm39) |
T5635A |
probably benign |
Het |
| Nktr |
A |
C |
9: 121,579,393 (GRCm39) |
I1154L |
unknown |
Het |
| Or14j8 |
A |
T |
17: 38,263,171 (GRCm39) |
V248D |
probably damaging |
Het |
| Or2a57 |
T |
G |
6: 43,213,228 (GRCm39) |
S229A |
probably damaging |
Het |
| Or4g17 |
T |
A |
2: 111,209,543 (GRCm39) |
L66Q |
probably damaging |
Het |
| Oxld1 |
T |
C |
11: 120,347,963 (GRCm39) |
D78G |
probably benign |
Het |
| Pde1b |
T |
C |
15: 103,433,256 (GRCm39) |
I255T |
probably benign |
Het |
| Pkp4 |
T |
A |
2: 59,138,481 (GRCm39) |
F244I |
probably benign |
Het |
| Polg2 |
C |
A |
11: 106,664,540 (GRCm39) |
V305L |
probably benign |
Het |
| Pramel34 |
C |
T |
5: 93,784,099 (GRCm39) |
C455Y |
probably damaging |
Het |
| Ptpn18 |
G |
A |
1: 34,512,445 (GRCm39) |
D417N |
possibly damaging |
Het |
| Sash1 |
T |
C |
10: 8,632,509 (GRCm39) |
D242G |
possibly damaging |
Het |
| Six4 |
T |
C |
12: 73,159,304 (GRCm39) |
T219A |
possibly damaging |
Het |
| Slc28a3 |
A |
C |
13: 58,710,835 (GRCm39) |
Y562* |
probably null |
Het |
| Soat1 |
A |
T |
1: 156,266,887 (GRCm39) |
W310R |
probably damaging |
Het |
| Son |
CATGGACTCCCAGATGTTAGCAACTAGCTCTATGGACTCCCAGATGTTAGCAACTAGCTCTATGGACTCCCAGATGTTAGCAACCAGCAGTATGGACTCCCAGATGTTAGCAACCAGCAGTATGGACTCCCAGATGTTAGCAACCAGCTCCATGGACTCCCAGATGTTAGCAAC |
CATGGACTCCCAGATGTTAGCAACTAGCTCTATGGACTCCCAGATGTTAGCAACCAGCAGTATGGACTCCCAGATGTTAGCAACCAGCAGTATGGACTCCCAGATGTTAGCAACCAGCTCCATGGACTCCCAGATGTTAGCAAC |
16: 91,453,579 (GRCm39) |
|
probably benign |
Het |
| Spef2 |
T |
C |
15: 9,740,671 (GRCm39) |
N30D |
probably benign |
Het |
| Spopfm2 |
A |
T |
3: 94,083,411 (GRCm39) |
N133K |
probably benign |
Het |
| Srebf2 |
T |
A |
15: 82,057,075 (GRCm39) |
I270N |
probably damaging |
Het |
| St8sia3 |
T |
C |
18: 64,404,589 (GRCm39) |
W289R |
probably damaging |
Het |
| Stx5a |
T |
A |
19: 8,720,868 (GRCm39) |
|
probably benign |
Het |
| Tacc1 |
T |
C |
8: 25,654,480 (GRCm39) |
D689G |
probably damaging |
Het |
| Tacc3 |
A |
G |
5: 33,818,628 (GRCm39) |
D21G |
probably benign |
Het |
| Tapt1 |
G |
A |
5: 44,346,030 (GRCm39) |
R307* |
probably null |
Het |
| Tbc1d9b |
T |
A |
11: 50,022,312 (GRCm39) |
V16E |
probably damaging |
Het |
| Tchhl1 |
G |
A |
3: 93,377,971 (GRCm39) |
R225K |
probably benign |
Het |
| Thumpd3 |
G |
A |
6: 113,032,730 (GRCm39) |
G156D |
probably benign |
Het |
| Tmem178 |
C |
T |
17: 81,252,331 (GRCm39) |
P72S |
probably benign |
Het |
| Tmem52 |
C |
T |
4: 155,553,926 (GRCm39) |
P46S |
probably benign |
Het |
| Tmem94 |
G |
T |
11: 115,677,082 (GRCm39) |
R118L |
possibly damaging |
Het |
| Tulp3 |
A |
T |
6: 128,303,792 (GRCm39) |
V269D |
probably benign |
Het |
| Ubr1 |
A |
G |
2: 120,720,255 (GRCm39) |
|
probably null |
Het |
| Upf1 |
G |
A |
8: 70,786,073 (GRCm39) |
S962L |
probably benign |
Het |
| Vcpip1 |
C |
T |
1: 9,816,745 (GRCm39) |
R546Q |
probably damaging |
Het |
| Vmn2r49 |
A |
C |
7: 9,722,820 (GRCm39) |
S151R |
probably benign |
Het |
| Wac |
T |
C |
18: 7,871,746 (GRCm39) |
|
probably null |
Het |
| Wrn |
C |
T |
8: 33,826,024 (GRCm39) |
|
probably null |
Het |
| Zfp286 |
C |
A |
11: 62,671,627 (GRCm39) |
D149Y |
probably benign |
Het |
| Zfp748 |
A |
G |
13: 67,690,091 (GRCm39) |
C390R |
probably damaging |
Het |
| Zfp873 |
A |
G |
10: 81,896,210 (GRCm39) |
T314A |
