Incidental Mutation 'R7466:Dennd4c'
| ID |
578756 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Dennd4c
|
| Ensembl Gene |
ENSMUSG00000038024 |
| Gene Name |
DENN/MADD domain containing 4C |
| Synonyms |
1700065A05Rik |
| MMRRC Submission |
045540-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R7466 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
4 |
| Chromosomal Location |
86748555-86850603 bp(+) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 86774331 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Glycine
at position 26
(D26G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000123367
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000045512]
[ENSMUST00000082026]
[ENSMUST00000142837]
|
| AlphaFold |
A6H8H2 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000045512
AA Change: D26G
PolyPhen 2
Score 0.703 (Sensitivity: 0.86; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000039860
Gene: ENSMUSG00000038024
AA Change: D26G
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
43 |
91 |
2.15e-5 |
PROSPERO |
|
uDENN
|
168 |
275 |
3.96e-24 |
SMART |
|
DENN
|
307 |
491 |
7.16e-72 |
SMART |
|
dDENN
|
557 |
631 |
1.85e-24 |
SMART |
|
low complexity region
|
983 |
1001 |
N/A |
INTRINSIC |
|
low complexity region
|
1013 |
1025 |
N/A |
INTRINSIC |
|
low complexity region
|
1045 |
1052 |
N/A |
INTRINSIC |
|
low complexity region
|
1102 |
1113 |
N/A |
INTRINSIC |
|
low complexity region
|
1175 |
1186 |
N/A |
INTRINSIC |
|
low complexity region
|
1377 |
1392 |
N/A |
INTRINSIC |
|
low complexity region
|
1472 |
1486 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000082026
AA Change: D26G
PolyPhen 2
Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000080685
Gene: ENSMUSG00000038024
AA Change: D26G
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
43 |
91 |
3.19e-5 |
PROSPERO |
|
uDENN
|
168 |
275 |
3.96e-24 |
SMART |
|
DENN
|
307 |
491 |
7.16e-72 |
SMART |
|
dDENN
|
557 |
631 |
1.85e-24 |
SMART |
|
low complexity region
|
983 |
1001 |
N/A |
INTRINSIC |
|
low complexity region
|
1013 |
1025 |
N/A |
INTRINSIC |
|
low complexity region
|
1045 |
1052 |
N/A |
INTRINSIC |
|
low complexity region
|
1102 |
1113 |
N/A |
INTRINSIC |
|
low complexity region
|
1175 |
1186 |
N/A |
INTRINSIC |
|
low complexity region
|
1377 |
1392 |
N/A |
INTRINSIC |
|
low complexity region
|
1472 |
1486 |
N/A |
INTRINSIC |
|
low complexity region
|
1724 |
1739 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000142837
AA Change: D26G
PolyPhen 2
Score 0.988 (Sensitivity: 0.73; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000123367
Gene: ENSMUSG00000038024
AA Change: D26G
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
43 |
91 |
2.68e-5 |
PROSPERO |
|
uDENN
|
168 |
275 |
3.96e-24 |
SMART |
|
DENN
|
307 |
491 |
7.16e-72 |
SMART |
|
dDENN
|
557 |
631 |
1.85e-24 |
SMART |
|
low complexity region
|
934 |
952 |
N/A |
INTRINSIC |
|
low complexity region
|
964 |
976 |
N/A |
INTRINSIC |
|
low complexity region
|
996 |
1003 |
N/A |
INTRINSIC |
|
low complexity region
|
