Incidental Mutation 'R0631:Itgae'
| ID |
57983 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Itgae
|
| Ensembl Gene |
ENSMUSG00000005947 |
| Gene Name |
integrin alpha E, epithelial-associated |
| Synonyms |
CD103, alpha-E1 |
| MMRRC Submission |
038820-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R0631 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
11 |
| Chromosomal Location |
73090583-73147446 bp(+) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 73114907 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Aspartic acid
at position 299
(V299D)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000099596
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000006101]
[ENSMUST00000102537]
|
| AlphaFold |
Q60677 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000006101
AA Change: V299D
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000006101
Gene: ENSMUSG00000005947
AA Change: V299D
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
Blast:Int_alpha
|
36 |
118 |
1e-24 |
BLAST |
|
VWA
|
193 |
380 |
1.13e-39 |
SMART |
|
Int_alpha
|
448 |
496 |
1.49e-3 |
SMART |
|
Int_alpha
|
502 |
559 |
6.83e-12 |
SMART |
|
Int_alpha
|
565 |
626 |
1.79e-15 |
SMART |
|
Int_alpha
|
633 |
685 |
6.29e0 |
SMART |
|
transmembrane domain
|
1115 |
1137 |
N/A |
INTRINSIC |
|
Pfam:Integrin_alpha
|
1138 |
1152 |
1.1e-6 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000102537
AA Change: V299D
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000099596
Gene: ENSMUSG00000005947
AA Change: V299D
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
Blast:Int_alpha
|
36 |
118 |
5e-25 |
BLAST |
|
VWA
|
193 |
380 |
1.13e-39 |
SMART |
|
Int_alpha
|
448 |
496 |
1.49e-3 |
SMART |
|
Int_alpha
|
502 |
559 |
6.83e-12 |
SMART |
|
Int_alpha
|
565 |
626 |
1.79e-15 |
SMART |
|
Int_alpha
|
633 |
685 |
6.29e0 |
SMART |
|
| Meta Mutation Damage Score |
0.7396 |
| Coding Region Coverage |
- 1x: 99.4%
- 3x: 99.1%
- 10x: 98.1%
- 20x: 96.8%
|
| Validation Efficiency |
97% (129/133) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains. In combination with the beta 7 integrin, this protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen. This protein is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory molecule for IEL activation. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygotes for a targeted null mutation exhibit reductions in the numbers of intestinal and vaginal intraepithelial lymphocytes and of T lymphocytes of the lamina propria. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 131 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4833427G06Rik |
T |
A |
9: 51,101,953 (GRCm38) |
R6S |
probably benign |
Het |
| Aadat |
T |
C |
8: 60,529,445 (GRCm38) |
|
probably benign |
Het |
| Afap1l2 |
T |
C |
19: 56,916,085 (GRCm38) |
E594G |
probably benign |
Het |
| Ak8 |
T |
G |
2: 28,735,665 (GRCm38) |
I240S |
probably damaging |
Het |
| Akap13 |
T |
C |
7: 75,614,996 (GRCm38) |
V174A |
probably damaging |
Het |
| Alppl2 |
G |
A |
1: 87,089,373 (GRCm38) |
T66I |
probably damaging |
Het |
| Ankrd61 |