possibly damaging |
Het |
| Zfyve1 |
C |
T |
12: 83,598,261 (GRCm39) |
D656N |
probably benign |
Het |
| Zmym1 |
T |
A |
4: 126,952,728 (GRCm39) |
K18* |
probably null |
Het |
|
| Other mutations in Nav1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01061:Nav1
|
APN |
1 |
135,378,368 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01455:Nav1
|
APN |
1 |
135,397,373 (GRCm39) |
missense |
probably benign |
0.44 |
|
IGL01650:Nav1
|
APN |
1 |
135,382,498 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01872:Nav1
|
APN |
1 |
135,381,814 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01967:Nav1
|
APN |
1 |
135,464,983 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02167:Nav1
|
APN |
1 |
135,398,699 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02278:Nav1
|
APN |
1 |
135,391,452 (GRCm39) |
splice site |
probably benign |
|
|
IGL02343:Nav1
|
APN |
1 |
135,382,490 (GRCm39) |
nonsense |
probably null |
|
|
IGL02378:Nav1
|
APN |
1 |
135,397,716 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL02554:Nav1
|
APN |
1 |
135,512,651 (GRCm39) |
synonymous |
silent |
|
|
IGL03148:Nav1
|
APN |
1 |
135,397,762 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL03286:Nav1
|
APN |
1 |
135,382,274 (GRCm39) |
missense |
probably benign |
|
|
IGL03372:Nav1
|
APN |
1 |
135,378,641 (GRCm39) |
missense |
probably damaging |
0.99 |
|
PIT4802001:Nav1
|
UTSW |
1 |
135,380,671 (GRCm39) |
missense |
unknown |
|
|
R0388:Nav1
|
UTSW |
1 |
135,376,655 (GRCm39) |
splice site |
probably benign |
|
|
R0390:Nav1
|
UTSW |
1 |
135,377,704 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R0395:Nav1
|
UTSW |
1 |
135,460,361 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R0395:Nav1
|
UTSW |
1 |
135,460,359 (GRCm39) |
nonsense |
probably null |
|
|
R0416:Nav1
|
UTSW |
1 |
135,398,864 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R0463:Nav1
|
UTSW |
1 |
135,379,945 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R0538:Nav1
|
UTSW |
1 |
135,392,430 (GRCm39) |
splice site |
probably benign |
|
|
R0594:Nav1
|
UTSW |
1 |
135,395,381 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R0696:Nav1
|
UTSW |
1 |
135,460,352 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0699:Nav1
|
UTSW |
1 |
135,380,687 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0759:Nav1
|
UTSW |
1 |
135,382,998 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R1164:Nav1
|
UTSW |
1 |
135,400,148 (GRCm39) |
missense |
probably benign |
|
|
R1169:Nav1
|
UTSW |
1 |
135,382,943 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1401:Nav1
|
UTSW |
1 |
135,388,163 (GRCm39) |
missense |
probably benign |
0.20 |
|
R1421:Nav1
|
UTSW |
1 |
135,512,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1642:Nav1
|
UTSW |
1 |
135,380,010 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1705:Nav1
|
UTSW |
1 |
135,512,337 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1713:Nav1
|
UTSW |
1 |
135,522,972 (GRCm39) |
intron |
probably benign |
|
|
R1728:Nav1
|
UTSW |
1 |
135,512,465 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R1729:Nav1
|
UTSW |
1 |
135,512,465 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R1730:Nav1
|
UTSW |
1 |
135,512,465 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R1739:Nav1
|
UTSW |
1 |