1053 |
1064 |
N/A |
INTRINSIC |
|
low complexity region
|
1126 |
1137 |
N/A |
INTRINSIC |
|
low complexity region
|
1328 |
1343 |
N/A |
INTRINSIC |
|
low complexity region
|
1423 |
1437 |
N/A |
INTRINSIC |
|
low complexity region
|
1675 |
1690 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.2%
|
| Validation Efficiency |
99% (83/84) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 83 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| AI182371 |
T |
A |
2: 35,088,741 (GRCm38) |
K203* |
probably null |
Het |
| Akr1c13 |
T |
C |
13: 4,192,437 (GRCm38) |
|
probably benign |
Het |
| Amer3 |
A |
G |
1: 34,587,993 (GRCm38) |
S438G |
probably damaging |
Het |
| Aqp9 |
T |
A |
9: 71,163,261 (GRCm38) |
|
probably null |
Het |
| Art4 |
G |
T |
6: 136,854,850 (GRCm38) |
H98N |
probably damaging |
Het |
| Bdh1 |
T |
C |
16: 31,447,604 (GRCm38) |
S70P |
probably benign |
Het |
| Ccdc61 |
A |
C |
7: 18,891,105 (GRCm38) |
Y503D |
probably damaging |
Het |
| Cd163l1 |
T |
C |
7: 140,220,706 (GRCm38) |
|
probably null |
Het |
| Cd180 |
A |
T |
13: 102,704,995 (GRCm38) |
N183I |
probably damaging |
Het |
| Cd200r2 |
C |
T |
16: 44,909,174 (GRCm38) |
A64V |
probably damaging |
Het |
| Ceacam9 |
A |
C |
7: 16,723,855 (GRCm38) |
K98Q |
probably benign |
Het |
| Cep44 |
AACGC |
A |
8: 56,540,983 (GRCm38) |
|
probably null |
Het |
| Cfap77 |
G |
T |
2: 28,955,613 (GRCm38) |
D247E |
probably benign |
Het |
| Cftr |
T |
C |
6: 18,227,973 (GRCm38) |
M388T |
probably benign |
Het |
| Chrnb1 |
G |
A |
11: 69,784,650 (GRCm38) |
H493Y |
probably damaging |
Het |
| Ckap2 |
A |
C |
8: 22,177,386 (GRCm38) |
M153R |
probably benign |
Het |
| Cnot6l |
A |
G |
5: 96,131,128 (GRCm38) |
V77A |
probably benign |
Het |
| Col12a1 |
C |
T |
9: 79,655,407 (GRCm38) |
E1798K |
possibly damaging |
Het |
| Cth |
T |
A |
3: 157,924,885 (GRCm38) |
D49V |
probably benign |
Het |
| Ctnnb1 |
T |
C |
9: 120,955,416 (GRCm38) |
S425P |
probably damaging |
Het |
| Ctnnd1 |
T |
C |
2: 84,610,785 (GRCm38) |
N690S |
probably benign |
Het |
| Cyhr1 |
C |
T |
15: 76,648,186 (GRCm38) |
D241N |
probably benign |
Het |
| Dlg5 |
G |
A |
14: 24,245,212 (GRCm38) |
P80L |
probably damaging |
Het |
| Eef2k |
A |
G |
7: 120,903,484 (GRCm38) |
|
probably null |
Het |
| Ephb2 |
C |
T |
4: 136,659,065 (GRCm38) |
R791H |
probably damaging |
Het |
| Erh |
T |
C |
12: 80,640,983 (GRCm38) |
Y22C |
probably benign |
Het |
| F5 |
C |
T |
1: 164,193,328 (GRCm38) |
T1124I |
possibly damaging |
Het |
| Fam220a |
T |
A |
5: 143,563,471 (GRCm38) |
C213S |
possibly damaging |
Het |
| Fat2 |
G |
T |
11: 55,310,432 (GRCm38) |
N605K |
probably damaging |
Het |
| Ganab |
C |
A |
19: 8,914,569 (GRCm38) |
S780* |
probably null |
Het |
| Gbgt1 |
C |
T |
2: 28,502,207 (GRCm38) |
P67S |
probably damaging |
Het |
| Gm17190 |
G |
T |
13: 96,082,779 (GRCm38) |
G208* |
probably null |
Het |
| Grhl2 |
A |
G |
15: 37,291,616 (GRCm38) |
Y316C |
probably damaging |
Het |
| H2-T10 |
T |
C |
17: 36,120,849 (GRCm38) |
T38A |
probably benign |
Het |
| Ins1 |
A |
G |
19: 52,264,420 (GRCm38) |