T |
A |
5: 143,894,879 (GRCm38) |
I36F |
probably damaging |
Het |
| Antxrl |
T |
A |
14: 34,058,801 (GRCm38) |
|
probably null |
Het |
| Arhgef2 |
G |
C |
3: 88,634,436 (GRCm38) |
V244L |
probably damaging |
Het |
| Arid1a |
A |
G |
4: 133,689,170 (GRCm38) |
I1098T |
unknown |
Het |
| Atr |
T |
C |
9: 95,874,777 (GRCm38) |
V903A |
possibly damaging |
Het |
| AW549877 |
A |
G |
15: 3,986,489 (GRCm38) |
|
probably benign |
Het |
| B3gnt6 |
C |
A |
7: 98,193,692 (GRCm38) |
A354S |
probably benign |
Het |
| Bnc1 |
A |
T |
7: 81,974,366 (GRCm38) |
I371N |
probably damaging |
Het |
| Camsap1 |
A |
T |
2: 25,933,647 (GRCm38) |
S1464T |
probably damaging |
Het |
| Cand2 |
G |
A |
6: 115,803,805 (GRCm38) |
E1217K |
probably damaging |
Het |
| Cass4 |
T |
C |
2: 172,432,411 (GRCm38) |
I728T |
probably damaging |
Het |
| Ccdc88a |
A |
T |
11: 29,493,752 (GRCm38) |
M1378L |
probably damaging |
Het |
| Ccdc9 |
C |
A |
7: 16,278,459 (GRCm38) |
W266L |
probably damaging |
Het |
| Cct6b |
C |
A |
11: 82,737,088 (GRCm38) |
|
probably null |
Het |
| Cd177 |
T |
C |
7: 24,756,686 (GRCm38) |
E219G |
probably benign |
Het |
| Cdkal1 |
A |
T |
13: 29,354,684 (GRCm38) |
Y497* |
probably null |
Het |
| Chmp2a |
T |
C |
7: 13,032,444 (GRCm38) |
E107G |
probably damaging |
Het |
| Chrna2 |
T |
G |
14: 66,149,308 (GRCm38) |
V301G |
probably benign |
Het |
| Chrna7 |
A |
G |
7: 63,099,643 (GRCm38) |
C364R |
probably benign |
Het |
| Cltc |
G |
T |
11: 86,712,613 (GRCm38) |
L796I |
probably benign |
Het |
| Col12a1 |
T |
C |
9: 79,703,376 (GRCm38) |
T249A |
probably damaging |
Het |
| Col13a1 |
G |
A |
10: 61,887,350 (GRCm38) |
Q270* |
probably null |
Het |
| Col6a1 |
C |
T |
10: 76,709,735 (GRCm38) |
V968M |
probably benign |
Het |
| Copb1 |
C |
A |
7: 114,233,282 (GRCm38) |
V511F |
probably benign |
Het |
| Daw1 |
C |
G |
1: 83,197,260 (GRCm38) |
S160R |
probably damaging |
Het |
| Ddx46 |
A |
G |
13: 55,639,777 (GRCm38) |
|
probably benign |
Het |
| Depdc7 |
T |
C |
2: 104,721,987 (GRCm38) |
K492E |
possibly damaging |
Het |
| Dmbt1 |
C |
T |
7: 131,097,653 (GRCm38) |
A1004V |
possibly damaging |
Het |
| Dnah7b |
G |
A |
1: 46,240,992 (GRCm38) |
V2694I |
probably benign |
Het |
| Dnhd1 |
T |
A |
7: 105,651,624 (GRCm38) |
F63I |
probably benign |
Het |
| Edc4 |
C |
A |
8: 105,890,792 (GRCm38) |
A1052E |
possibly damaging |
Het |
| Eif2s2 |
T |
A |
2: 154,884,358 (GRCm38) |
K129M |
probably damaging |
Het |
| Emx2 |
A |
G |
19: 59,464,028 (GRCm38) |
D248G |
probably damaging |
Het |
| Erich6b |
T |
C |
14: 75,659,009 (GRCm38) |
|
probably benign |
Het |
| Exoc3l4 |
A |
G |
12: 111,427,966 (GRCm38) |
K507E |
probably benign |
Het |
| Fanci |
T |
A |
7: 79,406,205 (GRCm38) |
V195E |
probably damaging |
Het |
| Fgfr2 |
T |
G |
7: 130,227,239 (GRCm38) |
|
probably benign |
Het |
| Frem1 |
A |
G |
4: 82,972,165 (GRCm38) |
S1007P |
probably damaging |
Het |
| Fry |
T |
C |
5: 150,496,352 (GRCm38) |
I993T |
possibly damaging |
Het |
| Fst |
A |
G |
13: 114,454,502 (GRCm38) |
S244P |
possibly damaging |
Het |
| Gcc1 |
T |
C |
6: 28,421,010 (GRCm38) |
T103A |
