Incidental Mutation 'R7476:Olfr1412'
ID579458
Institutional Source Beutler Lab
Gene Symbol Olfr1412
Ensembl Gene ENSMUSG00000046300
Gene Nameolfactory receptor 1412
SynonymsGA_x6K02T2R7CC-81165686-81164721, MOR208-4
MMRRC Submission
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.060) question?
Stock #R7476 (G1)
Quality Score225.009
Status Not validated
Chromosome1
Chromosomal Location92585779-92591375 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to C at 92589264 bp
ZygosityHeterozygous
Amino Acid Change Arginine to Serine at position 311 (R311S)
Ref Sequence ENSEMBL: ENSMUSP00000150943 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000062964] [ENSMUST00000190505]
Predicted Effect probably benign
Transcript: ENSMUST00000062964
AA Change: R311S

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000060291
Gene: ENSMUSG00000046300
AA Change: R311S

DomainStartEndE-ValueType
transmembrane domain 10 27 N/A INTRINSIC
Pfam:7tm_4 38 314 7.8e-47 PFAM
Pfam:7tm_1 48 321 1.4e-26 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000190505
AA Change: R311S

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.2%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 65 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
5730596B20Rik C T 6: 52,179,034 P27S unknown Het
Abi3bp A T 16: 56,614,746 K602* probably null Het
Adam29 G T 8: 55,873,195 H75N probably damaging Het
Ajap1 C T 4: 153,384,855 E373K probably damaging Het
Alg6 C A 4: 99,743,876 H206N probably damaging Het
Alox5 A T 6: 116,415,433 S376T probably benign Het
Arhgap19 A T 19: 41,782,363 Y321N probably benign Het
Brip1 A G 11: 86,157,808 V236A probably benign Het
C1ra C T 6: 124,522,699 P615S probably damaging Het
Ccdc69 C T 11: 55,051,198 V161I possibly damaging Het
Chil5 G A 3: 106,020,007 R163C possibly damaging Het
Cldnd1 A G 16: 58,729,544 D30G probably damaging Het
Colca2 G A 9: 51,277,600 A19V possibly damaging Het
Csmd1 A G 8: 15,895,731 C3561R probably damaging Het
Daxx T G 17: 33,911,281 V90G probably damaging Het
Dgkg T A 16: 22,622,304 probably benign Het
Dmrta2 A G 4: 109,982,025 H323R probably damaging Het
Dysf A T 6: 84,064,896 T161S probably benign Het
Fat1 G T 8: 45,031,274 R3183L probably benign Het
Fcho1 C A 8: 71,713,546 D347Y probably damaging Het
Gm21798 T C 15: 64,817,706 C5R unknown Het
Hmcn1 T C 1: 150,580,267 R5301G probably damaging Het
Hoxd11 T C 2: 74,684,115 F330L probably damaging Het
Lactbl1 A G 4: 136,637,639 D434G probably benign Het
Lgals8 A T 13: 12,448,481 N191K probably damaging Het
Lmod2 T A 6: 24,597,921 Y13* probably null Het
Malrd1 T C 2: 16,142,304 S1986P unknown Het
Map3k9 C T 12: 81,743,808 D324N probably damaging Het
Mcmbp C A 7: 128,703,582 K487N probably damaging Het
Mrpl4 G T 9: 21,002,771 probably benign Het
Nectin2 T C 7: 19,717,621 D496G possibly damaging Het
Nom1 T C 5: 29,442,536 S590P probably benign Het
Noto T C 6: 85,425,499 F156L probably damaging Het
Nrf1 T A 6: 30,116,272 D314E probably damaging Het
Nup93 T C 8: 94,303,632 L373P probably damaging Het