|
probably benign |
Het |
| Ippk |
T |
C |
13: 49,432,467 (GRCm38) |
|
probably null |
Het |
| Klc4 |
T |
A |
17: 46,639,910 (GRCm38) |
I258F |
probably benign |
Het |
| Manba |
C |
A |
3: 135,542,393 (GRCm38) |
L348I |
probably benign |
Het |
| Mgam |
A |
G |
6: 40,744,789 (GRCm38) |
N347S |
probably benign |
Het |
| Myo18b |
T |
C |
5: 112,723,892 (GRCm38) |
T2108A |
probably benign |
Het |
| Naip5 |
A |
T |
13: 100,221,986 (GRCm38) |
L914* |
probably null |
Het |
| Nsa2 |
C |
T |
13: 97,131,220 (GRCm38) |
A242T |
probably benign |
Het |
| Nsd2 |
G |
A |
5: 33,882,147 (GRCm38) |
W834* |
probably null |
Het |
| Olfr1134 |
T |
C |
2: 87,656,396 (GRCm38) |
N175S |
possibly damaging |
Het |
| Olfr1419 |
T |
A |
19: 11,870,316 (GRCm38) |
D300V |
possibly damaging |
Het |
| Olfr285 |
T |
C |
15: 98,313,380 (GRCm38) |
M57V |
probably damaging |
Het |
| Olfr469 |
A |
T |
7: 107,822,922 (GRCm38) |
C182* |
probably null |
Het |
| Pam |
A |
T |
1: 97,842,247 (GRCm38) |
D599E |
probably damaging |
Het |
| Phf20l1 |
A |
G |
15: 66,636,884 (GRCm38) |
K864R |
probably damaging |
Het |
| Plcl2 |
A |
G |
17: 50,608,468 (GRCm38) |
D835G |
probably damaging |
Het |
| Ppm1m |
C |
A |
9: 106,196,157 (GRCm38) |
A329S |
probably damaging |
Het |
| Prep |
T |
C |
10: 45,150,438 (GRCm38) |
V486A |
probably benign |
Het |
| Prkcb |
A |
T |
7: 122,516,844 (GRCm38) |
N182I |
probably damaging |
Het |
| Prkcz |
A |
G |
4: 155,271,602 (GRCm38) |
F355S |
probably damaging |
Het |
| Psg20 |
C |
T |
7: 18,684,467 (GRCm38) |
S125N |
probably benign |
Het |
| Psmd12 |
A |
G |
11: 107,492,057 (GRCm38) |
D234G |
probably benign |
Het |
| Pvrig |
A |
T |
5: 138,342,008 (GRCm38) |
M14L |
probably benign |
Het |
| Rabgap1l |
C |
T |
1: 160,226,484 (GRCm38) |
|
probably null |
Het |
| Rfc1 |
A |
T |
5: 65,275,426 (GRCm38) |
C764S |
probably damaging |
Het |
| Ryr3 |
T |
C |
2: 112,926,957 (GRCm38) |
D351G |
probably benign |
Het |
| Serpinb9g |
T |
C |
13: 33,495,167 (GRCm38) |
F340S |
probably benign |
Het |
| Sirpb1c |
C |
A |
3: 15,832,266 (GRCm38) |
L315F |
probably damaging |
Het |
| Slc24a1 |
C |
G |
9: 64,928,404 (GRCm38) |
E814Q |
unknown |
Het |
| Slc26a11 |
A |
T |
11: 119,374,502 (GRCm38) |
Q355L |
probably damaging |
Het |
| Sp100 |
C |
T |
1: 85,707,239 (GRCm38) |
L483F |
possibly damaging |
Het |
| St5 |
A |
G |
7: 109,525,346 (GRCm38) |
L1096P |
probably damaging |
Het |
| Ston1 |
T |
A |
17: 88,635,901 (GRCm38) |
M245K |
probably benign |
Het |
| Swap70 |
T |
A |
7: 110,274,772 (GRCm38) |
D442E |
probably benign |
Het |
| Syne2 |
T |
A |
12: 76,046,186 (GRCm38) |
V450D |
possibly damaging |
Het |
| Tbck |
T |
A |
3: 132,752,563 (GRCm38) |
N651K |
probably damaging |
Het |
| Timd4 |
A |
T |
11: 46,817,758 (GRCm38) |
T204S |
probably benign |
Het |
| Tmem102 |
A |
G |
11: 69,804,885 (GRCm38) |
L87P |
probably damaging |
Het |
| Tmem55a |
T |
A |
4: 14,912,477 (GRCm38) |
Y195* |
probably null |
Het |
| Tmprss11e |
T |
A |
5: 86,709,480 (GRCm38) |
T325S |
probably benign |
Het |
| Trpm1 |
G |
A |