probably damaging |
Het |
| Gdf2 |
C |
T |
14: 33,941,221 (GRCm38) |
P24L |
probably damaging |
Het |
| Gja3 |
T |
C |
14: 57,036,762 (GRCm38) |
D51G |
possibly damaging |
Het |
| Gm10305 |
A |
G |
4: 99,273,076 (GRCm38) |
D74G |
unknown |
Het |
| Gm12689 |
G |
T |
4: 99,296,021 (GRCm38) |
G37V |
unknown |
Het |
| Gm5424 |
C |
T |
10: 62,071,534 (GRCm38) |
|
noncoding transcript |
Het |
| Hephl1 |
T |
C |
9: 15,084,524 (GRCm38) |
E434G |
probably benign |
Het |
| Htatip2 |
T |
C |
7: 49,773,311 (GRCm38) |
C205R |
possibly damaging |
Het |
| Igf2r |
T |
C |
17: 12,717,274 (GRCm38) |
|
probably null |
Het |
| Ints2 |
T |
C |
11: 86,233,196 (GRCm38) |
I589V |
probably benign |
Het |
| Kcnma1 |
T |
C |
14: 23,509,784 (GRCm38) |
|
probably benign |
Het |
| Kif11 |
A |
G |
19: 37,413,117 (GRCm38) |
|
probably benign |
Het |
| Kif13a |
A |
G |
13: 46,778,888 (GRCm38) |
|
probably benign |
Het |
| Kif18a |
T |
A |
2: 109,298,322 (GRCm38) |
|
probably benign |
Het |
| Klhl29 |
T |
C |
12: 5,094,883 (GRCm38) |
T406A |
probably benign |
Het |
| Litaf |
A |
T |
16: 10,966,412 (GRCm38) |
|
probably benign |
Het |
| Lmntd1 |
T |
A |
6: 145,430,000 (GRCm38) |
I71F |
probably benign |
Het |
| Lrit3 |
A |
C |
3: 129,788,555 (GRCm38) |
C594W |
probably damaging |
Het |
| Lrp6 |
T |
A |
6: 134,479,775 (GRCm38) |
Q842L |
possibly damaging |
Het |
| Lrrcc1 |
T |
A |
3: 14,540,119 (GRCm38) |
|
probably benign |
Het |
| Macf1 |
A |
T |
4: 123,455,524 (GRCm38) |
L1829* |
probably null |
Het |
| Mapk1ip1 |
T |
C |
7: 138,835,955 (GRCm38) |
T249A |
possibly damaging |
Het |
| Mfap4 |
T |
C |
11: 61,487,180 (GRCm38) |
F173L |
probably damaging |
Het |
| Mfsd9 |
C |
A |
1: 40,790,474 (GRCm38) |
|
probably benign |
Het |
| Mgat4b |
T |
C |
11: 50,230,763 (GRCm38) |
S69P |
probably damaging |
Het |
| Mki67 |
A |
T |
7: 135,704,388 (GRCm38) |
V620D |
probably damaging |
Het |
| Moxd1 |
C |
T |
10: 24,252,954 (GRCm38) |
T201I |
probably damaging |
Het |
| Msh4 |
G |
C |
3: 153,866,420 (GRCm38) |
D774E |
probably benign |
Het |
| Myg1 |
C |
T |
15: 102,331,849 (GRCm38) |
R37C |
probably benign |
Het |
| Myrf |
C |
A |
19: 10,228,882 (GRCm38) |
A57S |
probably benign |
Het |
| Ndst1 |
G |
A |
18: 60,700,359 (GRCm38) |
|
probably benign |
Het |
| Nedd4l |
A |
T |
18: 65,208,503 (GRCm38) |
|
probably benign |
Het |
| Neil2 |
T |
A |
14: 63,183,400 (GRCm38) |
I281F |
possibly damaging |
Het |
| Nfatc2 |
T |
A |
2: 168,590,115 (GRCm38) |
D26V |
probably benign |
Het |
| Nt5c |
A |
G |
11: 115,490,714 (GRCm38) |
|
probably null |
Het |
| Olfr1095 |
T |
C |
2: 86,850,967 (GRCm38) |
T244A |
probably benign |
Het |
| Olfr1369-ps1 |
G |
T |
13: 21,115,908 (GRCm38) |
C72F |
probably damaging |
Het |
| Olfr202 |
A |
G |
16: 59,284,207 (GRCm38) |
C97R |
possibly damaging |
Het |
| Olfr372 |
T |
A |
8: 72,058,322 (GRCm38) |
I214N |
probably damaging |
Het |
| Olfr538 |
T |
G |
7: 140,574,507 (GRCm38) |
M118R |
probably damaging |
Het |
| Ovch2 |
A |
G |
7: 107,782,021 (GRCm38) |
S557P |
probably benign |
Het |
| Pik3cg |
A |
G |
12: 32,205,203 (GRCm38) |
S262P |
