Incidental Mutation 'R7466:Dennd4c'
| ID |
578756 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Dennd4c
|
| Ensembl Gene |
ENSMUSG00000038024 |
| Gene Name |
DENN domain containing 4C |
| Synonyms |
1700065A05Rik |
| MMRRC Submission |
045540-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R7466 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
4 |
| Chromosomal Location |
86666792-86768840 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 86692568 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Glycine
at position 26
(D26G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000123367
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000045512]
[ENSMUST00000082026]
[ENSMUST00000142837]
|
| AlphaFold |
A6H8H2 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000045512
AA Change: D26G
PolyPhen 2
Score 0.703 (Sensitivity: 0.86; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000039860
Gene: ENSMUSG00000038024
AA Change: D26G
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
43 |
91 |
2.15e-5 |
PROSPERO |
|
uDENN
|
168 |
275 |
3.96e-24 |
SMART |
|
DENN
|
307 |
491 |
7.16e-72 |
SMART |
|
dDENN
|
557 |
631 |
1.85e-24 |
SMART |
|
low complexity region
|
983 |
1001 |
N/A |
INTRINSIC |
|
low complexity region
|
1013 |
1025 |
N/A |
INTRINSIC |
|
low complexity region
|
1045 |
1052 |
N/A |
INTRINSIC |
|
low complexity region
|
1102 |
1113 |
N/A |
INTRINSIC |
|
low complexity region
|
1175 |
1186 |
N/A |
INTRINSIC |
|
low complexity region
|
1377 |
1392 |
N/A |
INTRINSIC |
|
low complexity region
|
1472 |
1486 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000082026
AA Change: D26G
PolyPhen 2
Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000080685
Gene: ENSMUSG00000038024
AA Change: D26G
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
43 |
91 |
3.19e-5 |
PROSPERO |
|
uDENN
|
168 |
275 |
3.96e-24 |
SMART |
|
DENN
|
307 |
491 |
7.16e-72 |
SMART |
|
dDENN
|
557 |
631 |
1.85e-24 |
SMART |
|
low complexity region
|
983 |
1001 |
N/A |
INTRINSIC |
|
low complexity region
|
1013 |
1025 |
N/A |
INTRINSIC |
|
low complexity region
|
1045 |
1052 |
N/A |
INTRINSIC |
|
low complexity region
|
1102 |
1113 |
N/A |
INTRINSIC |
|
low complexity region
|
1175 |
1186 |
N/A |
INTRINSIC |
|
low complexity region
|
1377 |
1392 |
N/A |
INTRINSIC |
|
low complexity region
|
1472 |
1486 |
N/A |
INTRINSIC |
|
low complexity region
|
1724 |
1739 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000142837
AA Change: D26G
PolyPhen 2
Score 0.988 (Sensitivity: 0.73; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000123367
Gene: ENSMUSG00000038024
AA Change: D26G
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
43 |
91 |
2.68e-5 |
PROSPERO |
|
uDENN
|
168 |
275 |
3.96e-24 |
SMART |
|
DENN
|
307 |
491 |
7.16e-72 |
SMART |
|
dDENN
|
557 |
631 |
1.85e-24 |
SMART |
|
low complexity region
|
934 |
952 |
N/A |
INTRINSIC |
|
low complexity region
|
964 |
976 |
N/A |
INTRINSIC |
|
low complexity region
|
996 |
1003 |
N/A |
INTRINSIC |
|
low complexity region
|
1053 |
1064 |
N/A |
INTRINSIC |
|
low complexity region
|
1126 |
1137 |
N/A |
INTRINSIC |
|
low complexity region
|
1328 |
1343 |
N/A |
INTRINSIC |
|
low complexity region
|
1423 |
1437 |
N/A |
INTRINSIC |
|
low complexity region
|
1675 |
1690 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.2%
|
| Validation Efficiency |
99% (83/84) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 83 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| AI182371 |
T |
A |
2: 34,978,753 (GRCm39) |
K203* |
probably null |
Het |
| Akr1c13 |
T |
C |
13: 4,242,436 (GRCm39) |
|
probably benign |
Het |
| Amer3 |
A |
G |
