Incidental Mutation 'R7471:Or8g37'
ID 579202
Institutional Source Beutler Lab
Gene Symbol Or8g37
Ensembl Gene ENSMUSG00000095774
Gene Name olfactory receptor family 8 subfamily G member 37
Synonyms Olfr970, GA_x6K02T2PVTD-33517322-33518257, MOR171-16
MMRRC Submission 045545-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.318) question?
Stock # R7471 (G1)
Quality Score 225.009
Status Validated
Chromosome 9
Chromosomal Location 39730937-39731872 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 39731423 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Leucine at position 163 (M163L)
Ref Sequence ENSEMBL: ENSMUSP00000150325 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071132] [ENSMUST00000213975] [ENSMUST00000215922]
AlphaFold Q8VFN3
Predicted Effect probably benign
Transcript: ENSMUST00000071132
AA Change: M163L

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000071132
Gene: ENSMUSG00000095774
AA Change: M163L

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 5.2e-53 PFAM
Pfam:7tm_1 41 290 1.6e-22 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213975
AA Change: M163L

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
Predicted Effect probably benign
Transcript: ENSMUST00000215922
AA Change: M163L

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.7%
Validation Efficiency 100% (73/73)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 72 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acaca T A 11: 84,168,608 (GRCm39) probably null Het
Ace T C 11: 105,864,308 (GRCm39) V483A probably damaging Het
Akap13 G A 7: 75,380,213 (GRCm39) R462H probably damaging Het
Angptl2 A T 2: 33,133,751 (GRCm39) T358S possibly damaging Het
Apoh C T 11: 108,298,131 (GRCm39) P144S probably damaging Het
Arid1a A G 4: 133,408,355 (GRCm39) W1666R unknown Het
Asap3 A G 4: 135,960,957 (GRCm39) H223R possibly damaging Het
Bcl2l12 A G 7: 44,645,977 (GRCm39) S81P possibly damaging Het
Brd10 A C 19: 29,707,139 (GRCm39) probably null Het
C8a A G 4: 104,674,822 (GRCm39) S550P probably benign Het
Cacna2d1 C G 5: 16,139,973 (GRCm39) probably benign Het
Ccdc170 A G 10: 4,470,803 (GRCm39) T216A probably benign Het
Chd7 A T 4: 8,859,197 (GRCm39) K2429I probably damaging Het
Chd8 T C 14: 52,441,569 (GRCm39) N2181S probably benign Het
Cimap1c C T 9: 56,759,783 (GRCm39) probably null Het
Clip3 T C 7: 30,001,377 (GRCm39) V342A possibly damaging Het
Cst5 C T 2: 149,247,496 (GRCm39) L71F probably benign Het
Cyp20a1 T C 1: 60,393,799 (GRCm39) F139S probably damaging Het
Dclre1b T A 3: 103,710,430 (GRCm39) R494W probably benign Het
Dicer1 A G 12: 104,660,969 (GRCm39) I1695T probably damaging Het
Dnah7a A G 1: 53,458,858 (GRCm39) L3760P probably damaging Het
Dock1 A G 7: 134,765,072 (GRCm39) D1688G possibly damaging Het
Drosha G A 15: 12,889,742 (GRCm39) R870Q probably damaging Het
Dsg2 G T 18: 20,713,675 (GRCm39) M215I probably benign Het
Dst A T 1: 34,233,651 (GRCm39) D3453V possibly damaging Het
Epha10 A T 4: 124,796,365 (GRCm39) Y358F Het
Ermp1 A T 19: 29,590,054 (GRCm39) M853K probably benign Het
Hace1 T G 10: 45,577,075 (GRCm39) I823S probably benign Het
Hectd3 A T 4: 116,853,785 (GRCm39) Y227F probably benign Het
Hells A G 19: 38,945,501 (GRCm39) N580S probably benign Het
Igkv12-44 A G 6: 69,791,718 (GRCm39) F82L probably damaging Het
Inpp5d A G 1: 87,623,122 (GRCm39) D405G probably damaging Het
Itsn2 G A 12: 4,758,198 (GRCm39) R1508H probably benign Het
Limk1 A T 5: 134,686,825 (GRCm39) probably null Het
Lingo1 T A 9: 56,528,167 (GRCm39) K147* probably null Het
Ltn1 T C 16: 87,194,787 (GRCm39) S1371G probably benign Het
Mab21l1 A G 3: 55,691,307 (GRCm39) D298G possibly damaging Het
Macf1 A T 4: 123,366,082 (GRCm39) V2893E probably benign Het