probably benign |
Het |
| Pla2g6 |
T |
A |
15: 79,306,396 (GRCm38) |
H322L |
probably damaging |
Het |
| Plch1 |
A |
T |
3: 63,699,219 (GRCm38) |
L1079Q |
probably benign |
Het |
| Plekhg4 |
T |
A |
8: 105,379,302 (GRCm38) |
V777D |
probably damaging |
Het |
| Plekhg5 |
A |
G |
4: 152,112,419 (GRCm38) |
D747G |
possibly damaging |
Het |
| Poln |
C |
A |
5: 34,118,958 (GRCm38) |
V318F |
possibly damaging |
Het |
| Pou5f2 |
T |
A |
13: 78,025,754 (GRCm38) |
S272T |
probably benign |
Het |
| Ppp1r3e |
T |
G |
14: 54,876,616 (GRCm38) |
S200R |
possibly damaging |
Het |
| Prl7d1 |
G |
A |
13: 27,710,182 (GRCm38) |
P135S |
probably benign |
Het |
| Ptgs2 |
G |
A |
1: 150,104,537 (GRCm38) |
V409I |
probably benign |
Het |
| Ptk2b |
T |
C |
14: 66,177,751 (GRCm38) |
T276A |
probably damaging |
Het |
| Ptpn3 |
T |
C |
4: 57,204,921 (GRCm38) |
T747A |
probably damaging |
Het |
| Qrfpr |
A |
G |
3: 36,221,989 (GRCm38) |
I84T |
probably damaging |
Het |
| Rab44 |
A |
G |
17: 29,139,144 (GRCm38) |
D102G |
possibly damaging |
Het |
| Rnf125 |
A |
T |
18: 20,979,083 (GRCm38) |
D57V |
possibly damaging |
Het |
| Rnf145 |
T |
C |
11: 44,560,024 (GRCm38) |
F392L |
probably damaging |
Het |
| Rttn |
A |
G |
18: 88,989,546 (GRCm38) |
N435S |
probably benign |
Het |
| Scn8a |
A |
G |
15: 101,035,537 (GRCm38) |
T1500A |
probably damaging |
Het |
| Sgsm1 |
A |
G |
5: 113,285,123 (GRCm38) |
|
probably benign |
Het |
| Sgsm3 |
A |
T |
15: 81,011,736 (GRCm38) |
*751C |
probably null |
Het |
| Slc35c2 |
A |
C |
2: 165,280,929 (GRCm38) |
L145R |
probably damaging |
Het |
| Slc4a7 |
A |
T |
14: 14,757,382 (GRCm38) |
E396V |
probably damaging |
Het |
| Smarca4 |
G |
C |
9: 21,658,984 (GRCm38) |
|
probably benign |
Het |
| Snapc3 |
T |
A |
4: 83,417,802 (GRCm38) |
V17D |
probably damaging |
Het |
| Snta1 |
G |
T |
2: 154,377,072 (GRCm38) |
Q448K |
probably benign |
Het |
| Sptbn2 |
A |
G |
19: 4,739,986 (GRCm38) |
D1334G |
probably benign |
Het |
| Stard5 |
A |
G |
7: 83,632,757 (GRCm38) |
R41G |
probably damaging |
Het |
| Stxbp5 |
T |
A |
10: 9,784,358 (GRCm38) |
N731I |
probably benign |
Het |
| Tmem135 |
T |
A |
7: 89,143,788 (GRCm38) |
K413* |
probably null |
Het |
| Tmem38a |
G |
A |
8: 72,580,018 (GRCm38) |
V114I |
probably benign |
Het |
| Tpr |
A |
G |
1: 150,422,531 (GRCm38) |
T1057A |
probably damaging |
Het |
| Ttc23l |
A |
T |
15: 10,539,980 (GRCm38) |
L139Q |
probably damaging |
Het |
| Ttn |
T |
A |
2: 76,755,296 (GRCm38) |
|
probably null |
Het |
| Tuba3b |
A |
G |
6: 145,619,576 (GRCm38) |
T257A |
probably damaging |
Het |
| Tubgcp6 |
A |
C |
15: 89,100,987 (GRCm38) |
Y1633D |
probably damaging |
Het |
| Txnl1 |
C |
T |
18: 63,671,573 (GRCm38) |
|
probably benign |
Het |
| Unc13b |
A |
G |
4: 43,182,849 (GRCm38) |
Q3186R |
possibly damaging |
Het |
| Vmn2r75 |
T |
A |
7: 86,163,270 (GRCm38) |
S514C |
probably null |
Het |
| Whrn |
G |
A |
4: 63,419,489 (GRCm38) |
T545I |
probably damaging |
Het |
| Zdhhc20 |
T |
C |
14: 57,857,640 (GRCm38) |
H154R |
probably damaging |
Het |
| Zfp462 |
A |
T |
4: 55,007,563 (GRCm38) |
M1L |
possibly damaging |
