Incidental Mutation 'R7468:Rnf123'
| ID |
578964 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Rnf123
|
| Ensembl Gene |
ENSMUSG00000041528 |
| Gene Name |
ring finger protein 123 |
| Synonyms |
KPC1 |
| MMRRC Submission |
045542-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.174)
|
| Stock # |
R7468 (G1)
|
| Quality Score |
190.009 |
|
Status
|
Validated
|
| Chromosome |
9 |
| Chromosomal Location |
108051534-108083346 bp(-) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 108069009 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Histidine to Glutamine
at position 322
(H322Q)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000125745
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000047746]
[ENSMUST00000160249]
[ENSMUST00000160649]
[ENSMUST00000161828]
[ENSMUST00000162355]
[ENSMUST00000162516]
[ENSMUST00000174504]
[ENSMUST00000178267]
|
| AlphaFold |
Q5XPI3 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000047746
AA Change: H322Q
PolyPhen 2
Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
|
| SMART Domains |
Protein: ENSMUSP00000040803
Gene: ENSMUSG00000041528
AA Change: H322Q
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
104 |
115 |
N/A |
INTRINSIC |
|
SPRY
|
132 |
253 |
1.52e-28 |
SMART |
|
low complexity region
|
471 |
488 |
N/A |
INTRINSIC |
|
low complexity region
|
508 |
518 |
N/A |
INTRINSIC |
|
coiled coil region
|
1047 |
1067 |
N/A |
INTRINSIC |
|
low complexity region
|
1242 |
1251 |
N/A |
INTRINSIC |
|
RING
|
1260 |
1297 |
5.27e-4 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000160249
AA Change: H322Q
PolyPhen 2
Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
|
| SMART Domains |
Protein: ENSMUSP00000124548
Gene: ENSMUSG00000041528
AA Change: H322Q
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
104 |
115 |
N/A |
INTRINSIC |
|
SPRY
|
132 |
253 |
1.52e-28 |
SMART |
|
low complexity region
|
471 |
488 |
N/A |
INTRINSIC |
|
low complexity region
|
508 |
518 |
N/A |
INTRINSIC |
|
coiled coil region
|
1041 |
1061 |
N/A |
INTRINSIC |
|
low complexity region
|
1236 |
1245 |
N/A |
INTRINSIC |
|
RING
|
1254 |
1291 |
5.27e-4 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000160649
AA Change: H322Q
PolyPhen 2
Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
|
| SMART Domains |
Protein: ENSMUSP00000125495
Gene: ENSMUSG00000041528
AA Change: H322Q
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
104 |
115 |
N/A |
INTRINSIC |
|
SPRY
|
132 |
253 |
1.52e-28 |
SMART |
|
low complexity region
|
471 |
488 |
N/A |
INTRINSIC |
|
low complexity region
|
508 |
518 |
N/A |
INTRINSIC |
|
coiled coil region
|
1041 |
1061 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000161828
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000162355
AA Change: H322Q
PolyPhen 2
Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
|
| SMART Domains |
Protein: ENSMUSP00000125745
Gene: ENSMUSG00000041528
AA Change: H322Q
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
104 |
115 |
N/A |
INTRINSIC |
|
SPRY
|
132 |
253 |
1.52e-28 |
SMART |
|
low complexity region
|
471 |
488 |
N/A |
INTRINSIC |
|
low complexity region
|
508 |
518 |
N/A |
INTRINSIC |
|
coiled coil region
|
1047 |
1067 |
N/A |
