Mutagenetix > Incidental Mutation

Incidental Mutation 'R7465:Olfr670'

578708

Institutional Source

Beutler Lab

Gene Symbol

Olfr670

Ensembl Gene

ENSMUSG00000044705

Gene Name

olfactory receptor 670

Synonyms

MOR32-8, GA_x6K02T2PBJ9-7589577-7588639

MMRRC Submission

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.068) question?

Stock #

R7465 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

104957114-104962620 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 104959917 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Histidine at position 272 (Y272H)

Ref Sequence

ENSEMBL: ENSMUSP00000151138 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000050482] [ENSMUST00000214216]

AlphaFold

Q7TRP3

Predicted Effect

probably benign
Transcript: ENSMUST00000050482
AA Change: Y272H

PolyPhen 2 Score 0.232 (Sensitivity: 0.91; Specificity: 0.88)

SMART Domains

Protein: ENSMUSP00000060289
Gene: ENSMUSG00000044705
AA Change: Y272H

Domain	Start	End	E-Value	Type
Pfam:7tm_4	33	311	3.7e-121	PFAM
Pfam:7TM_GPCR_Srsx	37	211	4.5e-7	PFAM
Pfam:7tm_1	43	293	3.9e-17	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000214216
AA Change: Y272H

PolyPhen 2 Score 0.232 (Sensitivity: 0.91; Specificity: 0.88)

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.7%
20x: 99.0%

Validation Efficiency

100% (59/59)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 56 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Agtr1a	A	T	13: 30,381,981	D343V	probably benign	Het
Anks1	G	A	17: 28,054,323	R972Q	possibly damaging	Het
Atp2a2	T	C	5: 122,461,700	K543E	probably benign	Het
Atp8b5	G	A	4: 43,271,269	V4I	probably benign	Het
Bcar3	A	T	3: 122,523,230	N617Y	probably benign	Het
Blm	A	G	7: 80,513,115	S163P	probably benign	Het
Cbx3	A	G	6: 51,478,530	D87G	probably benign	Het
Celsr1	A	G	15: 86,033,392	S127P	probably benign	Het
Cndp1	A	T	18: 84,619,541	M356K	probably damaging	Het
Cnn2	G	A	10: 79,992,527	E113K	probably damaging	Het
Col17a1	T	A	19: 47,668,105	R573*	probably null	Het
Cttnbp2	T	A	6: 18,501,992	E49V	probably damaging	Het
Dynlrb2	T	A	8: 116,514,957	V80E	possibly damaging	Het
Ehbp1	A	G	11: 22,138,001	V386A	probably benign	Het
Elfn1	C	T	5: 139,972,087	P282L	probably benign	Het
Fam69a	T	C	5: 107,909,684	D336G	probably damaging	Het
Fan1	G	A	7: 64,353,638	T812I	probably benign	Het
Fan1	T	A	7: 64,372,486	N340Y	probably damaging	Het
Fat1	G	A	8: 45,044,152	V4225I	probably benign	Het
Frem1	A	G	4: 82,914,835	C1873R	probably benign	Het
Fsd1l	T	C	4: 53,647,755	I66T	probably benign	Het
Gabrr1	C	A	4: 33,146,970	D52E	probably benign	Het
Il18rap	T	C	1: 40,543,089	L390P	probably damaging	Het
Il27ra	T	A	8: 84,039,612	D181V	probably benign	Het
Irgq	C	A	7: 24,534,409	H558Q	probably damaging	Het
Itsn2	C	T	12: 4,706,983	Q1358*	probably null	Het
Kmt2c	C	T	5: 25,302,849	G3197S	probably damaging	Het
Lrrk2	A	G	15: 91,767,340	Y1733C	probably damaging	Het
Mapk7	G	A	11: 61,490,453	A510V	probably damaging	Het
Mtch1	A	T	17: 29,332,724	C385S	probably benign	Het
Nfib	A	G	4: 82,353,521		probably null	Het
Nostrin	C	T	2: 69,185,507	T448M	possibly damaging	Het
Olfr1066	A	G	2: 86,455,806	V155A	probably benign	Het
Olfr1255	T	C	2: 89,816,536	L64P	probably damaging	Het
Olfr1436	T	C	19: 12,298,437	I232V	probably benign	Het
Olfr1441	T	A	19: 12,423,145	Y279N	probably damaging	Het
Olfr533	T	A	7: 140,466,798	V199D	probably damaging	Het
Pcdha2	T	C	18: 36,940,330	V338A	probably damaging	Het
Pcdhgc3	A	G	18: 37,807,745	T400A	probably benign	Het
Piezo2	C	T	18: 63,012,723	S2710N	probably benign	Het
Ppp4r1	T	A	17: 65,831,020	Y591*	probably null	Het
Ptpn18	G	A	1: 34,473,364	D417N	possibly damaging	Het
Rab42	T	C	4: 132,302,614	E99G	possibly damaging	Het
Rd3l	A	T	12: 111,979,482	W188R	probably damaging	Het
Sap30bp	A	G	11: 115,951,968	D89G	probably benign	Het
Sptbn4	T	C	7: 27,366,689	T1985A	probably benign	Het
Tec	T	C	5: 72,773,880	Y247C	probably damaging	Het
Tek	G	A	4: 94,827,826		probably null	Het
Tex14	T	C	11: 87,514,430	S723P	possibly damaging	Het
Thumpd3	T	A	6: 113,047,631	L62Q	probably damaging	Het
Tlr12	A	T	4: 128,616,170	D762E	probably damaging	Het
Tmem94	G	T	11: 115,786,256	R118L	possibly damaging	Het
Txndc16	T	A	14: 45,165,388	I316F	probably damaging	Het
Vamp1	T	C	6: 125,218,575	S2P	unknown	Het
Vmn1r211	T	A	13: 22,851,916	M194L	probably benign	Het
Zfp874a	T	A	13: 67,442,257	Q436L	probably damaging	Het