Het |
| Zfp831 |
A |
G |
2: 174,645,290 (GRCm38) |
K586R |
possibly damaging |
Het |
| Zfp990 |
A |
T |
4: 145,537,302 (GRCm38) |
H290L |
possibly damaging |
Het |
| Zfpm1 |
C |
T |
8: 122,336,874 (GRCm38) |
|
probably benign |
Het |
|
| Other mutations in Itgae |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00424:Itgae
|
APN |
11 |
73,145,635 (GRCm38) |
missense |
probably benign |
0.17 |
|
IGL00472:Itgae
|
APN |
11 |
73,113,694 (GRCm38) |
missense |
probably benign |
0.06 |
|
IGL00821:Itgae
|
APN |
11 |
73,123,148 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01625:Itgae
|
APN |
11 |
73,119,437 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL01639:Itgae
|
APN |
11 |
73,119,378 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL01743:Itgae
|
APN |
11 |
73,111,759 (GRCm38) |
missense |
probably benign |
0.02 |
|
IGL01911:Itgae
|
APN |
11 |
73,116,137 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01949:Itgae
|
APN |
11 |
73,118,184 (GRCm38) |
missense |
probably benign |
0.29 |
|
IGL02149:Itgae
|
APN |
11 |
73,103,894 (GRCm38) |
missense |
probably benign |
0.04 |
|
IGL02179:Itgae
|
APN |
11 |
73,134,018 (GRCm38) |
missense |
probably benign |
0.06 |
|
IGL02231:Itgae
|
APN |
11 |
73,090,622 (GRCm38) |
missense |
possibly damaging |
0.88 |
|
IGL02292:Itgae
|
APN |
11 |
73,118,535 (GRCm38) |
missense |
probably damaging |
0.98 |
|
IGL02378:Itgae
|
APN |
11 |
73,118,121 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL02525:Itgae
|
APN |
11 |
73,130,951 (GRCm38) |
missense |
probably damaging |
0.98 |
|
IGL02576:Itgae
|
APN |
11 |
73,118,505 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
IGL02729:Itgae
|
APN |
11 |
73,118,203 (GRCm38) |
splice site |
probably benign |
|
|
IGL02859:Itgae
|
APN |
11 |
73,114,867 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03074:Itgae
|
APN |
11 |
73,125,310 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL03107:Itgae
|
APN |
11 |
73,113,601 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03264:Itgae
|
APN |
11 |
73,115,574 (GRCm38) |
missense |
possibly damaging |
0.73 |
|
IGL03272:Itgae
|
APN |
11 |
73,133,854 (GRCm38) |
splice site |
probably null |
|
|
IGL03352:Itgae
|
APN |
11 |
73,131,730 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0134:Itgae
|
UTSW |
11 |
73,111,342 (GRCm38) |
missense |
probably benign |
0.00 |
|
R0225:Itgae
|
UTSW |
11 |
73,111,342 (GRCm38) |
missense |
probably benign |
0.00 |
|
R0320:Itgae
|
UTSW |
11 |
73,130,999 (GRCm38) |
missense |
possibly damaging |
0.74 |
|
R0344:Itgae
|
UTSW |
11 |
73,118,147 (GRCm38) |
missense |
probably benign |
0.13 |
|
R0403:Itgae
|
UTSW |
11 |
73,123,183 (GRCm38) |
missense |
possibly damaging |
0.89 |
|
R0833:Itgae
|
UTSW |
11 |
73,129,206 (GRCm38) |
missense |
probably benign |
0.02 |
|
R0836:Itgae
|
UTSW |
11 |
73,129,206 (GRCm38) |
missense |
probably benign |
0.02 |
|
R0973:Itgae
|
UTSW |
11 |
73,138,509 (GRCm38) |
nonsense |
probably null |
|
|
R1231:Itgae
|
UTSW |
11 |
73,119,379 (GRCm38) |
missense |
probably benign |
0.02 |
|
R1389:Itgae
|
UTSW |
11 |
