Incidental Mutation 'R7478:Zfp273'
ID 579628
Institutional Source Beutler Lab
Gene Symbol Zfp273
Ensembl Gene ENSMUSG00000030446
Gene Name zinc finger protein 273
Synonyms 6820416H06Rik
MMRRC Submission 045552-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.083) question?
Stock # R7478 (G1)
Quality Score 225.009
Status Validated
Chromosome 13
Chromosomal Location 67961935-67975119 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 67973251 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamine to Histidine at position 126 (Q126H)
Ref Sequence ENSEMBL: ENSMUSP00000137903 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000012725] [ENSMUST00000181391]
AlphaFold Q7M6W8
Predicted Effect probably benign
Transcript: ENSMUST00000012725
AA Change: Q93H

PolyPhen 2 Score 0.301 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000012725
Gene: ENSMUSG00000030446
AA Change: Q93H

DomainStartEndE-ValueType
KRAB 1 32 1.97e-1 SMART
ZnF_C2H2 48 70 1.95e-3 SMART
ZnF_C2H2 76 98 4.94e-5 SMART
ZnF_C2H2 104 126 6.32e-3 SMART
ZnF_C2H2 132 154 3.39e-3 SMART
ZnF_C2H2 160 182 2.99e-4 SMART
ZnF_C2H2 188 210 4.24e-4 SMART
ZnF_C2H2 216 238 1.45e-2 SMART
ZnF_C2H2 244 266 1.1e-2 SMART
ZnF_C2H2 272 294 2.91e-2 SMART
ZnF_C2H2 300 322 6.78e-3 SMART
ZnF_C2H2 328 350 2.71e-2 SMART
ZnF_C2H2 356 378 4.17e-3 SMART
ZnF_C2H2 384 406 1.38e-3 SMART
ZnF_C2H2 412 434 1.98e-4 SMART
ZnF_C2H2 440 462 1.2e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000181391
AA Change: Q126H

PolyPhen 2 Score 0.301 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000137903
Gene: ENSMUSG00000030446
AA Change: Q126H