1: 34,627,074 (GRCm39) |
S438G |
probably damaging |
Het |
| Aqp9 |
T |
A |
9: 71,070,543 (GRCm39) |
|
probably null |
Het |
| Art4 |
G |
T |
6: 136,831,848 (GRCm39) |
H98N |
probably damaging |
Het |
| Bdh1 |
T |
C |
16: 31,266,422 (GRCm39) |
S70P |
probably benign |
Het |
| Ccdc61 |
A |
C |
7: 18,625,030 (GRCm39) |
Y503D |
probably damaging |
Het |
| Cd180 |
A |
T |
13: 102,841,503 (GRCm39) |
N183I |
probably damaging |
Het |
| Cd200r2 |
C |
T |
16: 44,729,537 (GRCm39) |
A64V |
probably damaging |
Het |
| Ceacam9 |
A |
C |
7: 16,457,780 (GRCm39) |
K98Q |
probably benign |
Het |
| Cep44 |
AACGC |
A |
8: 56,994,018 (GRCm39) |
|
probably null |
Het |
| Cfap77 |
G |
T |
2: 28,845,625 (GRCm39) |
D247E |
probably benign |
Het |
| Cftr |
T |
C |
6: 18,227,972 (GRCm39) |
M388T |
probably benign |
Het |
| Chrnb1 |
G |
A |
11: 69,675,476 (GRCm39) |
H493Y |
probably damaging |
Het |
| Ckap2 |
A |
C |
8: 22,667,402 (GRCm39) |
M153R |
probably benign |
Het |
| Cnot6l |
A |
G |
5: 96,278,987 (GRCm39) |
V77A |
probably benign |
Het |
| Col12a1 |
C |
T |
9: 79,562,689 (GRCm39) |
E1798K |
possibly damaging |
Het |
| Cth |
T |
A |
3: 157,630,522 (GRCm39) |
D49V |
probably benign |
Het |
| Ctnnb1 |
T |
C |
9: 120,784,482 (GRCm39) |
S425P |
probably damaging |
Het |
| Ctnnd1 |
T |
C |
2: 84,441,129 (GRCm39) |
N690S |
probably benign |
Het |
| Dennd2b |
A |
G |
7: 109,124,553 (GRCm39) |
L1096P |
probably damaging |
Het |
| Dlg5 |
G |
A |
14: 24,295,280 (GRCm39) |
P80L |
probably damaging |
Het |
| Dnai3 |
T |
C |
3: 145,761,373 (GRCm39) |
D661G |
probably benign |
Het |
| Eef2k |
A |
G |
7: 120,502,707 (GRCm39) |
|
probably null |
Het |
| Ephb2 |
C |
T |
4: 136,386,376 (GRCm39) |
R791H |
probably damaging |
Het |
| Erh |
T |
C |
12: 80,687,757 (GRCm39) |
Y22C |
probably benign |
Het |
| F5 |
C |
T |
1: 164,020,897 (GRCm39) |
T1124I |
possibly damaging |
Het |
| Fam220a |
T |
A |
5: 143,549,226 (GRCm39) |
C213S |
possibly damaging |
Het |
| Fat2 |
G |
T |
11: 55,201,258 (GRCm39) |
N605K |
probably damaging |
Het |
| Ganab |
C |
A |
19: 8,891,933 (GRCm39) |
S780* |
probably null |
Het |
| Gbgt1 |
C |
T |
2: 28,392,219 (GRCm39) |
P67S |
probably damaging |
Het |
| Gm17190 |
G |
T |
13: 96,219,287 (GRCm39) |
G208* |
probably null |
Het |
| Grhl2 |
A |
G |
15: 37,291,860 (GRCm39) |
Y316C |
probably damaging |
Het |
| H2-T10 |
T |
C |
17: 36,431,741 (GRCm39) |
T38A |
probably benign |
Het |
| Ins1 |
A |
G |
19: 52,252,858 (GRCm39) |
|
probably benign |
Het |
| Ippk |
T |
C |
13: 49,585,943 (GRCm39) |
|
probably null |
Het |
| Klc4 |
T |
A |
17: 46,950,836 (GRCm39) |
I258F |
probably benign |
Het |
| Manba |
C |
A |
3: 135,248,154 (GRCm39) |
L348I |
probably benign |
Het |
| Mgam |
A |
G |
6: 40,721,723 (GRCm39) |
N347S |
probably benign |
Het |
| Myo18b |
T |
C |
5: 112,871,758 (GRCm39) |
T2108A |
probably benign |
Het |
| Naip5 |
A |
T |
13: 100,358,494 (GRCm39) |
L914* |
probably null |
Het |
| Nsa2 |
C |
T |
13: 97,267,728 (GRCm39) |
A242T |
probably benign |
Het |
| Nsd2 |
G |
A |
5: 34,039,491 (GRCm39) |
W834* |
probably null |
Het |
| Or10q3 |
T |
A |
19: 11,847,680 (GRCm39) |
D300V |
possibly damaging |
Het |
| Or5p50 |
A |
T |
7: 107,422,129 (GRCm39) |
C182* |
probably null |
Het |
| Or5w1 |
T |
C |
2: 87,486,740 (GRCm39) |
N175S |
possibly damaging |
Het |
| Or8s16 |
T |
C |
15: 98,211,261 (GRCm39) |
M57V |
probably damaging |
Het |
| Pam |
A |
T |
1: 97,769,972 (GRCm39) |
D599E |
probably damaging |
Het |
| Phf20l1 |
A |
G |
15: 66,508,733 (GRCm39) |
K864R |
probably damaging |
Het |
| Pip4p2 |
T |
A |
4: 14,912,477 (GRCm39) |
Y195* |
probably null |
Het |
| Plcl2 |
A |
G |
17: 50,915,496 (GRCm39) |