Other mutations in Olfr670

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00978:Olfr670	APN	7	104960716	missense	probably damaging	0.96
IGL01100:Olfr670	APN	7	104959995	missense	probably benign	0.07
IGL01351:Olfr670	APN	7	104960739	start gained	probably benign
IGL01478:Olfr670	APN	7	104960348	missense	probably damaging	0.97
IGL01835:Olfr670	APN	7	104960462	missense	probably benign	0.01
IGL02326:Olfr670	APN	7	104960646	missense	probably benign	0.12
IGL02434:Olfr670	APN	7	104960072	missense	probably benign	0.05
IGL02434:Olfr670	APN	7	104960074	nonsense	probably null
IGL02968:Olfr670	APN	7	104960244	missense	possibly damaging	0.90
R0055:Olfr670	UTSW	7	104960496	missense	possibly damaging	0.46
R0055:Olfr670	UTSW	7	104960496	missense	possibly damaging	0.46
R0345:Olfr670	UTSW	7	104960181	missense	probably damaging	1.00
R0401:Olfr670	UTSW	7	104959943	missense	probably damaging	1.00
R0646:Olfr670	UTSW	7	104959811	missense	probably benign	0.02
R1493:Olfr670	UTSW	7	104960502	missense	probably damaging	0.97
R1532:Olfr670	UTSW	7	104960265	missense	probably benign
R1557:Olfr670	UTSW	7	104960540	missense	probably damaging	0.99
R4072:Olfr670	UTSW	7	104960716	missense	probably damaging	0.96
R4074:Olfr670	UTSW	7	104960716	missense	probably damaging	0.96
R4075:Olfr670	UTSW	7	104960716	missense	probably damaging	0.96
R4076:Olfr670	UTSW	7	104960716	missense	probably damaging	0.96
R4229:Olfr670	UTSW	7	104960594	missense	probably benign	0.18
R4230:Olfr670	UTSW	7	104960594	missense	probably benign	0.18
R5374:Olfr670	UTSW	7	104959996	missense	probably damaging	1.00
R6006:Olfr670	UTSW	7	104960663	missense	probably damaging	0.99
R6891:Olfr670	UTSW	7	104959985	missense	probably damaging	1.00
R8105:Olfr670	UTSW	7	104960422	missense	probably benign	0.15
R8117:Olfr670	UTSW	7	104960149	missense	probably damaging	1.00
R8356:Olfr670	UTSW	7	104960727	missense	probably benign	0.00
R8510:Olfr670	UTSW	7	104960114	nonsense	probably null
R9145:Olfr670	UTSW	7	104959997	missense	probably damaging	1.00
R9168:Olfr670	UTSW	7	104959794	makesense	probably null
R9234:Olfr670	UTSW	7	104960444	missense	probably damaging	1.00
R9706:Olfr670	UTSW	7	104959988	missense	probably damaging	0.99
R9789:Olfr670	UTSW	7	104960450	missense	probably damaging	0.97

Predicted Primers

PCR Primer
(F):5'- GTAGACAAATACAATCTTTTCTCCCC -3'
(R):5'- ACATGGGGATTGCTCGTCTG -3'

Sequencing Primer
(F):5'- TTTTCTCCCCCAAAGGAAGATG -3'
(R):5'- ACTTATATCAATGGTGCTTGCCG -3'

Posted On

2019-10-07