7: 64,240,582 (GRCm38) |
V978M |
probably damaging |
Het |
| Wdr12 |
A |
T |
1: 60,094,511 (GRCm38) |
D19E |
probably benign |
Het |
| Wdr35 |
G |
A |
12: 9,005,773 (GRCm38) |
V482I |
probably benign |
Het |
| Wdr63 |
T |
C |
3: 146,055,618 (GRCm38) |
D661G |
probably benign |
Het |
| Zer1 |
T |
C |
2: 30,101,484 (GRCm38) |
|
probably null |
Het |
| Zfp503 |
T |
C |
14: 21,986,011 (GRCm38) |
D279G |
probably benign |
Het |
| Zfp870 |
A |
T |
17: 32,883,762 (GRCm38) |
C198S |
possibly damaging |
Het |
| Zfyve26 |
C |
T |
12: 79,287,807 (GRCm38) |
E146K |
probably benign |
Het |
| Zkscan6 |
T |
C |
11: 65,828,531 (GRCm38) |
V459A |
probably damaging |
Het |
|
| Other mutations in Dennd4c |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01309:Dennd4c
|
APN |
4 |
86,805,487 (GRCm38) |
splice site |
probably benign |
|
|
IGL01810:Dennd4c
|
APN |
4 |
86,799,551 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
IGL02203:Dennd4c
|
APN |
4 |
86,802,936 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL02217:Dennd4c
|
APN |
4 |
86,813,799 (GRCm38) |
missense |
probably benign |
|
|
IGL02236:Dennd4c
|
APN |
4 |
86,807,435 (GRCm38) |
missense |
possibly damaging |
0.68 |
|
IGL02256:Dennd4c
|
APN |
4 |
86,799,541 (GRCm38) |
missense |
probably damaging |
0.96 |
|
IGL02396:Dennd4c
|
APN |
4 |
86,825,000 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02523:Dennd4c
|
APN |
4 |
86,774,253 (GRCm38) |
unclassified |
probably benign |
|
|
IGL02615:Dennd4c
|
APN |
4 |
86,821,467 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL03069:Dennd4c
|
APN |
4 |
86,774,437 (GRCm38) |
nonsense |
probably null |
|
|
IGL03116:Dennd4c
|
APN |
4 |
86,788,820 (GRCm38) |
splice site |
probably benign |
|
|
IGL03117:Dennd4c
|
APN |
4 |
86,777,903 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
IGL03273:Dennd4c
|
APN |
4 |
86,777,796 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03329:Dennd4c
|
APN |
4 |
86,777,876 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03365:Dennd4c
|
APN |
4 |
86,807,426 (GRCm38) |
critical splice acceptor site |
probably null |
|
|
PIT4486001:Dennd4c
|
UTSW |
4 |
86,799,464 (GRCm38) |
nonsense |
probably null |
|
|
R0010:Dennd4c
|
UTSW |
4 |
86,781,577 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0032:Dennd4c
|
UTSW |
4 |
86,828,150 (GRCm38) |
critical splice donor site |
probably null |
|
|
R0032:Dennd4c
|
UTSW |
4 |
86,828,150 (GRCm38) |
critical splice donor site |
probably null |
|
|
R0092:Dennd4c
|
UTSW |
4 |
86,781,607 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0103:Dennd4c
|
UTSW |
4 |
86,812,446 (GRCm38) |
missense |
probably benign |
0.07 |
|
R0103:Dennd4c
|
UTSW |
4 |
86,812,446 (GRCm38) |
missense |
probably benign |
0.07 |
|
R0511:Dennd4c
|
UTSW |
4 |
86,826,022 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0515:Dennd4c
|
UTSW |
4 |
86,813,466 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R0578:Dennd4c
|
UTSW |
4 |
86,812,422 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0759:Dennd4c
|
UTSW |
4 |