INTRINSIC |
|
low complexity region
|
1242 |
1251 |
N/A |
INTRINSIC |
|
RING
|
1260 |
1297 |
5.27e-4 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000162516
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000174504
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000178267
AA Change: H322Q
PolyPhen 2
Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
|
| SMART Domains |
Protein: ENSMUSP00000136953
Gene: ENSMUSG00000041528
AA Change: H322Q
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
104 |
115 |
N/A |
INTRINSIC |
|
SPRY
|
132 |
253 |
1.52e-28 |
SMART |
|
low complexity region
|
471 |
488 |
N/A |
INTRINSIC |
|
low complexity region
|
508 |
518 |
N/A |
INTRINSIC |
|
coiled coil region
|
1041 |
1061 |
N/A |
INTRINSIC |
|
low complexity region
|
1236 |
1245 |
N/A |
INTRINSIC |
|
RING
|
1254 |
1291 |
5.27e-4 |
SMART |
|
| Meta Mutation Damage Score |
0.0804 |
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 99.1%
|
| Validation Efficiency |
98% (86/88) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene contains a C-terminal RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions, and an N-terminal SPRY domain. This protein displays E3 ubiquitin ligase activity toward the cyclin-dependent kinase inhibitor 1B which is also known as p27 or KIP1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 88 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abl2 |
T |
G |
1: 156,622,534 (GRCm38) |
N90K |
possibly damaging |
Het |
| Acox1 |
T |
C |
11: 116,178,175 (GRCm38) |
T415A |
possibly damaging |
Het |
| Acy1 |
T |
C |
9: 106,437,722 (GRCm38) |
M1V |
probably null |
Het |
| Akap13 |
G |
A |
7: 75,730,465 (GRCm38) |
R462H |
probably damaging |
Het |
| Alpk3 |
C |
A |
7: 81,100,998 (GRCm38) |
Y1505* |
probably null |
Het |
| Ankrd17 |
T |
C |
5: 90,243,043 (GRCm38) |
N2256S |
probably benign |
Het |
| Ankrd22 |
C |
A |
19: 34,149,292 (GRCm38) |
C46F |
possibly damaging |
Het |
| Arhgef5 |
A |
T |
6: 43,280,671 (GRCm38) |
K1291* |
probably null |
Het |
| Arl9 |
T |
A |
5: 77,010,429 (GRCm38) |
Y119* |
probably null |
Het |
| Asb14 |
T |
C |
14: 26,900,848 (GRCm38) |
V89A |
probably benign |
Het |
| Banp |
T |
G |
8: 121,949,849 (GRCm38) |
|
probably null |
Het |
| BC051142 |
T |
A |
17: 34,417,565 (GRCm38) |
|
probably null |
Het |
| Btn2a2 |
T |
C |
13: 23,482,763 (GRCm38) |
N224S |
probably benign |
Het |
| C1ra |
C |
T |
6: 124,522,444 (GRCm38) |
Q530* |
probably null |
Het |
| C2cd6 |
A |
C |
1: 59,068,685 (GRCm38) |
S273A |
probably benign |
Het |
| Cd1d2 |
A |
T |
3: 86,988,276 (GRCm38) |
|
probably null |
Het |
| Cdc42bpb |
T |
C |
12: 111,339,873 (GRCm38) |
D132G |
probably damaging |
Het |
| Cfap45 |
C |
A |
1: 172,535,310 (GRCm38) |
Y289* |
probably null |
Het |
| Chrdl2 |
T |
C |
7: 100,010,125 (GRCm38) |
|
probably null |
Het |
| Cst10 |
C |
T |
2: 149,405,576 (GRCm38) |
L71F |
probably benign |
Het |
| Dcaf11 |
T |
C |
14: 55,565,509 (GRCm38) |
F292L |
possibly damaging |
Het |
| Dgcr8 |
A |
G |
16: 18,259,623 (GRCm38) |
F641S |
probably damaging |
Het |
| Dnm3 |
G |
A |
1: 162,321,629 (GRCm38) |
|
probably null |
Het |
| Eral1 |
T |
C |
11: 78,075,393 (GRCm38) |
K320E |
probably damaging |
Het |
| Eva1a |
A |
G |
