Incidental Mutation 'R7481:Selplg'
ID 579795
Institutional Source Beutler Lab
Gene Symbol Selplg
Ensembl Gene ENSMUSG00000048163
Gene Name selectin, platelet (p-selectin) ligand
Synonyms Psgl-1, CD162, Psgl1
MMRRC Submission 045555-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.066) question?
Stock # R7481 (G1)
Quality Score 189.458
Status Not validated
Chromosome 5
Chromosomal Location 113956597-113970705 bp(-) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) GTCTGCCTCCATGGGTGCTGGCTGCGAGGTCTCTGCCTCCATGGGTGCTGGCTGCGAGGTCTCTGCCTCCATGGGTGCTGGCTGCGAGGTCTCTGCCTCCATGGGTGCTGGCTGCGAGGTCTCT to GTCTGCCTCCATGGGTGCTGGCTGCGAGGTCTCTGCCTCCATGGGTGCTGGCTGCGAGGTCTCTGCCTCCATGGGTGCTGGCTGCGAGGTCTCT at 113957756 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Gene Model predicted gene model for transcript(s): [ENSMUST00000100874] [ENSMUST00000199109]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000100874
SMART Domains Protein: ENSMUSP00000098436
Gene: ENSMUSG00000048163

DomainStartEndE-ValueType
signal peptide 1 17 N/A INTRINSIC
low complexity region 102 115 N/A INTRINSIC
internal_repeat_2 130 182 2.38e-13 PROSPERO
internal_repeat_1 133 186 5.75e-16 PROSPERO
internal_repeat_1 193 246 5.75e-16 PROSPERO
internal_repeat_2 200 252 2.38e-13 PROSPERO
transmembrane domain 328 350 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000199109
Predicted Effect probably benign
Transcript: ENSMUST00000201194
Predicted Effect probably benign
Transcript: ENSMUST00000201931
Predicted Effect probably benign
Transcript: ENSMUST00000202555
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2011]
PHENOTYPE: Mice homozygous for a null allele exhibit neutrophillia and impaired leukocyte adhesion and rolling. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 68 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4932414N04Rik T C 2: 68,494,575 (GRCm39) F68S unknown Het
Abcb6 A G 1: 75,150,248 (GRCm39) F637L probably damaging Het
Aldh3b3 A G 19: 4,014,549 (GRCm39) M95V probably benign Het
Arhgap45 A T 10: 79,858,134 (GRCm39) H387L possibly damaging Het
Avil C T 10: 126,843,460 (GRCm39) T130I probably benign Het
Bmal2 G A 6: 146,720,369 (GRCm39) A178T not run Het
C1ra G A 6: 124,494,684 (GRCm39) E316K probably benign Het
C3 C A 17: 57,527,136 (GRCm39) W771L probably damaging Het
C6 A G 15: 4,844,357 (GRCm39) I926M Het
Cacna1b G A 2: 24,506,874 (GRCm39) L1903F probably damaging Het
Car3 A T 3: 14,928,632 (GRCm39) M1L probably benign Het
Ccdc175 A G 12: 72,202,398 (GRCm39) I299T probably benign Het
Chd9 C T 8: 91,683,066 (GRCm39) T502I unknown Het
Clec4a1 G A 6: 122,904,998 (GRCm39) C99Y probably damaging Het
Col19a1 C T 1: 24,356,788 (GRCm39) G632R probably damaging Het
Dmbt1 A T 7: 130,681,241 (GRCm39) probably null Het
Dop1a A T 9: 86,417,985 (GRCm39) K1951N probably damaging Het
Dpf3 A C 12: 83,378,701 (GRCm39) L122R probably damaging Het
Edem3 A T 1: 151,683,973 (GRCm39) S687C probably damaging Het
Edem3 G A 1: 151,683,974 (GRCm39) S687N possibly damaging Het
Fig4 A G 10: 41,106,001 (GRCm39) probably null Het
Fmnl2 A G 2: 52,998,443 (GRCm39) T603A unknown Het