D835G |
probably damaging |
Het |
| Ppm1m |
C |
A |
9: 106,073,356 (GRCm39) |
A329S |
probably damaging |
Het |
| Prep |
T |
C |
10: 45,026,534 (GRCm39) |
V486A |
probably benign |
Het |
| Prkcb |
A |
T |
7: 122,116,067 (GRCm39) |
N182I |
probably damaging |
Het |
| Prkcz |
A |
G |
4: 155,356,059 (GRCm39) |
F355S |
probably damaging |
Het |
| Psg20 |
C |
T |
7: 18,418,392 (GRCm39) |
S125N |
probably benign |
Het |
| Psmd12 |
A |
G |
11: 107,382,883 (GRCm39) |
D234G |
probably benign |
Het |
| Pvrig-ps |
A |
T |
5: 138,340,270 (GRCm39) |
M14L |
probably benign |
Het |
| Rabgap1l |
C |
T |
1: 160,054,054 (GRCm39) |
|
probably null |
Het |
| Rfc1 |
A |
T |
5: 65,432,769 (GRCm39) |
C764S |
probably damaging |
Het |
| Ryr3 |
T |
C |
2: 112,757,302 (GRCm39) |
D351G |
probably benign |
Het |
| Scart1 |
T |
C |
7: 139,800,619 (GRCm39) |
|
probably null |
Het |
| Serpinb9g |
T |
C |
13: 33,679,150 (GRCm39) |
F340S |
probably benign |
Het |
| Sirpb1c |
C |
A |
3: 15,886,430 (GRCm39) |
L315F |
probably damaging |
Het |
| Slc24a1 |
C |
G |
9: 64,835,686 (GRCm39) |
E814Q |
unknown |
Het |
| Slc26a11 |
A |
T |
11: 119,265,328 (GRCm39) |
Q355L |
probably damaging |
Het |
| Sp100 |
C |
T |
1: 85,634,960 (GRCm39) |
L483F |
possibly damaging |
Het |
| Ston1 |
T |
A |
17: 88,943,329 (GRCm39) |
M245K |
probably benign |
Het |
| Swap70 |
T |
A |
7: 109,873,979 (GRCm39) |
D442E |
probably benign |
Het |
| Syne2 |
T |
A |
12: 76,092,960 (GRCm39) |
V450D |
possibly damaging |
Het |
| Tbck |
T |
A |
3: 132,458,324 (GRCm39) |
N651K |
probably damaging |
Het |
| Timd4 |
A |
T |
11: 46,708,585 (GRCm39) |
T204S |
probably benign |
Het |
| Tmem102 |
A |
G |
11: 69,695,711 (GRCm39) |
L87P |
probably damaging |
Het |
| Tmprss11e |
T |
A |
5: 86,857,339 (GRCm39) |
T325S |
probably benign |
Het |
| Trpm1 |
G |
A |
7: 63,890,330 (GRCm39) |
V978M |
probably damaging |
Het |
| Wdr12 |
A |
T |
1: 60,133,670 (GRCm39) |
D19E |
probably benign |
Het |
| Wdr35 |
G |
A |
12: 9,055,773 (GRCm39) |
V482I |
probably benign |
Het |
| Zer1 |
T |
C |
2: 29,991,496 (GRCm39) |
|
probably null |
Het |
| Zfp503 |
T |
C |
14: 22,036,079 (GRCm39) |
D279G |
probably benign |
Het |
| Zfp870 |
A |
T |
17: 33,102,736 (GRCm39) |
C198S |
possibly damaging |
Het |
| Zftraf1 |
C |
T |
15: 76,532,386 (GRCm39) |
D241N |
probably benign |
Het |
| Zfyve26 |
C |
T |
12: 79,334,581 (GRCm39) |
E146K |
probably benign |
Het |
| Zkscan6 |
T |
C |
11: 65,719,357 (GRCm39) |
V459A |
probably damaging |
Het |
|
| Other mutations in Dennd4c |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01309:Dennd4c
|
APN |
4 |
86,723,724 (GRCm39) |
splice site |
probably benign |
|
|
IGL01810:Dennd4c
|
APN |
4 |
86,717,788 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL02203:Dennd4c
|
APN |
4 |
86,721,173 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02217:Dennd4c
|
APN |
4 |
86,732,036 (GRCm39) |
missense |
probably benign |
|
|
IGL02236:Dennd4c
|
APN |
4 |
86,725,672 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
IGL02256:Dennd4c
|
APN |
4 |
86,717,778 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02396:Dennd4c
|
APN |
4 |
86,743,237 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02523:Dennd4c
|
APN |
4 |
86,692,490 (GRCm39) |
unclassified |
probably benign |
|
|
IGL02615:Dennd4c
|
APN |
4 |
86,739,704 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03069:Dennd4c
|
APN |
4 |
86,692,674 (GRCm39) |
nonsense |
probably null |
|
|
IGL03116:Dennd4c
|
APN |
4 |
86,707,057 (GRCm39) |
splice site |
probably benign |
|
|
IGL03117:Dennd4c
|
APN |
4 |
86,696,140 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL03273:Dennd4c
|