6: 82,092,021 (GRCm38) |
T110A |
possibly damaging |
Het |
| Fbxo42 |
A |
G |
4: 141,199,606 (GRCm38) |
D399G |
possibly damaging |
Het |
| Frs2 |
T |
C |
10: 117,074,102 (GRCm38) |
T452A |
possibly damaging |
Het |
| Git2 |
T |
A |
5: 114,733,897 (GRCm38) |
D542V |
probably damaging |
Het |
| Gm11639 |
G |
T |
11: 104,749,700 (GRCm38) |
S1088I |
probably benign |
Het |
| Grk2 |
T |
A |
19: 4,306,035 (GRCm38) |
|
probably benign |
Het |
| Gsg1l2 |
A |
G |
11: 67,785,284 (GRCm38) |
N158S |
possibly damaging |
Het |
| Hc |
T |
C |
2: 35,028,051 (GRCm38) |
N740S |
probably benign |
Het |
| Hectd1 |
T |
C |
12: 51,744,805 (GRCm38) |
|
probably null |
Het |
| Hemk1 |
A |
G |
9: 107,331,089 (GRCm38) |
|
probably null |
Het |
| Hormad2 |
G |
T |
11: 4,412,245 (GRCm38) |
Y126* |
probably null |
Het |
| Hr |
A |
G |
14: 70,558,212 (GRCm38) |
E399G |
possibly damaging |
Het |
| Ick |
A |
G |
9: 78,157,939 (GRCm38) |
K377R |
probably benign |
Het |
| Ilf3 |
C |
A |
9: 21,403,411 (GRCm38) |
H780N |
unknown |
Het |
| Inpp5e |
A |
T |
2: 26,408,149 (GRCm38) |
S147T |
probably benign |
Het |
| Jmjd6 |
T |
C |
11: 116,842,449 (GRCm38) |
D134G |
probably damaging |
Het |
| Kif23 |
G |
T |
9: 61,937,175 (GRCm38) |
Y120* |
probably null |
Het |
| Klk12 |
T |
A |
7: 43,773,356 (GRCm38) |
Y236N |
probably damaging |
Het |
| Kmt5b |
C |
A |
19: 3,802,799 (GRCm38) |
Y186* |
probably null |
Het |
| Krtap9-5 |
A |
G |
11: 99,949,306 (GRCm38) |
T278A |
unknown |
Het |
| Lca5 |
T |
A |
9: 83,423,456 (GRCm38) |
D99V |
probably damaging |
Het |
| Leng9 |
A |
G |
7: 4,148,801 (GRCm38) |
V292A |
probably benign |
Het |
| Lime1 |
A |
G |
2: 181,383,342 (GRCm38) |
R231G |
probably benign |
Het |
| Lrmp |
C |
A |
6: 145,173,701 (GRCm38) |
|
probably null |
Het |
| Mctp2 |
T |
A |
7: 72,211,690 (GRCm38) |
E402D |
probably damaging |
Het |
| Mrpl28 |
T |
A |
17: 26,124,615 (GRCm38) |
S116R |
probably damaging |
Het |
| Muc15 |
A |
T |
2: 110,731,517 (GRCm38) |
R99S |
probably benign |
Het |
| Myh2 |
G |
A |
11: 67,192,542 (GRCm38) |
A1444T |
probably benign |
Het |
| Mynn |
T |
A |
3: 30,603,676 (GRCm38) |
Y48N |
probably damaging |
Het |
| Myo1b |
A |
T |
1: 51,797,480 (GRCm38) |
V274E |
possibly damaging |
Het |
| Nemp1 |
T |
A |
10: 127,693,054 (GRCm38) |
M209K |
possibly damaging |
Het |
| Nlrc4 |
G |
T |
17: 74,445,512 (GRCm38) |
D625E |
probably benign |
Het |
| Olfr1192-ps1 |
T |
C |
2: 88,652,278 (GRCm38) |
L42P |
probably damaging |
Het |
| Olfr122 |
C |
T |
17: 37,772,019 (GRCm38) |
A122V |
probably damaging |
Het |
| Olfr96 |
T |
C |
17: 37,225,385 (GRCm38) |
F87L |
probably benign |
Het |
| Otog |
T |
C |
7: 46,264,119 (GRCm38) |
V792A |
probably benign |
Het |
| Paqr8 |
T |
C |
1: 20,935,218 (GRCm38) |
Y199H |
probably damaging |
Het |
| Popdc3 |
A |
G |
10: 45,315,021 (GRCm38) |
D76G |
probably damaging |
Het |
| Ppme1 |
T |
C |
7: 100,341,862 (GRCm38) |
N210D |
probably benign |
Het |
| Prdm15 |
A |
C |
16: 97,835,642 (GRCm38) |
Y158* |
probably null |
Het |
| Prrg2 |
A |
T |
7: 45,060,263 (GRCm38) |
L70Q |
probably benign |
Het |
| Psmg4 |
C |
T |
13: 34,177,983 (GRCm38) |
R85W |
probably damaging |
Het |
| Rab11fip4 |
A |
T |
11: 79,689,652 (GRCm38) |
T437S |
probably benign |