DomainStartEndE-ValueType
KRAB 5 65 9.25e-28 SMART
ZnF_C2H2 81 103 1.95e-3 SMART
ZnF_C2H2 109 131 4.94e-5 SMART
ZnF_C2H2 137 159 6.32e-3 SMART
ZnF_C2H2 165 187 3.39e-3 SMART
ZnF_C2H2 193 215 2.99e-4 SMART
ZnF_C2H2 221 243 4.24e-4 SMART
ZnF_C2H2 249 271 1.45e-2 SMART
ZnF_C2H2 277 299 1.1e-2 SMART
ZnF_C2H2 305 327 2.91e-2 SMART
ZnF_C2H2 333 355 6.78e-3 SMART
ZnF_C2H2 361 383 2.71e-2 SMART
ZnF_C2H2 389 411 4.17e-3 SMART
ZnF_C2H2 417 439 1.38e-3 SMART
ZnF_C2H2 445 467 1.98e-4 SMART
ZnF_C2H2 473 495 1.2e-3 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.9%
Validation Efficiency 100% (50/50)
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ahcyl2 A G 6: 29,903,266 (GRCm39) R516G probably damaging Het
Ak9 T C 10: 41,265,087 (GRCm39) F948S Het
Aldh3b3 A G 19: 4,014,549 (GRCm39) M95V probably benign Het
Ankrd34a T C 3: 96,505,816 (GRCm39) L340P possibly damaging Het
Arid1a T A 4: 133,412,482 (GRCm39) R1186W unknown Het
Arpc4 T A 6: 113,361,092 (GRCm39) M95K possibly damaging Het
Atrnl1 A G 19: 57,684,744 (GRCm39) E790G possibly damaging Het
C130074G19Rik T C 1: 184,606,624 (GRCm39) N103D probably damaging Het
C1ra G A 6: 124,494,684 (GRCm39) E316K probably benign Het
Camsap2 T C 1: 136,198,678 (GRCm39) T782A Het
Catsperd A G 17: 56,971,055 (GRCm39) I706M probably benign Het
Cbx2 T C 11: 118,919,941 (GRCm39) V502A probably damaging Het
Cd72 T G 4: 43,454,515 (GRCm39) I5L possibly damaging Het
Celsr3 A G 9: 108,720,777 (GRCm39) Y2609C probably benign Het
Col19a1 C T 1: 24,356,788 (GRCm39) G632R probably damaging Het
Efcc1 T C 6: 87,707,972 (GRCm39) V33A probably damaging Het
Eif4enif1 T A 11: 3,177,709 (GRCm39) L367* probably null Het
Eml2 T A 7: 18,940,066 (GRCm39) L627* probably null Het
F13b A G 1: 139,435,433 (GRCm39) T193A probably benign Het
Hif3a G A 7: 16,776,560 (GRCm39) T462I possibly damaging Het
Ifna7 T A 4: 88,734,913 (GRCm39) I150N probably damaging Het
Man2b2 G A 5: 36,967,657 (GRCm39) H904Y probably damaging Het
Midn A G 10: 79,991,156 (GRCm39) T389A possibly damaging Het
Myo19 A T 11: 84,776,626 (GRCm39) H94L probably benign Het
Naglu T C 11: 100,962,725 (GRCm39) Y177H probably damaging Het
Nek1 T A 8: 61,583,179 (GRCm39) D1272E probably benign Het
Nxn A T 11: 76,152,378 (GRCm39) V372E probably damaging Het
Obscn G A 11: 58,984,242 (GRCm39) R1738C probably damaging Het
Pcm1 A G 8: 41,714,410 (GRCm39) E266G probably benign Het
Pkd1l1 T C 11: 8,879,441 (GRCm39) N920S Het
Pkd1l3 C A 8: 110,359,947 (GRCm39) T944K probably damaging Het
Prl7d1 C A 13: 27,894,168 (GRCm39) E133* probably null Het
Qser1 G A 2: 104,619,859 (GRCm39) L228F probably damaging Het
Rasa3 A G 8: 13,664,605 (GRCm39) I69T possibly damaging Het
Rb1 A T 14: 73,506,577 (GRCm39) S391T probably damaging Het
Rnf220 T C 4: 117,153,333 (GRCm39) Y301C possibly damaging Het
Sertm1 A G 3: 54,806,749 (GRCm39) V92A possibly damaging Het
Slfn5 A G 11: 82,851,442 (GRCm39) K580E probably damaging Het
Stard4 T C 18: 33,338,377 (GRCm39) Y111C unknown Het
Tagap C A 17: 8,152,422 (GRCm39) Q536K possibly damaging Het
Tank T C 2: 61,480,513 (GRCm39) C351R probably damaging Het
Tarbp2 A T 15: 102,430,169 (GRCm39) M144L probably benign Het
Tdrd9 T C 12: 111,951,476 (GRCm39) Y89H probably damaging Het
Tecpr2 C A 12: 110,934,873 (GRCm39) T1373K probably benign Het
Tle1 G A 4: 72,055,349 (GRCm39) P434L probably damaging Het
Tmed5 A G 5: 108,272,495 (GRCm39) V201A probably benign Het
Ust A G 10: 8,266,650 (GRCm39) probably null Het
Vmn2r94 T C 17: 18,477,767 (GRCm39) T215A probably benign Het
Zfp764l1 C T 7: 126,992,496 (GRCm39) C38Y probably null Het
Other mutations in Zfp273
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03115:Zfp273 APN 13 67,973,769 (GRCm39) missense probably damaging 1.00
R1969:Zfp273 UTSW 13 67,973,282 (GRCm39) missense probably damaging 1.00
R2679:Zfp273 UTSW 13 67,973,895 (GRCm39) missense probably benign 0.39
R3736:Zfp273 UTSW 13 67,973,626 (GRCm39) nonsense probably null
R4832:Zfp273 UTSW 13 67,973,484 (GRCm39) missense probably benign 0.01
R4896:Zfp273 UTSW 13 67,973,673 (GRCm39) missense probably damaging 1.00
R5004:Zfp273 UTSW 13 67,973,673 (GRCm39) missense probably damaging 1.00
R5223:Zfp273 UTSW 13 67,974,298 (GRCm39) missense probably damaging 1.00
R5748:Zfp273 UTSW 13 67,973,450 (GRCm39) missense probably damaging 1.00
R5948:Zfp273 UTSW 13 67,973,918 (GRCm39) missense probably benign 0.43
R6102:Zfp273 UTSW 13 67,970,466 (GRCm39) missense probably damaging 1.00
R6668:Zfp273 UTSW 13 67,973,243 (GRCm39) missense probably damaging 0.99
R7192:Zfp273 UTSW 13 67,973,183 (GRCm39) missense possibly damaging 0.82
R7792:Zfp273 UTSW 13 67,974,135 (GRCm39) missense possibly damaging 0.71
R7874:Zfp273 UTSW 13 67,973,558 (GRCm39) missense probably benign 0.00
R8261:Zfp273 UTSW 13 67,974,070 (GRCm39) missense probably benign 0.12
R8424:Zfp273 UTSW 13 67,970,471 (GRCm39) missense probably benign 0.17
R8716:Zfp273 UTSW 13 67,974,053 (GRCm39) missense probably damaging 1.00
R8843:Zfp273 UTSW 13 67,970,387 (GRCm39) missense possibly damaging 0.80
R9010:Zfp273 UTSW 13 67,974,177 (GRCm39) missense probably damaging 1.00
R9131:Zfp273 UTSW 13 67,973,685 (GRCm39) missense probably damaging 1.00
X0028:Zfp273 UTSW 13 67,971,261 (GRCm39) missense probably benign 0.20
Z1088:Zfp273 UTSW 13 67,973,513 (GRCm39) missense possibly damaging 0.91
Z1176:Zfp273 UTSW 13 67,971,265 (GRCm39) missense probably null
Predicted Primers PCR Primer
(F):5'- GCCTGGTCTACAAAGTGAGTT -3'
(R):5'- GTGCGAACACTAAAGGCCT -3'

Sequencing Primer
(F):5'- CCTGGTCTACAAAGTGAGTTCCAGG -3'
(R):5'- GTACTCTTCGGTGAACAATAAGTCC -3'
Posted On 2019-10-07