73,125,362 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1433:Itgae
|
UTSW |
11 |
73,115,592 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1534:Itgae
|
UTSW |
11 |
73,145,605 (GRCm38) |
missense |
possibly damaging |
0.58 |
|
R1833:Itgae
|
UTSW |
11 |
73,117,162 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R1914:Itgae
|
UTSW |
11 |
73,118,643 (GRCm38) |
splice site |
probably benign |
|
|
R1915:Itgae
|
UTSW |
11 |
73,118,643 (GRCm38) |
splice site |
probably benign |
|
|
R2061:Itgae
|
UTSW |
11 |
73,118,622 (GRCm38) |
missense |
probably benign |
0.00 |
|
R2380:Itgae
|
UTSW |
11 |
73,145,569 (GRCm38) |
missense |
probably benign |
0.00 |
|
R2435:Itgae
|
UTSW |
11 |
73,121,937 (GRCm38) |
nonsense |
probably null |
|
|
R2680:Itgae
|
UTSW |
11 |
73,114,926 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2886:Itgae
|
UTSW |
11 |
73,140,687 (GRCm38) |
missense |
probably benign |
0.04 |
|
R3873:Itgae
|
UTSW |
11 |
73,113,616 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3923:Itgae
|
UTSW |
11 |
73,116,143 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R4010:Itgae
|
UTSW |
11 |
73,111,339 (GRCm38) |
missense |
probably benign |
0.00 |
|
R4059:Itgae
|
UTSW |
11 |
73,112,134 (GRCm38) |
missense |
probably benign |
|
|
R4212:Itgae
|
UTSW |
11 |
73,119,352 (GRCm38) |
missense |
probably benign |
|
|
R4213:Itgae
|
UTSW |
11 |
73,119,352 (GRCm38) |
missense |
probably benign |
|
|
R4691:Itgae
|
UTSW |
11 |
73,119,519 (GRCm38) |
nonsense |
probably null |
|
|
R4736:Itgae
|
UTSW |
11 |
73,114,880 (GRCm38) |
missense |
possibly damaging |
0.79 |
|
R5152:Itgae
|
UTSW |
11 |
73,130,995 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5201:Itgae
|
UTSW |
11 |
73,110,556 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5307:Itgae
|
UTSW |
11 |
73,145,638 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5362:Itgae
|
UTSW |
11 |
73,111,849 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5448:Itgae
|
UTSW |
11 |
73,133,908 (GRCm38) |
critical splice donor site |
probably null |
|
|
R5645:Itgae
|
UTSW |
11 |
73,129,248 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5672:Itgae
|
UTSW |
11 |
73,145,551 (GRCm38) |
missense |
possibly damaging |
0.96 |
|
R6079:Itgae
|
UTSW |
11 |
73,115,574 (GRCm38) |
missense |
possibly damaging |
0.73 |
|
R6138:Itgae
|
UTSW |
11 |
73,115,574 (GRCm38) |
missense |
possibly damaging |
0.73 |
|
R6226:Itgae
|
UTSW |
11 |
73,140,757 (GRCm38) |
missense |
probably benign |
0.11 |
|
R6244:Itgae
|
UTSW |
11 |
73,145,601 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R6326:Itgae
|
UTSW |
11 |
73,131,693 (GRCm38) |
missense |
possibly damaging |
0.88 |
|
R6332:Itgae
|
UTSW |
11 |
73,111,402 (GRCm38) |
splice site |
probably null |
|
|
R6502:Itgae
|
UTSW |
11 |
73,145,592 (GRCm38) |
missense |
probably benign |
0.10 |
|
R6825:Itgae
|
UTSW |
11 |
73,118,496 (GRCm38) |
missense |
possibly damaging |
0.89 |
|
R7016:Itgae
|
UTSW |
11 |
73,119,516 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R7020:Itgae
|
UTSW |
11 |
73,111,369 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7069:Itgae