Het |
| Rap2a |
T |
A |
14: 120,478,926 (GRCm38) |
M67K |
probably damaging |
Het |
| Rxfp2 |
A |
T |
5: 150,067,336 (GRCm38) |
T521S |
possibly damaging |
Het |
| Scrn2 |
T |
G |
11: 97,033,166 (GRCm38) |
V292G |
possibly damaging |
Het |
| Serpina3n |
C |
A |
12: 104,411,397 (GRCm38) |
P303H |
probably benign |
Het |
| Spop |
C |
T |
11: 95,485,901 (GRCm38) |
T260M |
probably damaging |
Het |
| Surf2 |
G |
A |
2: 26,919,342 (GRCm38) |
G224D |
probably benign |
Het |
| Synm |
T |
G |
7: 67,733,223 (GRCm38) |
N669T |
unknown |
Het |
| Tmprss13 |
T |
C |
9: 45,328,423 (GRCm38) |
S10P |
unknown |
Het |
| Trav9d-1 |
T |
A |
14: 52,792,513 (GRCm38) |
S25T |
probably benign |
Het |
| Trpc3 |
A |
T |
3: 36,624,416 (GRCm38) |
I840K |
probably damaging |
Het |
| Tssc4 |
C |
A |
7: 143,069,262 (GRCm38) |
|
probably benign |
Het |
| Ttc39d |
G |
T |
17: 80,216,150 (GRCm38) |
R79S |
possibly damaging |
Het |
| Txlnb |
T |
A |
10: 17,799,334 (GRCm38) |
S78R |
probably damaging |
Het |
| Vmn1r142 |
T |
A |
7: 22,163,359 (GRCm38) |
Q226L |
possibly damaging |
Het |
| Vmn1r230 |
T |
C |
17: 20,846,884 (GRCm38) |
S112P |
probably damaging |
Het |
| Wrnip1 |
T |
C |
13: 32,816,377 (GRCm38) |
F456L |
possibly damaging |
Het |
| Zc3h8 |
G |
T |
2: 128,933,295 (GRCm38) |
H148Q |
probably benign |
Het |
| Zcchc3 |
A |
G |
2: 152,414,695 (GRCm38) |
V28A |
probably benign |
Het |
| Zdbf2 |
T |
A |
1: 63,307,510 (GRCm38) |
C1683S |
probably benign |
Het |
| Zfp874a |
T |
C |
13: 67,425,604 (GRCm38) |
|
probably null |
Het |
| Zmym4 |
A |
G |
4: 126,882,236 (GRCm38) |
S1260P |
probably benign |
Het |
|
| Other mutations in Rnf123 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00950:Rnf123
|
APN |
9 |
108,067,395 (GRCm38) |
critical splice donor site |
probably null |
|
|
IGL01358:Rnf123
|
APN |
9 |
108,069,182 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01464:Rnf123
|
APN |
9 |
108,052,302 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01637:Rnf123
|
APN |
9 |
108,058,238 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01669:Rnf123
|
APN |
9 |
108,058,356 (GRCm38) |
missense |
probably damaging |
0.98 |
|
IGL01905:Rnf123
|
APN |
9 |
108,071,370 (GRCm38) |
splice site |
probably benign |
|
|
IGL02070:Rnf123
|
APN |
9 |
108,068,302 (GRCm38) |
nonsense |
probably null |
|
|
IGL02072:Rnf123
|
APN |
9 |
108,068,302 (GRCm38) |
nonsense |
probably null |
|
|
IGL02073:Rnf123
|
APN |
9 |
108,068,302 (GRCm38) |
nonsense |
probably null |
|
|
IGL02074:Rnf123
|
APN |
9 |
108,066,889 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02079:Rnf123
|
APN |
9 |
108,068,302 (GRCm38) |
nonsense |
probably null |
|
|
IGL02080:Rnf123
|
APN |
9 |
108,068,302 (GRCm38) |
nonsense |
probably null |
|
|
IGL02231:Rnf123
|
APN |
9 |
108,066,399 (GRCm38) |
missense |
probably benign |
0.17 |
|
IGL02281:Rnf123
|
APN |
9 |
108,071,452 (GRCm38) |
missense |
probably benign |
0.01 |
|
IGL02336:Rnf123
|
APN |
9 |
108,061,842 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02543:Rnf123
|
APN |
9 |
108,066,348 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02565:Rnf123
|
APN |
9 |
108,052,212 (GRCm38) |
critical splice donor site |
probably null |
|
|
IGL02571:Rnf123
|
APN |
9 |