Frmd6 T A 12: 70,933,829 (GRCm39) L249Q probably damaging Het
Glrx3 T C 7: 137,046,751 (GRCm39) C48R probably damaging Het
Gm40460 CACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAG CACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAG 7: 141,794,554 (GRCm39) probably benign Het
Gm6133 A T 18: 78,393,008 (GRCm39) M1L probably benign Het
Gm9195 G A 14: 72,720,116 (GRCm39) T105I probably benign Het
Hk2 G A 6: 82,737,150 (GRCm39) T54I probably benign Het
Jade1 G A 3: 41,559,125 (GRCm39) G402D probably benign Het
Kmt2a T C 9: 44,720,368 (GRCm39) D3873G unknown Het
Map6 A T 7: 98,918,345 (GRCm39) T373S possibly damaging Het
Megf9 T C 4: 70,351,679 (GRCm39) T481A probably damaging Het
Mtcl3 G T 10: 29,072,519 (GRCm39) V604L probably damaging Het
Mtus1 T A 8: 41,537,652 (GRCm39) K21N probably damaging Het
Muc5b C T 7: 141,414,908 (GRCm39) T2618I unknown Het
Nbas A G 12: 13,406,960 (GRCm39) I852M probably damaging Het
Or14j1 T A 17: 38,146,289 (GRCm39) M133K probably damaging Het
Or4a70 C T 2: 89,324,636 (GRCm39) V7I probably benign Het
Or5b121 A T 19: 13,507,817 (GRCm39) Q304L probably damaging Het
Or5d39 A G 2: 87,980,105 (GRCm39) I86T probably benign Het
Pank4 A G 4: 155,054,495 (GRCm39) N156S probably damaging Het
Pcdhga8 A G 18: 37,860,990 (GRCm39) E682G probably benign Het
Pde10a C A 17: 9,168,262 (GRCm39) D312E possibly damaging Het
Pkhd1l1 A G 15: 44,376,307 (GRCm39) T990A probably benign Het
Rab11fip1 T C 8: 27,646,609 (GRCm39) T156A probably damaging Het
Rhbdd2 T A 5: 135,665,031 (GRCm39) S121T possibly damaging Het
Rsf1 CGGCGGCGG CGGCGGCGGGGGCGGCGG 7: 97,229,124 (GRCm39) probably benign Het
Ryr3 C A 2: 112,508,438 (GRCm39) R3418S probably benign Het
Ryr3 C A 2: 112,508,439 (GRCm39) R3418M possibly damaging Het
Sbno2 G A 10: 79,893,333 (GRCm39) P1323S probably benign Het
Sec24d T C 3: 123,144,412 (GRCm39) C630R probably damaging Het
Skp2 A T 15: 9,113,905 (GRCm39) V371E probably damaging Het
Strbp A T 2: 37,490,766 (GRCm39) S496R probably benign Het
Stxbp4 G A 11: 90,485,639 (GRCm39) T236I possibly damaging Het
Terf2 C T 8: 107,799,353 (GRCm39) probably null Het
Thnsl1 A T 2: 21,216,599 (GRCm39) T118S probably benign Het
Tlnrd1 A T 7: 83,531,546 (GRCm39) V295E probably damaging Het
Ttll6 A G 11: 96,045,672 (GRCm39) T630A probably benign Het
Usp9y G T Y: 1,432,180 (GRCm39) A435E probably benign Het
Vil1 A C 1: 74,459,058 (GRCm39) R187S probably damaging Het
Vmn2r31 A T 7: 7,387,579 (GRCm39) V664E possibly damaging Het
Wdr17 T C 8: 55,114,371 (GRCm39) I693M probably benign Het
Wdr82 C T 9: 106,053,865 (GRCm39) T72I probably damaging Het
Zbtb5 A G 4: 44,994,905 (GRCm39) S160P probably benign Het
Zfat G A 15: 68,050,715 (GRCm39) Q769* probably null Het
Zfp764l1 C T 7: 126,992,496 (GRCm39) C38Y probably null Het
Zfp937 T A 2: 150,081,266 (GRCm39) I432K probably benign Het
Zglp1 C T 9: 20,973,903 (GRCm39) S261N probably benign Het
Other mutations in Selplg
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01412:Selplg APN 5 113,957,529 (GRCm39) missense probably damaging 1.00
IGL01488:Selplg APN 5 113,957,697 (GRCm39) missense possibly damaging 0.78