|
UTSW |
11 |
73,116,143 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R7132:Itgae
|
UTSW |
11 |
73,111,358 (GRCm38) |
missense |
possibly damaging |
0.93 |
|
R7473:Itgae
|
UTSW |
11 |
73,140,678 (GRCm38) |
missense |
possibly damaging |
0.87 |
|
R7599:Itgae
|
UTSW |
11 |
73,121,960 (GRCm38) |
missense |
possibly damaging |
0.62 |
|
R7637:Itgae
|
UTSW |
11 |
73,113,631 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7763:Itgae
|
UTSW |
11 |
73,123,269 (GRCm38) |
critical splice donor site |
probably null |
|
|
R7829:Itgae
|
UTSW |
11 |
73,138,792 (GRCm38) |
missense |
probably benign |
|
|
R7860:Itgae
|
UTSW |
11 |
73,120,273 (GRCm38) |
critical splice acceptor site |
probably null |
|
|
R7978:Itgae
|
UTSW |
11 |
73,134,087 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R8197:Itgae
|
UTSW |
11 |
73,120,384 (GRCm38) |
missense |
probably benign |
|
|
R8911:Itgae
|
UTSW |
11 |
73,113,621 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9155:Itgae
|
UTSW |
11 |
73,125,263 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R9284:Itgae
|
UTSW |
11 |
73,121,926 (GRCm38) |
missense |
probably benign |
0.25 |
|
R9355:Itgae
|
UTSW |
11 |
73,116,080 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9414:Itgae
|
UTSW |
11 |
73,111,803 (GRCm38) |
missense |
possibly damaging |
0.59 |
|
R9595:Itgae
|
UTSW |
11 |
73,125,356 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R9618:Itgae
|
UTSW |
11 |
73,120,345 (GRCm38) |
missense |
possibly damaging |
0.78 |
|
U15987:Itgae
|
UTSW |
11 |
73,115,574 (GRCm38) |
missense |
possibly damaging |
0.73 |
|
X0024:Itgae
|
UTSW |
11 |
73,111,376 (GRCm38) |
missense |
probably benign |
0.01 |
|
Z1186:Itgae
|
UTSW |
11 |
73,103,887 (GRCm38) |
missense |
possibly damaging |
0.74 |
|
Z1186:Itgae
|
UTSW |
11 |
73,134,127 (GRCm38) |
missense |
probably benign |
0.36 |
|
Z1186:Itgae
|
UTSW |
11 |
73,121,957 (GRCm38) |
missense |
probably benign |
0.00 |
|
Z1186:Itgae
|
UTSW |
11 |
73,121,931 (GRCm38) |
missense |
probably benign |
0.00 |
|
Z1186:Itgae
|
UTSW |
11 |
73,118,087 (GRCm38) |
missense |
probably benign |
0.01 |
|
Z1186:Itgae
|
UTSW |
11 |
73,115,640 (GRCm38) |
missense |
probably benign |
|
|
Z1186:Itgae
|
UTSW |
11 |
73,103,960 (GRCm38) |
missense |
probably damaging |
1.00 |
|
Z1187:Itgae
|
UTSW |
11 |
73,103,887 (GRCm38) |
missense |
possibly damaging |
0.74 |
|
Z1187:Itgae
|
UTSW |
11 |
73,103,960 (GRCm38) |
missense |
probably damaging |
1.00 |
|
Z1187:Itgae
|
UTSW |
11 |
73,115,640 (GRCm38) |
missense |
probably benign |
|
|
Z1187:Itgae
|
UTSW |
11 |
73,118,087 (GRCm38) |
missense |
probably benign |
0.01 |
|
Z1187:Itgae
|
UTSW |
11 |
73,121,931 (GRCm38) |
missense |
probably benign |
0.00 |
|
Z1187:Itgae
|
UTSW |
11 |
73,121,957 (GRCm38) |
missense |
probably benign |
0.00 |
|
Z1187:Itgae
|
UTSW |
11 |
73,134,127 (GRCm38) |
missense |
probably benign |
0.36 |
|
Z1188:Itgae
|
UTSW |
11 |
73,103,887 (GRCm38) |
missense |
possibly damaging |
0.74 |
|
Z1188:Itgae
|
UTSW |
11 |
73,134,127 (GRCm38) |
missense |
probably benign |