108,068,302 (GRCm38) |
nonsense |
probably null |
|
|
IGL02572:Rnf123
|
APN |
9 |
108,068,302 (GRCm38) |
nonsense |
probably null |
|
|
IGL02574:Rnf123
|
APN |
9 |
108,068,302 (GRCm38) |
nonsense |
probably null |
|
|
IGL02586:Rnf123
|
APN |
9 |
108,068,302 (GRCm38) |
nonsense |
probably null |
|
|
IGL02589:Rnf123
|
APN |
9 |
108,068,302 (GRCm38) |
nonsense |
probably null |
|
|
IGL02600:Rnf123
|
APN |
9 |
108,068,302 (GRCm38) |
nonsense |
probably null |
|
|
IGL02601:Rnf123
|
APN |
9 |
108,068,302 (GRCm38) |
nonsense |
probably null |
|
|
IGL02602:Rnf123
|
APN |
9 |
108,068,302 (GRCm38) |
nonsense |
probably null |
|
|
IGL02603:Rnf123
|
APN |
9 |
108,068,302 (GRCm38) |
nonsense |
probably null |
|
|
IGL02609:Rnf123
|
APN |
9 |
108,068,302 (GRCm38) |
nonsense |
probably null |
|
|
IGL02628:Rnf123
|
APN |
9 |
108,068,302 (GRCm38) |
nonsense |
probably null |
|
|
IGL02629:Rnf123
|
APN |
9 |
108,070,789 (GRCm38) |
splice site |
probably benign |
|
|
IGL02629:Rnf123
|
APN |
9 |
108,068,302 (GRCm38) |
nonsense |
probably null |
|
|
IGL02630:Rnf123
|
APN |
9 |
108,068,302 (GRCm38) |
nonsense |
probably null |
|
|
IGL02631:Rnf123
|
APN |
9 |
108,068,302 (GRCm38) |
nonsense |
probably null |
|
|
IGL02632:Rnf123
|
APN |
9 |
108,068,302 (GRCm38) |
nonsense |
probably null |
|
|
IGL02650:Rnf123
|
APN |
9 |
108,069,748 (GRCm38) |
missense |
probably benign |
0.29 |
|
IGL02690:Rnf123
|
APN |
9 |
108,068,302 (GRCm38) |
nonsense |
probably null |
|
|
IGL02691:Rnf123
|
APN |
9 |
108,068,302 (GRCm38) |
nonsense |
probably null |
|
|
IGL02692:Rnf123
|
APN |
9 |
108,068,302 (GRCm38) |
nonsense |
probably null |
|
|
IGL02693:Rnf123
|
APN |
9 |
108,068,302 (GRCm38) |
nonsense |
probably null |
|
|
IGL02713:Rnf123
|
APN |
9 |
108,068,302 (GRCm38) |
nonsense |
probably null |
|
|
IGL02736:Rnf123
|
APN |
9 |
108,068,302 (GRCm38) |
nonsense |
probably null |
|
|
IGL02929:Rnf123
|
APN |
9 |
108,069,076 (GRCm38) |
missense |
probably benign |
|
|
R1175:Rnf123
|
UTSW |
9 |
108,077,373 (GRCm38) |
missense |
probably benign |
|
|
R1465:Rnf123
|
UTSW |
9 |
108,071,466 (GRCm38) |
splice site |
probably benign |
|
|
R1502:Rnf123
|
UTSW |
9 |
108,068,510 (GRCm38) |
splice site |
probably null |
|
|
R1682:Rnf123
|
UTSW |
9 |
108,077,398 (GRCm38) |
missense |
probably benign |
0.16 |
|
R1817:Rnf123
|
UTSW |
9 |
108,062,926 (GRCm38) |
missense |
probably benign |
0.41 |
|
R1855:Rnf123
|
UTSW |
9 |
108,061,791 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2394:Rnf123
|
UTSW |
9 |
108,063,536 (GRCm38) |
missense |
probably benign |
0.00 |
|
R2483:Rnf123
|
UTSW |
9 |
108,063,521 (GRCm38) |
missense |
probably benign |
0.16 |
|
R3896:Rnf123
|
UTSW |
9 |
108,069,103 (GRCm38) |
splice site |
probably benign |
|
|
R3940:Rnf123
|
UTSW |
9 |
108,064,035 (GRCm38) |
splice site |
probably benign |
|
|
R4206:Rnf123
|
UTSW |
9 |
108,063,963 (GRCm38) |
missense |
probably benign |
0.01 |
|
R4641:Rnf123
|
UTSW |
9 |
108,058,587 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4714:Rnf123
|
UTSW |
9 |
108,052,439 (GRCm38) |
splice site |
probably null |
|
|
R4767:Rnf123
|
UTSW |
9 |
108,052,089 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4849:Rnf123
|
UTSW |
9 |