APN |
4 |
86,696,033 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03329:Dennd4c
|
APN |
4 |
86,696,113 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03365:Dennd4c
|
APN |
4 |
86,725,663 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
PIT4486001:Dennd4c
|
UTSW |
4 |
86,717,701 (GRCm39) |
nonsense |
probably null |
|
|
R0010:Dennd4c
|
UTSW |
4 |
86,699,814 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0032:Dennd4c
|
UTSW |
4 |
86,746,387 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0032:Dennd4c
|
UTSW |
4 |
86,746,387 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0092:Dennd4c
|
UTSW |
4 |
86,699,844 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0103:Dennd4c
|
UTSW |
4 |
86,730,683 (GRCm39) |
missense |
probably benign |
0.07 |
|
R0103:Dennd4c
|
UTSW |
4 |
86,730,683 (GRCm39) |
missense |
probably benign |
0.07 |
|
R0511:Dennd4c
|
UTSW |
4 |
86,744,259 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0515:Dennd4c
|
UTSW |
4 |
86,731,703 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R0578:Dennd4c
|
UTSW |
4 |
86,730,659 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0759:Dennd4c
|
UTSW |
4 |
86,707,066 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0784:Dennd4c
|
UTSW |
4 |
86,763,145 (GRCm39) |
missense |
probably benign |
0.37 |
|
R1156:Dennd4c
|
UTSW |
4 |
86,725,703 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1370:Dennd4c
|
UTSW |
4 |
86,729,747 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1381:Dennd4c
|
UTSW |
4 |
86,692,769 (GRCm39) |
missense |
probably benign |
0.24 |
|
R1569:Dennd4c
|
UTSW |
4 |
86,704,331 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R1747:Dennd4c
|
UTSW |
4 |
86,725,675 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1764:Dennd4c
|
UTSW |
4 |
86,721,247 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1838:Dennd4c
|
UTSW |
4 |
86,743,415 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1997:Dennd4c
|
UTSW |
4 |
86,755,634 (GRCm39) |
missense |
probably benign |
|
|
R2244:Dennd4c
|
UTSW |
4 |
86,692,780 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2348:Dennd4c
|
UTSW |
4 |
86,729,764 (GRCm39) |
missense |
probably benign |
0.04 |
|
R2968:Dennd4c
|
UTSW |
4 |
86,699,881 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R3033:Dennd4c
|
UTSW |
4 |
86,743,557 (GRCm39) |
small deletion |
probably benign |
|
|
R3401:Dennd4c
|
UTSW |
4 |
86,692,780 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3402:Dennd4c
|
UTSW |
4 |
86,692,780 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3403:Dennd4c
|
UTSW |
4 |
86,692,780 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3855:Dennd4c
|
UTSW |
4 |
86,698,084 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3939:Dennd4c
|
UTSW |
4 |
86,692,517 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4164:Dennd4c
|
UTSW |
4 |
86,725,764 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4384:Dennd4c
|
UTSW |
4 |
86,729,687 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4435:Dennd4c
|
UTSW |
4 |
86,716,312 (GRCm39) |
missense |
probably benign |
0.44 |
|
R4788:Dennd4c
|
UTSW |
4 |
86,738,200 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4801:Dennd4c
|
UTSW |
4 |
86,738,121 (GRCm39) |
nonsense |
probably null |
|
|
R4802:Dennd4c
|
UTSW |
4 |
86,738,121 (GRCm39) |
nonsense |
probably null |
|
|
R4818:Dennd4c
|
UTSW |
4 |
86,743,511 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4923:Dennd4c
|
UTSW |
4 |
86,725,775 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4958:Dennd4c
|
UTSW |
4 |
86,699,916 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5025:Dennd4c
|
UTSW |
4 |