86,788,829 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0784:Dennd4c
|
UTSW |
4 |
86,844,908 (GRCm38) |
missense |
probably benign |
0.37 |
|
R1156:Dennd4c
|
UTSW |
4 |
86,807,466 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1370:Dennd4c
|
UTSW |
4 |
86,811,510 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1381:Dennd4c
|
UTSW |
4 |
86,774,532 (GRCm38) |
missense |
probably benign |
0.24 |
|
R1569:Dennd4c
|
UTSW |
4 |
86,786,094 (GRCm38) |
missense |
possibly damaging |
0.59 |
|
R1747:Dennd4c
|
UTSW |
4 |
86,807,438 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1764:Dennd4c
|
UTSW |
4 |
86,803,010 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1838:Dennd4c
|
UTSW |
4 |
86,825,178 (GRCm38) |
missense |
probably benign |
0.00 |
|
R1997:Dennd4c
|
UTSW |
4 |
86,837,397 (GRCm38) |
missense |
probably benign |
|
|
R2244:Dennd4c
|
UTSW |
4 |
86,774,543 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2348:Dennd4c
|
UTSW |
4 |
86,811,527 (GRCm38) |
missense |
probably benign |
0.04 |
|
R2968:Dennd4c
|
UTSW |
4 |
86,781,644 (GRCm38) |
missense |
possibly damaging |
0.93 |
|
R3033:Dennd4c
|
UTSW |
4 |
86,825,320 (GRCm38) |
small deletion |
probably benign |
|
|
R3401:Dennd4c
|
UTSW |
4 |
86,774,543 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3402:Dennd4c
|
UTSW |
4 |
86,774,543 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3403:Dennd4c
|
UTSW |
4 |
86,774,543 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3855:Dennd4c
|
UTSW |
4 |
86,779,847 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3939:Dennd4c
|
UTSW |
4 |
86,774,280 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4164:Dennd4c
|
UTSW |
4 |
86,807,527 (GRCm38) |
missense |
probably benign |
0.01 |
|
R4384:Dennd4c
|
UTSW |
4 |
86,811,450 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4435:Dennd4c
|
UTSW |
4 |
86,798,075 (GRCm38) |
missense |
probably benign |
0.44 |
|
R4788:Dennd4c
|
UTSW |
4 |
86,819,963 (GRCm38) |
missense |
probably benign |
0.00 |
|
R4801:Dennd4c
|
UTSW |
4 |
86,819,884 (GRCm38) |
nonsense |
probably null |
|
|
R4802:Dennd4c
|
UTSW |
4 |
86,819,884 (GRCm38) |
nonsense |
probably null |
|
|
R4818:Dennd4c
|
UTSW |
4 |
86,825,274 (GRCm38) |
missense |
probably benign |
0.00 |
|
R4923:Dennd4c
|
UTSW |
4 |
86,807,538 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4958:Dennd4c
|
UTSW |
4 |
86,781,679 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5025:Dennd4c
|
UTSW |
4 |
86,795,299 (GRCm38) |
critical splice donor site |
probably null |
|
|
R5434:Dennd4c
|
UTSW |
4 |
86,811,456 (GRCm38) |
missense |
probably benign |
0.10 |
|
R5662:Dennd4c
|
UTSW |
4 |
86,795,288 (GRCm38) |
missense |
probably benign |
0.13 |
|
R5802:Dennd4c
|
UTSW |
4 |
86,811,453 (GRCm38) |
missense |
probably benign |
0.02 |
|
R5849:Dennd4c
|
UTSW |
4 |
86,825,986 (GRCm38) |
missense |
possibly damaging |
0.58 |
|
R5861:Dennd4c
|
UTSW |
4 |
86,791,352 (GRCm38) |
missense |
probably benign |
0.30 |
|
R5970:Dennd4c
|
UTSW |
4 |
86,825,512 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6163:Dennd4c