108,056,091 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4899:Rnf123
|
UTSW |
9 |
108,063,680 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5274:Rnf123
|
UTSW |
9 |
108,064,003 (GRCm38) |
frame shift |
probably null |
|
|
R5275:Rnf123
|
UTSW |
9 |
108,064,003 (GRCm38) |
frame shift |
probably null |
|
|
R5276:Rnf123
|
UTSW |
9 |
108,064,003 (GRCm38) |
frame shift |
probably null |
|
|
R5294:Rnf123
|
UTSW |
9 |
108,064,003 (GRCm38) |
frame shift |
probably null |
|
|
R5295:Rnf123
|
UTSW |
9 |
108,064,003 (GRCm38) |
frame shift |
probably null |
|
|
R5394:Rnf123
|
UTSW |
9 |
108,070,731 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5717:Rnf123
|
UTSW |
9 |
108,067,424 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6186:Rnf123
|
UTSW |
9 |
108,069,958 (GRCm38) |
missense |
possibly damaging |
0.55 |
|
R6449:Rnf123
|
UTSW |
9 |
108,056,053 (GRCm38) |
missense |
probably benign |
0.17 |
|
R6502:Rnf123
|
UTSW |
9 |
108,068,332 (GRCm38) |
missense |
possibly damaging |
0.46 |
|
R6944:Rnf123
|
UTSW |
9 |
108,063,623 (GRCm38) |
missense |
probably benign |
0.02 |
|
R7003:Rnf123
|
UTSW |
9 |
108,063,683 (GRCm38) |
critical splice acceptor site |
probably null |
|
|
R7088:Rnf123
|
UTSW |
9 |
108,058,536 (GRCm38) |
missense |
probably null |
1.00 |
|
R7092:Rnf123
|
UTSW |
9 |
108,068,600 (GRCm38) |
missense |
probably benign |
0.07 |
|
R7100:Rnf123
|
UTSW |
9 |
108,056,639 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7257:Rnf123
|
UTSW |
9 |
108,069,029 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7453:Rnf123
|
UTSW |
9 |
108,070,408 (GRCm38) |
splice site |
probably null |
|
|
R7517:Rnf123
|
UTSW |
9 |
108,070,274 (GRCm38) |
nonsense |
probably null |
|
|
R7577:Rnf123
|
UTSW |
9 |
108,070,619 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8296:Rnf123
|
UTSW |
9 |
108,062,890 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8322:Rnf123
|
UTSW |
9 |
108,068,507 (GRCm38) |
missense |
probably benign |
0.26 |
|
R8754:Rnf123
|
UTSW |
9 |
108,071,164 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8783:Rnf123
|
UTSW |
9 |
108,069,073 (GRCm38) |
missense |
probably benign |
|
|
R9052:Rnf123
|
UTSW |
9 |
108,059,731 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9156:Rnf123
|
UTSW |
9 |
108,063,028 (GRCm38) |
splice site |
probably benign |
|
|
R9170:Rnf123
|
UTSW |
9 |
108,071,176 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9332:Rnf123
|
UTSW |
9 |
108,067,505 (GRCm38) |
missense |
probably benign |
0.00 |
|
R9385:Rnf123
|
UTSW |
9 |
108,052,268 (GRCm38) |
missense |
probably benign |
0.02 |
|
R9394:Rnf123
|
UTSW |
9 |
108,065,706 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9432:Rnf123
|
UTSW |
9 |
108,059,809 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R9717:Rnf123
|
UTSW |
9 |
108,077,764 (GRCm38) |
missense |
probably benign |
0.43 |
|
Z1176:Rnf123
|
UTSW |
9 |
108,062,981 (GRCm38) |
missense |
probably damaging |
1.00 |
|
Z1176:Rnf123
|
UTSW |
9 |
108,058,395 (GRCm38) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GTTTCCTTAGCCTGGGACATC -3'
(R):5'- TTCCAGGCAGTGCTAAGTGTG -3'
Sequencing Primer
(F):5'- TTCCTTAGCCTGGGACATCACAAC -3'
(R):5'- TAAGTGTGGAGCTGGACCC -3'
|
| Posted On |
2019-10-07 |
Incidental Mutation