IGL02355:Selplg APN 5 113,957,467 (GRCm39) missense probably benign 0.00
IGL02362:Selplg APN 5 113,957,467 (GRCm39) missense probably benign 0.00
PIT4142001:Selplg UTSW 5 113,957,689 (GRCm39) missense probably benign 0.00
R0375:Selplg UTSW 5 113,958,069 (GRCm39) missense probably damaging 0.99
R1222:Selplg UTSW 5 113,957,434 (GRCm39) missense possibly damaging 0.95
R1840:Selplg UTSW 5 113,957,905 (GRCm39) missense possibly damaging 0.66
R2925:Selplg UTSW 5 113,958,240 (GRCm39) missense possibly damaging 0.92
R4512:Selplg UTSW 5 113,957,124 (GRCm39) missense probably benign 0.05
R4702:Selplg UTSW 5 113,957,094 (GRCm39) missense probably benign 0.31
R4703:Selplg UTSW 5 113,957,094 (GRCm39) missense probably benign 0.31
R4704:Selplg UTSW 5 113,957,094 (GRCm39) missense probably benign 0.31
R4968:Selplg UTSW 5 113,957,787 (GRCm39) missense possibly damaging 0.93
R5075:Selplg UTSW 5 113,958,045 (GRCm39) missense probably benign 0.00
R6159:Selplg UTSW 5 113,957,162 (GRCm39) missense probably benign 0.02
R6345:Selplg UTSW 5 113,958,210 (GRCm39) missense probably benign 0.03
R6550:Selplg UTSW 5 113,958,210 (GRCm39) missense probably benign 0.03
R6554:Selplg UTSW 5 113,958,210 (GRCm39) missense probably benign 0.03
R6997:Selplg UTSW 5 113,957,756 (GRCm39) unclassified probably benign
R7050:Selplg UTSW 5 113,957,756 (GRCm39) unclassified probably benign
R7094:Selplg UTSW 5 113,957,756 (GRCm39) unclassified probably benign
R7235:Selplg UTSW 5 113,957,756 (GRCm39) unclassified probably benign
R7604:Selplg UTSW 5 113,957,756 (GRCm39) unclassified probably benign
R7674:Selplg UTSW 5 113,957,756 (GRCm39) unclassified probably benign
R7846:Selplg UTSW 5 113,957,481 (GRCm39) missense probably damaging 1.00
R7887:Selplg UTSW 5 113,957,756 (GRCm39) unclassified probably benign
R8051:Selplg UTSW 5 113,957,502 (GRCm39) missense probably damaging 0.99
R8823:Selplg UTSW 5 113,957,756 (GRCm39) unclassified probably benign
R8834:Selplg UTSW 5 113,957,691 (GRCm39) missense possibly damaging 0.64
R8955:Selplg UTSW 5 113,957,756 (GRCm39) unclassified probably benign
R9036:Selplg UTSW 5 113,957,756 (GRCm39) unclassified probably benign
R9152:Selplg UTSW 5 113,957,467 (GRCm39) missense probably benign 0.00
R9241:Selplg UTSW 5 113,957,647 (GRCm39) missense possibly damaging 0.83
R9249:Selplg UTSW 5 113,957,756 (GRCm39) unclassified probably benign
R9361:Selplg UTSW 5 113,957,756 (GRCm39) unclassified probably benign
R9381:Selplg UTSW 5 113,957,917 (GRCm39) missense probably benign 0.05
R9434:Selplg UTSW 5 113,957,756 (GRCm39) unclassified probably benign
R9446:Selplg UTSW 5 113,957,756 (GRCm39) unclassified probably benign
R9482:Selplg UTSW 5 113,957,756 (GRCm39) unclassified probably benign
R9670:Selplg UTSW 5 113,957,756 (GRCm39) unclassified probably benign
R9779:Selplg UTSW 5 113,957,756 (GRCm39) unclassified probably benign
Z1177:Selplg UTSW 5 113,957,412 (GRCm39) missense probably benign 0.30
Predicted Primers PCR Primer
(F):5'- GCTGCAGACGTTGTAAACAG -3'
(R):5'- GTGGAGTCTAACCTCAGTAGAGAC -3'

Sequencing Primer
(F):5'- TTTACAGCCTGAATCCTGGGAAGC -3'
(R):5'- GTCTAACCTCAGTAGAGACCGTCC -3'
Posted On 2019-10-07