0.36 |
|
Z1188:Itgae
|
UTSW |
11 |
73,121,957 (GRCm38) |
missense |
probably benign |
0.00 |
|
Z1188:Itgae
|
UTSW |
11 |
73,121,931 (GRCm38) |
missense |
probably benign |
0.00 |
|
Z1188:Itgae
|
UTSW |
11 |
73,118,087 (GRCm38) |
missense |
probably benign |
0.01 |
|
Z1188:Itgae
|
UTSW |
11 |
73,115,640 (GRCm38) |
missense |
probably benign |
|
|
Z1188:Itgae
|
UTSW |
11 |
73,103,960 (GRCm38) |
missense |
probably damaging |
1.00 |
|
Z1189:Itgae
|
UTSW |
11 |
73,103,887 (GRCm38) |
missense |
possibly damaging |
0.74 |
|
Z1189:Itgae
|
UTSW |
11 |
73,134,127 (GRCm38) |
missense |
probably benign |
0.36 |
|
Z1189:Itgae
|
UTSW |
11 |
73,121,957 (GRCm38) |
missense |
probably benign |
0.00 |
|
Z1189:Itgae
|
UTSW |
11 |
73,121,931 (GRCm38) |
missense |
probably benign |
0.00 |
|
Z1189:Itgae
|
UTSW |
11 |
73,118,087 (GRCm38) |
missense |
probably benign |
0.01 |
|
Z1189:Itgae
|
UTSW |
11 |
73,115,640 (GRCm38) |
missense |
probably benign |
|
|
Z1189:Itgae
|
UTSW |
11 |
73,103,960 (GRCm38) |
missense |
probably damaging |
1.00 |
|
Z1190:Itgae
|
UTSW |
11 |
73,134,127 (GRCm38) |
missense |
probably benign |
0.36 |
|
Z1190:Itgae
|
UTSW |
11 |
73,121,957 (GRCm38) |
missense |
probably benign |
0.00 |
|
Z1190:Itgae
|
UTSW |
11 |
73,121,931 (GRCm38) |
missense |
probably benign |
0.00 |
|
Z1190:Itgae
|
UTSW |
11 |
73,118,087 (GRCm38) |
missense |
probably benign |
0.01 |
|
Z1190:Itgae
|
UTSW |
11 |
73,115,640 (GRCm38) |
missense |
probably benign |
|
|
Z1190:Itgae
|
UTSW |
11 |
73,103,960 (GRCm38) |
missense |
probably damaging |
1.00 |
|
Z1190:Itgae
|
UTSW |
11 |
73,103,887 (GRCm38) |
missense |
possibly damaging |
0.74 |
|
Z1191:Itgae
|
UTSW |
11 |
73,134,127 (GRCm38) |
missense |
probably benign |
0.36 |
|
Z1191:Itgae
|
UTSW |
11 |
73,121,957 (GRCm38) |
missense |
probably benign |
0.00 |
|
Z1191:Itgae
|
UTSW |
11 |
73,121,931 (GRCm38) |
missense |
probably benign |
0.00 |
|
Z1191:Itgae
|
UTSW |
11 |
73,118,087 (GRCm38) |
missense |
probably benign |
0.01 |
|
Z1191:Itgae
|
UTSW |
11 |
73,115,640 (GRCm38) |
missense |
probably benign |
|
|
Z1191:Itgae
|
UTSW |
11 |
73,103,960 (GRCm38) |
missense |
probably damaging |
1.00 |
|
Z1191:Itgae
|
UTSW |
11 |
73,103,887 (GRCm38) |
missense |
possibly damaging |
0.74 |
|
Z1192:Itgae
|
UTSW |
11 |
73,121,957 (GRCm38) |
missense |
probably benign |
0.00 |
|
Z1192:Itgae
|
UTSW |
11 |
73,121,931 (GRCm38) |
missense |
probably benign |
0.00 |
|
Z1192:Itgae
|
UTSW |
11 |
73,118,087 (GRCm38) |
missense |
probably benign |
0.01 |
|
Z1192:Itgae
|
UTSW |
11 |
73,115,640 (GRCm38) |
missense |
probably benign |
|
|
Z1192:Itgae
|
UTSW |
11 |
73,103,960 (GRCm38) |
missense |
probably damaging |
1.00 |
|
Z1192:Itgae
|
UTSW |
11 |
73,103,887 (GRCm38) |
missense |
possibly damaging |
0.74 |
|
Z1192:Itgae
|
UTSW |
11 |
73,134,127 (GRCm38) |
missense |
probably benign |
0.36 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGTGTGATGCAAATCCGCCCTC -3'
(R):5'- ACCAGGACTCATCTCAGTGGTCTC -3'
Sequencing Primer
(F):5'- CAAATCCGCCCTCTTCCG -3'
(R):5'- TTCAGCCAGTGAGCTATGC -3'
|
| Posted On |
2013-07-11 |
Incidental Mutation