135,512,465 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R1740:Nav1
|
UTSW |
1 |
135,386,127 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1762:Nav1
|
UTSW |
1 |
135,512,465 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R1783:Nav1
|
UTSW |
1 |
135,512,465 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R1784:Nav1
|
UTSW |
1 |
135,512,465 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R1785:Nav1
|
UTSW |
1 |
135,512,465 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R1895:Nav1
|
UTSW |
1 |
135,386,396 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1896:Nav1
|
UTSW |
1 |
135,388,475 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1901:Nav1
|
UTSW |
1 |
135,400,148 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1902:Nav1
|
UTSW |
1 |
135,400,148 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1925:Nav1
|
UTSW |
1 |
135,534,967 (GRCm39) |
utr 5 prime |
probably benign |
|
|
R1939:Nav1
|
UTSW |
1 |
135,393,636 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1971:Nav1
|
UTSW |
1 |
135,460,091 (GRCm39) |
missense |
probably benign |
0.06 |
|
R2063:Nav1
|
UTSW |
1 |
135,376,742 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2066:Nav1
|
UTSW |
1 |
135,376,742 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2084:Nav1
|
UTSW |
1 |
135,535,158 (GRCm39) |
unclassified |
probably benign |
|
|
R2090:Nav1
|
UTSW |
1 |
135,534,903 (GRCm39) |
utr 5 prime |
probably benign |
|
|
R2107:Nav1
|
UTSW |
1 |
135,376,742 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2110:Nav1
|
UTSW |
1 |
135,376,742 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2111:Nav1
|
UTSW |
1 |
135,376,742 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2112:Nav1
|
UTSW |
1 |
135,376,742 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2136:Nav1
|
UTSW |
1 |
135,382,174 (GRCm39) |
missense |
probably null |
0.18 |
|
R2268:Nav1
|
UTSW |
1 |
135,399,974 (GRCm39) |
nonsense |
probably null |
|
|
R2269:Nav1
|
UTSW |
1 |
135,399,974 (GRCm39) |
nonsense |
probably null |
|
|
R2847:Nav1
|
UTSW |
1 |
135,378,382 (GRCm39) |
splice site |
probably null |
|
|
R2869:Nav1
|
UTSW |
1 |
135,388,495 (GRCm39) |
synonymous |
silent |
|
|
R2871:Nav1
|
UTSW |
1 |
135,388,495 (GRCm39) |
synonymous |
silent |
|
|
R2872:Nav1
|
UTSW |
1 |
135,388,495 (GRCm39) |
synonymous |
silent |
|
|
R2904:Nav1
|
UTSW |
1 |
135,512,976 (GRCm39) |
missense |
probably benign |
|
|
R3690:Nav1
|
UTSW |
1 |
135,395,382 (GRCm39) |
missense |
probably benign |
0.11 |
|
R3716:Nav1
|
UTSW |
1 |
135,378,368 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3717:Nav1
|
UTSW |
1 |
135,378,368 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3718:Nav1
|
UTSW |
1 |
135,378,368 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3815:Nav1
|
UTSW |
1 |
135,398,862 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R4282:Nav1
|
UTSW |
1 |
135,385,651 (GRCm39) |
intron |
probably benign |
|
|
R4361:Nav1
|
UTSW |
1 |
135,535,175 (GRCm39) |
unclassified |
probably benign |
|
|
R4610:Nav1
|
UTSW |
1 |
135,520,186 (GRCm39) |
intron |
probably benign |
|
|
R4730:Nav1
|
UTSW |
1 |
135,535,049 (GRCm39) |
unclassified |
probably benign |
|
|
R4784:Nav1
|
UTSW |
1 |
135,386,477 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4788:Nav1