Mapk8ip1 T C 2: 92,219,489 (GRCm39) D114G probably benign Het
Med15 A T 16: 17,540,729 (GRCm39) W6R probably benign Het
Mrps34 T C 17: 25,114,431 (GRCm39) L97P probably damaging Het
Myrfl A T 10: 116,697,417 (GRCm39) F36I possibly damaging Het
Nifk G A 1: 118,260,204 (GRCm39) S253N probably damaging Het
Nmnat1 T A 4: 149,557,758 (GRCm39) T95S probably damaging Het
Oasl1 T A 5: 115,073,985 (GRCm39) I298N probably damaging Het
Or51a8 A G 7: 102,549,760 (GRCm39) Y62C probably benign Het
Or56b35 T G 7: 104,963,712 (GRCm39) L167R probably damaging Het
Polr2b C T 5: 77,468,913 (GRCm39) R230* probably null Het
Prkra T A 2: 76,477,545 (GRCm39) E53D probably benign Het
Rasgrp4 T A 7: 28,845,405 (GRCm39) L376Q probably damaging Het
Rwdd3 A G 3: 120,964,961 (GRCm39) S65P probably benign Het
Satb1 G A 17: 52,090,029 (GRCm39) P273S probably damaging Het
Scg3 T C 9: 75,589,374 (GRCm39) E93G probably damaging Het
Sf3a1 T C 11: 4,117,724 (GRCm39) F162S possibly damaging Het
Sorcs1 A G 19: 50,250,701 (GRCm39) Y377H probably damaging Het
Sptbn4 G A 7: 27,108,439 (GRCm39) A661V possibly damaging Het
Stk36 A G 1: 74,673,479 (GRCm39) N996S unknown Het
Tbca A T 13: 94,968,923 (GRCm39) I37F probably damaging Het
Tc2n A T 12: 101,672,716 (GRCm39) V75E probably damaging Het
Tdrkh A T 3: 94,333,263 (GRCm39) S243C probably damaging Het
Tjp1 T C 7: 64,964,438 (GRCm39) D911G probably damaging Het
Tmbim6 A G 15: 99,299,324 (GRCm39) probably benign Het
Tob1 T A 11: 94,104,708 (GRCm39) D81E probably benign Het
Ttpal T A 2: 163,448,945 (GRCm39) probably null Het
Usp37 A T 1: 74,534,787 (GRCm39) probably null Het
Vmn1r235 A G 17: 21,482,658 (GRCm39) I328V probably benign Het
Vmn1r28 T A 6: 58,242,850 (GRCm39) L231* probably null Het
Xirp1 G A 9: 119,848,176 (GRCm39) Q236* probably null Het
Zc3h7b A G 15: 81,664,682 (GRCm39) T514A probably damaging Het
Zfp524 A G 7: 5,021,200 (GRCm39) I243V probably benign Het
Zfp655 T A 5: 145,181,542 (GRCm39) Y467N possibly damaging Het
Zfp985 A T 4: 147,667,388 (GRCm39) K85N possibly damaging Het
Other mutations in Or8g37
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01388:Or8g37 APN 9 39,731,298 (GRCm39) missense probably damaging 1.00
IGL02674:Or8g37 APN 9 39,730,934 (GRCm39) splice site probably null
R0659:Or8g37 UTSW 9 39,731,112 (GRCm39) missense possibly damaging 0.78
R0686:Or8g37 UTSW 9 39,730,964 (GRCm39) missense probably damaging 0.98
R1952:Or8g37 UTSW 9 39,731,363 (GRCm39) missense probably benign 0.09
R2068:Or8g37 UTSW 9 39,731,846 (GRCm39) missense probably benign 0.00
R4472:Or8g37 UTSW 9 39,731,870 (GRCm39) makesense probably null
R4798:Or8g37 UTSW 9 39,731,193 (GRCm39) missense probably benign 0.13
R5035:Or8g37 UTSW 9 39,731,390 (GRCm39) missense possibly damaging 0.82
R5339:Or8g37 UTSW 9 39,731,229 (GRCm39) missense probably damaging 0.97
R6751:Or8g37 UTSW 9 39,731,193 (GRCm39) missense probably benign 0.13
R7211:Or8g37 UTSW 9 39,731,154 (GRCm39) missense possibly damaging 0.76
R7609:Or8g37 UTSW 9 39,731,583 (GRCm39) missense probably benign
R7638:Or8g37 UTSW 9 39,731,189 (GRCm39) missense probably damaging 1.00
R7890:Or8g37 UTSW 9 39,731,310 (GRCm39) missense probably damaging 0.99
R7918:Or8g37 UTSW 9 39,731,406 (GRCm39) missense probably damaging 0.98
R8548:Or8g37 UTSW 9 39,731,537 (GRCm39) missense probably benign 0.00
R8817:Or8g37 UTSW 9 39,730,939 (GRCm39) start codon destroyed probably null 0.40
R8868:Or8g37 UTSW 9 39,731,252 (GRCm39) missense probably benign
R9689:Or8g37 UTSW 9 39,731,801 (GRCm39) missense possibly damaging 0.95
Z1176:Or8g37 UTSW 9 39,731,651 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CCTGAATGTATGACTCAGCTCTAC -3'
(R):5'- CTTTGGACCTGCCTTCAGTG -3'

Sequencing Primer
(F):5'- GCAATCTGTAACCCCTTG -3'
(R):5'- GGACCTGCCTTCAGTGGATTTAATC -3'
Posted On 2019-10-07