|
UTSW |
4 |
86,805,591 (GRCm38) |
missense |
possibly damaging |
0.56 |
|
R6356:Dennd4c
|
UTSW |
4 |
86,825,449 (GRCm38) |
missense |
probably benign |
|
|
R6661:Dennd4c
|
UTSW |
4 |
86,799,389 (GRCm38) |
missense |
possibly damaging |
0.66 |
|
R6855:Dennd4c
|
UTSW |
4 |
86,836,457 (GRCm38) |
missense |
probably benign |
|
|
R6983:Dennd4c
|
UTSW |
4 |
86,799,493 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7035:Dennd4c
|
UTSW |
4 |
86,812,337 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7126:Dennd4c
|
UTSW |
4 |
86,807,430 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7185:Dennd4c
|
UTSW |
4 |
86,811,450 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7212:Dennd4c
|
UTSW |
4 |
86,802,991 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7324:Dennd4c
|
UTSW |
4 |
86,829,738 (GRCm38) |
missense |
unknown |
|
|
R7329:Dennd4c
|
UTSW |
4 |
86,841,081 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7329:Dennd4c
|
UTSW |
4 |
86,779,874 (GRCm38) |
missense |
possibly damaging |
0.81 |
|
R7479:Dennd4c
|
UTSW |
4 |
86,799,353 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7538:Dennd4c
|
UTSW |
4 |
86,774,516 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7599:Dennd4c
|
UTSW |
4 |
86,811,612 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7688:Dennd4c
|
UTSW |
4 |
86,795,140 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7725:Dennd4c
|
UTSW |
4 |
86,786,093 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7751:Dennd4c
|
UTSW |
4 |
86,828,942 (GRCm38) |
missense |
probably benign |
0.05 |
|
R7790:Dennd4c
|
UTSW |
4 |
86,799,517 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R8056:Dennd4c
|
UTSW |
4 |
86,844,976 (GRCm38) |
missense |
probably null |
0.71 |
|
R8307:Dennd4c
|
UTSW |
4 |
86,825,872 (GRCm38) |
missense |
probably benign |
0.12 |
|
R8494:Dennd4c
|
UTSW |
4 |
86,841,075 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8531:Dennd4c
|
UTSW |
4 |
86,826,082 (GRCm38) |
critical splice donor site |
probably null |
|
|
R9014:Dennd4c
|
UTSW |
4 |
86,836,429 (GRCm38) |
missense |
probably benign |
0.00 |
|
R9014:Dennd4c
|
UTSW |
4 |
86,821,465 (GRCm38) |
missense |
probably benign |
0.07 |
|
R9017:Dennd4c
|
UTSW |
4 |
86,825,112 (GRCm38) |
missense |
probably benign |
0.33 |
|
R9142:Dennd4c
|
UTSW |
4 |
86,837,400 (GRCm38) |
missense |
probably benign |
0.32 |
|
R9224:Dennd4c
|
UTSW |
4 |
86,819,933 (GRCm38) |
nonsense |
probably null |
|
|
R9570:Dennd4c
|
UTSW |
4 |
86,828,971 (GRCm38) |
missense |
possibly damaging |
0.71 |
|
R9644:Dennd4c
|
UTSW |
4 |
86,795,126 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R9649:Dennd4c
|
UTSW |
4 |
86,824,923 (GRCm38) |
missense |
probably benign |
0.00 |
|
R9658:Dennd4c
|
UTSW |
4 |
86,836,388 (GRCm38) |
nonsense |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- GTGGTACCTGATTATTCCTAACTCAAG -3'
(R):5'- TGTAAGGGGCGGCTTATCTCTC -3'
Sequencing Primer
(F):5'- CTCAAGAATGTCTTCATCTTGATCAG -3'
(R):5'- CTGTAGCACAGGAAAAGCTCTG -3'
|
| Posted On |
2019-10-07 |
Incidental Mutation