|
UTSW |
1 |
135,397,461 (GRCm39) |
missense |
probably benign |
|
|
R4808:Nav1
|
UTSW |
1 |
135,382,942 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4996:Nav1
|
UTSW |
1 |
135,393,709 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5284:Nav1
|
UTSW |
1 |
135,377,701 (GRCm39) |
nonsense |
probably null |
|
|
R5514:Nav1
|
UTSW |
1 |
135,398,299 (GRCm39) |
missense |
probably benign |
0.04 |
|
R5769:Nav1
|
UTSW |
1 |
135,379,995 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5834:Nav1
|
UTSW |
1 |
135,460,144 (GRCm39) |
missense |
probably benign |
0.07 |
|
R5898:Nav1
|
UTSW |
1 |
135,512,884 (GRCm39) |
missense |
probably benign |
|
|
R6081:Nav1
|
UTSW |
1 |
135,398,560 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6344:Nav1
|
UTSW |
1 |
135,378,534 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6378:Nav1
|
UTSW |
1 |
135,382,433 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7001:Nav1
|
UTSW |
1 |
135,382,349 (GRCm39) |
splice site |
probably null |
|
|
R7185:Nav1
|
UTSW |
1 |
135,398,746 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R7291:Nav1
|
UTSW |
1 |
135,393,597 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7361:Nav1
|
UTSW |
1 |
135,380,591 (GRCm39) |
missense |
unknown |
|
|
R7390:Nav1
|
UTSW |
1 |
135,512,656 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7502:Nav1
|
UTSW |
1 |
135,397,404 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7601:Nav1
|
UTSW |
1 |
135,388,176 (GRCm39) |
missense |
unknown |
|
|
R7625:Nav1
|
UTSW |
1 |
135,395,483 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7639:Nav1
|
UTSW |
1 |
135,398,860 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7786:Nav1
|
UTSW |
1 |
135,397,733 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7808:Nav1
|
UTSW |
1 |
135,379,986 (GRCm39) |
missense |
unknown |
|
|
R7815:Nav1
|
UTSW |
1 |
135,512,377 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R7825:Nav1
|
UTSW |
1 |
135,377,782 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8030:Nav1
|
UTSW |
1 |
135,464,977 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8370:Nav1
|
UTSW |
1 |
135,398,882 (GRCm39) |
nonsense |
probably null |
|
|
R8405:Nav1
|
UTSW |
1 |
135,382,508 (GRCm39) |
missense |
unknown |
|
|
R8720:Nav1
|
UTSW |
1 |
135,388,464 (GRCm39) |
missense |
unknown |
|
|
R8868:Nav1
|
UTSW |
1 |
135,512,943 (GRCm39) |
missense |
probably benign |
0.05 |
|
R8973:Nav1
|
UTSW |
1 |
135,512,463 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9039:Nav1
|
UTSW |
1 |
135,371,487 (GRCm39) |
missense |
unknown |
|
|
R9261:Nav1
|
UTSW |
1 |
135,388,095 (GRCm39) |
missense |
unknown |
|
|
R9523:Nav1
|
UTSW |
1 |
135,379,929 (GRCm39) |
missense |
unknown |
|
|
Z1088:Nav1
|
UTSW |
1 |
135,398,462 (GRCm39) |
missense |
probably benign |
0.01 |
|
Z1176:Nav1
|
UTSW |
1 |
135,400,158 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Nav1
|
UTSW |
1 |
135,380,624 (GRCm39) |
missense |
unknown |
|
|
Z1177:Nav1
|
UTSW |
1 |
135,397,469 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
| Predicted Primers |
PCR Primer
(F):5'- AGCAGTTCGTCATCCGATTTGC -3'
(R):5'- TGAAGGTCTTCAAGTCCGGC -3'
Sequencing Primer
(F):5'- GTCATCCGATTTGCCATCATCG -3'
(R):5'- TTCAAGTCCGGCAGCGTG -3'
|
| Posted On |
2019-10-07 |
Incidental Mutation