Olfr1002 T A 2: 85,648,168 Q51L not run Het
Olfr1168 A T 2: 88,184,966 M30L probably benign Het
Olfr1205 A G 2: 88,831,588 Q157R probably benign Het
Olfr1239 T C 2: 89,417,499 K305E possibly damaging Het
Olfr1369-ps1 A C 13: 21,116,021 I110L probably benign Het
Pclo A T 5: 14,521,331 K243N probably damaging Het
Pdgfra T A 5: 75,170,603 C290S probably damaging Het
Pnlip G A 19: 58,679,634 probably null Het
Ptprm A T 17: 66,725,791 H1022Q probably benign Het
Rfx2 T C 17: 56,803,527 D153G probably benign Het
Rps6ka2 T C 17: 7,271,633 F317L probably damaging Het
Rtl1 T A 12: 109,591,105 E1433D unknown Het
Sarnp A G 10: 128,833,354 T27A probably benign Het
Shc3 A T 13: 51,448,006 M295K probably benign Het
Slc1a3 T A 15: 8,643,084 M304L probably damaging Het
Slco1a6 G T 6: 142,103,001 T351K possibly damaging Het
Snrk A G 9: 122,157,222 N219S probably damaging Het
Spats2 T A 15: 99,212,141 V473E probably benign Het
Stk35 T C 2: 129,810,725 L382P probably damaging Het
Tbx10 T C 19: 3,999,034 V315A probably benign Het
Tdpoz1 A G 3: 93,670,775 L234P probably damaging Het
Ttn T G 2: 76,714,145 E32832D probably benign Het
Ttn T C 2: 76,771,186 Y18678C probably damaging Het
Ugt2a2 A T 5: 87,474,494 M205K probably damaging Het
Utrn C A 10: 12,640,951 V2300L probably benign Het
Vmn1r175 T C 7: 23,808,422 N260S probably benign Het
Vmn1r63 T A 7: 5,803,001 I211L probably benign Het
Vmn1r83 A G 7: 12,321,615 W172R possibly damaging Het
Xirp2 T C 2: 67,510,634 L1073P probably benign Het
Zfp82 A G 7: 30,056,172 V495A possibly damaging Het
Other mutations in Olfr1412
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01472:Olfr1412 APN 1 92588972 missense possibly damaging 0.52
IGL02177:Olfr1412 APN 1 92588757 missense possibly damaging 0.96
IGL02507:Olfr1412 APN 1 92588926 missense possibly damaging 0.68
IGL02888:Olfr1412 APN 1 92589203 missense probably damaging 1.00
IGL03001:Olfr1412 APN 1 92588551 missense probably damaging 1.00
R1771:Olfr1412 UTSW 1 92589115 missense probably benign 0.03
R1780:Olfr1412 UTSW 1 92588389 missense probably benign 0.01
R2215:Olfr1412 UTSW 1 92588986 missense probably benign 0.00
R2437:Olfr1412 UTSW 1 92588966 missense possibly damaging 0.46
R3176:Olfr1412 UTSW 1 92588813 missense probably benign 0.32
R3177:Olfr1412 UTSW 1 92588813 missense probably benign 0.32
R3276:Olfr1412 UTSW 1 92588813 missense probably benign 0.32
R3277:Olfr1412 UTSW 1 92588813 missense probably benign 0.32
R4475:Olfr1412 UTSW 1 92588579 missense probably benign 0.00
R4892:Olfr1412 UTSW 1 92588921 missense probably benign 0.05
R5910:Olfr1412 UTSW 1 92588707 missense probably damaging 1.00
R6808:Olfr1412 UTSW 1 92589046 missense probably damaging 0.99
R7130:Olfr1412 UTSW 1 92588912 missense probably benign 0.10
Z1088:Olfr1412 UTSW 1 92588551 missense probably damaging 1.00
Z1177:Olfr1412 UTSW 1 92588378 nonsense probably null
Predicted Primers PCR Primer
(F):5'- CTGTGGCTCCCATTTGACAG -3'
(R):5'- TCCTGGCATACAAGAGGATGG -3'

Sequencing Primer
(F):5'- GGCTCCCATTTGACAGCTGTG -3'
(R):5'- TGGAAGAAATCACACATAAATGCCAG -3'
Posted On2019-10-07