86,713,536 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5434:Dennd4c
|
UTSW |
4 |
86,729,693 (GRCm39) |
missense |
probably benign |
0.10 |
|
R5662:Dennd4c
|
UTSW |
4 |
86,713,525 (GRCm39) |
missense |
probably benign |
0.13 |
|
R5802:Dennd4c
|
UTSW |
4 |
86,729,690 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5849:Dennd4c
|
UTSW |
4 |
86,744,223 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R5861:Dennd4c
|
UTSW |
4 |
86,709,589 (GRCm39) |
missense |
probably benign |
0.30 |
|
R5970:Dennd4c
|
UTSW |
4 |
86,743,749 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6163:Dennd4c
|
UTSW |
4 |
86,723,828 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R6356:Dennd4c
|
UTSW |
4 |
86,743,686 (GRCm39) |
missense |
probably benign |
|
|
R6661:Dennd4c
|
UTSW |
4 |
86,717,626 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R6855:Dennd4c
|
UTSW |
4 |
86,754,694 (GRCm39) |
missense |
probably benign |
|
|
R6983:Dennd4c
|
UTSW |
4 |
86,717,730 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7035:Dennd4c
|
UTSW |
4 |
86,730,574 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7126:Dennd4c
|
UTSW |
4 |
86,725,667 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7185:Dennd4c
|
UTSW |
4 |
86,729,687 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7212:Dennd4c
|
UTSW |
4 |
86,721,228 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7324:Dennd4c
|
UTSW |
4 |
86,747,975 (GRCm39) |
missense |
unknown |
|
|
R7329:Dennd4c
|
UTSW |
4 |
86,759,318 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7329:Dennd4c
|
UTSW |
4 |
86,698,111 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R7479:Dennd4c
|
UTSW |
4 |
86,717,590 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7538:Dennd4c
|
UTSW |
4 |
86,692,753 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7599:Dennd4c
|
UTSW |
4 |
86,729,849 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7688:Dennd4c
|
UTSW |
4 |
86,713,377 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7725:Dennd4c
|
UTSW |
4 |
86,704,330 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7751:Dennd4c
|
UTSW |
4 |
86,747,179 (GRCm39) |
missense |
probably benign |
0.05 |
|
R7790:Dennd4c
|
UTSW |
4 |
86,717,754 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8056:Dennd4c
|
UTSW |
4 |
86,763,213 (GRCm39) |
missense |
probably null |
0.71 |
|
R8307:Dennd4c
|
UTSW |
4 |
86,744,109 (GRCm39) |
missense |
probably benign |
0.12 |
|
R8494:Dennd4c
|
UTSW |
4 |
86,759,312 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8531:Dennd4c
|
UTSW |
4 |
86,744,319 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9014:Dennd4c
|
UTSW |
4 |
86,754,666 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9014:Dennd4c
|
UTSW |
4 |
86,739,702 (GRCm39) |
missense |
probably benign |
0.07 |
|
R9017:Dennd4c
|
UTSW |
4 |
86,743,349 (GRCm39) |
missense |
probably benign |
0.33 |
|
R9142:Dennd4c
|
UTSW |
4 |
86,755,637 (GRCm39) |
missense |
probably benign |
0.32 |
|
R9224:Dennd4c
|
UTSW |
4 |
86,738,170 (GRCm39) |
nonsense |
probably null |
|
|
R9570:Dennd4c
|
UTSW |
4 |
86,747,208 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R9644:Dennd4c
|
UTSW |
4 |
86,713,363 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9649:Dennd4c
|
UTSW |
4 |
86,743,160 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9658:Dennd4c
|
UTSW |
4 |
86,754,625 (GRCm39) |
nonsense |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- GTGGTACCTGATTATTCCTAACTCAAG -3'
(R):5'- TGTAAGGGGCGGCTTATCTCTC -3'
Sequencing Primer
(F):5'- CTCAAGAATGTCTTCATCTTGATCAG -3'
(R):5'- CTGTAGCACAGGAAAAGCTCTG -3'
|
| Posted On |
2019-10-07 |
Incidental Mutation